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Collaboration Agreement (Details Narrative) - USD ($)
3 Months Ended 9 Months Ended
Jun. 30, 2018
Aug. 16, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Royalties/licensing fees     $ 3,546,586 $ 4,686,445 $ 15,495,697 $ 14,147,297  
Amendment To Co-Venture Agreement [Member]              
Royalty percentage   10.00%          
Percentage of revenue paid for cost of equipment   14.00%          
Co-Venture Agreement [Member]              
Royalties/licensing fees     41,038 $ 40,852 512,545 $ 245,082  
Co-Venture Agreement [Member] | TEC [Member]              
Number of common stock held     $ 3,353,495   3,353,495    
Issued and outstanding percentage     8.40%        
Impairment loss $ 134,140       134,140    
Fair value, investment     $ 1,240,793   $ 1,240,793   $ 1,374,933
Number of warrants to purchase shares of common stock     153,459   153,459    
Warrant exercise price per share     $ .41   $ .41