10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 10-Q

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2023

or

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number: 000-29089

Agenus Inc.

(exact name of registrant as specified in its charter)

Delaware	06-1562417
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

3 Forbes Road, Lexington, Massachusetts 02421

(Address of principal executive offices, including zip code)

Registrant’s telephone number, including area code:

(781) 674-4400

Securities registered or to be registered pursuant to Section 12(b) of the Act.

Title of each class	Trading symbol(s)	Name of each exchange on which registered
Common stock, par value $0.01	AGEN	The Nasdaq Capital Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☒
Non-accelerated filer	☐	Smaller reporting company	☐
		Emerging growth company	☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

Number of shares outstanding of the issuer’s Common Stock as of August 4, 2023: 379,572,187 shares.

Agenus Inc.

Six Months Ended June 30, 2023

Table of Contents

		Page
PART I
ITEM 1.	Financial Statements:	2
	Condensed Consolidated Balance Sheets as of June 30, 2023 (Unaudited) and December 31, 2022	2
	Condensed Consolidated Statements of Operations and Comprehensive Loss for the three and six months ended June 30, 2023 and 2022 (Unaudited)	3
	Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders’ Equity (Deficit) for the three and six months ended June 30, 2023 and 2022 (Unaudited)	4
	Condensed Consolidated Statements of Cash Flows for the six months ended June 30, 2023 and 2022 (Unaudited)	6
	Notes to Unaudited Condensed Consolidated Financial Statements	7
ITEM 2.	Management's Discussion and Analysis of Financial Condition and Results of Operations	17
ITEM 3.	Quantitative and Qualitative Disclosures About Market Risk	22
ITEM 4.	Controls and Procedures	23
PART II
ITEM 1.	Legal Proceedings	24
ITEM 1A.	Risk Factors	24
ITEM 5.	Other Information	24
ITEM 6.	Exhibits	24
	Signatures	25

PART I - FINANCIAL INFORMATION

Item 1. Financial Statements

AGENUS INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEETS

(Amounts in thousands, except share and per share amounts)

	June 30, 2023 (unaudited)			December 31, 2022
ASSETS
Cash and cash equivalents	$	143,205		$	178,674
Short-term investments		14,647			14,684
Accounts receivable		1,341			2,741
Prepaid expenses		8,699			13,829
Other current assets		2,843			3,194
Total current assets		170,735			213,122
Property, plant and equipment, net of accumulated amortization and depreciation of    $58,489 and $54,075 at June 30, 2023 and December 31, 2022, respectively		143,358			133,017
Operating lease right-of-use assets		30,528			31,269
Goodwill		24,728			25,467
Acquired intangible assets, net of accumulated amortization of $17,123 and    $16,148 at June 30, 2023 and December 31, 2022, respectively		4,986			6,228
Other long-term assets		9,258			4,453
Total assets	$	383,593		$	413,556
LIABILITIES AND STOCKHOLDERS’ DEFICIT
Current portion, long-term debt	$	622		$	575
Current portion, liability related to sale of future royalties and milestones		97,778			83,510
Current portion, deferred revenue		7,828			12,269
Current portion, operating lease liabilities		1,905			1,943
Accounts payable		52,473			40,939
Accrued liabilities		30,194			38,259
Other current liabilities		13,268			11,457
Total current liabilities		204,068			188,952
Long-term debt, net of current portion		12,673			12,584
Liability related to sale of future royalties and milestones, net of current portion		169,142			187,753
Deferred revenue, net of current portion		1,143			1,143
Operating lease liabilities, net of current portion		62,253			63,326
Other long-term liabilities		11,075			14,700
Commitments and contingencies
STOCKHOLDERS’ DEFICIT
Series A-1 convertible preferred stock; 31,620 shares designated, issued, and    outstanding at June 30, 2023 and December 31, 2022; liquidation value    of $33,779 at June 30, 2023		0			0
Common stock, par value $0.01 per share; 800,000,000 shares authorized;    367,491,091 and 305,573,397 shares issued at June 30, 2023    and December 31, 2022, respectively		3,675			3,056
Additional paid-in capital		1,751,024			1,644,658
Accumulated other comprehensive income (loss)		(717	)		915
Accumulated deficit		(1,847,177	)		(1,709,907	)
Total stockholders’ deficit attributable to Agenus Inc.		(93,195	)		(61,278	)
Non-controlling interest		16,434			6,376
Total stockholders’ deficit		(76,761	)		(54,902	)
Total liabilities and stockholders’ deficit	$	383,593		$	413,556

See accompanying notes to unaudited condensed consolidated financial statements.

2

AGENUS INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

(Unaudited)

(Amounts in thousands, except per share amounts)

	Three Months Ended June 30,						Six Months Ended June 30,
	2023			2022			2023			2022
Revenue:
Research and development	$	2,489		$	1,907		$	5,101		$	8,647
Royalty sales milestone		—			17,316			—			17,316
Service revenue		739			1,559			1,923			3,126
Non-cash royalty revenue related to the sale of future royalties		22,068			144			41,174			17,778
Total revenues		25,296			20,926			48,198			46,867
Operating expenses:
Cost of service revenue		(254	)		(2,024	)		(2,548	)		(2,567	)
Research and development		(59,285	)		(44,960	)		(116,402	)		(87,404	)
General and administrative		(20,415	)		(18,914	)		(38,653	)		(37,866	)
Contingent purchase price consideration fair value adjustment		(8	)		407			398			943
Operating loss		(54,666	)		(44,565	)		(109,007	)		(80,027	)
Other income (expense):
Non-operating income (expense)		(244	)		9,061			(204	)		9,118
Interest expense, net		(18,520	)		(13,731	)		(35,112	)		(28,930	)
Net loss		(73,430	)		(49,235	)		(144,323	)		(99,839	)
Dividends on Series A-1 convertible preferred stock		(53	)		(53	)		(107	)		(106	)
Less: net loss attributable to non-controlling interest		(4,414	)		(2,801	)		(7,053	)		(5,081	)
Net loss attributable to Agenus Inc. common stockholders	$	(69,069	)	$	(46,487	)	$	(137,377	)	$	(94,864	)
Per common share data:
Basic and diluted net loss attributable to Agenus Inc. common stockholders	$	(0.20	)	$	(0.17	)	$	(0.41	)	$	(0.35	)
Weighted average number of Agenus Inc. common shares outstanding:
Basic and diluted		351,379			277,033			334,339			267,723
Other comprehensive loss:
Foreign currency translation gain (loss)	$	(1,634	)	$	1,179		$	(1,632	)	$	657
Other comprehensive gain (loss)		(1,634	)		1,179			(1,632	)		657
Comprehensive loss	$	(70,703	)	$	(45,308	)	$	(139,009	)	$	(94,207	)

See accompanying notes to unaudited condensed consolidated financial statements.

3

AGENUS INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY (DEFICIT)

(Unaudited)

(Amounts in thousands)

	Series A-1
	Convertible
	Preferred Stock				Common Stock									Treasury Stock
	Number of Shares		Par Value		Number of Shares			Par Value			Additional Paid-In Capital			Number of Shares			Amount			Accumulated Other Comprehensive Income (Loss)			Non-controlling Interest			Accumulated Deficit			Total
Balance at December 31, 2022		32	$	0		305,574		$	3,056		$	1,644,658			—		$	—		$	915		$	6,376		$	(1,709,907	)	$	(54,902	)
Net loss		—		—		—			—			—			—			—			—			(2,639	)		(68,254	)		(70,893	)
Other comprehensive income		—		—		—			—			—			—			—			2			—			—			2
Share-based compensation		—		—		—			—			4,566			—			—			—			919			—			5,485
Shares sold at the market		—		—		33,785			338			60,245			—			—			—			—			—			60,583
Issuance of director deferred shares		—		—		250			3			980			—			—			—			—			—			983
Issuance of shares for services		—		—		132			1			317			—			—			—			—			—			318
Vesting of nonvested shares		—		—		5			—			—			—			—			—			—			—			—
Exercise of stock options and employee share purchases		—		—		197			2			327			—			—			—			45			—			374
Issuance of subsidiary shares for employee bonus		—		—		—			—			—			—			—			—			726			—			726
Issuance of shares for employee bonus		—		—		2,716			27			4,198			(10	)		(2,429	)		—			—			—			1,796
Retirement of treasury shares		—		—		(996	)		(10	)		—			10			2,429			—			—			—			2,419
Balance at March 31, 2023		32	$	0		341,663		$	3,417		$	1,715,291			—		$	—		$	917		$	5,427		$	(1,778,161	)	$	(53,109	)
Net loss		—		—		—			—			—			—			—			—			(4,414	)		(69,016	)		(73,430	)
Other comprehensive income		—		—		—			—			—			—			—			(1,634	)		—			—			(1,634	)
Share-based compensation		—		—		—			—			5,154			—			—			—			888			—			6,042
Shares sold at the market		—		—		24,557			246			42,001			—			—			—			—			—			42,247
Vesting of nonvested shares		—		—		17			—			—			—			—			—			—			—			—
MiNK stock dividend		—		—		—			—			(14,888	)		—			—			—			14,888			—			—
MiNK stock purchases		—		—		—			—			405			—			—			—			(640	)		—			(235	)
Issuance of subsidiary shares for employee bonus		—		—		—			—			—			—			—			—			285			—			285
Issuance of shares for employee bonus		—		—		1,928			19			3,061			(7	)		(1,642	)		—			—			—			1,438
Retirement of treasury shares		—		—		(673	)		(7	)		—			7			1,642			—			—			—			1,635
Balance at June 30, 2023		32	$	0		367,492		$	3,675		$	1,751,024			—		$	—		$	(717	)	$	16,434		$	(1,847,177	)	$	(76,761	)

See accompanying notes to unaudited condensed consolidated financial statements.

4

AGENUS INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS’ EQUITY (DEFICIT)

(Unaudited)

(Amounts in thousands)

	Series A-1
	Convertible
	Preferred Stock				Common Stock									Treasury Stock
	Number of Shares		Par Value		Number of Shares			Par Value			Additional Paid-In Capital			Number of Shares			Amount			Accumulated Other Comprehensive Income (Loss)			Non-controlling Interest			Accumulated Deficit			Total
Balance at December 31, 2021		32	$	0		256,899		$	2,569		$	1,520,212			—		$	—		$	1,492		$	13,469		$	(1,489,833	)	$	47,909
Net loss		—		—		—			—			—			—			—			—			(2,279	)		(48,325	)		(50,604	)
Other comprehensive loss		—		—		—			—			—			—			—			(522	)		—			—			(522	)
Share-based compensation		—		—		—			—			4,205			—			—			—			742			—			4,947
Shares sold at the market		—		—		7,039			70			19,112			—			—			—			—			—			19,182
Issuance of director deferred shares		—		—		5			—			19			—			—			—			—			—			19
Issuance of shares for services		—		—		21			1			80			—			—			—			—			—			81
Vesting of nonvested shares		—		—		143			1			(1	)		—			—			—			—			—			—
Exercise of stock options and employee share purchases		—		—		136			1			367			—			—			—			—			—			368
Issuance of shares for employee bonus		—		—		3,845			38			6,245			(1,347	)		(3,380	)		—			—			—			2,903
Retirement of treasury shares		—		—		(1,347	)		(13	)		—			1,347			3,380			—			—			—			3,367
Balance at March 31, 2022		32	$	0		266,741		$	2,667		$	1,550,239			—		$	—		$	970		$	11,932		$	(1,538,158	)	$	27,650
Net loss		—		—		—			—			—			—			—			—			(2,801	)		(46,434	)		(49,235	)
Other comprehensive income		—		—		—			—			—			—			—			1,179			—			—			1,179
Share-based compensation		—		—		—			—			3,818			—			—			—			797			—			4,615
Shares sold at the market		—		—		15,782			158			28,079			—			—			—			—			—			28,237
Issuance of shares for milestone achievement		—		—		180			2			498			—			—			—			—			—			500
Issuance of shares for services		—		—		7			1			19			—			—			—			—			—			20
Exercise of stock options		—		—		6			—			14			—			—			—			—			—			14
Issuance of subsidiary shares for employee bonus		—		—		—			—			—			—			—			—			294			—			294
Issuance of shares for employee bonus		—		—		246			2			363			(100	)		(251	)		—			—			—			114
Retirement of treasury shares		—		—		(100	)		(1	)		—			100			251			—			—			—			250
Balance at June 30, 2022		32	$	0		282,862		$	2,829		$	1,583,030			—		$	—		$	2,149		$	10,222		$	(1,584,592	)	$	13,638

See accompanying notes to unaudited condensed consolidated financial statements.

5

AGENUS INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(Amounts in thousands, except per share amounts)

	Six Months Ended June 30,
	2023			2022
Cash flows from operating activities:
Net loss	$	(144,323	)	$	(99,839	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		5,535			3,350
Share-based compensation		11,527			9,625
Non-cash royalty revenue		(41,174	)		(17,778	)
Non-cash interest expense		36,920			28,588
Loss (gain) on sale of assets		49			(6,601	)
Other, net		249			—
Gain on partial forgiveness of liability		—			(2,791	)
Change in fair value of contingent obligations		(398	)		(943	)
Changes in operating assets and liabilities:
Accounts receivable		1,021			(17,130	)
Prepaid expenses		5,427			(2,947	)
Accounts payable		7,969			363
Deferred revenue		(4,439	)		(3,284	)
Accrued liabilities and other current liabilities		8,135			(1,553	)
Other operating assets and liabilities		(5,067	)		15,096
Net cash used in operating activities		(118,569	)		(95,844	)
Cash flows from investing activities:
Purchases of plant and equipment		(6,279	)		(22,996	)
Proceeds from sale of property, plant and equipment		350			10,002
Purchase of long-term investment		(5,396	)		—
Cash paid for business acquisition		—			(3,652	)
Purchases of available-for-sale securities		(14,647	)		(9,945	)
Proceeds from sale of available-for-sale securities		15,000			15,000
Net cash used in investing activities		(10,972	)		(11,591	)
Cash flows from financing activities:
Net proceeds from sale of equity		102,829			47,419
Proceeds from employee stock purchases and option exercises		397			382
Purchase of treasury shares to satisfy tax withholdings		(4,566	)		(3,789	)
Purchase of subsidiary shares		(236	)		—
Payment of finance lease obligation		(3,911	)		(178	)
Net cash provided by financing activities		94,513			43,834
Effect of exchange rate changes on cash		(441	)		55
Net decrease in cash, cash equivalents and restricted cash		(35,469	)		(63,546	)
Cash, cash equivalents and restricted cash, beginning of period		181,343			294,600
Cash, cash equivalents and restricted cash, end of period	$	145,874		$	231,054
Supplemental cash flow information:
Cash paid for interest	$	1,705		$	568
Supplemental disclosures - non-cash activities:
Purchases of plant and equipment in accounts payable and    accrued liabilities	$	4,762		$	10,555
Issuance of common stock, $0.01 par value, in connection with payment for services		318			101
Insurance financing agreement		707			933
Issuance of common stock, $0.01 par value, for payment of certain employee bonuses		7,288			6,634
Issuance of common stock, $0.01 par value, for milestone achievement		—			500
Issuance of subsidiary shares for employee bonus		1,011			294
Lease right-of-use assets obtained in exchange for new operating lease liabilities		287			9,148
Lease right-of-use assets obtained in exchange for new finance lease liabilities		4,635			648

See accompanying notes to unaudited condensed consolidated financial statements.

6

AGENUS INC. AND SUBSIDIARIES

NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

June 30, 2023

Note A - Business, Liquidity and Basis of Presentation

Agenus Inc. (including its subsidiaries, collectively referred to as “Agenus,” the “Company,” “we,” “us,” and “our”) is a clinical-stage company focused on developing therapies that harness the body’s immune system to combat cancer and infections. Our pipeline includes immune-modulatory antibodies, adoptive cell therapies through our subsidiary MiNK Therapeutics, Inc. (“MiNK”), and vaccine adjuvants through our subsidiary SaponiQx, Inc. (“SaponiQx”). Our approach to Immuno-oncology (“I-O”) emphasizes speed, innovation, and effective combination therapies to drive success. We believe that combination therapies and a deep understanding of each patient’s cancer will significantly expand the patient population benefiting from I-O treatments.

In addition to our diverse pipeline, we have built fully integrated capabilities encompassing novel target discovery, antibody generation, cell line development, and good manufacturing practice clinical manufacturing. We believe these integrated capabilities enable us to develop novel candidates on accelerated timelines compared to industry standards. Through strategic partnerships, we leverage our scientific expertise and capabilities to advance innovation in the field.

Our I-O portfolio is driven by several platforms and programs, which we plan to utilize individually and in combination:

•Multiple antibody discovery platforms, including proprietary display technologies, to identify future antibody candidates.

•Antibody candidate programs, including our lead asset, botensilimab, an Fc-enhanced CTLA-4 antibody. Data presented at the 2023 ESMO World Congress Gastrointestinal Cancer conference (“ESMO GI”) demonstrated significant activity in microsatellite stable colorectal cancer when combined with balstilimab (PD-1). In a late-breaking presentation at ESMO GI, the combination of botensilimab/balstilimab showed a median Overall Survival of 20.9 months for patients without active liver metastases, surpassing the recently reported 12.9 month benchmark with standard of care in this population. In April 2023, the botensilimab/balstilimab combination received Fast Track designation from the United States Food and Drug Administration (“FDA”) for the treatment of non-MSI-H/deficient mismatch repair (dMMR) metastatic colorectal cancer patients without active liver involvement.

•Our saponin-based vaccine adjuvant platform, primarily centered around our STIMULONTM cultured plant cell (“cpc”) QS-21 adjuvant (“STIMULON cpc QS-21”).

•A pipeline of novel allogeneic invariant natural killer T cell therapies for treating cancer and other immune-mediated diseases, controlled by MiNK.

Our business activities encompass various areas such as product research, preclinical and clinical development, intellectual property prosecution, manufacturing, regulatory and clinical affairs, corporate finance and development activities, and support of collaborations. Our strategy includes developing and commercializing product candidates through existing and new collaborations.

Our cash, cash equivalents and short-term investments at June 30, 2023 were $157.9 million, a decrease of $35.5 million from December 31, 2022. Cash and cash equivalents of our subsidiary, MiNK, at March 31, 2023, were $14.9 million. MiNK cash can only be accessed by Agenus through a declaration of a dividend by the MiNK Board of Directors or through settlement of intercompany balances.

We have incurred losses since our inception. As of June 30, 2023, we had an accumulated deficit of $1.8 billion.

We have historically financed our operations through income and revenues generated from corporate partnerships, advance royalty sales and equity issuances. Based on our current plans and projections, we believe our cash resources of $157.9 million at June 30, 2023 will be sufficient to satisfy our liquidity needs for more than one year from when these financial statements were issued.

Management consistently monitors our liquidity position and has the flexibility to adjust spending as necessary to preserve and extend liquidity. We regularly assess the likelihood of success of our programs, and our funding decisions are based on these evaluations. We are prepared to discontinue funding of any activities that do not impact our core priorities and to restrict capital expenditures and/or reduce the scale of our operations. Potential funding sources may include collaborations, out-licensing and/or partnering opportunities for our portfolio programs and product candidates with multiple parties, milestone payments from our existing partnerships, additional third-party agreements, asset sales, project financing, and/or sales of equity securities.

