CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Revenues:
Net product sales	$ 240,917	$ 201,020	$ 665,692	$ 546,784
Other	1,551	722	6,567	1,221
Total revenues	242,468	201,742	672,259	548,005
Operating expenses:
Research and development	65,155	59,433	135,911	131,379
Selling, general and administrative	68,626	16,656	161,673	98,775
Cost of product sales	27,968	22,676	81,632	63,577
Total operating expenses	161,749	98,765	379,216	293,731
Operating income	80,719	102,977	293,043	254,274
Other (expense) income:
Interest income	1,138	1,016	3,225	2,520
Interest expense	(4,384)	(5,416)	(12,149)	(16,256)
Equity loss in affiliate	(48)	(43)	(110)	(110)
Other, net	31,068	(278)	31,710	(1,301)
Total other (expense) income, net	27,774	(4,721)	22,676	(15,147)
Income from continuing operations before income taxes	108,493	98,256	315,719	239,127
Income tax expense	(30,382)	(17,641)	(94,532)	(65,073)
Income from continuing operations	78,111	80,615	221,187	174,054
Discontinued operations:
Income from discontinued operations, net of tax				7
Gain on disposal of discontinued operations, net of tax		3,783		618
Income from discontinued operations		3,783		625
Net income	$ 78,111	$ 84,398	$ 221,187	$ 174,679
Basic
Continuing operations (in dollars per share)	$ 1.52	$ 1.38	$ 4.20	$ 3.00
Discontinued operations (in dollars per share)	$ 0.00	$ 0.07	$ 0.00	$ 0.01
Net income per basic common share (in dollars per share)	$ 1.52	$ 1.45	$ 4.20	$ 3.01
Diluted
Continuing operations (in dollars per share)	$ 1.46	$ 1.32	$ 4.11	$ 2.80
Discontinued operations (in dollars per share)	$ 0.00	$ 0.06	$ 0.00	$ 0.01
Net income per diluted common share (in dollars per share)	$ 1.46	$ 1.38	$ 4.11	$ 2.81
Weighted average number of common shares outstanding:
Basic (in shares)	51,514	58,321	52,626	58,087
Diluted (in shares)	53,590	61,210	53,849	62,062