Share Tracking Award Plans (Details 2) - Share tracking award plans (STAP) - USD ($) $ in Thousands	3 Months Ended	6 Months Ended
Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation expense before taxes	$ 46,932		$ 281,150
Share-based compensation (benefit) before taxes		$ (2,149)		$ (63,103)
Related income tax expense	(19,477)		(116,677)
Related income tax (benefit)		752		22,086
Share-based compensation expense, net of taxes	27,455		164,473
Share-based compensation (benefit) net of taxes		(1,397)		(41,017)
Share-based compensation expense capitalized as part of inventory	1,599	826	3,914	562
Cash payments on awards exercised during the period			178,300	61,700
Research and development
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation expense before taxes	13,313	928	88,221
Share-based compensation (benefit) before taxes				(25,745)
Selling, general and administrative
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation expense before taxes	32,323		182,038
Share-based compensation (benefit) before taxes		(2,039)		(34,011)
Cost of product sales
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation expense before taxes	$ 1,296		$ 10,891
Share-based compensation (benefit) before taxes		$ (1,038)		$ (3,347)

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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Aggregate cash paid by the entity during the period to settle equity instruments granted under equity-based payment arrangements.

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