The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) for interim financial information and with the instructions to Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete annual consolidated financial statements. In the opinion of our management, the condensed consolidated financial statements include all

7

normal and recurring adjustments considered necessary for a fair presentation of our financial position and operating results. All significant intercompany transactions and accounts have been eliminated in consolidation. Operating results for the six months ended June 30, 2023, are not necessarily indicative of the results that may be expected for the year ending December 31, 2023. For further information, refer to our consolidated financial statements and footnotes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2022 filed with the Securities and Exchange Commission (“SEC”).

The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Management bases its estimates on historical experience and on various assumptions that are believed to be reasonable under the circumstances. Actual results could differ materially from those estimates.

For our foreign subsidiaries, the local currency is the functional currency. Assets and liabilities of our foreign subsidiaries are translated into U.S. dollars using rates in effect at the balance sheet date while revenues and expenses are translated into U.S. dollars using average exchange rates during the period. The cumulative translation adjustment resulting from changes in exchange rates are included in the consolidated balance sheets as a component of accumulated other comprehensive income in total stockholders’ equity (deficit).

During the quarter ended June 30, 2023, we deconsolidated certain foreign subsidiaries and recognized a gain of $132,000, included in "Other income (expense)" on our condensed consolidated statements of operations and comprehensive loss.

Note B - Net Loss Per Share

Basic net loss per common share is calculated by dividing the net loss attributable to common stockholders by the weighted average number of common shares outstanding (including common shares issuable under our Amended and Restated Directors’ Deferred Compensation Plan, or “DDCP”). Diluted loss per common share is calculated by dividing loss attributable to common stockholders by the weighted average number of common shares outstanding (including common shares issuable under our DDCP) plus the dilutive effect of outstanding instruments such as warrants, stock options, non-vested shares and convertible preferred stock. Because we reported a net loss attributable to common stockholders for all periods presented, diluted loss per common share is the same as basic loss per common share, as the effect of utilizing the fully diluted share count would have reduced the net loss per common share. The following securities (listed on an as-if-converted-to-Common-Stock basis) have been excluded from the computation of diluted weighted average shares outstanding as of June 30, 2023 and 2022, as they would be anti-dilutive (in thousands):

	Three and Six Months Ended June 30,
	2023		2022
Warrants		1,980		1,980
Stock options		44,396		36,476
Non-vested shares		542		271
Series A-1 convertible preferred stock		333		333

Note C - Investments

Cash equivalents and short-term investments consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023				December 31, 2022
	Cost		Estimated Fair Value		Cost		Estimated Fair Value
Institutional money market funds	$	72,375	$	72,375	$	149,856	$	149,856
U.S. Treasury Bills		69,291		69,291		29,522		29,522
Total	$	141,666	$	141,666	$	179,378	$	179,378

As a result of the short-term nature of these investments, there were minimal unrealized holding gains or losses for the three and six months ended June 30, 2023 and 2022.

Of the investments listed above, $127.0 million and $164.7 million were classified as cash equivalents and $14.6 million and $14.7 million as short-term investments on our condensed consolidated balance sheets as of June 30, 2023 and December 31, 2022, respectively.

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Note D - Goodwill and Acquired Intangible Assets

The following table sets forth the changes in the carrying amount of goodwill for the six months ended June 30, 2023 (in thousands):

Balance, December 31, 2022	$	25,467
Disposals	$	(805	)
Foreign currency translation adjustment		66
Balance, June 30, 2023	$	24,728

Acquired intangible assets consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	As of June 30, 2023
	Amortization period  (years)	Gross carrying amount		Accumulated amortization			Net carrying amount
Intellectual property	7-15 years	$	16,840	$	(14,756	)	$	2,084
Trademarks	4-4.5 years		1,214		(1,145	)		69
Other	2-7 years		1,998		(1,222	)		776
In-process research and development	Indefinite		2,057		—			2,057
Total		$	22,109	$	(17,123	)	$	4,986

	As of December 31, 2022
	Amortization period  (years)	Gross carrying amount		Accumulated amortization			Net carrying amount
Intellectual property	7-15 years	$	16,790	$	(13,782	)	$	3,008
Trademarks	4-4.5 years		1,272		(1,139	)		133
Other	2-6 years		2,278		(1,227	)		1,051
In-process research and development	Indefinite		2,036		—			2,036
Total		$	22,376	$	(16,148	)	$	6,228

The weighted average amortization period of our finite-lived intangible assets is 9 years. Amortization expense related to acquired intangibles is estimated at $0.6 million for the remainder of 2023, $0.6 million for the year ending December 31, 2024, $0.5 million for the years ending December 31, 2025 and 2026 and $0.4 million for the year ending December 31, 2027.

Note E - Debt

Debt obligations consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

Debt instrument	Balance at June 30, 2023
Current Portion:
Debentures	$	146
Other		476
Long-term Portion:
2015 Subordinated Notes		12,673
Total	$	13,295

Debt instrument	Balance at December 31, 2022
Current Portion:
Debentures	$	146
Other		429
Long-term Portion:
2015 Subordinated Notes		12,584
Total	$	13,159

As of both June 30, 2023 and December 31, 2022, the principal amount of our outstanding debt balance was $13.6 million.

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Note F – Liability Related to the Sale of Future Royalties and Milestones

The following table shows the activity within the liability account in the six months ended June 30, 2023 (in thousands):

	Period from December 31, 2022 to June 30, 2023
Liability related to sale of future royalties and milestones - beginning balance	$	271,560
Non-cash royalty revenue		(41,174	)
Non-cash interest expense recognized		36,801
Liability related to sale of future royalties and milestones - ending balance		267,187
Less: unamortized transaction costs		(267	)
Liability related to sale of future royalties and milestones, net	$	266,920

Healthcare Royalty Partners

In January 2018, we, through our wholly-owned subsidiary Antigenics, LLC (“Antigenics”), entered into a Royalty Purchase Agreement (the “HCR Royalty Purchase Agreement”) with Healthcare Royalty Partners III, L.P. and certain of its affiliates (collectively, “HCR”). Pursuant to the terms of the HCR Royalty Purchase Agreement, we sold to HCR 100% of Antigenics’ worldwide rights to receive royalties from GlaxoSmithKline (“GSK”) on sales of GSK’s vaccines containing our QS-21 STIMULON adjuvant. At closing, we received gross proceeds of $190.0 million from HCR. Although we sold all of our rights to receive royalties on sales of GSK’s vaccines containing QS-21, as a result of our obligation to HCR, we are required to account for the $190.0 million in proceeds from this transaction as a liability on our condensed consolidated balance sheet that will be recognized into revenue in proportion to the royalty payments from GSK to HCR over the estimated life of the HCR Royalty Purchase Agreement. The liability is classified between the current and non-current portion of liability related to sale of future royalties and milestones in the condensed consolidated balance sheets based on the estimated royalty payments to be received by HCR in the next 12 months from the financial statement reporting date.

During the six months ended June 30, 2023, we recognized $41.2 million of non-cash royalty revenue, and we recorded $36.8 million of related non-cash interest expense related to the HCR Royalty Purchase Agreement.

As royalties are remitted to HCR from GSK, the balance of the recorded liability will be effectively repaid over the life of the HCR Royalty Purchase Agreement. To determine the amortization of the recorded liability, we are required to estimate the total amount of future royalty payments to be received by HCR. The sum of these amounts less the $190.0 million proceeds we received will be recorded as interest expense over the life of the HCR Royalty Purchase Agreement. Periodically, we assess the estimated royalty payments to be paid to HCR from GSK, and to the extent the amount or timing of the payments is materially different from our original estimates, we will prospectively adjust the amortization of the liability, and the related recognition of interest expense. During the six months ended June 30, 2023, our estimate of the effective annual interest rate over the life of the agreement increased to 30.4%, which results in a life of contract interest rate of 23.6%.

Note G - Accrued and Other Current Liabilities

Accrued liabilities consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023		December 31, 2022
Payroll	$	7,957	$	15,872
Professional fees		5,771		6,946
Contract manufacturing costs		2,857		1,848
Research services		8,511		7,074
Other		5,098		6,519
Total	$	30,194	$	38,259

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Other current liabilities consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023		December 31, 2022
Finance lease liabilities	$	9,894	$	7,952
Other		3,374		3,505
Total	$	13,268	$	11,457

Note H - Fair Value Measurements

Assets and liabilities measured at fair value are summarized below (in thousands):

Description	June 30, 2023		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Assets:
Cash equivalents (Note C)	$	127,020	$	127,020	$	—	$	—
Short-term investments (Note C)		14,647		14,647		—		—
Long-term investments		5,015		5,015		—		—
Total	$	146,682	$	146,682	$	—	$	—
Liabilities:
Contingent purchase price considerations	$	476	$	—	$	—	$	476
Total	$	476	$	—	$	—	$	476
Description	December 31, 2022		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Assets:
Cash equivalents (Note C)	$	164,694	$	—	$	—	$	—
Short-term investments (Note C)		14,689		—		—		—
Total	$	179,383	$	—	$	—	$	—
Liabilities:
Contingent purchase price consideration	$	874	$	—	$	—	$	874
Total	$	874	$	—	$	—	$	874

We measure our contingent purchase price considerations at fair value. The fair values of our contingent purchase price considerations at June 30, 2023 and December 31, 2022, of $0.5 million and $0.9 million, respectively, included in "Other long-term liabilities" in our condensed consolidated balance sheets, are based on significant inputs not observable in the market, which require them to be reported as Level 3 liabilities within the fair value hierarchy. The valuation of these liabilities use assumptions we believe would be made by a market participant and are mainly based on estimates from a Monte Carlo simulation of our share price, as well as other factors impacting the probability of triggering the milestone payments. Share price was evolved using a geometric Brownian motion, calculated daily for the life of the contingent purchase price considerations.

The fair value of our outstanding debt balance at June 30, 2023 and December 31, 2022 was $13.3 million and $13.2 million, respectively, based on the Level 2 valuation hierarchy of the fair value measurements standard using a present value methodology that was derived by evaluating the nature and terms of each note and considering the prevailing economic and market conditions at the balance sheet date. The principal amount of our outstanding debt balance at both June 30, 2023 and December 31, 2022 was $13.6 million.

Note I - Revenue from Contracts with Customers

Gilead Collaboration Agreement

On December 20, 2018, we entered into a series of agreements with Gilead Sciences, Inc. (“Gilead”) focused on the development and commercialization of up to five novel immuno-oncology therapies. Pursuant to the terms of the license agreement, the option and license agreements and the stock purchase agreement we entered into with Gilead (collectively, the “Gilead

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Collaboration Agreements”), at the closing of the transaction on January 23, 2019, we received an upfront cash payment from Gilead of $120.0 million and Gilead made a $30.0 million equity investment in Agenus. On November 6, 2020, we received notice from Gilead that it was returning AGEN1423 to us and voluntarily terminating the applicable license agreement. The termination was effective as of February 4, 2021. In the third quarter of 2021 we ceased development of AGEN1223 and in October 2021 the AGEN1223 option and license agreement was formally terminated. The AGEN2373 option and license agreement and the stock purchase agreement remain in full force and effect. We remain eligible to receive a $50.0 million exercise fee and, if exercised, up to $520.0 million in aggregate potential milestones.

Collaboration Revenue

For the three months ended June 30, 2023 and 2022, we recognized approximately $2.0 million and $1.2 million, respectively, of research and development revenue based on the partial satisfaction of the over time performance obligations as of quarter end.

For the six months ended June 30, 2023, we recognized approximately $4.4 million of research and development revenue based on the partial satisfaction of the over time performance obligations as of period end. For the six months ended June 30, 2022, we recognized research and development revenue of $5.0 million related to the achievement of a milestone and $2.6 million based on the partial satisfaction of the over time performance obligations as of period end.

We expect to recognize deferred research and development revenue of $7.8 million for the remainder of 2023 related to performance obligations that are unsatisfied or partially unsatisfied as of June 30, 2023.

Disaggregation of Revenue

The following table presents revenue (in thousands) for the three and six months ended June 30, 2023 and 2022, disaggregated by geographic region and revenue type. Revenue by geographic region is allocated based on the domicile of our respective business operations.

	Three months ended June 30, 2023
	United States		Rest of World		Total
Revenue Type
Research and development services		444		—		444
Other services		—		739		739
Recognition of deferred revenue		2,045		—		2,045
Non-cash royalties		22,068		—		22,068
	$	24,557	$	739	$	25,296
	Three months ended June 30, 2022
Revenue Type
Royalty sales milestone	$	17,316	$	—	$	17,316
Research and development services		660		—		660
Other services		—		1,559		1,559
Recognition of deferred revenue		1,247		—		1,247
Non-cash royalties		144		—		144
	$	19,367	$	1,559	$	20,926

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	Six months ended June 30, 2023
	United States		Rest of World		Total
Revenue Type
Research and development services		711		—		711
Other services		—		1,923		1,923
Recognition of deferred revenue		4,390		—		4,390
Non-cash royalties		41,174		—		41,174
	$	46,275	$	1,923	$	48,198
	Six months ended June 30, 2022
Revenue Type
License fees and milestones	$	5,000	$	—	$	5,000
Royalty sales milestone		17,316		—		17,316
Research and development services		1,032		—		1,032
Other services		—		3,126		3,126
Recognition of deferred revenue		2,615		—		2,615
Non-cash royalties		17,778		—		17,778
	$	43,741	$	3,126	$	46,867

Contract Balances

Contract assets primarily relate to our rights to consideration for work completed in relation to our research and development services performed but not billed at the reporting date. The contract assets are transferred to receivables when the rights become unconditional. Currently, we do not have any contract assets which have not transferred to a receivable. We had no asset impairment charges related to contract assets in the period. Contract liabilities primarily relate to contracts where we received payments but have not yet satisfied the related performance obligations. The advance consideration received from customers for research and development services or licenses bundled with other promises is a contract liability until the underlying performance obligations are transferred to the customer.

The following table provides information about contract liabilities from contracts with customers (in thousands):

Six months ended June 30, 2023	Balance at beginning of period		Additions		Deductions			Balance at end of period
Contract liabilities:
Deferred revenue	$	13,412	$	6	$	(4,447	)	$	8,971

The change in contract liabilities is primarily related to the recognition of $4.4 million of revenue related to the Gilead Collaboration Agreements during the six months ended June 30, 2023. Deferred revenue related to the Gilead Collaboration Agreements of $7.8 million as of June 30, 2023, which was comprised of the $142.5 million initial transaction price, less $134.7 million of license and collaboration revenue recognized from the effective date of the contract, will be recognized as the combined performance obligation is satisfied.

We also recorded a $1.3 million receivable as of June 30, 2023, for research and development and other services provided.

During the six months ended June 30, 2023, we did not recognize any revenue from amounts included in the contract asset or the contract liability balances from performance obligations satisfied in previous periods. None of the costs to obtain or fulfill a contract were capitalized.

Note J - Share-based Compensation Plans

We primarily use the Black-Scholes option pricing model to value stock options granted to employees and non-employees, including stock options granted to members of our Board of Directors. However, the fair value of stock option market-based awards is

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calculated based on a Monte Carlo simulation as of the date of issuance. All stock options have 10-year terms and generally vest ratably over a 3 or 4-year period.

A summary of option activity for the six months ended June 30, 2023 is presented below:

	Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Outstanding at December 31, 2022		35,984,967		$	3.51
Granted		9,439,902			2.35
Exercised		(46,750	)		1.68
Forfeited		(532,835	)		2.58
Expired		(448,863	)		3.78
Outstanding at June 30, 2023		44,396,421		$	3.27		6.91	$	53,747
Vested or expected to vest at June 30, 2023		44,396,421		$	3.27		6.91	$	53,747
Exercisable at June 30, 2023		26,931,597		$	3.60		5.88	$	7,016

The weighted average grant-date fair values of stock options granted during the six months ended June 30, 2023 and 2022 were $1.49 and $1.76, respectively.

As of June 30, 2023, there was approximately $32.7 million of total unrecognized share-based compensation expense related to these stock options and stock options granted under subsidiary plans which, if all milestones are achieved, will be recognized over a weighted average period of 2.0 years.

Certain employees and consultants have been granted non-vested stock. The fair value of non-vested market-based awards is calculated based on a Monte Carlo simulation as of the date of issuance. The fair value of other non-vested stock is calculated based on the closing sale price of our common stock on the date of issuance.

A summary of non-vested stock activity for the six months ended June 30, 2023 is presented below:

	Non-vested Shares			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2022		355,802		$	2.50
Granted		4,971,652			2.41
Vested		(4,665,474	)		2.45
Forfeited		(120,000	)		1.88
Outstanding at June 30, 2023		541,980		$	2.37

As of June 30, 2023, there was approximately $1.2 million of unrecognized share-based compensation expense related to these non-vested shares and non-vested shares granted under subsidiary plans which will be recognized over a period of 2.0 years.

During the six months ended June 30, 2023, 150,291 shares were issued under the 2019 Employee Stock Purchase Plan, 46,750 shares were issued as a result of stock option exercises and 21,666 shares were issued as a result of the vesting of non-vested stock. Additionally, 4,643,808 shares were issued as payment for certain employee bonuses, with 1,668,767 of those shares being withheld to cover taxes, resulting in a net share issuance of 2,975,041.

The impact on our results of operations from share-based compensation for the three and six months ended June 30, 2023 and 2022, was as follows (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Research and development	$	1,656	$	1,192	$	3,389	$	2,531
General and administrative		4,386		3,423		8,138		7,031
Total share-based compensation expense	$	6,042	$	4,615	$	11,527	$	9,562

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Note K – Restricted Cash

As of both June 30, 2023, and December 31, 2022, we maintained non-current restricted cash of $2.7 million. This amount is included within “Other long-term assets” in our condensed consolidated balance sheets and is comprised of letters of credit required under two of our facility leases.

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Six Months Ended June 30, 2023				Six Months Ended June 30, 2022
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	178,674	$	143,205	$	291,931	$	228,385
Restricted cash		2,669		2,669		2,669		2,669
Cash, cash equivalents and restricted cash	$	181,343	$	145,874	$	294,600	$	231,054

Note L – Equity

On June 23, 2023, we filed an Automatic Shelf Registration Statement on Form S-3ASR (file no. 333-272911) (the “Registration Statement”). The Registration Statement included both a base prospectus that covered the potential offering, issuance and sale from time to time of common stock, preferred stock, warrants, debt securities and units of Agenus and a prospectus supplement for the potential offer and sale of up to 184,638,269 shares of common stock (the “Placement Shares”) in “at the market” offerings pursuant to an At Market Issuance Sales Agreement by and between Agenus and B. Riley Securities, Inc. (the “Sales Agent”), dated as of July 22, 2020 (the “Sales Agreement”). Sales pursuant to the Sales Agreement will be made only upon our instruction to the Sales Agent, and we cannot provide assurances that we will issue any additional Placement Shares pursuant to the Sales Agreement.

During the three and six months ended June 30, 2023, we received net proceeds of approximately $42.2 million and $102.8 million from the sale of approximately 24.6 million and 58.3 million shares of our common stock, respectively, in at-the-market offerings under the Sales Agreement.

Note M – Non-controlling Interest

Non-controlling interest recorded in our condensed consolidated financial statements as of June 30, 2023 and December 31, 2022, relates to the following approximate interests in certain consolidated subsidiaries, which we do not own.

