Share Tracking Award Plans (Details 2) (Share tracking award plans (STAP), USD $)	3 Months Ended
Mar. 31, 2014	Mar. 31, 2013
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation (benefit) expense before taxes	$ (60,955,000)	$ 29,503,000
Related income tax benefit (expense)	21,334,000	(9,884,000)
Share-based compensation (benefit) expense, net of taxes	(39,621,000)	19,619,000
Share-based compensation capitalized as part of inventory	(265,000)	270,000
Cash payments on awards exercised during the period	20,500,000	8,300,000
Research and development
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation (benefit) expense before taxes	(26,674,000)	13,495,000
Selling, general and administrative
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation (benefit) expense before taxes	(31,972,000)	14,930,000
Cost of product sales
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation (benefit) expense before taxes	$ (2,309,000)	$ 1,078,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 1

-Subparagraph (b)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SAB TOPIC 14.F)

-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

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-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Staff Accounting Bulletin (SAB)

-Number Topic 14

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The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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No definition available.

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Represents the compensation cost capitalized during the period arising from equity-based compensation arrangements (for example, shares of stock, units, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

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- Definition

Aggregate cash paid by the entity during the period to settle equity instruments granted under equity-based payment arrangements.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

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- Definition

The total recognized tax benefit related to compensation cost for equity-based payment arrangements recognized in income during the period.

+ References

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