-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Qblw7JHJ1k8+TE8k9tKEJSif8i4Xx8UinDvWsztdPlFTxvQipGdN9p9fHbc+YlZk
 TDzLQVIAOg65FEC6mKEIWQ==

<SEC-DOCUMENT>0001144204-08-036857.txt : 20080626
<SEC-HEADER>0001144204-08-036857.hdr.sgml : 20080626
<ACCEPTANCE-DATETIME>20080626140208
ACCESSION NUMBER:		0001144204-08-036857
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080624
FILED AS OF DATE:		20080626
DATE AS OF CHANGE:		20080626

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CHEMBIO DIAGNOSTICS, INC.
		CENTRAL INDEX KEY:			0001092662
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				880425691
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3661 HORSEBLOCK ROAD
		CITY:			MEDFORD
		STATE:			NY
		ZIP:			11763
		BUSINESS PHONE:		(631) 924-1135

	MAIL ADDRESS:	
		STREET 1:		3661 HORSEBLOCK ROAD
		CITY:			MEDFORD
		STATE:			NY
		ZIP:			11763

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Chembio Diagnostics Inc.
		DATE OF NAME CHANGE:	20040607

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TRADING SOLUTIONS COM INC
		DATE OF NAME CHANGE:	19990805

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			CRESTVIEW CAPITAL MASTER LLC
		CENTRAL INDEX KEY:			0001303225

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30379
		FILM NUMBER:		08919004

	BUSINESS ADDRESS:	
		STREET 1:		95 REVERE DRIVE
		STREET 2:		SUITE A
		CITY:			NORTHBROOK
		STATE:			IL
		ZIP:			60062
		BUSINESS PHONE:		847-559-0060

	MAIL ADDRESS:	
		STREET 1:		95 REVERE DRIVE
		STREET 2:		SUITE A
		CITY:			NORTHBROOK
		STATE:			IL
		ZIP:			60062

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Crestview Capital Partners, LLC
		CENTRAL INDEX KEY:			0001396338
		STATE OF INCORPORATION:			IL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30379
		FILM NUMBER:		08919003

	BUSINESS ADDRESS:	
		STREET 1:		95 REVERE DRIVE, SUITE A
		CITY:			NORTHBROOK
		STATE:			IL
		ZIP:			60062
		BUSINESS PHONE:		847-559-0060

	MAIL ADDRESS:	
		STREET 1:		95 REVERE DRIVE, SUITE A
		CITY:			NORTHBROOK
		STATE:			IL
		ZIP:			60062
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v118329_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-06-24</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001092662</issuerCik>
        <issuerName>CHEMBIO DIAGNOSTICS, INC.</issuerName>
        <issuerTradingSymbol>CEMI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001303225</rptOwnerCik>
            <rptOwnerName>CRESTVIEW CAPITAL MASTER LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>95 REVERE DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE A</rptOwnerStreet2>
            <rptOwnerCity>NORTHBROOK</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60062</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001396338</rptOwnerCik>
            <rptOwnerName>Crestview Capital Partners, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CRESTVIEW CAPITAL FUNDS</rptOwnerStreet1>
            <rptOwnerStreet2>95 REVERE DRIVE, SUITE A</rptOwnerStreet2>
            <rptOwnerCity>NORTHBROOK</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60062</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common stock</value>
            </securityTitle>
            <transactionDate>
                <value>2008-06-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>X</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6169056</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.45</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>24145310</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common stock</value>
            </securityTitle>
            <transactionDate>
                <value>2008-06-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>X</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>5237879</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.45</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>18907431</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>.45</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-06-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>X</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4611679</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2008-06-24</value>
            </exerciseDate>
            <expirationDate>
                <value>2010-01-28</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>4611679</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>.45</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-06-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>X</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1557377</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2008-06-24</value>
            </exerciseDate>
            <expirationDate>
                <value>2011-03-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1557377</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On June 24, 2008, the Reporting Person exercised, by means of a cashless exercise at an effective price per share equal to
 $0.45, two common stock purchase warrants, for a total sale of 6,169,056 shares of common stock underlying such common stock
 purchase warrants.  As a result of the cashless exercise, the Reporting Person beneficially owned 6,169,056 shares of common
 stock immediately following such cashless exercise and the Reporting Person immediately thereafter disposed of 5,237,879
 shares of common stock. The net effect of the transaction is that the two common stock purchase warrants are no longer
 beneficially owned by the Reporting Person and the Reporting Person beneficially owns 931,177 shares of common stock.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Daniel I. Warsh - (Manager) CRESTVIEW CAPITAL PARTNERS, LLC, its sole Manager</signatureName>
        <signatureDate>2008-06-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Daniel I. Warsh - (Manager) CRESTVIEW CAPITAL PARTNERS, LLC</signatureName>
        <signatureDate>2008-06-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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