	June 30, 2023			December 31, 2022
MiNK Therapeutics, Inc.		38	%		22	%
SaponiQx, Inc.		30	%		30	%

Changes in non-controlling interest for the periods ended June 30, 2023 and December 31, 2022, were as follows (in thousands):

	June 30, 2023			December 31, 2022
Beginning balance	$	6,376		$	13,469
Net loss attributable to non-controlling interest		(7,053	)		(10,582	)
Other items:
Distribution of subsidiary shares to Agenus stockholders		14,888			—
Purchase of subsidiary shares		(640	)		—
Issuance of subsidiary shares for employee bonus		1,011			294
Issuance of subsidiary shares under employee stock purchase plan		45			—
Subsidiary share-based compensation		1,807			3,195
Total other items		17,111			3,489
Ending balance	$	16,434		$	6,376

Distribution of subsidiary shares to Agenus stockholders

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On March 29, 2023, our Board of Directors declared a stock dividend (the "Dividend") consisting of an aggregate of 5.0 million shares (the "Dividend Stock") of common stock, par value $0.00001 per share, of MiNK held by Agenus to record holders of Agenus' common stock, par value $0.01 per share as of the close of business on April 17, 2023 (the "Record Date").

On May 1, 2023, we paid the Dividend and distributed 0.0146 of a share of the Dividend Stock for each share of Agenus Common Stock outstanding as of the close of business on the Record Date. No fractional shares were issued in connection with the Dividend and the shareholders of Agenus who were entitled to receive fractional shares of the Dividend Stock received cash (without interest) in lieu of such fractional shares. Subsequent to the distribution of the Dividend Stock, we maintained a controlling voting interest in MiNK.

Purchase of subsidiary shares

In May 2023, we purchased 195,788 shares of MiNK common stock in multiple open market transactions.

Note N – Related Party Transactions

In 2023, our Audit and Finance Committee approved a contract between Avillion Life Sciences LTD ("Avillion") and Agenus for the performance of up to $450,000 of clinical consulting services. Allison Jeynes, a member of our Board of Directors, is chief executive officer of Avillion. For the three and six months ended June 30, 2023, approximately $222,000 and $450,000, respectively, related to these services is included in “Research and development” expense in our condensed consolidated statements of operations.

Note O - Recent Accounting Pronouncements

Recently Issued and Adopted

In January 2017, the Financial Accounting Standards Board issued ASU 2017-04, Intangibles – Goodwill and Other (Topic 350) that will eliminate the requirement to calculate the implied fair value of goodwill to measure a goodwill impairment charge. Instead, an impairment charge will be based on the excess of a reporting unit’s carrying amount over its fair value. We adopted the standard on January 1, 2023. The adoption did not have a material impact on our consolidated financial statements.

No other new accounting pronouncement issued or effective during the six months ended June 30, 2023 had or is expected to have a material impact on our consolidated financial statements or disclosures.

Note P – Subsequent Events

At the Market Offerings

During the period of July 1, 2023 through August 4, 2023, we sold approximately 13.2 million shares of our common stock under the Sales Agreement, totaling net proceeds of approximately $20.3 million.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

Forward Looking Statements

This Quarterly Report on Form 10-Q and other written and oral statements we make from time to time contain certain “forward-looking” statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 (the “Exchange Act”). You can identify these forward-looking statements by the fact they use words such as “could,” “expect,” “anticipate,” “estimate,” “target,” “may,” “project,” “guidance,” “intend,” “plan,” “believe,” “will,” “potential,” “opportunity,” “future” and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance. You can also identify forward-looking statements by the fact that they do not relate strictly to historical or current facts. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes to differ materially from current expectations. These statements relate to, among other things, our business strategy, our research and development, our product development efforts, our ability to commercialize our product candidates, the activities of our licensees, our prospects for initiating partnerships or collaborations, the timing of the introduction of products, the effect of new accounting pronouncements, uncertainty regarding our future operating results and our profitability, anticipated sources of funds as well as our plans, objectives, expectations, and intentions.

More detailed descriptions of these risks and uncertainties and other risks and uncertainties applicable to our business that we believe could cause actual results to differ materially from any forward-looking statements are included in in Part I-Item 1A “Risk Factors” of our Annual Report on Form 10-K for the fiscal year ended December 31, 2022. We encourage you to read those descriptions carefully. Although we believe we have been prudent in our plans and assumptions, no assurance can be given that any goal or plan set forth in forward-looking statements can be achieved. We caution investors not to place significant reliance on forward-looking statements contained in this document; such statements need to be evaluated in light of all the information contained in this document. Furthermore, the statements speak only as of the date of this document, and we undertake no obligation to update or revise these statements.

ASV®, Agenus™, MiNK™, Prophage™, Retrocyte Display™ and STIMULON™ are trademarks of Agenus Inc. and its subsidiaries. All rights reserved.

Overview

We are a clinical-stage company focused on developing therapies that harness the body’s immune system to combat cancer and infections. Our pipeline includes immune-modulatory antibodies, adoptive cell therapies through our subsidiary MiNK Therapeutics, Inc. (“MiNK”), and vaccine adjuvants through our subsidiary SaponiQx, Inc. (“SaponiQx”). Our approach to Immuno-oncology (“I-O”) emphasizes speed, innovation, and effective combination therapies to drive success. We believe that combination therapies and a deep understanding of each patient’s cancer will significantly expand the patient population benefiting from I-O treatments.

In addition to our diverse pipeline, we have built fully integrated capabilities encompassing novel target discovery, antibody generation, cell line development, and good manufacturing practice clinical manufacturing. We believe these integrated capabilities enable us to develop novel candidates on accelerated timelines compared to industry standards. Through strategic partnerships, we leverage our scientific expertise and capabilities to advance innovation in the field.

Our I-O portfolio is driven by several platforms and programs, which we plan to utilize individually and in combination:

•Multiple antibody discovery platforms, including proprietary display technologies, to identify future antibody candidates.

•Antibody candidate programs, including our lead asset, botensilimab, an Fc-enhanced CTLA-4 antibody. Data presented at the 2023 ESMO World Congress Gastrointestinal Cancer conference (“ESMO GI”) demonstrated significant activity in microsatellite stable colorectal cancer when combined with balstilimab (PD-1). In a late-breaking presentation at ESMO GI, the combination of botensilimab/balstilimab showed a median Overall Survival of 20.9 months for patients without active liver metastases, surpassing the recently reported 12.9 month benchmark with standard of care in this population.

•Our saponin-based vaccine adjuvant platform, primarily centered around our STIMULON cultured plant cell (“cpc”) QS-21 adjuvant (“STIMULON cpc QS-21”).

•A pipeline of novel allogeneic invariant natural killer T cell (“iNKT”) therapies for treating cancer and other immune-mediated diseases, controlled by MiNK.

We regularly evaluate development, commercialization, and partnering strategies for each product candidate based on various factors, including pre-clinical and clinical trial results, competitive positioning, funding requirements, and available resources. Our lead program, botensilimab (AGEN1181), is progressing through multiple clinical programs designed to support accelerated development as a monotherapy and in combination with balstilimab. In 2022, we initiated global Phase 2 trials for botensilimab in

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microsatellite stable colorectal cancer, melanoma, and pancreatic cancer. In April 2023, the botensilimab/balstilimab combination received Fast Track designation from the United States Food and Drug Administration (“FDA”) for the treatment of non-MSI-H/deficient mismatch repair (dMMR) metastatic colorectal cancer patients without active liver involvement. We intend to file our first biologics license application for the botensilimab/balstilimab combination in colorectal cancer in 2024.

We have established collaborations with several companies, including Bristol-Myers Squibb Company (“BMS”), Betta Pharmaceuticals Co., Ltd. (“Betta”), Gilead Sciences, Inc. (“Gilead”), Incyte Corporation (“Incyte”), and Merck Sharpe & Dohme (“Merck”). These collaborations, along with our internal programs, have resulted in over a dozen antibody programs currently in pre-clinical or clinical development.

Our collaboration agreement with Incyte grants Incyte exclusive licenses for monospecific antibodies targeting GITR, OX40, TIM-3, LAG-3, and an undisclosed target. Incyte has been advancing these antibodies in clinical trials. Incyte has notified us of their intent to terminate the OX40 program, effective October 2023, and both the GITR program and undisclosed program, effective May 2024. Upon termination, the rights to the OX40, GITR, and undisclosed programs revert back to us. Incyte is responsible for all future development expenses for the remaining programs, and we are eligible to receive up to an additional $315.0 million in potential milestone payments, along with royalties on future sales.

Under our collaboration and license agreement with Merck, we have exclusively licensed a monospecific antibody targeting ILT4 to them, which is currently being advanced in a Phase 2 clinical trial. Merck is responsible for all future development expenses, and we are eligible to receive up to an additional $85.0 million in potential milestone payments, as well as royalties on future sales.

In September 2018, through our subsidiary Agenus Royalty Fund, LLC, we entered into a royalty purchase agreement (the “XOMA Royalty Purchase Agreement”) with XOMA (US) LLC ("XOMA"). Pursuant to the agreement, XOMA purchased 33% of all future royalties and 10% of all future milestone payments that we are entitled to receive from Incyte and Merck, after satisfying our obligations to a third party. As of June 30, 2023, we remain eligible to receive up to $283.5 million and $76.5 million in potential development, regulatory, and commercial milestones from Incyte and Merck, respectively, after accounting for our obligations under the XOMA Royalty Purchase Agreement.

In December 2018, we entered into collaboration agreements with Gilead for the development and commercialization of up to five novel I-O therapies (the “Gilead Collaboration Agreements”). Gilead received worldwide exclusive rights to our bispecific antibody, AGEN1423, and the exclusive option to license AGEN1223, a bispecific antibody, and AGEN2373, a monospecific antibody. All three assets are currently in clinical development. Gilead elected to return AGEN1423 to us in November 2020 and terminated the license agreement. We ceased development of AGEN1223 in the third quarter of 2021, and the option and license agreement for AGEN1223 were formally terminated in October 2021. The AGEN2373 option agreement remains in place, and we are responsible for developing the program until the option decision point. If Gilead exercises the option, we may opt-in to share development and commercialization costs in the United States in exchange for a 50:50 profit (loss) share and revised milestone payments. In March 2022, we received a $5.0 million clinical milestone under the AGEN2373 option agreement. Pursuant to the terms of the AGEN2373 option agreement, we remain eligible to receive a $50.0 million option exercise fee and up to an additional $520.0 million in aggregate milestone payments, as well as royalties on future sales.

In June 2020, we entered into a license and collaboration agreement (the “Betta License Agreement”) with Betta, pursuant to which we granted Betta an exclusive license to develop, manufacture and commercialize balstilimab and zalifrelimab in Republic of China, Hong Kong, Macau and Taiwan (“Greater China”). Under the terms of the Betta License Agreement, we received $15.0 million upfront and are eligible to receive up to $100.0 million in milestone payments plus royalties on any future sales in Greater China.

In May 2021, we entered into a License, Development, and Commercialization Agreement with BMS for our pre-clinical anti-TIGIT bispecific antibody program, AGEN1777. BMS received an exclusive worldwide license to develop, manufacture, and commercialize AGEN1777 and its derivatives. We retained an option to access the licensed antibodies for use in clinical studies in combination with certain pipeline assets. We received a non-refundable upfront cash payment of $200.0 million and are eligible to receive up to $1.36 billion in development, regulatory, and commercial milestone payments, along with tiered royalties. BMS is responsible for all associated costs, and we have the option to co-fund a minority of global development costs in exchange for increased tiered royalties. We also have the option to co-promote AGEN1777 in the U.S. In October 2021, we achieved a $20.0 million milestone upon the dosing of the first patient in the AGEN1777 Phase 1 clinical trial.

In September 2021, we launched SaponiQx to lead innovation in novel adjuvant discovery and vaccine design, focusing on our saponin-based adjuvants. We are particularly dedicated to the development of the next-generation cultured plant cell QS-21. To support this initiative, we partnered with Ginkgo Bioworks, Inc. to develop SaponiQx’s saponin products from sustainably sourced raw materials. Our goal is to meet the demands of the vaccine industry, especially for pandemic vaccines.

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Our bark extract QS-21 adjuvant is partnered with GlaxoSmithKline (“GSK”) and plays a vital role in multiple GSK vaccine programs. These programs are at various stages, including GSK’s approved shingles vaccine, SHINGRIX, which received FDA approval in the United States in October 2017.

In January 2018, we entered into a Royalty Purchase Agreement with Healthcare Royalty Partners III, L.P. and its affiliates (“HCR”). HCR purchased our worldwide rights to receive royalties from GSK on GSK’s sales of vaccines containing our QS-21 adjuvant. We do not incur clinical development costs for products partnered with GSK.

Under the agreement with HCR, we were entitled to receive milestone payments based on GSK’s vaccine sales. These milestones include $15.1 million upon GSK reaching $2.0 billion in last-twelve-months net sales prior to 2024 (the “First HCR Milestone”) and $25.25 million upon GSK reaching $2.75 billion in last-twelve-months net sales prior to 2026 (the “Second HCR Milestone”). We received the First HCR Milestone after GSK’s net sales of SHINGRIX for the twelve months ended December 31, 2019, exceeded $2.0 billion, and we received the Second HCR Milestone after GSK’s net sales of SHINGRIX for the twelve months ended June 30, 2022, exceeded $2.75 billion.

Our business activities encompass various areas such as product research, preclinical and clinical development, intellectual property prosecution, manufacturing, regulatory and clinical affairs, corporate finance and development activities, and support of collaborations. Our strategy includes developing and commercializing product candidates through existing and new collaborations.

Agenus' subsidiary MiNK completed a successful Initial Public Offering in October 2021 and is publicly traded on Nasdaq under the symbol INKT. MiNK is a clinical-stage precision oncology company developing unmodified and engineered invariant natural killer T cell therapies for cancer and other immune-mediated diseases. Their lead product candidate, agenT-797, is an off-the-shelf, allogeneic, native iNKT cell therapy. A Phase 1 clinical trial for the treatment of solid tumors as a monotherapy and in combination with approved checkpoint inhibitors (KEYTRUDA® and OPDIVO®) has been initiated and enrolled, and data was presented in April at the American Association for Cancer Research Annual Meeting. The presentation showcased the activity of agenT-797 alone and in combination with anti-PD-1, with a 42% tumor reduction in a patient with metastatic gastric cancer who had no response to prior anti-PD-1 therapy or standard chemotherapy. Benefit was seen in additional solid tumor types, including durable disease stabilization and biomarker responses in NSCLC, testicular, and appendiceal cancers, that were refractory to anti-PD-1. MiNK is also evaluating agenT-797 as a variant-agnostic therapy for patients with viral acute respiratory distress syndrome, and top-line data from a Phase 1 clinical trial demonstrated a 77% survival rate in older, mechanically ventilated patients with COVID-19 respiratory failure. Through an assignment and license agreement with Agenus, MiNK owns the INKT technology and has the rights to develop a proprietary pipeline of engineered CAR-INKTs, TCRs, and INKT bispecific engagers.

Historical Results of Operations

Three months ended June 30, 2023 compared to the three months ended June 30, 2022

Research and development revenue

We recognized research and development revenue of approximately $2.5 million and $1.9 million during the three months ended June 30, 2023 and 2022, respectively. Research and development revenues in the second quarter of 2023 primarily consisted of $2.0 million related to the recognition of deferred revenue earned under our Gilead Collaboration Agreements. Research and development revenues in the second quarter of 2022 primarily consisted of $1.2 million related to the recognition of deferred revenue earned under our Gilead Collaboration Agreements.

Non-cash royalty revenue related to the sale of future royalties

In January 2018, we sold 100% of our worldwide rights to receive royalties from GSK on sales of GSK’s vaccines containing our QS-21 STIMULON adjuvant to HCR. As described in Note F to our Condensed Consolidated Financial Statements, this transaction has been recorded as a liability that amortizes over the estimated life of our Royalty Purchase Agreement with HCR. As a result of this liability accounting, even though the royalties are remitted directly to HCR, we record these royalties from GSK as revenue. Non-cash royalty revenue related to our agreement with GSK increased $22.0 million, to approximately $22.1 million for the three months ended June 30, 2023, from $0.1 million for the three months ended June 30, 2022, mainly due to the achievement of the final sales milestone under the HCR agreement and the recognition of these royalties as royalty milestone revenue in the three months ended June 30, 2022.

Research and development expense

Research and development expense includes the costs associated with our internal research and development activities, including compensation and benefits, occupancy costs, manufacturing costs, costs of consultants, and administrative costs. Research and development expense increased 32% to $59.3 million for the three months ended June 30, 2023 from $45.0 million for the three months ended June 30, 2022. Increased expenses in the three months ended June 30, 2023 primarily relate to a $10.5 million increase in third-party services and other expenses, largely due to the timing of expenses related to the advancement of our antibody programs,

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a $2.1 million increase in personnel related expenses, primarily due to increased headcount, a $1.2 million increase in expenses attributable to the activities of our subsidiaries and a $0.5 million increase in other research and development expenses.

General and administrative expense

General and administrative expense consists primarily of personnel costs, facility expenses, and professional fees. General and administrative expenses increased 8% to $20.4 million for the three months ended June 30, 2023 from $18.9 million for the three months ended June 30, 2022. Increased expenses in the three months ended June 30, 2023 primarily relate to a $2.0 million increase in personnel related expenses, largely due to increased headcount, and a $0.2 million increase in other general and administrative expenses. These increases were partially offset $0.6 million decrease in expenses attributable to the activities of our subsidiaries.

Non-operating income (expense)

Non-operating expense increased $9.3 million for the three months ended June 30, 2023, from income of $9.1 million for the three months ended June 30, 2022 to expense of $0.2 million for the three months ended June 30, 2023, primarily due to de minimis activity in the three months ended June 30, 2023, compared to the recognition of a $6.6 million gain on the sale of property, plant and equipment and a $2.8 million gain on the partial forgiveness of a liability in the three months ended June 30, 2022.

Interest expense, net

Interest expense, net increased to approximately $18.5 million for the three months ended June 30, 2023 from $13.7 million for the three months ended June 30, 2022, mainly due to increased non-cash interest recorded in connection with our Royalty Purchase Agreement with HCR and increased interest expense recorded in connection with our finance leases, partially offset by increased interest income earned on our cash equivalents and short-term investments.

Six months ended June 30, 2023 compared to the six months ended June 30, 2022

Research and development revenue

We recognized research and development revenue of approximately $5.1 million and $8.6 million during the six months ended June 30, 2023 and 2022, respectively. Research and development revenues in the first half of 2023 primarily consisted of $4.4 million related to the recognition of deferred revenue earned under our Gilead Collaboration Agreements. Research and development revenues in the first half of 2022 primarily consisted of a $5.0 million milestone and $2.6 million related to the recognition of deferred revenue, both earned under our Gilead Collaboration Agreements.

