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STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities:      
Net income (loss) $ 8,140 $ (6,408) $ (31,383)
Adjustments to reconcile net income (loss) to net cash generated from (used in) operations:      
Stock-based compensation 7,058 6,013 5,201
Accretion of interest expense 1,929 2,848 3,678
Amortization of debt financing costs 21 22 29
Depreciation and amortization of property and equipment 87 155 141
Changes in operating assets and liabilities:      
Trade receivables (3,639) (2,887) (1,906)
Inventory (682) 815 249
Prepaid expenses and other current assets (1,322) 799 (531)
Other assets 0 (7) 10
Accounts payable 965 (561) (495)
Accrued clinical expenses 296 835 (2,952)
Other accrued liabilities 5,696 1,381 575
Deferred revenue (158) 125 8
Net cash provided by (used in) operating activities 18,391 3,130 (27,376)
Cash flows from investing activities:      
Purchases of property and equipment (194) (17) (174)
Cash used in investing activities (194) (17) (174)
Cash flows from financing activities:      
Proceeds from exercise of warrants, net of issuance costs 0 17,088 0
Proceeds from exercise of stock options, net of issuance costs 7,683 5,193 1,777
Payments related to long-term obligation (14,779) (9,207) (4,856)
Net cash provided by (used in) financing activities (7,096) 13,074 (3,079)
Net increase (decrease) in cash and cash equivalents 11,101 16,187 (30,629)
Cash and cash equivalents, at beginning of period 40,435 24,248 54,877
Cash and cash equivalents, at end of period $ 51,536 $ 40,435 $ 24,248