<SEC-DOCUMENT>0000939798-16-000153-index.html : 20161031
<SEC-HEADER>0000939798-16-000153.hdr.sgml : 20161031
<ACCEPTANCE-DATETIME>20161031092404
ACCESSION NUMBER:		0000939798-16-000153
CONFORMED SUBMISSION TYPE:	S-1/A
PUBLIC DOCUMENT COUNT:		10
FILED AS OF DATE:		20161031
DATE AS OF CHANGE:		20161031

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OXIS INTERNATIONAL INC
		CENTRAL INDEX KEY:			0000109657
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				941620407
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213270
		FILM NUMBER:		161960203

	BUSINESS ADDRESS:	
		STREET 1:		100 SOUTH ASHLEY DRIVE
		STREET 2:		SUITE 600
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33602
		BUSINESS PHONE:		(800) 304-9888

	MAIL ADDRESS:	
		STREET 1:		100 SOUTH ASHLEY DRIVE
		STREET 2:		SUITE 600
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33602

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DDI PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DIAGNOSTIC DATA INC /DE/
		DATE OF NAME CHANGE:	19850312
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1/A
<SEQUENCE>1
<FILENAME>oxisamendthree.htm
<DESCRIPTION>OXIS S-1 AMENDMENT NO. 3
<TEXT>
Document 1 - file: oxisamendthree.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5
<SEQUENCE>2
<FILENAME>opinionlegalityofshares.htm
<DESCRIPTION>OPINION REGARDING LEGALITY OF SHARES
<TEXT>
Document 2 - file: opinionlegalityofshares.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.3
<SEQUENCE>3
<FILENAME>exhibittenthree.htm
<DESCRIPTION>LICENSE AGREEMENT WITH ID4 PHARMA LLC
<TEXT>
Document 3 - file: exhibittenthree.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.4
<SEQUENCE>4
<FILENAME>exhibittenfour.htm
<DESCRIPTION>LICENSE AGREEMENT WITH THE UNIVERSITY OF MINNESOTA
<TEXT>
Document 4 - file: exhibittenfour.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.5
<SEQUENCE>5
<FILENAME>exhibittenfive.htm
<DESCRIPTION>LICENSE AGREEMENT WITH DANIEL A. VALLERA AND JEFFREY LION
<TEXT>
Document 5 - file: exhibittenfive.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.6
<SEQUENCE>6
<FILENAME>exhibittensix.htm
<DESCRIPTION>LICENSE AGREEMENT WITH MULTICELL IMMUNOTHERAPEUTICS, INC
<TEXT>
Document 6 - file: exhibittensix.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>7
<FILENAME>auditorconsent.htm
<DESCRIPTION>AUDITOR CONSENT
<TEXT>
Document 7 - file: auditorconsent.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>image00001.jpg
<TEXT>
Document 9 - file: image00001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>image00002.jpg
<TEXT>
Document 10 - file: image00002.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>image00003.jpg
<TEXT>
Document 11 - file: image00003.jpg

</DOCUMENT>
</SEC-DOCUMENT>