Non-cash royalty revenue related to the sale of future royalties

In January 2018, we sold 100% of our worldwide rights to receive royalties from GSK on sales of GSK’s vaccines containing our QS-21 STIMULON adjuvant to HCR. As described in Note F to our Condensed Consolidated Financial Statements, this transaction has been recorded as a liability that amortizes over the estimated life of our Royalty Purchase Agreement with HCR. As a result of this liability accounting, even though the royalties are remitted directly to HCR, we record these royalties from GSK as revenue. Non-cash royalty revenue related to our agreement with GSK increased $23.4 million, to approximately $41.2 million for the six months ended June 30, 2023, from $17.8 million for the six months ended June 30, 2022, due to increased net sales of GSK’s vaccines containing our QS-21 STIMULON adjuvant and the achievement of the final sales milestone under the HCR agreement and the recognition of these royalties as royalty milestone revenue in the six months ended June 30, 2022.

Research and development expense

Research and development expense includes the costs associated with our internal research and development activities, including compensation and benefits, occupancy costs, manufacturing costs, costs of consultants, and administrative costs. Research and development expense increased 33% to $116.4 million for the six months ended June 30, 2023 from $87.4 million for the six months ended June 30, 2022. Increased expenses in the six months ended June 30, 2023 primarily relate to a $21.8 million increase in third-party services and other expenses, largely due to the timing of expenses related to the advancement of our antibody programs, a $3.5 million increase in personnel related expenses, primarily due to increased headcount, a $2.6 million increase in expenses attributable to the activities of our subsidiaries and a $1.0 million increase in other research and development expenses.

General and administrative expense

General and administrative expense consists primarily of personnel costs, facility expenses, and professional fees. General and administrative expenses increased 2% to $38.7 million for the six months ended June 30, 2023 from $37.9 million for the six months ended June 30, 2022. Increased expenses in the six months ended June 30, 2023 primarily relate to a $2.0 million increase in personnel related expenses, largely due to increased headcount, and a $0.8 million increase in other general and administrative expenses. These increases were partially offset by a $1.3 million decrease in professional fees, primarily due to reduced consulting and external legal costs, and a $0.7 million decrease in expenses attributable to the activities of our subsidiaries.

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Non-operating income (expense)

Non-operating expense increased $9.3 million for the six months ended June 30, 2023, from income of $9.1 million for the six months ended June 30, 2022 to expense of $0.2 million for the six months ended June 30, 2023, primarily due to de minimis activity in the six months ended June 30, 2023, compared to the recognition of a $6.6 million gain on the sale of property, plant and equipment and a $2.8 million gain on the partial forgiveness of a liability in the six months ended June 30, 2022.

Interest expense, net

Interest expense, net increased to approximately $35.1 million for the six months ended June 30, 2023 from $28.9 million for the six months ended June 30, 2022, mainly due to increased non-cash interest recorded in connection with our Royalty Purchase Agreement with HCR and increased interest expense recorded in connection with our finance leases, partially offset by increased interest income earned on our cash equivalents and short-term investments.

Research and Development Programs

For the six months ended June 30, 2023, our research and development programs consisted largely of our antibody programs as indicated in the following table (in thousands).

		Six Months Ended June 30,		Year Ended December 31,
Research and Development Program	Product	2023		2022		2021		2020
Antibody programs	Various	$	82,402	$	133,108	$	141,266	$	118,200
Vaccine adjuvant	QS-21 STIMULON		7,816		10,789		5,912		304
Cell therapies	Various		9,292		24,300		15,507		11,022
Other research and development programs	Various		16,892		18,494		15,923		13,091
Total research and development expenses		$	116,402	$	186,691	$	178,608	$	142,617

Research and development program costs include compensation and other direct costs plus an allocation of indirect costs, based on certain assumptions and our review of the status of each program. Our product candidates are in various stages of development and significant additional expenditures will be required if we start new clinical trials, encounter delays in our programs, apply for regulatory approvals, continue development of our technologies, expand our operations, and/or bring our product candidates to market. The total cost of any particular clinical trial is dependent on a number of factors such as trial design, length of the trial, number of clinical sites, number of patients, and trial sponsorship. The process of obtaining and maintaining regulatory approvals for new therapeutic products is lengthy, expensive, and uncertain. Because of the current stage of our product candidates, among other factors, we are unable to reliably estimate the cost of completing our research and development programs or the timing for bringing such programs to various markets or substantial partnering or out-licensing arrangements, and, therefore, when, if ever, material cash inflows are likely to commence.

Liquidity and Capital Resources

We have incurred annual operating losses since inception, and we had an accumulated deficit of $1.8 billion as of June 30, 2023. We expect to incur significant losses over the next several years as we continue development of our technologies and product candidates, manage our regulatory processes, initiate and continue clinical trials, and prepare for potential commercialization of products. To date, we have financed our operations primarily through corporate partnerships, advance royalty sales and the issuance of equity. From our inception through June 30, 2023, we have raised aggregate net proceeds of approximately $1.8 billion through the sale of common and preferred stock, the exercise of stock options and warrants, proceeds from our Employee Stock Purchase Plan, royalty monetization transactions, and the issuance of convertible and other notes.

We maintain an effective registration statement (the “Registration Statement”), covering common stock, preferred stock, warrants, debt securities and units. The Registration Statement includes prospectuses covering the offer, issuance and sale of up to 184.6 million shares of our common stock from time to time in “at-the-market offerings” pursuant to an At Market Issuance Sales Agreement (the “Sales Agreement”) with B. Riley Securities, Inc. as our sales agent. We sold approximately 58.3 million and 13.2 million shares of our common stock pursuant to the Sales Agreement during the six months ended June 30, 2023 and the period of July 1, 2023 through August 4, 2023, respectively, for aggregate net proceeds totaling $123.1 million. As of August 4, 2023, approximately 171.4 million shares remained available for sale under the Sales Agreement.

We have funded our operations largely from cash received from partners, royalty financing transactions and equity offerings. We transact at-the-market sales from time to time in order to manage our cash balances to make sure cash balances do not drop below

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a certain level based on our anticipated uses of cash. We execute at-the-market offerings based on market conditions and our stock price. We do not have in place a program whereby at-the-market offerings are executed automatically based on our trading volume.

As of June 30, 2023, we had debt outstanding of $13.6 million in principal. In November 2022, we amended all of the outstanding 2015 Subordinated Notes, extending the due date by two years to February 2025.

Our cash, cash equivalents and short-term investments at June 30, 2023 were $157.9 million, a decrease of $35.5 million from December 31, 2022. Cash and cash equivalents of our subsidiary, MiNK, at March 31, 2023, were $14.9 million. MiNK cash can only be accessed by Agenus through a declaration of a dividend by the MiNK Board of Directors or through settlement of intercompany balances.

Based on our current plans and projections, we believe our cash resources of $157.9 million as of June 30, 2023, will be sufficient to satisfy our liquidity needs for more than one year from when these financial statements were issued.

Management consistently monitors our liquidity position and has the flexibility to adjust spending as necessary to preserve and extend liquidity. We regularly assess the likelihood of success of our programs, and our funding decisions are based on these evaluations. We are prepared to discontinue funding of any activities that do not impact our core priorities and to restrict capital expenditures and/or reduce the scale of our operations. Potential funding sources may include collaborations, out-licensing and/or partnering opportunities for our portfolio programs and product candidates with multiple parties, milestone payments from our existing partnerships, additional third-party agreements, asset sales, project financing, and/or sales of equity securities.

Our future cash requirements include, but are not limited to, supporting clinical trial and regulatory efforts and continuing our other research and development programs. Since inception, we have entered into various agreements with contract manufacturers, institutions, and clinical research organizations (collectively “third party providers”) to perform pre-clinical activities and to conduct and monitor our clinical studies and trials. Under these agreements, subject to the enrollment of patients and performance by the applicable third-party provider, we have estimated our total payments to be $600.0 million over the term of the related activities. Through June 30, 2023, we have expensed $500.9 million as research and development expenses and $480.6 million has been paid under these agreements. The timing of expense recognition and future payments related to these agreements is subject to the enrollment of patients and performance by the applicable third-party provider. We plan to enter into additional agreements with third party providers and we anticipate significant additional expenditures will be required to initiate and advance our various programs.

Part of our strategy is to develop and commercialize some of our product candidates by continuing our existing collaboration arrangements with academic and collaboration partners and licensees and by entering into new collaborations. As a result of our collaboration agreements, we will not completely control the efforts to attempt to bring those product candidates to market. For example, our collaboration with Incyte for the development, manufacture and commercialization of CPM antibodies against certain targets is managed by a joint steering committee, which is controlled by Incyte.

Net cash used in operating activities for the six months ended June 30, 2023 and 2022 was $118.6 million and $95.8 million, respectively. Our future ability to generate cash from operations will depend on achieving regulatory approval and market acceptance of our product candidates, achieving benchmarks as defined in existing collaboration agreements, and our ability to enter into new collaborations. See “Management’s Discussion and Analysis of Financial Condition and Results of Operations—Forward Looking Statements” in Part I, Item 2 of this Quarterly Report on Form 10-Q and the risks highlighted in Part I, Item 1A "Risk Factors" of our 2022 Form 10-K.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

Our primary market risk exposure is foreign currency exchange rate risk. International revenues and expenses are generally transacted by our foreign subsidiaries and are denominated in local currency. Approximately 1.6% and 1.7% of our cash used in operations for the six months ended June 30, 2023 and the year ended December 31, 2022, respectively, was from our foreign subsidiaries. We are exposed to foreign currency exchange rate fluctuation risk related to our transactions denominated in foreign currencies. We do not currently employ specific strategies, such as the use of derivative instruments or hedging, to manage these exposures. Our currency exposures vary but are primarily concentrated in the British Pound, Euro, and Swiss Franc, in large part due to our subsidiaries, Agenus UK Limited and AgenTus Therapeutics Limited, both with operations in England, AgenTus Therapeutics SA, a company formerly with operations in Belgium, and Agenus Switzerland a company formerly with operations in Switzerland.

We had cash, cash equivalents and short-term investments at June 30, 2023 of $157.9 million, which are exposed to the impact of interest rate changes, and our interest income fluctuates as interest rates change. Additionally, in the normal course of business, we are exposed to fluctuations in interest rates as we seek debt financing and invest excess cash. Due to the short-term nature of our investments in money market funds and U.S. Treasury Bills, our carrying value approximates the fair value of these investments at June 30, 2023.

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There has been no material change to our interest rate exposure and our approach toward interest rate and foreign currency exchange rate exposures, as described in our Annual Report on Form 10-K for the year ended December 31, 2022.

We invest our cash and cash equivalents in accordance with our investment policy. The primary objectives of our investment policy are to preserve principal, maintain proper liquidity to meet operating needs, and maximize yields. We review our investment policy periodically and amend it as deemed necessary. Currently, the investment policy prohibits investing in any structured investment vehicles and asset-backed commercial paper. Although our investments are subject to credit risk, our investment policy specifies credit quality standards for our investments and limits the amount of credit exposure from any single issue, issuer, or type of investment. We do not invest in derivative financial instruments. Accordingly, we do not believe that there is currently any material market risk exposure with respect to derivatives or other financial instruments that would require disclosure under this item.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Under the supervision and with the participation of our management, including our Principal Executive Officer and Principal Financial Officer, we conducted an evaluation of the effectiveness of our disclosure controls and procedures, as such term is defined under Rule 13a-15(e) and Rule 15d-15(e) promulgated under the Exchange Act. Based on this evaluation, our Principal Executive Officer and our Principal Financial Officer concluded that, as of the end of the period covered by this Quarterly Report on Form 10-Q, our disclosure controls and procedures were effective and were designed to ensure that information we are required to disclose in the reports that we file or submit under the Exchange Act is accumulated and communicated to management, including our Principal Executive Officer and Principal Financial Officer, as appropriate, to allow timely decisions regarding required disclosure, and is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms. It should be noted that any system of controls is designed to provide reasonable, but not absolute, assurances that the system will achieve its stated goals under all reasonably foreseeable circumstances. Our Principal Executive Officer and Principal Financial Officer have each concluded that our disclosure controls and procedures as of the end of the period covered by this report are effective at a level that provides such reasonable assurances.

Changes in Internal Control Over Financial Reporting

There was no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) that occurred during the three months ended June 30, 2023 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II - OTHER INFORMATION

Item 1. Legal Proceedings

We are not party to any material legal proceedings.

Item 1A. Risk Factors

Our results of operations and financial condition are subject to numerous risks and uncertainties described in our Annual Report on Form 10-K for the fiscal year ended December 31, 2022. There have been no material changes to the risk factors described in Part I, Item 1A "Risk Factors" of our 2022 Form 10-K.

Item 5. Other Information

Trading Plans of Our Directors and Officers

During the quarter ended June 30, 2023, none of our directors or executive officers adopted or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as each item is defined in Item 408 of Regulation S-K.

Item 6. Exhibits

Exhibit No.	Description
31.1	Certification of Principal Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as amended. Filed herewith.
31.2	Certification of Principal Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as amended. Filed herewith.
32.1	Certification of Principal Executive Officer and Principal Financial Officer pursuant to 18 U.S.C. Section 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. Submitted herewith.
101.INS	XBRL Instance Document (the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document)
101.SCH	Inline XBRL Taxonomy Extension Schema Document
101.CAL	Inline XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF	Inline XBRL Taxonomy Extension Definition Linkbase Document
101.LAB	Inline XBRL Taxonomy Extension Label Linkbase Document
101.PRE	Inline XBRL Taxonomy Extension Presentation Linkbase Document
104	Cover Page Interactive Data File (embedded within the Inline XBRL document and included in Exhibit 101)

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AGENUS INC.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

Date:	August 8, 2023	AGENUS INC.
		/s/ CHRISTINE M. KLASKIN
		Christine M. Klaskin VP, Finance, Principal Financial Officer, Principal Accounting Officer

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EX-31.1

Exhibit 31.1

Certification Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as amended

I, Garo H. Armen, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Agenus Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this report;

4.The Registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the Registrant and have:

a.designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b.designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with U.S. generally accepted accounting principles;

c.evaluated the effectiveness of the Registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d.disclosed in this report any change in the Registrant’s internal control over financial reporting that occurred during the Registrant’s most recent fiscal quarter (the Registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the Registrant’s internal control over financial reporting; and

5.The Registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the Registrant’s auditors and the audit committee of the Registrant’s board of directors (or persons performing the equivalent function):

a.all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the Registrant’s ability to record, process, summarize and report financial information; and

b.any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant’s internal control over financial reporting.

Date: August 8, 2023	/s/ GARO H. ARMEN, PH.D.
	Garo H. Armen, Ph.D.
	Chief Executive Officer and Principal Executive Officer

EX-31.2

Exhibit 31.2

Certification Pursuant to Rules 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as amended

I, Christine M. Klaskin, certify that:

1.I have reviewed this Quarterly Report on Form 10-Q of Agenus Inc.;

2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this report;

4.The Registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the Registrant and have:

a.designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b.designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with U.S. generally accepted accounting principles;

c.evaluated the effectiveness of the Registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d.disclosed in this report any change in the Registrant’s internal control over financial reporting that occurred during the Registrant’s most recent fiscal quarter (the Registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the Registrant’s internal control over financial reporting; and

5.The Registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the Registrant’s auditors and the audit committee of the Registrant’s board of directors (or persons performing the equivalent function):

a.all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the Registrant’s ability to record, process, summarize and report financial information; and

b.any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant’s internal control over financial reporting.

Date: August 8, 2023	/s/ CHRISTINE M. KLASKIN
	Christine M. Klaskin
	VP, Finance and Principal Financial Officer

EX-32.1

Exhibit 32.1

Certification

Pursuant to 18 U.S.C. Section 1350,

As Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

In connection with the Quarterly Report on Form 10-Q of Agenus Inc. (the “Company”) for the quarterly period ended June 30, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), each of the undersigned to his/her knowledge hereby certifies, pursuant to 18 U.S.C. Section 1350, that:

(i)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

(ii)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

/s/ GARO H. ARMEN, PH.D.

Garo H. Armen, Ph.D.

Chief Executive Officer and Principal Executive Officer

/s/ CHRISTINE M. KLASKIN

Christine M. Klaskin

VP, Finance and Principal Financial Officer

Date: August 8, 2023

A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

The foregoing certification is being furnished to the Securities and Exchange Commission as an exhibit to the Report and should not be considered filed as part of the Report.

XML

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2023	Aug. 04, 2023
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2023
Document Fiscal Period Focus	Q2
Document Fiscal Year Focus	2023
Entity Registrant Name	AGENUS INC
Entity Central Index Key	0001098972
Entity Current Reporting Status	Yes
Trading Symbol	AGEN
Security Exchange Name	NASDAQ
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Shell Company	false
Entity Small Business	false
Entity Emerging Growth Company	false
Title of 12(b) Security	Common stock, par value $0.01
Entity Interactive Data Current	Yes
Entity Common Stock, Shares Outstanding		379,572,187
Entity File Number	000-29089
Entity Tax Identification Number	06-1562417
Entity Address, Address Line One	3 Forbes Road
Entity Address, City or Town	Lexington
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02421
City Area Code	781
Local Phone Number	674-4400
Document Quarterly Report	true
Document Transition Report	false
Entity Incorporation, State or Country Code	DE

XML

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
ASSETS
Cash and cash equivalents	$ 143,205	$ 178,674
Short-term investments	14,647	14,684
Accounts receivable	1,341	2,741
Prepaid expenses	8,699	13,829
Other current assets	2,843	3,194
Total current assets	170,735	213,122
Property, plant and equipment, net of accumulated amortization and depreciation of $58,489 and $54,075 at June 30, 2023 and December 31, 2022, respectively	143,358	133,017
Operating lease right-of-use assets	30,528	31,269
Goodwill	24,728	25,467
Acquired intangible assets, net of accumulated amortization of $17,123 and $16,148 at June 30, 2023 and December 31, 2022, respectively	4,986	6,228
Other long-term assets	9,258	4,453
Total assets	383,593	413,556
LIABILITIES AND STOCKHOLDERS' DEFICIT
Current portion, long-term debt	622	575
Current portion, liability related to sale of future royalties and milestones	97,778	83,510
Current portion, deferred revenue	7,828	12,269
Current portion, operating lease liabilities	1,905	1,943
Accounts payable	52,473	40,939
Accrued liabilities	30,194	38,259
Other current liabilities	13,268	11,457
Total current liabilities	204,068	188,952
Long-term debt, net of current portion	12,673	12,584
Liability related to sale of future royalties and milestones, net of current portion	169,142	187,753
Deferred revenue, net of current portion	1,143	1,143
Operating lease liabilities, net of current portion	62,253	63,326
Other long-term liabilities	11,075	14,700
Commitments and contingencies
STOCKHOLDERS' (DEFICIT) EQUITY
Common stock, par value $0.01 per share; 800,000,000 shares authorized; 367,491,091 and 305,573,397 shares issued at June 30, 2023 and December 31, 2022, respectively	3,675	3,056
Additional paid-in capital	1,751,024	1,644,658
Accumulated other comprehensive income (loss)	(717)	915
Accumulated deficit	(1,847,177)	(1,709,907)
Total stockholders' deficit attributable to Agenus Inc.	(93,195)	(61,278)
Non-controlling interest	16,434	6,376
Total stockholders' deficit	(76,761)	(54,902)
Total liabilities and stockholders' deficit	383,593	413,556
Series A-1 convertible preferred stock [Member]
STOCKHOLDERS' (DEFICIT) EQUITY
Series A-1 convertible preferred stock; 31,620 shares designated, issued, and outstanding at June 30, 2023 and December 31, 2022; liquidation value of $33,779 at June 30, 2023	$ 0	$ 0

