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Property and Equipment (Detail) (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2011
Year
Dec. 31, 2010
Property, Plant and Equipment [Line Items]    
Useful life (Years), minimum 3  
Useful life (Years), maximum 5  
Property and equipment $ 129,432 $ 98,458
Less: Accumulated depreciation and amortization (75,467) (67,774)
Property, plant and equipment, net 53,965 30,684
Clinical and manufacturing equipment
   
Property, Plant and Equipment [Line Items]    
Useful life (Years) 5  
Property and equipment 59,991 48,373
Computer hardware
   
Property, Plant and Equipment [Line Items]    
Useful life (Years) 3  
Property and equipment 19,096 16,246
Computer software
   
Property, Plant and Equipment [Line Items]    
Useful life (Years), minimum 3  
Useful life (Years), maximum 5  
Property and equipment 18,972 12,776
Furniture and fixtures
   
Property, Plant and Equipment [Line Items]    
Useful life (Years) 5  
Property and equipment 5,797 4,873
Leasehold improvements
   
Property, Plant and Equipment [Line Items]    
Useful life Shorter of lease term or economic life of the asset  
Property and equipment 4,588 3,406
Building
   
Property, Plant and Equipment [Line Items]    
Useful life (Years), maximum 20  
Property and equipment 1,913  
Land
   
Property, Plant and Equipment [Line Items]    
Property and equipment 1,162  
Construction in progress
   
Property, Plant and Equipment [Line Items]    
Property and equipment $ 17,913 $ 12,784