Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Payables and Accruals [Abstract]
Accrued clinical trial expenses	$ 4,988	$ 6,635
Accrued professional fees	9,421	13,398
Accrued technical operation expenses	10,176	9,371
Accrued royalty payable	1,830	409
Accrued interest payable	1,663	3,631
Accrued sales allowances and related costs	4,640	818
Accrued construction costs	4,693	2,946
Other accrued expenses	1,497	1,046
Total accrued expenses	$ 38,908	$ 38,254