XML

Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Property plant and equipment, accumulated amortization and depreciation	$ 58,489	$ 54,075
Acquired intangible assets, accumulated amortization	$ 17,123	$ 16,148
Common stock, par value	$ 0.01	$ 0.01
Common stock, shares authorized	800,000,000	800,000,000
Common stock, shares issued	367,491,091	305,573,397
Series A-1 convertible preferred stock [Member]
Series A-1 convertible preferred stock, shares designated	31,620	31,620
Series A-1 convertible preferred stock, shares issued	31,620	31,620
Series A-1 convertible preferred stock, shares outstanding	31,620	31,620
Series A-1 convertible preferred stock, liquidation value	$ 33,779

XML

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue:
Total revenues	$ 25,296	$ 20,926	$ 48,198	$ 46,867
Operating expenses:
Cost of service revenue	(254)	(2,024)	(2,548)	(2,567)
Research and development	(59,285)	(44,960)	(116,402)	(87,404)
General and administrative	(20,415)	(18,914)	(38,653)	(37,866)
Contingent purchase price consideration fair value adjustment	(8)	407	398	943
Operating loss	(54,666)	(44,565)	(109,007)	(80,027)
Other income (expense):
Non-operating income (expense)	(244)	9,061	(204)	9,118
Interest expense, net	(18,520)	(13,731)	(35,112)	(28,930)
Net loss	(73,430)	(49,235)	(144,323)	(99,839)
Dividends on Series A-1 convertible preferred stock	(53)	(53)	(107)	(106)
Less: net loss attributable to non-controlling interest	(4,414)	(2,801)	(7,053)	(5,081)
Net loss attributable to Agenus Inc. common stockholders	$ (69,069)	$ (46,487)	$ (137,377)	$ (94,864)
Per common share data:
Basic net loss attributable to Agenus Inc. common stockholders	$ (0.2)	$ (0.17)	$ (0.41)	$ (0.35)
Diluted net loss attributable to Agenus Inc. common stockholders	$ (0.2)	$ (0.17)	$ (0.41)	$ (0.35)
Weighted average number of Agenus Inc. common shares outstanding:
Basic	351,379	277,033	334,339	267,723
Diluted	351,379	277,033	334,339	267,723
Other comprehensive loss:
Foreign currency translation gain (loss)	$ (1,634)	$ 1,179	$ (1,632)	$ 657
Other comprehensive gain (loss)	(1,634)	1,179	(1,632)	657
Comprehensive loss	(70,703)	(45,308)	(139,009)	(94,207)
Research and Development [Member]
Revenue:
Total revenues	2,489	1,907	5,101	8,647
Royalty Sales Milestone [Member]
Revenue:
Total revenues		17,316		17,316
Service Revenue [Member]
Revenue:
Total revenues	739	1,559	1,923	3,126
Non-Cash Royalty Revenue Related to the Sale of Future Royalties [Member]
Revenue:
Total revenues	$ 22,068	$ 144	$ 41,174	$ 17,778

XML

Condensed Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) (Unaudited) - USD ($) $ in Thousands	Total	MiNK Therapeutics, Inc.	Common Stock [Member]	Additional Paid-in Capital [Member]	Additional Paid-in Capital [Member] MiNK Therapeutics, Inc.	Treasury Stock [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Non-controlling Interest [Member]	Non-controlling Interest [Member] MiNK Therapeutics, Inc.	Accumulated Deficit [Member]	Series A-1 convertible preferred stock [Member] Preferred Stock [Member]
Stockholders' Equity, Beginning Balance at Dec. 31, 2021	$ 47,909		$ 2,569	$ 1,520,212			$ 1,492	$ 13,469		$ (1,489,833)
Balance, shares at Dec. 31, 2021			256,899,000
Temporary Equity, Beginning Balance at Dec. 31, 2021											$ 0
Temporary Equity, shares at Dec. 31, 2021											32,000
Net loss	(50,604)							(2,279)		(48,325)
Other comprehensive income (loss)	(522)						(522)
Share-based compensation	4,947			4,205				742
Shares sold at the market	19,182		$ 70	19,112
Shares sold at the market, shares			7,039,000
Issuance of director deferred shares	19			19
Issuance of director deferred shares, shares			5,000
Issuance of shares for services	81		$ 1	80
Issuance of shares for services, shares			21,000
Vesting of nonvested shares			$ 1	(1)
Vesting of nonvested shares, shares			143,000
Exercise of stock options and employee share purchases	368		$ 1	367
Exercise of stock options and employee share purchases, shares			136,000
Issuance of shares for employee bonus	2,903		$ 38	6,245		$ (3,380)
Issuance of shares for employee bonus, Shares			3,845,000			(1,347,000)
Retirement of treasury shares	3,367		$ (13)			$ 3,380
Retirement of treasury shares, share			(1,347,000)			1,347,000
Stockholders' Equity, Ending Balance at Mar. 31, 2022	27,650		$ 2,667	1,550,239			970	11,932		(1,538,158)
Temporary Equity, Ending Balance at Mar. 31, 2022											$ 0
Balance, shares at Mar. 31, 2022			266,741,000
Temporary Equity, shares at Mar. 31, 2022											32,000
Stockholders' Equity, Beginning Balance at Dec. 31, 2021	47,909		$ 2,569	1,520,212			1,492	13,469		(1,489,833)
Balance, shares at Dec. 31, 2021			256,899,000
Temporary Equity, Beginning Balance at Dec. 31, 2021											$ 0
Temporary Equity, shares at Dec. 31, 2021											32,000
Net loss	(99,839)
Other comprehensive income (loss)	657
Stockholders' Equity, Ending Balance at Jun. 30, 2022	13,638		$ 2,829	1,583,030			2,149	10,222		(1,584,592)
Temporary Equity, Ending Balance at Jun. 30, 2022											$ 0
Balance, shares at Jun. 30, 2022			282,862,000
Temporary Equity, shares at Jun. 30, 2022											32,000
Stockholders' Equity, Beginning Balance at Dec. 31, 2021	47,909		$ 2,569	1,520,212			1,492	13,469		(1,489,833)
Balance, shares at Dec. 31, 2021			256,899,000
Temporary Equity, Beginning Balance at Dec. 31, 2021											$ 0
Temporary Equity, shares at Dec. 31, 2021											32,000
Share-based compensation								3,195
Stockholders' Equity, Ending Balance at Dec. 31, 2022	(54,902)		$ 3,056	1,644,658			915	6,376		(1,709,907)
Temporary Equity, Ending Balance at Dec. 31, 2022											$ 0
Balance, shares at Dec. 31, 2022			305,574,000
Temporary Equity, shares at Dec. 31, 2022											32,000
Stockholders' Equity, Beginning Balance at Mar. 31, 2022	27,650		$ 2,667	1,550,239			970	11,932		(1,538,158)
Balance, shares at Mar. 31, 2022			266,741,000
Temporary Equity, Beginning Balance at Mar. 31, 2022											$ 0
Temporary Equity, shares at Mar. 31, 2022											32,000
Net loss	(49,235)							(2,801)		(46,434)
Other comprehensive income (loss)	1,179						1,179
Share-based compensation	4,615			3,818				797
Shares sold at the market	28,237		$ 158	28,079
Shares sold at the market, shares			15,782,000
Issuance of shares for milestone achievement	500		$ 2	498
Issuance of shares for milestone achievement, shares			180,000
Issuance of shares for services	20		$ 1	19
Issuance of shares for services, shares			7,000
Exercise of stock options	14			14
Exercise of stock options, shares			6,000
Issuance of subsidiary shares to noncontrolling interest	294							294
Issuance of shares for employee bonus	114		$ 2	363		$ (251)
Issuance of shares for employee bonus, Shares			246,000			(100,000)
Retirement of treasury shares	250		$ (1)			$ 251
Retirement of treasury shares, share			(100,000)			100,000
Stockholders' Equity, Ending Balance at Jun. 30, 2022	13,638		$ 2,829	1,583,030			2,149	10,222		(1,584,592)
Temporary Equity, Ending Balance at Jun. 30, 2022											$ 0
Balance, shares at Jun. 30, 2022			282,862,000
Temporary Equity, shares at Jun. 30, 2022											32,000
Stockholders' Equity, Beginning Balance at Dec. 31, 2022	(54,902)		$ 3,056	1,644,658			915	6,376		(1,709,907)
Balance, shares at Dec. 31, 2022			305,574,000
Temporary Equity, Beginning Balance at Dec. 31, 2022											$ 0
Temporary Equity, shares at Dec. 31, 2022											32,000
Net loss	(70,893)							(2,639)		(68,254)
Other comprehensive income (loss)	2						2
Share-based compensation	5,485			4,566				919
Shares sold at the market	60,583		$ 338	60,245
Shares sold at the market, shares			33,785,000
Issuance of director deferred shares	983		$ 3	980
Issuance of director deferred shares, shares			250,000
Issuance of shares for services	318		$ 1	317
Issuance of shares for services, shares			132,000
Issuance of subsidiary shares to noncontrolling interest	726							726
Vesting of nonvested shares, shares			5,000
Exercise of stock options and employee share purchases	374		$ 2	327				45
Exercise of stock options and employee share purchases, shares			197,000
Issuance of shares for employee bonus	1,796		$ 27	4,198		$ (2,429)
Issuance of shares for employee bonus, Shares			2,716,000			(10,000)
Retirement of treasury shares	2,419		$ (10)			$ 2,429
Retirement of treasury shares, share			(996,000)			10,000
Stockholders' Equity, Ending Balance at Mar. 31, 2023	(53,109)		$ 3,417	1,715,291			917	5,427		(1,778,161)
Temporary Equity, Ending Balance at Mar. 31, 2023											$ 0
Balance, shares at Mar. 31, 2023			341,663,000
Temporary Equity, shares at Mar. 31, 2023											32,000
Stockholders' Equity, Beginning Balance at Dec. 31, 2022	(54,902)		$ 3,056	1,644,658			915	6,376		(1,709,907)
Balance, shares at Dec. 31, 2022			305,574,000
Temporary Equity, Beginning Balance at Dec. 31, 2022											$ 0
Temporary Equity, shares at Dec. 31, 2022											32,000
Net loss	(144,323)
Other comprehensive income (loss)	$ (1,632)
Share-based compensation								1,807
Exercise of stock options, shares	46,750
Stockholders' Equity, Ending Balance at Jun. 30, 2023	$ (76,761)		$ 3,675	1,751,024			(717)	16,434		(1,847,177)
Temporary Equity, Ending Balance at Jun. 30, 2023											$ 0
Balance, shares at Jun. 30, 2023			367,492,000
Temporary Equity, shares at Jun. 30, 2023											32,000
Stockholders' Equity, Beginning Balance at Mar. 31, 2023	(53,109)		$ 3,417	1,715,291			917	5,427		(1,778,161)
Balance, shares at Mar. 31, 2023			341,663,000
Temporary Equity, Beginning Balance at Mar. 31, 2023											$ 0
Temporary Equity, shares at Mar. 31, 2023											32,000
Net loss	(73,430)							(4,414)		(69,016)
Other comprehensive income (loss)	(1,634)						(1,634)
Share-based compensation	6,042			5,154				888
Shares sold at the market	42,247		$ 246	42,001
Shares sold at the market, shares			24,557,000
Issuance of subsidiary shares to noncontrolling interest	285							285
Vesting of nonvested shares, shares			17,000
MiNK stock dividend					$ (14,888)				$ 14,888
MiNK stock purchases		$ (235)			$ 405				$ (640)
Issuance of shares for employee bonus	1,438		$ 19	3,061		$ (1,642)
Issuance of shares for employee bonus, Shares			1,928,000			(7,000)
Retirement of treasury shares	1,635		$ (7)			$ 1,642
Retirement of treasury shares, share			(673,000)			7,000
Stockholders' Equity, Ending Balance at Jun. 30, 2023	$ (76,761)		$ 3,675	$ 1,751,024			$ (717)	$ 16,434		$ (1,847,177)
Temporary Equity, Ending Balance at Jun. 30, 2023											$ 0
Balance, shares at Jun. 30, 2023			367,492,000
Temporary Equity, shares at Jun. 30, 2023											32,000

XML

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities:
Net loss	$ (144,323)	$ (99,839)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	5,535	3,350
Share-based compensation	11,527	9,625
Non-cash royalty revenue	(41,174)	(17,778)
Non-cash interest expense	36,920	28,588
Loss (gain) on sale of assets	49	(6,601)
Other, net	249
Gain on partial forgiveness of liability		(2,791)
Change in fair value of contingent obligations	(398)	(943)
Changes in operating assets and liabilities:
Accounts receivable	1,021	(17,130)
Prepaid expenses	5,427	(2,947)
Accounts payable	7,969	363
Deferred revenue	(4,439)	(3,284)
Accrued liabilities and other current liabilities	8,135	(1,553)
Other operating assets and liabilities	(5,067)	15,096
Net cash used in operating activities	(118,569)	(95,844)
Cash flows from investing activities:
Purchases of plant and equipment	(6,279)	(22,996)
Proceeds from sale of property, plant and equipment	350	10,002
Purchase of long-term investment	(5,396)
Cash paid for business acquisition		(3,652)
Purchases of available-for-sale securities	(14,647)	(9,945)
Proceeds from sale of available-for-sale securities	15,000	15,000
Net cash used in investing activities	(10,972)	(11,591)
Cash flows from financing activities:
Net proceeds from sale of equity	102,829	47,419
Proceeds from employee stock purchases and option exercises	397	382
Purchase of treasury shares to satisfy tax withholdings	(4,566)	(3,789)
Purchase of subsidiary shares	(236)
Payment of finance lease obligation	(3,911)	(178)
Net cash provided by financing activities	94,513	43,834
Effect of exchange rate changes on cash	(441)	55
Net decrease in cash, cash equivalents and restricted cash	(35,469)	(63,546)
Cash, cash equivalents and restricted cash, beginning of period	181,343	294,600
Cash, cash equivalents and restricted cash, end of period	145,874	231,054
Supplemental cash flow information:
Cash paid for interest	1,705	568
Supplemental disclosures - non-cash activities:
Purchases of plant and equipment in accounts payable and accrued liabilities	4,762	10,555
Insurance financing agreement	707	933
Issuance of subsidiary shares for employee bonus	1,011	294
Lease right-of-use assets obtained in exchange for new operating lease liabilities	287	9,148
Lease right-of-use assets obtained in exchange for new finance lease liabilities	4,635	648
Payment for Services [Member]
Supplemental disclosures - non-cash activities:
Issuance of common stock	318	101
Employee Bonus [Member]
Supplemental disclosures - non-cash activities:
Issuance of common stock	$ 7,288	6,634
Milestone Achievement [Member]
Supplemental disclosures - non-cash activities:
Issuance of common stock		$ 500

XML

Condensed Consolidated Statements of Cash Flows (Unaudited) (Parenthetical)	Jun. 30, 2023 $ / shares
Supplemental disclosures - non-cash activities:
Common stock, par value	$ 0.01
Payment for Services [Member]
Supplemental disclosures - non-cash activities:
Common stock, par value	0.01
Employee Bonus [Member]
Supplemental disclosures - non-cash activities:
Common stock, par value	0.01
Milestone Achievement [Member]
Supplemental disclosures - non-cash activities:
Common stock, par value	$ 0.01

XML

Insider Trading Arrangements	6 Months Ended
	Jun. 30, 2023
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

XML

Business, Liquidity and Basis of Presentation

6 Months Ended

Jun. 30, 2023

Description Of Business [Abstract]

Business, Liquidity and Basis of Presentation

Note A - Business, Liquidity and Basis of Presentation

Agenus Inc. (including its subsidiaries, collectively referred to as “Agenus,” the “Company,” “we,” “us,” and “our”) is a clinical-stage company focused on developing therapies that harness the body’s immune system to combat cancer and infections. Our pipeline includes immune-modulatory antibodies, adoptive cell therapies through our subsidiary MiNK Therapeutics, Inc. (“MiNK”), and vaccine adjuvants through our subsidiary SaponiQx, Inc. (“SaponiQx”). Our approach to Immuno-oncology (“I-O”) emphasizes speed, innovation, and effective combination therapies to drive success. We believe that combination therapies and a deep understanding of each patient’s cancer will significantly expand the patient population benefiting from I-O treatments.

In addition to our diverse pipeline, we have built fully integrated capabilities encompassing novel target discovery, antibody generation, cell line development, and good manufacturing practice clinical manufacturing. We believe these integrated capabilities enable us to develop novel candidates on accelerated timelines compared to industry standards. Through strategic partnerships, we leverage our scientific expertise and capabilities to advance innovation in the field.

Our I-O portfolio is driven by several platforms and programs, which we plan to utilize individually and in combination:

•Multiple antibody discovery platforms, including proprietary display technologies, to identify future antibody candidates.

•Antibody candidate programs, including our lead asset, botensilimab, an Fc-enhanced CTLA-4 antibody. Data presented at the 2023 ESMO World Congress Gastrointestinal Cancer conference (“ESMO GI”) demonstrated significant activity in microsatellite stable colorectal cancer when combined with balstilimab (PD-1). In a late-breaking presentation at ESMO GI, the combination of botensilimab/balstilimab showed a median Overall Survival of 20.9 months for patients without active liver metastases, surpassing the recently reported 12.9 month benchmark with standard of care in this population. In April 2023, the botensilimab/balstilimab combination received Fast Track designation from the United States Food and Drug Administration (“FDA”) for the treatment of non-MSI-H/deficient mismatch repair (dMMR) metastatic colorectal cancer patients without active liver involvement.

•Our saponin-based vaccine adjuvant platform, primarily centered around our STIMULONTM cultured plant cell (“cpc”) QS-21 adjuvant (“STIMULON cpc QS-21”).

•A pipeline of novel allogeneic invariant natural killer T cell therapies for treating cancer and other immune-mediated diseases, controlled by MiNK.

Our business activities encompass various areas such as product research, preclinical and clinical development, intellectual property prosecution, manufacturing, regulatory and clinical affairs, corporate finance and development activities, and support of collaborations. Our strategy includes developing and commercializing product candidates through existing and new collaborations.

Our cash, cash equivalents and short-term investments at June 30, 2023 were $157.9 million, a decrease of $35.5 million from December 31, 2022. Cash and cash equivalents of our subsidiary, MiNK, at March 31, 2023, were $14.9 million. MiNK cash can only be accessed by Agenus through a declaration of a dividend by the MiNK Board of Directors or through settlement of intercompany balances.

We have incurred losses since our inception. As of June 30, 2023, we had an accumulated deficit of $1.8 billion.

We have historically financed our operations through income and revenues generated from corporate partnerships, advance royalty sales and equity issuances. Based on our current plans and projections, we believe our cash resources of $157.9 million at June 30, 2023 will be sufficient to satisfy our liquidity needs for more than one year from when these financial statements were issued.

Management consistently monitors our liquidity position and has the flexibility to adjust spending as necessary to preserve and extend liquidity. We regularly assess the likelihood of success of our programs, and our funding decisions are based on these evaluations. We are prepared to discontinue funding of any activities that do not impact our core priorities and to restrict capital expenditures and/or reduce the scale of our operations. Potential funding sources may include collaborations, out-licensing and/or partnering opportunities for our portfolio programs and product candidates with multiple parties, milestone payments from our existing partnerships, additional third-party agreements, asset sales, project financing, and/or sales of equity securities.

