Significant Agreements (Narrative) (Details)	1 Months Ended				4 Months Ended	12 Months Ended
	Dec. 31, 2016 USD ($)	Sep. 30, 2016 USD ($)	Jan. 31, 2016 USD ($)	Mar. 31, 2014 USD ($)	Dec. 31, 2016 USD ($)	Dec. 31, 2016 USD ($) item	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)	Dec. 31, 1999 USD ($) shares
Debt And Credit Agreements [Line Items]
Number of Patents | item						2
Cost incurred under the agreement						$ 23,844,000	$ 15,419,000	$ 18,372,000
Stanford license agreement
Debt And Credit Agreements [Line Items]
Issuance of common stock in conjunction with a license agreement | shares									30,000
Stanford license agreement | Annual Payment
Debt And Credit Agreements [Line Items]
Royalty payments to be made									$ 50,000
Centric Health Resources, Inc.
Debt And Credit Agreements [Line Items]
Initial agreement period						3 years
Agreement termination, written notice period						180 days
Agreement with PCAS
Debt And Credit Agreements [Line Items]
Initial agreement period						5 years
Agreement termination, written notice period						12 months
Automatic extension period						1 year
Right to terminate agreement if unable to manufacture product, period						9 months
Agreement with Alcami Corporation
Debt And Credit Agreements [Line Items]
Initial agreement period						3 years
Agreement termination, written notice period						12 months
Automatic extension period						2 years
Right to terminate agreement if unable to manufacture product, period						4 months
Termination notice period for manufacturer						18 months
Purchase obligations	$ 0				$ 0	$ 0
Chiltern [Member]
Debt And Credit Agreements [Line Items]
Commitment amount related to service agreement			$ 2,100,000
Cost incurred under the agreement						$ 741,000
Quotient Clinical Limited [Member]
Debt And Credit Agreements [Line Items]
Initial agreement period	1 year	2 years
Commitment amount related to service agreement	$ 2,200,000	$ 2,200,000		$ 3,000,000
Cost incurred under the agreement	$ 0				$ 100,000