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Share Tracking Awards Plans - Expense Recognized (Details) - Share tracking award plans (STAP) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Share-based compensation expense (benefit) recognized in connection with the STAP        
Share-based compensation expense (benefit) before taxes $ 45.8 $ (121.6) $ (116.5) $ 159.6
Related income tax (expense) benefit (17.1) 45.9 42.6 (60.2)
Share-based compensation expense, net of taxes 28.7 (75.7) (73.9) 99.4
Cash payments on awards exercised during the period     52.7 218.2
Cost of product sales        
Share-based compensation expense (benefit) recognized in connection with the STAP        
Share-based compensation expense (benefit) before taxes 3.5 (8.1) (8.7) 2.8
Research and development        
Share-based compensation expense (benefit) recognized in connection with the STAP        
Share-based compensation expense (benefit) before taxes 8.1 (31.1) (31.6) 57.1
Selling, general and administrative        
Share-based compensation expense (benefit) recognized in connection with the STAP        
Share-based compensation expense (benefit) before taxes $ 34.2 $ (82.4) $ (76.2) $ 99.7