Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2019

Stockholders' Equity Note [Abstract]

Schedule of share-based compensation, stock options, activity

	Shares Underlying Options			Weighted Average Exercise Price		Weighted average Remaining Contractual  Life(years)		Aggregate Intrinsic Value
Outstanding at December 31, 2018		302,772		$	18.30		7.20	$	-
Granted		99,072			2.32				-
Forfeited		(21,448	)		13.09
Outstanding at June 30, 2019		380,396		$	14.43		7.35	$	-

Schedule of share-based compensation

	Three Months ended June 30,				Six Months ended June 30,
	2019		2018		2019		2018
Research and development	$	3,758	$	5,005	$	7,475	$	6,710
Selling, general and administrative		146,404		902,909		630,644		1,641,092
Total	$	150,162	$	907,914	$	638,119	$	1,647,802

Schedule of share-based payment award, stock options, valuation assumptions

	For the six months ended June 30,
	2019			2018
Fair value of common stock	$	2.32		$	$10.92 - $13.26
Expected volatility		151.76	%		118.10% -118.83	%
Dividend yield	$	-		$	-
Risk-free interest		2.70	%		2.87% -3.00	%
Expected life (years)		5.5			5.33

Schedule of common stock warrant activity

	Number of Warrants			Weighted Average Exercise Price		Weighted Average Remaining Contractual Life (Years)
Outstanding at December 31, 2018		863,084		$	6.00		2.51
Exercised, K Warrants		(277,778	)		0.06		-
Outstanding at June 30, 2019		585,306		$	9.79		3.20