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Debt - Narrative (Details) - USD ($)
1 Months Ended 12 Months Ended
Feb. 28, 2018
Sep. 30, 2016
Oct. 31, 2016
Jan. 31, 2016
Dec. 31, 2017
Sep. 29, 2016
Jun. 29, 2012
Debt              
Payment of end of term charge       $ 390,000      
Hercules              
Debt              
Maximum borrowing capacity of term loan             $ 25,000,000
Interest rate (as a percent)             9.25%
A&R Loan Agreement              
Debt              
Maximum borrowing capacity of term loan   $ 55,000,000          
Interest rate (as a percent)     9.25%        
Amount outstanding   35,000,000       $ 25,000,000  
Amount of borrowings during the period   $ 10,000,000 $ 20,000,000        
Facility fee paid (as a percent)         0.375%    
Backend fee (as a percent)     4.15%        
Facility fee     $ 337,500        
Minimum cash liquidity requirement eliminated         $ 25,000,000    
Additional interest rate in event of default (as a percent)         5.00%    
A&R Loan Agreement | License Agreement with AstraZeneca              
Debt              
Amount outstanding     $ 20,000,000        
A&R Loan Agreement | Prime Rate              
Debt              
Basis spread (as a percent)     (4.50%)        
Forecast | A&R Loan Agreement              
Debt              
Prepayment of debt $ 58,000,000