Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2019

Stockholders' Equity Note [Abstract]

Schedule of share-based compensation, stock options, activity

	Shares Underlying Options			Weighted Average Exercise Price		Weighted average Remaining Contractual Life (years)		Aggregate Intrinsic Value
Outstanding at December 31, 2018		302,772		$	18.30		7.20	$	-
Granted		99,072			2.32				-
Forfeited		(21,448	)		13.09				-
Outstanding at September 30, 2019		380,396		$	14.43		7.09	$	-

Schedule of share-based compensation

	Three Months ended September 30,				Nine Months ended September 30,
	2019		2018		2019		2018
Research and development	$	3,799	$	2,127	$	11,274	$	8,837
Selling, general and administrative		(53,862)		785,609		576,782		2,426,701
Total	$	(50,063)	$	787,736	$	588,056	$	2,435,538

Schedule of share-based payment award, stock options, valuation assumptions

	For the three and nine months ended September 30,
	2019		2018
Fair value of common stock	$	2.32		$10.92 – $13.26
Expected volatility		151.76%		118.10% - 143.50%
Dividend yield	$	-	$	-
Risk-free interest		2.70%		2.85% - 3.00%
Expected life (years)		5.5		5.125 - 5.33

Schedule of common stock warrant activity

	Number of Warrants			Weighted Average Exercise Price		Weighted Average Remaining Contractual Life (Years)
Outstanding and exercisable at December 31, 2018		863,084		$	6.00		2.51
Exercised, K Warrants		(277,778	)		0.06		-
Outstanding and exercisable at September 30, 2019		585,306		$	8.85		2.95