Income Taxes (Tables)

12 Months Ended

Dec. 31, 2020

Income Tax Disclosure [Abstract]

Schedule of Loss Before Income Taxes in the US and Globally

The Company's loss before income taxes in the US and globally was as follows (in thousands):

	Years Ended December 31,
	2020		2019		2018
US	$	(207,120)	$	(201,161)	$	(286,211)
Foreign	(85,568)		(52,399)		(37,865)
Total	$	(292,688)	$	(253,560)	$	(324,076)

Schedule of Components Income Tax (Benefit) Provision

The Company's income tax provision consisted of the following (in thousands):

	Years Ended December 31,
	2020		2019		2018
Current:
Federal	$	—	$	—	$	—
State	268		10		4
Foreign	1,134		767		197
	1,402		777		201
Deferred:
Federal	—		—		—
State	—		—		—
Foreign	—		—		—
	—		—		—
Total	$	1,402	$	777	$	201

Reconciliation Between Federal Statutory Tax Rate and Effective Tax Rate

The reconciliation between the federal statutory tax rates and the Company's effective tax rate is as follows:

	Years Ended December 31,
	2020		2019		2018
Statutory federal tax rate	21	%	21	%	21	%
Permanent items	—	%	(1)	%	—	%
State income taxes, net of federal benefit	4	%	6	%	5	%
R&D and other tax credits	2	%	2	%	2	%
Foreign income taxes	1	%	1	%	(1)	%
Change in valuation allowance	(32)	%	(32)	%	(27)	%
Change in Irish trading status	4	%	3	%	—	%
Effective tax rate	—	%	—	%	—	%

Schedule of Components of Deferred Tax Assets and Liabilities

The components of the deferred tax assets and liabilities consist of the following:

	As of December 31,
	2020		2019
Deferred tax assets:
Net operating loss carryforwards	$	377,093	$	304,266
General business credits	123,305		114,887
Product license	5,652		6,456
Inventory	3,767		3,129
Lease liabilities	12,421		16,439
Stock-based compensation	21,664		20,587
Other	8,550		6,038
Deferred tax assets	$	552,452	$	471,802
Deferred tax liabilities:
Intangibles	$	(9,163)	$	(14,316)
Right-of-use assets	(11,054)		(15,485)
Convertible debt	(22,474)		(28,524)
Deferred tax liabilities	$	(42,691)	$	(58,325)
Net deferred tax assets	$	509,761	$	413,477
Valuation allowance	(509,761)		(413,477)
Net deferred tax assets	$	—	$	—

Schedule of Unrecognized Tax Benefits

The following table summarizes the gross amounts of unrecognized tax benefits (in thousands):

	2020		2019
Balance as of January 1,	$	4,836	$	4,087
Additions related to prior period tax positions	—		—
Reductions related to prior period tax positions	(32)		(60)
Additions related to current period tax positions	829		809
Balance as of December 31,	$	5,633	$	4,836