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Share Tracking Awards Plans - Expense Recognized (Details) - Share tracking award plans (STAP) - USD ($)
$ in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Share based compensation benefit recognized in connection with the STAP        
Share-based compensation benefit before taxes $ (14.9) $ (14.4) $ (39.5) $ (162.3)
Related income tax expense 5.5 7.4 14.5 59.7
Share-based compensation benefit, net of taxes (9.4) (7.0) (25.0) (102.6)
Cash payments on awards exercised during the period     44.5 30.4
Cost of product sales        
Share based compensation benefit recognized in connection with the STAP        
Share-based compensation benefit before taxes (0.9) (0.2) (2.6) (12.2)
Research and development        
Share based compensation benefit recognized in connection with the STAP        
Share-based compensation benefit before taxes (2.9) (2.3) (8.7) (39.7)
Selling, general and administrative        
Share based compensation benefit recognized in connection with the STAP        
Share-based compensation benefit before taxes $ (11.1) $ (11.9) $ (28.2) $ (110.4)