The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) for interim financial information and with the instructions to Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete annual consolidated financial statements. In the opinion of our management, the condensed consolidated financial statements include all

normal and recurring adjustments considered necessary for a fair presentation of our financial position and operating results. All significant intercompany transactions and accounts have been eliminated in consolidation. Operating results for the six months ended June 30, 2023, are not necessarily indicative of the results that may be expected for the year ending December 31, 2023. For further information, refer to our consolidated financial statements and footnotes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2022 filed with the Securities and Exchange Commission (“SEC”).

The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Management bases its estimates on historical experience and on various assumptions that are believed to be reasonable under the circumstances. Actual results could differ materially from those estimates.

For our foreign subsidiaries, the local currency is the functional currency. Assets and liabilities of our foreign subsidiaries are translated into U.S. dollars using rates in effect at the balance sheet date while revenues and expenses are translated into U.S. dollars using average exchange rates during the period. The cumulative translation adjustment resulting from changes in exchange rates are included in the consolidated balance sheets as a component of accumulated other comprehensive income in total stockholders’ equity (deficit).

During the quarter ended June 30, 2023, we deconsolidated certain foreign subsidiaries and recognized a gain of $132,000, included in "Other income (expense)" on our condensed consolidated statements of operations and comprehensive loss.

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Net Loss Per Share

6 Months Ended

Jun. 30, 2023

Earnings Per Share [Abstract]

Net Loss Per Share

Note B - Net Loss Per Share

Basic net loss per common share is calculated by dividing the net loss attributable to common stockholders by the weighted average number of common shares outstanding (including common shares issuable under our Amended and Restated Directors’ Deferred Compensation Plan, or “DDCP”). Diluted loss per common share is calculated by dividing loss attributable to common stockholders by the weighted average number of common shares outstanding (including common shares issuable under our DDCP) plus the dilutive effect of outstanding instruments such as warrants, stock options, non-vested shares and convertible preferred stock. Because we reported a net loss attributable to common stockholders for all periods presented, diluted loss per common share is the same as basic loss per common share, as the effect of utilizing the fully diluted share count would have reduced the net loss per common share. The following securities (listed on an as-if-converted-to-Common-Stock basis) have been excluded from the computation of diluted weighted average shares outstanding as of June 30, 2023 and 2022, as they would be anti-dilutive (in thousands):

	Three and Six Months Ended June 30,
	2023		2022
Warrants		1,980		1,980
Stock options		44,396		36,476
Non-vested shares		542		271
Series A-1 convertible preferred stock		333		333

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Investments

6 Months Ended

Jun. 30, 2023

Cash and Cash Equivalents [Abstract]

Investments

Note C - Investments

Cash equivalents and short-term investments consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023				December 31, 2022
	Cost		Estimated Fair Value		Cost		Estimated Fair Value
Institutional money market funds	$	72,375	$	72,375	$	149,856	$	149,856
U.S. Treasury Bills		69,291		69,291		29,522		29,522
Total	$	141,666	$	141,666	$	179,378	$	179,378

As a result of the short-term nature of these investments, there were minimal unrealized holding gains or losses for the three and six months ended June 30, 2023 and 2022.

Of the investments listed above, $127.0 million and $164.7 million were classified as cash equivalents and $14.6 million and $14.7 million as short-term investments on our condensed consolidated balance sheets as of June 30, 2023 and December 31, 2022, respectively.

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Goodwill and Acquired Intangible Assets

6 Months Ended

Jun. 30, 2023

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill and Acquired Intangible Assets

Note D - Goodwill and Acquired Intangible Assets

The following table sets forth the changes in the carrying amount of goodwill for the six months ended June 30, 2023 (in thousands):

Balance, December 31, 2022	$	25,467
Disposals	$	(805	)
Foreign currency translation adjustment		66
Balance, June 30, 2023	$	24,728

Acquired intangible assets consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	As of June 30, 2023
	Amortization period  (years)	Gross carrying amount		Accumulated amortization			Net carrying amount
Intellectual property	7-15 years	$	16,840	$	(14,756	)	$	2,084
Trademarks	4-4.5 years		1,214		(1,145	)		69
Other	2-7 years		1,998		(1,222	)		776
In-process research and development	Indefinite		2,057		—			2,057
Total		$	22,109	$	(17,123	)	$	4,986

	As of December 31, 2022
	Amortization period  (years)	Gross carrying amount		Accumulated amortization			Net carrying amount
Intellectual property	7-15 years	$	16,790	$	(13,782	)	$	3,008
Trademarks	4-4.5 years		1,272		(1,139	)		133
Other	2-6 years		2,278		(1,227	)		1,051
In-process research and development	Indefinite		2,036		—			2,036
Total		$	22,376	$	(16,148	)	$	6,228

The weighted average amortization period of our finite-lived intangible assets is 9 years. Amortization expense related to acquired intangibles is estimated at $0.6 million for the remainder of 2023, $0.6 million for the year ending December 31, 2024, $0.5 million for the years ending December 31, 2025 and 2026 and $0.4 million for the year ending December 31, 2027.

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Debt

6 Months Ended

Jun. 30, 2023

Debt Disclosure [Abstract]

Debt

Note E - Debt

Debt obligations consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

Debt instrument	Balance at June 30, 2023
Current Portion:
Debentures	$	146
Other		476
Long-term Portion:
2015 Subordinated Notes		12,673
Total	$	13,295

Debt instrument	Balance at December 31, 2022
Current Portion:
Debentures	$	146
Other		429
Long-term Portion:
2015 Subordinated Notes		12,584
Total	$	13,159

As of both June 30, 2023 and December 31, 2022, the principal amount of our outstanding debt balance was $13.6 million.

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Liability Related to the Sale of Future Royalties and Milestones

6 Months Ended

Jun. 30, 2023

Liability Related To Sale Of Future Royalties And Milestones [Abstract]

Liability Related to the Sale of Future Royalties and Milestones

Note F – Liability Related to the Sale of Future Royalties and Milestones

The following table shows the activity within the liability account in the six months ended June 30, 2023 (in thousands):

	Period from December 31, 2022 to June 30, 2023
Liability related to sale of future royalties and milestones - beginning balance	$	271,560
Non-cash royalty revenue		(41,174	)
Non-cash interest expense recognized		36,801
Liability related to sale of future royalties and milestones - ending balance		267,187
Less: unamortized transaction costs		(267	)
Liability related to sale of future royalties and milestones, net	$	266,920

Healthcare Royalty Partners

In January 2018, we, through our wholly-owned subsidiary Antigenics, LLC (“Antigenics”), entered into a Royalty Purchase Agreement (the “HCR Royalty Purchase Agreement”) with Healthcare Royalty Partners III, L.P. and certain of its affiliates (collectively, “HCR”). Pursuant to the terms of the HCR Royalty Purchase Agreement, we sold to HCR 100% of Antigenics’ worldwide rights to receive royalties from GlaxoSmithKline (“GSK”) on sales of GSK’s vaccines containing our QS-21 STIMULON adjuvant. At closing, we received gross proceeds of $190.0 million from HCR. Although we sold all of our rights to receive royalties on sales of GSK’s vaccines containing QS-21, as a result of our obligation to HCR, we are required to account for the $190.0 million in proceeds from this transaction as a liability on our condensed consolidated balance sheet that will be recognized into revenue in proportion to the royalty payments from GSK to HCR over the estimated life of the HCR Royalty Purchase Agreement. The liability is classified between the current and non-current portion of liability related to sale of future royalties and milestones in the condensed consolidated balance sheets based on the estimated royalty payments to be received by HCR in the next 12 months from the financial statement reporting date.

During the six months ended June 30, 2023, we recognized $41.2 million of non-cash royalty revenue, and we recorded $36.8 million of related non-cash interest expense related to the HCR Royalty Purchase Agreement.

As royalties are remitted to HCR from GSK, the balance of the recorded liability will be effectively repaid over the life of the HCR Royalty Purchase Agreement. To determine the amortization of the recorded liability, we are required to estimate the total amount of future royalty payments to be received by HCR. The sum of these amounts less the $190.0 million proceeds we received will be recorded as interest expense over the life of the HCR Royalty Purchase Agreement. Periodically, we assess the estimated royalty payments to be paid to HCR from GSK, and to the extent the amount or timing of the payments is materially different from our original estimates, we will prospectively adjust the amortization of the liability, and the related recognition of interest expense. During the six months ended June 30, 2023, our estimate of the effective annual interest rate over the life of the agreement increased to 30.4%, which results in a life of contract interest rate of 23.6%.

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Accrued and Other Current Liabilities

6 Months Ended

Jun. 30, 2023

Other Liabilities Disclosure [Abstract]

Accrued and Other Current Liabilities

Note G - Accrued and Other Current Liabilities

Accrued liabilities consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023		December 31, 2022
Payroll	$	7,957	$	15,872
Professional fees		5,771		6,946
Contract manufacturing costs		2,857		1,848
Research services		8,511		7,074
Other		5,098		6,519
Total	$	30,194	$	38,259

Other current liabilities consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023		December 31, 2022
Finance lease liabilities	$	9,894	$	7,952
Other		3,374		3,505
Total	$	13,268	$	11,457

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Fair Value Measurements

6 Months Ended

Jun. 30, 2023

Fair Value Measurements [Abstract]

Fair Value Measurements

Note H - Fair Value Measurements

Assets and liabilities measured at fair value are summarized below (in thousands):

Description	June 30, 2023		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Assets:
Cash equivalents (Note C)	$	127,020	$	127,020	$	—	$	—
Short-term investments (Note C)		14,647		14,647		—		—
Long-term investments		5,015		5,015		—		—
Total	$	146,682	$	146,682	$	—	$	—
Liabilities:
Contingent purchase price considerations	$	476	$	—	$	—	$	476
Total	$	476	$	—	$	—	$	476
Description	December 31, 2022		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Assets:
Cash equivalents (Note C)	$	164,694	$	—	$	—	$	—
Short-term investments (Note C)		14,689		—		—		—
Total	$	179,383	$	—	$	—	$	—
Liabilities:
Contingent purchase price consideration	$	874	$	—	$	—	$	874
Total	$	874	$	—	$	—	$	874

We measure our contingent purchase price considerations at fair value. The fair values of our contingent purchase price considerations at June 30, 2023 and December 31, 2022, of $0.5 million and $0.9 million, respectively, included in "Other long-term liabilities" in our condensed consolidated balance sheets, are based on significant inputs not observable in the market, which require them to be reported as Level 3 liabilities within the fair value hierarchy. The valuation of these liabilities use assumptions we believe would be made by a market participant and are mainly based on estimates from a Monte Carlo simulation of our share price, as well as other factors impacting the probability of triggering the milestone payments. Share price was evolved using a geometric Brownian motion, calculated daily for the life of the contingent purchase price considerations.

The fair value of our outstanding debt balance at June 30, 2023 and December 31, 2022 was $13.3 million and $13.2 million, respectively, based on the Level 2 valuation hierarchy of the fair value measurements standard using a present value methodology that was derived by evaluating the nature and terms of each note and considering the prevailing economic and market conditions at the balance sheet date. The principal amount of our outstanding debt balance at both June 30, 2023 and December 31, 2022 was $13.6 million.

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Revenue from Contracts with Customers

6 Months Ended

Jun. 30, 2023

Collaboration [Abstract]

Revenue from Contracts with Customers

Note I - Revenue from Contracts with Customers

Gilead Collaboration Agreement

On December 20, 2018, we entered into a series of agreements with Gilead Sciences, Inc. (“Gilead”) focused on the development and commercialization of up to five novel immuno-oncology therapies. Pursuant to the terms of the license agreement, the option and license agreements and the stock purchase agreement we entered into with Gilead (collectively, the “Gilead

Collaboration Agreements”), at the closing of the transaction on January 23, 2019, we received an upfront cash payment from Gilead of $120.0 million and Gilead made a $30.0 million equity investment in Agenus. On November 6, 2020, we received notice from Gilead that it was returning AGEN1423 to us and voluntarily terminating the applicable license agreement. The termination was effective as of February 4, 2021. In the third quarter of 2021 we ceased development of AGEN1223 and in October 2021 the AGEN1223 option and license agreement was formally terminated. The AGEN2373 option and license agreement and the stock purchase agreement remain in full force and effect. We remain eligible to receive a $50.0 million exercise fee and, if exercised, up to $520.0 million in aggregate potential milestones.

Collaboration Revenue

For the three months ended June 30, 2023 and 2022, we recognized approximately $2.0 million and $1.2 million, respectively, of research and development revenue based on the partial satisfaction of the over time performance obligations as of quarter end.

For the six months ended June 30, 2023, we recognized approximately $4.4 million of research and development revenue based on the partial satisfaction of the over time performance obligations as of period end. For the six months ended June 30, 2022, we recognized research and development revenue of $5.0 million related to the achievement of a milestone and $2.6 million based on the partial satisfaction of the over time performance obligations as of period end.

We expect to recognize deferred research and development revenue of $7.8 million for the remainder of 2023 related to performance obligations that are unsatisfied or partially unsatisfied as of June 30, 2023.

Disaggregation of Revenue

The following table presents revenue (in thousands) for the three and six months ended June 30, 2023 and 2022, disaggregated by geographic region and revenue type. Revenue by geographic region is allocated based on the domicile of our respective business operations.

	Three months ended June 30, 2023
	United States		Rest of World		Total
Revenue Type
Research and development services		444		—		444
Other services		—		739		739
Recognition of deferred revenue		2,045		—		2,045
Non-cash royalties		22,068		—		22,068
	$	24,557	$	739	$	25,296
	Three months ended June 30, 2022
Revenue Type
Royalty sales milestone	$	17,316	$	—	$	17,316
Research and development services		660		—		660
Other services		—		1,559		1,559
Recognition of deferred revenue		1,247		—		1,247
Non-cash royalties		144		—		144
	$	19,367	$	1,559	$	20,926

	Six months ended June 30, 2023
	United States		Rest of World		Total
Revenue Type
Research and development services		711		—		711
Other services		—		1,923		1,923
Recognition of deferred revenue		4,390		—		4,390
Non-cash royalties		41,174		—		41,174
	$	46,275	$	1,923	$	48,198
	Six months ended June 30, 2022
Revenue Type
License fees and milestones	$	5,000	$	—	$	5,000
Royalty sales milestone		17,316		—		17,316
Research and development services		1,032		—		1,032
Other services		—		3,126		3,126
Recognition of deferred revenue		2,615		—		2,615
Non-cash royalties		17,778		—		17,778
	$	43,741	$	3,126	$	46,867

Contract Balances

Contract assets primarily relate to our rights to consideration for work completed in relation to our research and development services performed but not billed at the reporting date. The contract assets are transferred to receivables when the rights become unconditional. Currently, we do not have any contract assets which have not transferred to a receivable. We had no asset impairment charges related to contract assets in the period. Contract liabilities primarily relate to contracts where we received payments but have not yet satisfied the related performance obligations. The advance consideration received from customers for research and development services or licenses bundled with other promises is a contract liability until the underlying performance obligations are transferred to the customer.

The following table provides information about contract liabilities from contracts with customers (in thousands):

Six months ended June 30, 2023	Balance at beginning of period		Additions		Deductions			Balance at end of period
Contract liabilities:
Deferred revenue	$	13,412	$	6	$	(4,447	)	$	8,971

The change in contract liabilities is primarily related to the recognition of $4.4 million of revenue related to the Gilead Collaboration Agreements during the six months ended June 30, 2023. Deferred revenue related to the Gilead Collaboration Agreements of $7.8 million as of June 30, 2023, which was comprised of the $142.5 million initial transaction price, less $134.7 million of license and collaboration revenue recognized from the effective date of the contract, will be recognized as the combined performance obligation is satisfied.

We also recorded a $1.3 million receivable as of June 30, 2023, for research and development and other services provided.

During the six months ended June 30, 2023, we did not recognize any revenue from amounts included in the contract asset or the contract liability balances from performance obligations satisfied in previous periods. None of the costs to obtain or fulfill a contract were capitalized.

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Share-Based Compensation Plans

6 Months Ended

Jun. 30, 2023

Share-Based Payment Arrangement, Noncash Expense [Abstract]

Share-Based Compensation Plans

Note J - Share-based Compensation Plans

We primarily use the Black-Scholes option pricing model to value stock options granted to employees and non-employees, including stock options granted to members of our Board of Directors. However, the fair value of stock option market-based awards is

calculated based on a Monte Carlo simulation as of the date of issuance. All stock options have 10-year terms and generally vest ratably over a 3 or 4-year period.

A summary of option activity for the six months ended June 30, 2023 is presented below:

	Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Outstanding at December 31, 2022		35,984,967		$	3.51
Granted		9,439,902			2.35
Exercised		(46,750	)		1.68
Forfeited		(532,835	)		2.58
Expired		(448,863	)		3.78
Outstanding at June 30, 2023		44,396,421		$	3.27		6.91	$	53,747
Vested or expected to vest at June 30, 2023		44,396,421		$	3.27		6.91	$	53,747
Exercisable at June 30, 2023		26,931,597		$	3.60		5.88	$	7,016

The weighted average grant-date fair values of stock options granted during the six months ended June 30, 2023 and 2022 were $1.49 and $1.76, respectively.

As of June 30, 2023, there was approximately $32.7 million of total unrecognized share-based compensation expense related to these stock options and stock options granted under subsidiary plans which, if all milestones are achieved, will be recognized over a weighted average period of 2.0 years.

Certain employees and consultants have been granted non-vested stock. The fair value of non-vested market-based awards is calculated based on a Monte Carlo simulation as of the date of issuance. The fair value of other non-vested stock is calculated based on the closing sale price of our common stock on the date of issuance.

A summary of non-vested stock activity for the six months ended June 30, 2023 is presented below:

	Non-vested Shares			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2022		355,802		$	2.50
Granted		4,971,652			2.41
Vested		(4,665,474	)		2.45
Forfeited		(120,000	)		1.88
Outstanding at June 30, 2023		541,980		$	2.37

As of June 30, 2023, there was approximately $1.2 million of unrecognized share-based compensation expense related to these non-vested shares and non-vested shares granted under subsidiary plans which will be recognized over a period of 2.0 years.

During the six months ended June 30, 2023, 150,291 shares were issued under the 2019 Employee Stock Purchase Plan, 46,750 shares were issued as a result of stock option exercises and 21,666 shares were issued as a result of the vesting of non-vested stock. Additionally, 4,643,808 shares were issued as payment for certain employee bonuses, with 1,668,767 of those shares being withheld to cover taxes, resulting in a net share issuance of 2,975,041.

The impact on our results of operations from share-based compensation for the three and six months ended June 30, 2023 and 2022, was as follows (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Research and development	$	1,656	$	1,192	$	3,389	$	2,531
General and administrative		4,386		3,423		8,138		7,031
Total share-based compensation expense	$	6,042	$	4,615	$	11,527	$	9,562

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Restricted Cash

6 Months Ended

Jun. 30, 2023

Cash and Cash Equivalents [Abstract]

Restricted Cash

Note K – Restricted Cash

As of both June 30, 2023, and December 31, 2022, we maintained non-current restricted cash of $2.7 million. This amount is included within “Other long-term assets” in our condensed consolidated balance sheets and is comprised of letters of credit required under two of our facility leases.

