<SEC-DOCUMENT>0000939798-16-000145-index.html : 20160824
<SEC-HEADER>0000939798-16-000145.hdr.sgml : 20160824
<ACCEPTANCE-DATETIME>20160823191506
ACCESSION NUMBER:		0000939798-16-000145
CONFORMED SUBMISSION TYPE:	S-1
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20160824
DATE AS OF CHANGE:		20160823

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OXIS INTERNATIONAL INC
		CENTRAL INDEX KEY:			0000109657
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				941620407
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213270
		FILM NUMBER:		161848086

	BUSINESS ADDRESS:	
		STREET 1:		100 SOUTH ASHLEY DRIVE
		STREET 2:		SUITE 600
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33602
		BUSINESS PHONE:		(800) 304-9888

	MAIL ADDRESS:	
		STREET 1:		100 SOUTH ASHLEY DRIVE
		STREET 2:		SUITE 600
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33602

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DDI PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DIAGNOSTIC DATA INC /DE/
		DATE OF NAME CHANGE:	19850312
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1
<SEQUENCE>1
<FILENAME>oxissone.htm
<DESCRIPTION>OXIS FORM S-1
<TEXT>
Document 1 - file: oxissone.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-3.3
<SEQUENCE>2
<FILENAME>amendmentcertorg.htm
<DESCRIPTION>CERTIFICATE OF AMENDMENT OF CERTIFICATE OF INCORPORATION
<TEXT>
Document 2 - file: amendmentcertorg.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.4
<SEQUENCE>3
<FILENAME>seriesjstockdesignation.htm
<DESCRIPTION>DESIGNATION FOR SERIES J PREFERRED STOCK
<TEXT>
Document 3 - file: seriesjstockdesignation.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5
<SEQUENCE>4
<FILENAME>opinionrelegalityofshares.htm
<DESCRIPTION>OPINION RE LEGALITY OF SHARES
<TEXT>
Document 4 - file: opinionrelegalityofshares.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-21
<SEQUENCE>5
<FILENAME>subsidiaries.htm
<DESCRIPTION>SUBSIDIARIES OF THE REGISTRANT
<TEXT>
Document 5 - file: subsidiaries.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>6
<FILENAME>auditorconsent.htm
<DESCRIPTION>CONSENT OF THE INDEPENDENT ACCOUNTANT
<TEXT>
Document 6 - file: auditorconsent.htm

</DOCUMENT>
</SEC-DOCUMENT>