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Stockholders' Equity - Share-based Compensation Expense (Details) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Stock Options And Restricted Stock Units        
Share-based compensation expense related to outstanding awards        
Share-based compensation expense (benefit) before taxes $ 3.8 $ 2.5 $ 22.3 $ 2.5
Related income tax benefit (1.4) (0.9) (8.2) (0.9)
Share-based compensation expense, net of taxes 2.4 1.6 14.1 1.6
Cost of product sales | Stock Options And Restricted Stock Units        
Share-based compensation expense related to outstanding awards        
Share-based compensation expense (benefit) before taxes 0.1   0.3  
Research and development | Stock Options And Restricted Stock Units        
Share-based compensation expense related to outstanding awards        
Share-based compensation expense (benefit) before taxes 0.5   1.0  
Selling, general and administrative | Stock Options | Officer        
Share-based compensation expense related to outstanding awards        
Share-based compensation expense (benefit) before taxes     9.8  
Selling, general and administrative | Stock Options And Restricted Stock Units        
Share-based compensation expense related to outstanding awards        
Share-based compensation expense (benefit) before taxes $ 3.2 $ 2.5 $ 21.0 $ 2.5