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Six Months Ended June 30, 2023				Six Months Ended June 30, 2022
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	178,674	$	143,205	$	291,931	$	228,385
Restricted cash		2,669		2,669		2,669		2,669
Cash, cash equivalents and restricted cash	$	181,343	$	145,874	$	294,600	$	231,054

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Equity

6 Months Ended

Jun. 30, 2023

Equity [Abstract]

Equity

Note L – Equity

On June 23, 2023, we filed an Automatic Shelf Registration Statement on Form S-3ASR (file no. 333-272911) (the “Registration Statement”). The Registration Statement included both a base prospectus that covered the potential offering, issuance and sale from time to time of common stock, preferred stock, warrants, debt securities and units of Agenus and a prospectus supplement for the potential offer and sale of up to 184,638,269 shares of common stock (the “Placement Shares”) in “at the market” offerings pursuant to an At Market Issuance Sales Agreement by and between Agenus and B. Riley Securities, Inc. (the “Sales Agent”), dated as of July 22, 2020 (the “Sales Agreement”). Sales pursuant to the Sales Agreement will be made only upon our instruction to the Sales Agent, and we cannot provide assurances that we will issue any additional Placement Shares pursuant to the Sales Agreement.

During the three and six months ended June 30, 2023, we received net proceeds of approximately $42.2 million and $102.8 million from the sale of approximately 24.6 million and 58.3 million shares of our common stock, respectively, in at-the-market offerings under the Sales Agreement.

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Non-controlling Interest

6 Months Ended

Jun. 30, 2023

Noncontrolling Interest [Abstract]

Non-controlling Interest

Note M – Non-controlling Interest

Non-controlling interest recorded in our condensed consolidated financial statements as of June 30, 2023 and December 31, 2022, relates to the following approximate interests in certain consolidated subsidiaries, which we do not own.

	June 30, 2023			December 31, 2022
MiNK Therapeutics, Inc.		38	%		22	%
SaponiQx, Inc.		30	%		30	%

Changes in non-controlling interest for the periods ended June 30, 2023 and December 31, 2022, were as follows (in thousands):

	June 30, 2023			December 31, 2022
Beginning balance	$	6,376		$	13,469
Net loss attributable to non-controlling interest		(7,053	)		(10,582	)
Other items:
Distribution of subsidiary shares to Agenus stockholders		14,888			—
Purchase of subsidiary shares		(640	)		—
Issuance of subsidiary shares for employee bonus		1,011			294
Issuance of subsidiary shares under employee stock purchase plan		45			—
Subsidiary share-based compensation		1,807			3,195
Total other items		17,111			3,489
Ending balance	$	16,434		$	6,376

Distribution of subsidiary shares to Agenus stockholders

On March 29, 2023, our Board of Directors declared a stock dividend (the "Dividend") consisting of an aggregate of 5.0 million shares (the "Dividend Stock") of common stock, par value $0.00001 per share, of MiNK held by Agenus to record holders of Agenus' common stock, par value $0.01 per share as of the close of business on April 17, 2023 (the "Record Date").

On May 1, 2023, we paid the Dividend and distributed 0.0146 of a share of the Dividend Stock for each share of Agenus Common Stock outstanding as of the close of business on the Record Date. No fractional shares were issued in connection with the Dividend and the shareholders of Agenus who were entitled to receive fractional shares of the Dividend Stock received cash (without interest) in lieu of such fractional shares. Subsequent to the distribution of the Dividend Stock, we maintained a controlling voting interest in MiNK.

Purchase of subsidiary shares

In May 2023, we purchased 195,788 shares of MiNK common stock in multiple open market transactions.

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Related Party Transactions

6 Months Ended

Jun. 30, 2023

Related Party Transactions [Abstract]

Related Party Transactions

Note N – Related Party Transactions

In 2023, our Audit and Finance Committee approved a contract between Avillion Life Sciences LTD ("Avillion") and Agenus for the performance of up to $450,000 of clinical consulting services. Allison Jeynes, a member of our Board of Directors, is chief executive officer of Avillion. For the three and six months ended June 30, 2023, approximately $222,000 and $450,000, respectively, related to these services is included in “Research and development” expense in our condensed consolidated statements of operations.

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Recent Accounting Pronouncements

6 Months Ended

Jun. 30, 2023

Accounting Standards Update and Change in Accounting Principle [Abstract]

Recent Accounting Pronouncements

Note O - Recent Accounting Pronouncements

Recently Issued and Adopted

In January 2017, the Financial Accounting Standards Board issued ASU 2017-04, Intangibles – Goodwill and Other (Topic 350) that will eliminate the requirement to calculate the implied fair value of goodwill to measure a goodwill impairment charge. Instead, an impairment charge will be based on the excess of a reporting unit’s carrying amount over its fair value. We adopted the standard on January 1, 2023. The adoption did not have a material impact on our consolidated financial statements.

No other new accounting pronouncement issued or effective during the six months ended June 30, 2023 had or is expected to have a material impact on our consolidated financial statements or disclosures.

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Subsequent Events

6 Months Ended

Jun. 30, 2023

Subsequent Events [Abstract]

Subsequent Events

Note P – Subsequent Events

At the Market Offerings

During the period of July 1, 2023 through August 4, 2023, we sold approximately 13.2 million shares of our common stock under the Sales Agreement, totaling net proceeds of approximately $20.3 million.

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Net Loss Per Share (Tables)

6 Months Ended

Jun. 30, 2023

Earnings Per Share [Abstract]

Schedule of Anti-dilutive Securities Excluded from Computation of Diluted Weighted Average Shares Outstanding

The following securities

	Three and Six Months Ended June 30,
	2023		2022
Warrants		1,980		1,980
Stock options		44,396		36,476
Non-vested shares		542		271
Series A-1 convertible preferred stock		333		333

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Investments (Tables)

6 Months Ended

Jun. 30, 2023

Cash and Cash Equivalents [Abstract]

Schedule of Cash Equivalents

Cash equivalents and short-term investments consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023				December 31, 2022
	Cost		Estimated Fair Value		Cost		Estimated Fair Value
Institutional money market funds	$	72,375	$	72,375	$	149,856	$	149,856
U.S. Treasury Bills		69,291		69,291		29,522		29,522
Total	$	141,666	$	141,666	$	179,378	$	179,378

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Goodwill and Acquired Intangible Assets (Tables)

6 Months Ended

Jun. 30, 2023

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Changes in Goodwill

The following table sets forth the changes in the carrying amount of goodwill for the six months ended June 30, 2023 (in thousands):

Balance, December 31, 2022	$	25,467
Disposals	$	(805	)
Foreign currency translation adjustment		66
Balance, June 30, 2023	$	24,728

Schedule of Acquired Intangible Assets

Acquired intangible assets consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	As of June 30, 2023
	Amortization period  (years)	Gross carrying amount		Accumulated amortization			Net carrying amount
Intellectual property	7-15 years	$	16,840	$	(14,756	)	$	2,084
Trademarks	4-4.5 years		1,214		(1,145	)		69
Other	2-7 years		1,998		(1,222	)		776
In-process research and development	Indefinite		2,057		—			2,057
Total		$	22,109	$	(17,123	)	$	4,986

	As of December 31, 2022
	Amortization period  (years)	Gross carrying amount		Accumulated amortization			Net carrying amount
Intellectual property	7-15 years	$	16,790	$	(13,782	)	$	3,008
Trademarks	4-4.5 years		1,272		(1,139	)		133
Other	2-6 years		2,278		(1,227	)		1,051
In-process research and development	Indefinite		2,036		—			2,036
Total		$	22,376	$	(16,148	)	$	6,228

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Debt (Tables)

6 Months Ended

Jun. 30, 2023

Debt Disclosure [Abstract]

Schedule of Debt Obligations

Debt obligations consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

Debt instrument	Balance at June 30, 2023
Current Portion:
Debentures	$	146
Other		476
Long-term Portion:
2015 Subordinated Notes		12,673
Total	$	13,295

Debt instrument	Balance at December 31, 2022
Current Portion:
Debentures	$	146
Other		429
Long-term Portion:
2015 Subordinated Notes		12,584
Total	$	13,159

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Liability Related to the Sale of Future Royalties and Milestones (Tables)

6 Months Ended

Jun. 30, 2023

Liability Related To Sale Of Future Royalties And Milestones [Abstract]

Schedule of Liability Account

The following table shows the activity within the liability account in the six months ended June 30, 2023 (in thousands):

	Period from December 31, 2022 to June 30, 2023
Liability related to sale of future royalties and milestones - beginning balance	$	271,560
Non-cash royalty revenue		(41,174	)
Non-cash interest expense recognized		36,801
Liability related to sale of future royalties and milestones - ending balance		267,187
Less: unamortized transaction costs		(267	)
Liability related to sale of future royalties and milestones, net	$	266,920

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Accrued and Other Current Liabilities (Tables)

6 Months Ended

Jun. 30, 2023

Other Liabilities Disclosure [Abstract]

Schedule of Accrued Liabilities

Accrued liabilities consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023		December 31, 2022
Payroll	$	7,957	$	15,872
Professional fees		5,771		6,946
Contract manufacturing costs		2,857		1,848
Research services		8,511		7,074
Other		5,098		6,519
Total	$	30,194	$	38,259

Schedule of Other Current Liabilities

Other current liabilities consisted of the following as of June 30, 2023 and December 31, 2022 (in thousands):

	June 30, 2023		December 31, 2022
Finance lease liabilities	$	9,894	$	7,952
Other		3,374		3,505
Total	$	13,268	$	11,457

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Fair Value Measurements (Tables)

6 Months Ended

Jun. 30, 2023

Fair Value Disclosures [Abstract]

Schedule of Assets and Liabilities measured at Fair Value

Assets and liabilities measured at fair value are summarized below (in thousands):

Description	June 30, 2023		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Assets:
Cash equivalents (Note C)	$	127,020	$	127,020	$	—	$	—
Short-term investments (Note C)		14,647		14,647		—		—
Long-term investments		5,015		5,015		—		—
Total	$	146,682	$	146,682	$	—	$	—
Liabilities:
Contingent purchase price considerations	$	476	$	—	$	—	$	476
Total	$	476	$	—	$	—	$	476
Description	December 31, 2022		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Assets:
Cash equivalents (Note C)	$	164,694	$	—	$	—	$	—
Short-term investments (Note C)		14,689		—		—		—
Total	$	179,383	$	—	$	—	$	—
Liabilities:
Contingent purchase price consideration	$	874	$	—	$	—	$	874
Total	$	874	$	—	$	—	$	874

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Revenue from Contracts with Customers (Tables)

6 Months Ended

Jun. 30, 2023

Collaboration [Abstract]

Summary of Disaggregation of Revenue

The following table presents revenue (in thousands) for the three and six months ended June 30, 2023 and 2022, disaggregated by geographic region and revenue type. Revenue by geographic region is allocated based on the domicile of our respective business operations.

	Three months ended June 30, 2023
	United States		Rest of World		Total
Revenue Type
Research and development services		444		—		444
Other services		—		739		739
Recognition of deferred revenue		2,045		—		2,045
Non-cash royalties		22,068		—		22,068
	$	24,557	$	739	$	25,296
	Three months ended June 30, 2022
Revenue Type
Royalty sales milestone	$	17,316	$	—	$	17,316
Research and development services		660		—		660
Other services		—		1,559		1,559
Recognition of deferred revenue		1,247		—		1,247
Non-cash royalties		144		—		144
	$	19,367	$	1,559	$	20,926

	Six months ended June 30, 2023
	United States		Rest of World		Total
Revenue Type
Research and development services		711		—		711
Other services		—		1,923		1,923
Recognition of deferred revenue		4,390		—		4,390
Non-cash royalties		41,174		—		41,174
	$	46,275	$	1,923	$	48,198
	Six months ended June 30, 2022
Revenue Type
License fees and milestones	$	5,000	$	—	$	5,000
Royalty sales milestone		17,316		—		17,316
Research and development services		1,032		—		1,032
Other services		—		3,126		3,126
Recognition of deferred revenue		2,615		—		2,615
Non-cash royalties		17,778		—		17,778
	$	43,741	$	3,126	$	46,867

Schedule of Information about Contract Assets and Contract Liabilities from Contracts with Customers

The following table provides information about contract liabilities from contracts with customers (in thousands):

Six months ended June 30, 2023	Balance at beginning of period		Additions		Deductions			Balance at end of period
Contract liabilities:
Deferred revenue	$	13,412	$	6	$	(4,447	)	$	8,971

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Share-Based Compensation Plans (Tables)

6 Months Ended

Jun. 30, 2023

Share-Based Payment Arrangement, Noncash Expense [Abstract]

Schedule of Stock Option Activity

A summary of option activity for the six months ended June 30, 2023 is presented below:

	Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Outstanding at December 31, 2022		35,984,967		$	3.51
Granted		9,439,902			2.35
Exercised		(46,750	)		1.68
Forfeited		(532,835	)		2.58
Expired		(448,863	)		3.78
Outstanding at June 30, 2023		44,396,421		$	3.27		6.91	$	53,747
Vested or expected to vest at June 30, 2023		44,396,421		$	3.27		6.91	$	53,747
Exercisable at June 30, 2023		26,931,597		$	3.60		5.88	$	7,016

Summary of Non-vested Stock Activity

A summary of non-vested stock activity for the six months ended June 30, 2023 is presented below:

	Non-vested Shares			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2022		355,802		$	2.50
Granted		4,971,652			2.41
Vested		(4,665,474	)		2.45
Forfeited		(120,000	)		1.88
Outstanding at June 30, 2023		541,980		$	2.37

Schedule of Share-Based Compensation Expense

The impact on our results of operations from share-based compensation for the three and six months ended June 30, 2023 and 2022, was as follows (in thousands):

	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Research and development	$	1,656	$	1,192	$	3,389	$	2,531
General and administrative		4,386		3,423		8,138		7,031
Total share-based compensation expense	$	6,042	$	4,615	$	11,527	$	9,562

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Restricted Cash (Tables)

6 Months Ended

Jun. 30, 2023

Cash and Cash Equivalents [Abstract]

Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents and restricted cash that sums to the total of the same such amounts shown in the condensed consolidated statements of cash flows (in thousands):

	Six Months Ended June 30, 2023				Six Months Ended June 30, 2022
	Beginning of Period		End of Period		Beginning of Period		End of Period
Cash and cash equivalents	$	178,674	$	143,205	$	291,931	$	228,385
Restricted cash		2,669		2,669		2,669		2,669
Cash, cash equivalents and restricted cash	$	181,343	$	145,874	$	294,600	$	231,054

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Non-controlling Interest (Tables)

6 Months Ended

Jun. 30, 2023

Noncontrolling Interest [Abstract]

Schedule Of Approximate Interests In Certain Consolidated Subsidiaries

Non-controlling interest recorded in our condensed consolidated financial statements as of June 30, 2023 and December 31, 2022, relates to the following approximate interests in certain consolidated subsidiaries, which we do not own.

	June 30, 2023			December 31, 2022
MiNK Therapeutics, Inc.		38	%		22	%
SaponiQx, Inc.		30	%		30	%

Schedule Of Changes In Non-controlling Interest

Changes in non-controlling interest for the periods ended June 30, 2023 and December 31, 2022, were as follows (in thousands):

	June 30, 2023			December 31, 2022
Beginning balance	$	6,376		$	13,469
Net loss attributable to non-controlling interest		(7,053	)		(10,582	)
Other items:
Distribution of subsidiary shares to Agenus stockholders		14,888			—
Purchase of subsidiary shares		(640	)		—
Issuance of subsidiary shares for employee bonus		1,011			294
Issuance of subsidiary shares under employee stock purchase plan		45			—
Subsidiary share-based compensation		1,807			3,195
Total other items		17,111			3,489
Ending balance	$	16,434		$	6,376

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Business, Liquidity and Basis of Presentation (Narrative) (Details) - USD ($)	3 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022	Mar. 31, 2023	Jun. 30, 2022	Dec. 31, 2021
Product Information [Line Items]
Cash, cash equivalents and short term investment	$ 157,900,000
Decrease cash, cash equivalents and short term investment		$ 35,500,000
Accumulated deficit	1,847,177,000	1,709,907,000
Cash and cash equivalents	143,205,000	$ 178,674,000		$ 228,385,000	$ 291,931,000
Other income (expense)
Product Information [Line Items]
Gain on deconsolidation of certain foreign subsidiaries	$ 132,000
MiNK Therapeutics, Inc.
Product Information [Line Items]
Cash and cash equivalents			$ 14,900,000

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Net Loss Per Share (Schedule of Anti-dilutive Securities Excluded from Computation of Diluted Weighted Average Shares Outstanding) (Details) - shares	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Warrants [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	1,980,000	1,980,000	1,980,000	1,980,000
Employee Stock Option
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	44,396,000	36,476,000	44,396,000	36,476,000
Non-vested Shares [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	542,000	271,000	542,000	271,000
Series A-1 convertible preferred stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	333,000	333,000	333,000	333,000

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Investments (Schedule of Cash Equivalents and Short Term Investments) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	$ 157,900
Cost [Member]
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	141,666	$ 179,378
Estimated Fair Value [Member]
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	141,666	179,378
Institutional Money Market Funds [Member] | Cost [Member]
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	72,375	149,856
Institutional Money Market Funds [Member] | Estimated Fair Value [Member]
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	72,375	149,856
U.S. Treasury Bills [Member] | Cost [Member]
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	69,291	29,522
U.S. Treasury Bills [Member] | Estimated Fair Value [Member]
Cash And Cash Equivalents [Line Items]
Cash equivalents and short term investments	$ 69,291	$ 29,522

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Investments Additional Informations (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Cash And Cash Equivalents [Line Items]
Cash equivalents	$ 127,000	$ 164,700
Short-term investments	14,647	14,684
Short Term Investments [Member]
Cash And Cash Equivalents [Line Items]
Short-term investments	$ 14,600	$ 14,700

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Goodwill and Acquired Intangible Assets (Schedule of Changes in Goodwill) (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($)
Goodwill [Roll Forward]
Beginning balance	$ 25,467
Disposals	(805)
Foreign currency translation adjustment	66
Ending balance	$ 24,728

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Goodwill and Acquired Intangible Assets (Acquired Intangible Assets) (Details) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Finite-Lived Intangible Assets [Line Items]
Intangible Assets, Gross (Excluding Goodwill)	$ 22,109	$ 22,376
Accumulated amortization	(17,123)	(16,148)
Net carrying amount	4,986	6,228
Indefinite-lived Intangible Assets Acquired	2,057	2,036
Intellectual Property [Member]
Finite-Lived Intangible Assets [Line Items]
Gross carrying amount	16,840	16,790
Accumulated amortization	(14,756)	(13,782)
Net carrying amount	$ 2,084	$ 3,008
Intellectual Property [Member] | Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Amortization period (years)	7 years	7 years
Intellectual Property [Member] | Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Amortization period (years)	15 years	15 years
Trademarks [Member]
Finite-Lived Intangible Assets [Line Items]
Gross carrying amount	$ 1,214	$ 1,272
Accumulated amortization	(1,145)	(1,139)
Net carrying amount	$ 69	$ 133
Trademarks [Member] | Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Amortization period (years)	4 years	4 years
Trademarks [Member] | Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Amortization period (years)	4 years 6 months	4 years 6 months
Other [Member]
Finite-Lived Intangible Assets [Line Items]
Gross carrying amount	$ 1,998	$ 2,278
Accumulated amortization	(1,222)	(1,227)
Net carrying amount	$ 776	$ 1,051
Other [Member] | Minimum [Member]
Finite-Lived Intangible Assets [Line Items]
Amortization period (years)	2 years	2 years
Other [Member] | Maximum [Member]
Finite-Lived Intangible Assets [Line Items]
Amortization period (years)	7 years	6 years

