Consolidated Balance Sheets (Parenthetical) - $ / shares	Dec. 31, 2021	Dec. 31, 2020
Preferred stock, shares authorized	20,000,000	20,000,000
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares outstanding	36,866,956	27,088,584
Common stock, shares issued	36,866,956	27,088,584
Convertible Preferred Stock Series H [Member]
Preferred stock, shares authorized	8,500	8,500
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares issued	8	8
Preferred stock, shares outstanding	8	8
Convertible Preferred Stock Series H-3 [Member]
Preferred stock, shares authorized	8,461	8,461
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares issued	1,234	1,234
Preferred stock, shares outstanding	1,234	1,234
Convertible Preferred Stock Series H-6 [Member]
Preferred stock, shares authorized	50,000	50,000
Preferred stock, par value	$ 0.0001	$ 0.0001
Preferred stock, shares issued	50	50
Preferred stock, shares outstanding	50	50