UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    Form 13F

                               Form 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: September 30, 2010

Check here if Amendment [ ]; Amendment Number:
                                               ----------

     This Amendment (Check only one.): [ ] is a restatement
                                       [ ] adds new holdings entries

Institutional Investment Manager Filing This Report:

Name:      Manulife Financial Corporation
Address:   200 Bloor Street East - NT Main
           Toronto, Ontario, Canada M4W 1E5

Form 13F File Number: 028-11519

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name:    Kenneth Pogrin
Title:   Attorney in Fact
Phone:   (416) 852-3758


Kenneth Pogrin*                     Toronto, Ontario, Canada   November 12, 2010
---------------------------------   ------------------------   -----------------
[Signature]                         [City, State]              [Date]

*    Signed pursuant to a Power of Attorney dated January 17, 2008 included as
     an Exhibit to Schedule 13G filed with the Securities and Exchange
     Commission by Manulife Financial Corporation on January 24, 2008.

Report Type (check only one.):

[ ]  13F HOLDINGS REPORT. (Check here if all holdings of this reporting
     manager are reported in this report.

[X]  13F NOTICE. (Check here if no holdings reported are in this report, and all
     holdings are reported by other reporting manager(s).

[ ]  13F COMBINATION REPORT. (Check here if a portion of the holdings for this
     report manager are reported in this report and a portion are reported by
     other reporting manager(s).

List of Other Managers Reporting for this Manager:



Form 13F File Number   Name
--------------------   ----
                    
028-04428              The Manufacturers Life Insurance Company
028-10490              MFC Global Investment Management (USA) Limited
028-03983              John Hancock Life Insurance Company (U.S.A.)
028-03673              MFC Global Investment Management (U.S.), LLC