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Consolidated Statements of Cash Flows (unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Operating activities    
Net loss $ (321,676) $ (191,877)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 7,011 6,829
Amortization of intangible assets 3,790 3,745
Stock-based compensation expense 34,501 27,379
Loss on extinguishment of debt 17,689 0
Amortization of debt issuance costs 1,348 1,048
Accretion of debt discount 20,707 14,139
Finance lease amortization expense 809 809
Change in fair value of deferred and contingent consideration liabilities 8,300 0
Noncash operating lease expense 11,218 5,168
Changes in operating assets and liabilities:    
Accounts receivable (2,875) 4,036
Inventory (18,588) (15,116)
Prepaid expenses and other current assets (2,097) 631
Other assets (20,994) (4,786)
Accounts payable (18,854) 9,120
Accrued liabilities and other 6,108 (10,613)
Accrued compensation (5,567) (3,068)
Net cash used in operating activities (279,170) (152,556)
Investing activities    
Purchase of fixed assets (6,147) (5,307)
Cash paid for Business Acquisition, net (6,920) 0
Net cash used in investing activities (13,067) (5,307)
Financing activities    
Proceeds from exercise of stock options, ESPP, and RSU vestings 16,021 13,896
Proceeds from issuance of common stock, net 269,886 245,865
Payment on extinguishment of 1.75% convertible senior notes due 2025 (12,578) 0
Payment of principal on 1.75% convertible senior notes due 2025 (225,000) 0
Proceeds from issuance of 0.75% convertible senior notes due 2028 575,000 0
Payment of debt issuance costs (15,702) 0
Payments of finance lease principal (791) (769)
Net cash provided by financing activities 606,836 258,992
Effect of exchange rates on cash and cash equivalents (799) 195
Net increase in cash and cash equivalents 313,800 101,324
Cash and cash equivalents at beginning of period 532,756 487,429
Cash and cash equivalents at end of period 846,556 588,753
Supplemental disclosures of cash flow information:    
Cash paid for interest 8,202 8,847
Cash paid for income taxes $ 1,451 $ 780