Net Loss per Share (Tables)

12 Months Ended

Dec. 31, 2021

Earnings Per Share [Abstract]

Reconciliation of Shares Used in Calculating Basic and Diluted Earnings Per Share

A reconciliation of shares used in calculating basic and diluted net loss per share follows:

	Year Ended December 31,
	2021		2020		2019
Net loss (in thousands)	$	(124,974)	$	(107,594)	$	(96,071)
Weighted average number of shares outstanding, basic and diluted	69,606,105		65,888,450		62,593,026
Net loss per share, basic and diluted	$	(1.80)	$	(1.63)	$	(1.53)

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share

The anti-dilutive securities excluded from the shares used to calculate diluted net loss per share are as follows:

	December 31,
	2021	2020
Shares subject to outstanding common stock options and employee stock purchase plan	4,782,487	4,330,686
Restricted stock units	3,732,013	2,953,252
Conversion option of the 2024 Notes	5,961,186	5,961,186
Conversion option of the 2026 Notes	6,879,283	6,879,283
	21,354,969	20,124,407