Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 716,782	$ 532,756
Accounts receivable	24,351	16,562
Inventory	67,009	49,592
Prepaid expenses and other current assets	28,898	23,982
Total current assets	837,040	622,892
Marketable securities	50,043	0
Fixed assets, net	52,955	53,953
Finance lease right-of-use assets	9,256	10,334
Operating lease right-of-use assets	33,305	32,946
Intangibles, net	73,809	49,261
Goodwill	136,110	0
Other assets	50,990	26,769
Total assets	1,243,508	796,155
Current liabilities:
Accounts payable	35,784	42,853
Accrued liabilities	60,665	37,807
Accrued compensation	28,581	25,591
Finance lease liabilities	609	1,081
Operating lease liabilities	9,527	11,475
Total current liabilities	135,166	118,807
Debt, long-term	566,588	356,318
Contingent consideration	75,668	0
Finance lease liabilities, long-term	14,103	14,713
Operating lease liabilities, long-term	21,441	21,255
Other long-term liabilities	20,074	9,178
Total liabilities	833,040	520,271
Shareholders' equity:
Common stock, $0.01 par value; 500,000,000 authorized shares, 118,738,266 and 102,763,060 issued and outstanding shares at December 31, 2021 and December 31, 2020, respectively	1,187	1,028
Additional paid-in capital	2,673,556	2,105,252
Accumulated deficit	(2,265,243)	(1,830,589)
Accumulated other comprehensive income	968	193
Total shareholders' equity	410,468	275,884
Total liabilities and shareholders' equity	$ 1,243,508	$ 796,155