Share Tracking Award Plans (Tables) (Share tracking award plans (STAP))

6 Months Ended

Jun. 30, 2013

Share tracking award plans (STAP)

Awards granted under the STAP

Summary of assumptions to estimate the fair value of share tracking awards

	June 30, 2013		June 30, 2012
Expected volatility	34.1	%	36.0	%
Risk-free interest rate	1.1	%	0.6	%
Expected term of awards (in years)	4.3		4.0
Expected forfeiture rate	9.4	%	6.9	%
Expected dividend yield	0.0	%	0.0	%

Summary of activity and status of STAP awards

	Number of Awards		Weighted- Average Exercise Price		Weighted Average Remaining Contractual Term (in Years)	Aggregate Intrinsic Value (in Thousands)
Outstanding at January 1, 2013	7,962,375		$	49.00
Granted	3,303,094		57.11
Exercised	(1,103,444	)	40.87
Forfeited	(85,909	)	54.71
Outstanding at June 30, 2013	10,076,116		$	52.50	7.7	$	134,500
Exercisable at June 30, 2013	3,980,411		$	47.07	6.7	$	74,693
Expected to vest at June 30, 2013	5,196,964		$	55.47	8.9	$	53,854

Share-based compensation expense (benefit) relating to the STAP

Share-based compensation expense (benefit) recognized in connection with the STAP is as follows (in thousands):

	Three Months Ended June 30,						Six Months Ended June 30,
	2013			2012			2013			2012
Research and development	$	14,069		$	4,221		$	27,564		$	3,143
Selling, general and administrative	14,831			4,564			29,761			3,657
Cost of product sales	239			324			1,317			278
Share-based compensation expense before taxes	29,139			9,109			58,642			7,078
Related income tax (benefit) expense	(9,674		)	(3,360		)	(19,469		)	(2,611		)
Share-based compensation expense, net of taxes	$	19,465		$	5,749		$	39,173		$	4,467
Share-based compensation capitalized as part of inventory	$	53		$	154		$	323		$	146