TEXT-EXTRACT 2 filename2.txt February 26, 2019 Raymond Urbanski, M.D., Ph.D. Chief Executive Officer and Chairman of the Board GT Biopharma, Inc. 310 N. Westlake Blvd Suite 206 Westlake Village, CA 91362 Re: GT Biopharma, Inc. Registration Statement on Form S-3 Filed February 14, 2019 File No. 333-229667 Dear Dr. Urbanski: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jeffrey Gabor at 202-551-2544 with any questions. Sincerely, Division of Corporation Finance Office of Healthcare & Insurance cc: Gary R. Henrie, Esq.