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Goodwill and Acquired Intangible Assets (Narrative) (Details) $ in Millions	6 Months Ended
	Jun. 30, 2023 USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]
Acquired Finite-lived Intangible Assets, Weighted Average Useful Life	9 years
Finite-Lived Intangible Assets, Estimated Amortization Expense, Remainder of 2023	$ 0.6
Finite-Lived Intangible Assets, Estimated Amortization Expense, December 31, 2024	0.6
Finite-Lived Intangible Assets, Estimated Amortization Expense, December 31, 2025	0.5
Finite-Lived Intangible Assets, Estimated Amortization Expense, December 31, 2026	0.5
Finite-Lived Intangible Assets, Estimated Amortization Expense, December 31, 2027	$ 0.4

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Debt - Schedule of Debt Obligations (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Debt Instrument [Line Items]
Other	$ 476	$ 429
Total	13,295	13,159
2015 Subordinated Notes [Member]
Debt Instrument [Line Items]
2015 Subordinated Notes	12,673	12,584
Debentures [Member]
Debt Instrument [Line Items]
Debentures	$ 146	$ 146

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Debt (Narrative) (Details) - USD ($) $ in Millions	Jun. 30, 2023	Dec. 31, 2022
Debt Disclosure [Abstract]
Principal amount of outstanding debt	$ 13.6	$ 13.6

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Liability Related to the Sale of Future Royalties and Milestones (Schedule of Liability Account) (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($)
Liability Related To Sale Of Future Royalties And Milestones [Abstract]
Liability related to sale of future royalties and milestones - beginning balance	$ 271,560
Non-cash royalty revenue	(41,174)
Non-cash interest expense recognized	36,801
Liability related to sale of future royalties and milestones - ending balance	267,187
Less: unamortized transaction costs	(267)
Liability related to sale of future royalties and milestones, net	$ 266,920

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Liability Related to the Sale of Future Royalties and Milestones (Narrative) (Details) - USD ($) $ in Thousands		6 Months Ended
	Jan. 19, 2018	Jun. 30, 2023
Liability Related To Sale Of Future Royalties And Milestones [Line Items]
Non-cash royalty revenue recognized		$ 41,174
Non-cash interest expense		36,801
HCR [Member] | GSK Agreements [Member] | Royalty Purchase Agreement [Member]
Liability Related To Sale Of Future Royalties And Milestones [Line Items]
Percentage of purchase of worldwide rights to receive royalties	100.00%
Gross proceeds received for royalty rights	$ 190,000
Non-cash royalty revenue recognized		41,200
Non-cash interest expense		$ 36,800
Effective annual interest rate		30.40%
Prospective effective annual interest rate		23.60%

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Accrued and Other Current Liabilities (Schedule of Accrued Liabilities) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Payroll	$ 7,957	$ 15,872
Professional fees	5,771	6,946
Contract manufacturing costs	2,857	1,848
Research services	8,511	7,074
Other	5,098	6,519
Total	$ 30,194	$ 38,259

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Accrued and Other Current Liabilities (Schedule of Other Current Liabilities) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Other Liabilities, Current [Abstract]
Finance lease liabilities	$ 9,894	$ 7,952
Other	3,374	3,505
Total	$ 13,268	$ 11,457

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Fair Value Measurements (Narrative) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Contingent purchase price considerations	$ 476	$ 874
Long-term Debt, Gross	13,600	13,600
Level 2 [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Contingent purchase price considerations	0	0
Debt Instrument, Fair Value Disclosure	$ 13,300	$ 13,200

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Fair Value Measurements (Schedule of Assets and Liabilities Measured at Fair Value) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Cash equivalents	$ 127,020	$ 164,694
Short-term investments	14,647	14,689
Long-term investments	5,015
Total	146,682	179,383
Contingent purchase price considerations	476	874
Total	476	874
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Cash equivalents	127,020	0
Short-term investments	14,647	0
Long-term investments	5,015
Total	146,682	0
Contingent purchase price considerations	0	0
Total	0	0
Significant Other Observable Inputs (Level 2) [Member]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Cash equivalents	0	0
Short-term investments	0	0
Long-term investments	0
Total	0	0
Contingent purchase price considerations	0	0
Total	0	0
Significant Unobservable Inputs (Level 3) [Member]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Cash equivalents	0	0
Short-term investments	0	0
Long-term investments	0
Total	0	0
Contingent purchase price considerations	476	874
Total	$ 476	$ 874

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Revenue from Contracts with Customers (Narrative) (Details) - USD ($)		3 Months Ended				6 Months Ended
	Jan. 23, 2019	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 20, 2018
Revenue From Contract With Customer [Line Items]
Shares sold at the market		$ 42,247,000	$ 60,583,000	$ 28,237,000	$ 19,182,000
Revenue		25,296,000		20,926,000		$ 48,198,000	$ 46,867,000
Asset impairment charges						0
Contract with customer, liability, revenue recognized						4,447,000
Receivables for R & D services		1,300,000				1,300,000
Capitalized contract , cost		0				0
Research and Development Revenue [Member]
Revenue From Contract With Customer [Line Items]
Revenue		2,489,000		1,907,000		5,101,000	8,647,000
Gilead Collaboration Agreement [Member]
Revenue From Contract With Customer [Line Items]
Contract with customer, liability, revenue recognized						4,400,000
Contract with customer, net asset liability		7,800,000				7,800,000
Initial transaction price						142,500,000
Gilead Collaboration Agreement [Member] | License and Collaboration Revenue [Member]
Revenue From Contract With Customer [Line Items]
Revenue			$ 134,700,000
Gilead Sciences, Inc. [Member] | Collaborative Arrangement [Member]
Revenue From Contract With Customer [Line Items]
Fee received	$ 120,000,000
Shares sold at the market	30,000,000
Upfront license exercise fee	$ 50,000,000
Milestone Payments Receivable								$ 520,000,000.0
Transaction price recognized							2,600,000
Gilead Sciences, Inc. [Member] | Collaborative Arrangement [Member] | Research and Development Revenue [Member]
Revenue From Contract With Customer [Line Items]
Revenue		$ 2,000,000		$ 1,200,000		$ 4,400,000	$ 5,000,000

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Revenue from Contracts with Customers (Narrative) (Details 1) - Gilead Sciences, Inc. [Member] $ in Millions	Jun. 30, 2023 USD ($)
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2023-07-01
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction [Line Items]
Expect to recognize deferred research and development revenue	$ 7.8
Revenue, remaining performance obligation, expected timing of satisfaction, period	6 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date: 2024-01-01
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction [Line Items]
Revenue, remaining performance obligation, expected timing of satisfaction, period	1 year

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Revenue from Contracts with Customers (Summary of Disaggregation of Revenue) (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Disaggregation Of Revenue [Line Items]
Revenue	$ 25,296	$ 20,926	$ 48,198	$ 46,867
License Fee Revenue [Member]
Disaggregation Of Revenue [Line Items]
Revenue				5,000
Royalty Sales Milestone [Member]
Disaggregation Of Revenue [Line Items]
Revenue		17,316		17,316
Research and development services [Member]
Disaggregation Of Revenue [Line Items]
Revenue	444	660	711	1,032
Other services [Member]
Disaggregation Of Revenue [Line Items]
Revenue	739	1,559	1,923	3,126
Recognition of deferred revenue [Member]
Disaggregation Of Revenue [Line Items]
Revenue	2,045	1,247	4,390	2,615
Non-cash royalty revenue [Member]
Disaggregation Of Revenue [Line Items]
Revenue	22,068	144	41,174	17,778
Non-Cash Royalty Revenue Related to the Sale of Future Royalties [Member]
Disaggregation Of Revenue [Line Items]
Revenue	22,068	144	41,174	17,778
United States [Member]
Disaggregation Of Revenue [Line Items]
Revenue	24,557	19,367	46,275	43,741
United States [Member] | License Fee Revenue [Member]
Disaggregation Of Revenue [Line Items]
Revenue				5,000
United States [Member] | Royalty Sales Milestone [Member]
Disaggregation Of Revenue [Line Items]
Revenue		17,316		17,316
United States [Member] | Research and development services [Member]
Disaggregation Of Revenue [Line Items]
Revenue	444	660	711	1,032
United States [Member] | Recognition of deferred revenue [Member]
Disaggregation Of Revenue [Line Items]
Revenue	2,045	1,247	4,390	2,615
United States [Member] | Non-cash royalty revenue [Member]
Disaggregation Of Revenue [Line Items]
Revenue	22,068	144	41,174	17,778
Rest of World [Member]
Disaggregation Of Revenue [Line Items]
Revenue	739	1,559	1,923	3,126
Rest of World [Member] | Other services [Member]
Disaggregation Of Revenue [Line Items]
Revenue	$ 739	$ 1,559	$ 1,923	$ 3,126

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Revenue from Contracts with Customers (Schedule of Information about Contract Assets and Contract Liabilities from Contracts with Customers) (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($)
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Abstract]
Deferred revenue, Beginning Balance	$ 13,412
Additions	6
Deferred revenue, Deductions	(4,447)
Deferred revenue, Ending Balance	$ 8,971

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Share-Based Compensation Plans (Narrative) (Details) - USD ($) $ / shares in Units, $ in Millions	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Weighted average grant-date fair value of options granted	$ 1.49	$ 1.76
Shares issued from exercise of options	46,750
Shares issued from vesting of non vested stock	$ 2.45
Employee Stock Option
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Unrecognized share-based compensation expense	$ 32.7
Unrecognized share-based compensation expense, weighted average period	2 years
Restricted Stock [Member]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Unrecognized share-based compensation expense, Other than option	$ 1.2
Unrecognized share-based compensation expense, weighted average period	2 years
2009 EIP [Member]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Deferred Compensation Arrangement with Individual, Maximum Contractual Term	10 years
2009 EIP [Member] | Minimum [Member]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Vesting period	3 years
2009 EIP [Member] | Maximum [Member]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Vesting period	4 years
2019 ESPP [Member]
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Shares issued under ESPP	150,291
Shares issued from exercise of options	46,750
Shares issued from vesting of non vested stock	$ 21,666
A2020 Employee Bonus
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Additional share issued for employee bonus	4,643,808
Share withheld to cover taxes	1,668,767
Share issued net	2,975,041

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Share-Based Compensation Plans (Schedule of Stock Option Activity) (Details)	6 Months Ended
	Jun. 30, 2023 USD ($) $ / shares shares
Share-Based Payment Arrangement, Noncash Expense [Abstract]
Options Outstanding, Beginning Balance | shares	35,984,967
Options Granted | shares	9,439,902
Options Exercised | shares	(46,750)
Options Forfeited | shares	(532,835)
Options Expired | shares	(448,863)
Options Outstanding, Ending Balance | shares	44,396,421
Options Vested or expected to vest | shares	44,396,421
Options Exercisable | shares	26,931,597
Options Outstanding, Weighted Average Exercise Price, Beginning Balance | $ / shares	$ 3.51
Options Granted, Weighted Average Exercise Price | $ / shares	2.35
Options Exercised, Weighted Average Exercise Price | $ / shares	1.68
Options Forfeited, Weighted Average Exercise Price | $ / shares	2.58
Options Expired, Weighted Average Exercise Price | $ / shares	3.78
Options Outstanding, Weighted Average Exercise Price, Ending Balance | $ / shares	3.27
Options Vested or expected to vest, Weighted Average Exercise Price | $ / shares	3.27
Options Exercisable, Weighted Average Exercise Price | $ / shares	$ 3.6
Options Outstanding, Weighted Average Remaining Contractual Term	6 years 10 months 28 days
Options Vested or expected to vest, Weighted Average Remaining Contractual Term	6 years 10 months 28 days
Options Exercisable, Weighted Average Remaining Contractual Term	5 years 10 months 17 days
Options Outstanding, Aggregate Intrinsic Value | $	$ 53,747
Options Vested or expected to vest, Aggregate Intrinsic Value | $	53,747
Options Exercisable, Aggregate Intrinsic Value | $	$ 7,016

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Share-Based Compensation Plans (Summary of Non-vested Stock Activity) (Details)	6 Months Ended
	Jun. 30, 2023 $ / shares shares
Share-Based Payment Arrangement, Noncash Expense [Abstract]
Non-vested Shares Outstanding, Beginning Balance | shares	355,802
Non-vested Shares Granted | shares	4,971,652
Non-vested Shares Vested | shares	(4,665,474)
Non-vested Shares Forfeited | shares	(120,000)
Non-vested Shares Outstanding, Ending Balance | shares	541,980
Non-vested Shares Outstanding, Weighted Average Grant Date Fair Value, Beginning Balance | $ / shares	$ 2.50
Non-vested Shares Granted, Weighted Average Grant Date Fair Value | $ / shares	2.41
Non-vested Shares Vested, Weighted Average Grant Date Fair Value | $ / shares	2.45
Non-vested Shares Forfeited, Weighted Average Grant Date Fair Value | $ / shares	1.88
Non-vested Shares Outstanding, Weighted Average Grant Date Fair Value, Ending Balance | $ / shares	$ 2.37

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Share-Based Compensation Plans (Schedule of Share-Based Compensation Expense) (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 6,042	$ 4,615	$ 11,527	$ 9,562
Research and Development [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	1,656	1,192	3,389	2,531
General and Administrative [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 4,386	$ 3,423	$ 8,138	$ 7,031

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Restricted Cash (Narrative) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022	Jun. 30, 2022	Dec. 31, 2021
Cash and Cash Equivalents [Abstract]
Restricted cash	$ 2,669	$ 2,669	$ 2,669	$ 2,669

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Restricted Cash (Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022	Jun. 30, 2022	Dec. 31, 2021
Cash and Cash Equivalents [Abstract]
Cash and cash equivalents	$ 143,205	$ 178,674	$ 228,385	$ 291,931
Restricted cash	2,669	2,669	2,669	2,669
Cash, cash equivalents and restricted cash	$ 145,874	$ 181,343	$ 231,054	$ 294,600

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Equity (Narrative) (Details) - At Market Issuance Sales Agreement [Member] - B. Riley FBR, Inc. [Member] - New Sales Agreement [Member] - USD ($) $ in Millions	3 Months Ended	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2023	Jun. 23, 2023
Class Of Stock [Line Items]
Shares sold at the market, shares			184,638,269
Net proceeds from issuance of common stock	$ 42.2	$ 102.8
Shares sold at the market, shares	24,600,000	58,300,000

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Non-controlling Interest - Schedule Of Approximate Interests In Certain Consolidated Subsidiaries (Details)	Jun. 30, 2023	Dec. 31, 2022
MiNK Therapeutics, Inc.
Minority Interest [Line Items]
Percentage of Non-controlling interest	38.00%	22.00%
SaponiQx, Inc.
Minority Interest [Line Items]
Percentage of Non-controlling interest	30.00%	30.00%

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Non-controlling Interest - Schedule Of Changes In Non-controlling Interest (Details) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended		12 Months Ended
	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Minority Interest [Line Items]
Beginning balance		$ 6,376			$ 6,376
Less: net loss attributable to non-controlling interest	$ (4,414)		$ (2,801)		(7,053)	$ (5,081)
Issuance of subsidiary shares for employee bonus					1,011	294
Share-based compensation	6,042	5,485	4,615	$ 4,947
Ending balance	16,434				16,434		$ 6,376
Non-controlling Interest [Member]
Minority Interest [Line Items]
Beginning balance		6,376		13,469	6,376	$ 13,469	13,469
Less: net loss attributable to non-controlling interest					(7,053)		(10,582)
Distribution of subsidiary shares to Agenus stockholders					14,888
Purchase of subsidiary shares					(640)
Issuance of subsidiary shares for employee bonus					1,011		294
Issuance of subsidiary shares under employee stock purchase plan					45
Share-based compensation	888	$ 919	$ 797	$ 742	1,807		3,195
Total other items					17,111		3,489
Ending balance	$ 16,434				$ 16,434		$ 6,376

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Non-controlling Interest - Additional Information (Details) - USD ($)			1 Months Ended	3 Months Ended
	May 01, 2023	Mar. 29, 2023	May 31, 2023	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Dec. 31, 2022
Minority Interest [Line Items]
Issuance of subsidiary shares to noncontrolling interest				$ 285,000	$ 726,000	$ 294,000
Date of declared stock dividend		Mar. 29, 2023
Dividends common stock, shares		5,000,000
Common stock, par value		$ 0.01		$ 0.01			$ 0.01
Close of business, date of record		Apr. 17, 2023
Dividend Paid [Member]
Minority Interest [Line Items]
Dividends, date to be paid	May 01, 2023
Dividend distribution price per share	$ 0.0146
Number of fractional shares issued	0
MiNK Therapeutics, Inc.
Minority Interest [Line Items]
Common stock, par value		$ 0.00001
Purchase of common stock in multiple open market transactions			$ 195,788

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Related Party Transactions (Narrative) (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Related Party Transaction [Line Items]
Total revenues	$ 25,296,000	$ 20,926,000	$ 48,198,000	$ 46,867,000
Research and Development Manufacturing Services [Member]
Related Party Transaction [Line Items]
Total expenses	$ 222,000		450,000
Clinical Research Services [Member]
Related Party Transaction [Line Items]
Total expenses			$ 450,000

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Recent Accounting Pronouncements - Additional Information (Details)	6 Months Ended
	Jun. 30, 2023
Accounting Standards Update and Change in Accounting Principle [Abstract]
Change in Accounting Principle, Accounting Standards Update, Adoption Date	Jan. 01, 2023
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]	true
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]	true
Accounting Standards Update [Extensible Enumeration]	us-gaap:AccountingStandardsUpdate201704Member

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Subsequent Events (Narrative) (Details) - USD ($) $ / shares in Units, $ in Millions			1 Months Ended
	May 01, 2023	Mar. 29, 2023	Aug. 04, 2023	Jun. 30, 2023	Dec. 31, 2022
Subsequent Event [Line Items]
Date of declared stock dividend		Mar. 29, 2023
Dividends common stock, shares		5,000,000
Common stock, par value		$ 0.01		$ 0.01	$ 0.01
Close of business, date of record		Apr. 17, 2023
MiNK Therapeutics, Inc.
Subsequent Event [Line Items]
Common stock, par value		$ 0.00001
Ownership percentage on common stock				38.00%	22.00%
Dividend Paid [Member]
Subsequent Event [Line Items]
Dividend distribution price per share	$ 0.0146
Dividends, date to be paid	May 01, 2023
Number of fractional shares issued	0
Subsequent Event [Member] | At Market Issuance Sales Agreement [Member]
Subsequent Event [Line Items]
Net proceeds from issuance of common stock			$ 20.3
Shares sold at the market, shares			13,200,000