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Balance Sheet Components - Property and Equipment (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Property, Plant and Equipment, Net [Abstract]      
Property and equipment $ 1,441,027 $ 1,035,973  
Less: Accumulated depreciation and impairment charges (359,101) (301,252)  
Total property, plant and equipment, net 1,081,926 734,721  
Depreciation 92,100 80,100 $ 73,100
Clinical and manufacturing equipment      
Property, Plant and Equipment, Net [Abstract]      
Property and equipment $ 452,876 372,077  
Building      
Property, Plant and Equipment [Line Items]      
Estimated useful life 20 years    
Property, Plant and Equipment, Net [Abstract]      
Property and equipment $ 310,344 244,166  
Leasehold improvements      
Property, Plant and Equipment, Net [Abstract]      
Property and equipment $ 61,289 63,541  
Computer software and hardware      
Property, Plant and Equipment [Line Items]      
Estimated useful life 3 years    
Property, Plant and Equipment, Net [Abstract]      
Property and equipment $ 117,986 108,068  
Land      
Property, Plant and Equipment, Net [Abstract]      
Property and equipment 58,869 34,598  
Furniture, fixtures and other      
Property, Plant and Equipment, Net [Abstract]      
Property and equipment 71,977 50,031  
Construction in progress      
Property, Plant and Equipment, Net [Abstract]      
Property and equipment $ 367,686 $ 163,492  
Maximum | Clinical and manufacturing equipment      
Property, Plant and Equipment [Line Items]      
Estimated useful life 10 years    
Maximum | Furniture, fixtures and other      
Property, Plant and Equipment [Line Items]      
Estimated useful life 5 years    
Minimum | Furniture, fixtures and other      
Property, Plant and Equipment [Line Items]      
Estimated useful life 2 years