Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2019

Stockholders' Equity Note [Abstract]

Schedule of share-based compensation, stock options, activity

	Shares Underlying Options			Weighted Average Exercise Price		Weighted average Remaining Contractual Life (years)		Aggregate Intrinsic Value
Outstanding at December 31, 2018		302,772		$	18.30		7.20	$	-
Granted		99,072			2.32		9.84		63,802
Forfeited		(20,432	)		13.20		-		-
Outstanding at March 31, 2019		381,412		$	14.41		7.60	$	241,597

Schedule of share-based compensation,

	Three Months ended March 31,
	2019		2018
Research and development	$	3,717	$	1,613
Selling, general and administrative		484,240		738,275
Total	$	487,957	$	739,888

Schedule of share-based payment award, stock options, valuation assumptions

Fair value of common stock	$	2.32
Expected volatility		151.76	%
Dividend yield	$	0
Risk-free interest		2.70	%
Expected life (years)		5.5

Schedule of common stock warrant activity

	Number of Warrants			Weighted Average Exercise Price		Weighted Average Remaining Contractual Life (years)
Outstanding, December 31, 2018		863,084		$	6.00		2.51
Exercised, K warrants		(277,778	)		0.06		-
Outstanding, March 31, 2019		585,306		$	8.85		3.45