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Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Accounting Policies [Abstract]      
Accumulated deficit $ (567,332) $ (528,685)  
Cash and cash equivalent 28 60 $ 576
Research and development costs $ 1,667 $ 9,067