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Stockholders' Equity - Stock Options Activity and Status (Details) - Stock Options - USD ($)
$ / shares in Units, $ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Number of Options        
Outstanding at the beginning of the period (in shares)     4,459,291  
Granted (in shares)     1,958,843  
Exercised (in shares) (40,565) (42,443) (428,541) (196,984)
Forfeited/canceled (in shares)     (64,586)  
Outstanding at the end of the period (in shares) 5,925,007   5,925,007  
Exercisable at the end of the period (in shares) 3,114,975   3,114,975  
Unvested at the end of the period (in shares) 2,810,032   2,810,032  
Weighted-Average Exercise Price        
Outstanding at the beginning of the period (in dollars per share)     $ 104.97  
Granted (in dollars per share)     145.72  
Exercised (in dollars per share)     89.17  
Forfeited/canceled (in dollars per share)     132.86  
Outstanding at the end of the period (in dollars per share) $ 119.28   119.28  
Exercisable at the end of period (in dollars per share) 102.70   102.70  
Unvested at the end of period (in dollars per share) $ 137.66   $ 137.66  
Weighted Average Remaining Contractual Term (Years)        
Outstanding at the end of the period     7 years 3 months 18 days  
Exercisable at the end of the period     5 years 8 months 12 days  
Unvested at the end of the period     9 years 1 month 6 days  
Aggregate Intrinsic Value        
Outstanding at the end of the period (in dollars) $ 64.4   $ 64.4  
Exercisable at the end of the period (in dollars) 63.8   63.8  
Unvested at the end of period (in dollars) $ 0.6   $ 0.6  
Weighted average fair value of a stock option (in dollars per share)     $ 56.07 $ 42.55
Aggregate grant date fair value     $ 109.8 $ 69.2
Total fair value of employee stock options that vested     $ 13.1 $ 19.9