Share Tracking Award Plans (Details 2) (Share tracking award plans (STAP), USD $)	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Share-based compensation (benefit) expense related to outstanding awards
Share-based compensation expense (benefit) before taxes	$ 27,059,000	$ (47,641,000)	$ 34,136,000	$ (38,437,000)
Related income tax (benefit) expense	(9,909,000)	17,613,000	(12,501,000)	14,210,000
Share-based compensation expense (benefit), net of taxes	17,150,000	(30,028,000)	21,635,000	(24,227,000)
Share-based compensation capitalized as part of inventory	462,000	(812,000)	608,000	(458,000)
Cash payments on awards exercised during the period			25,700,000	27,900,000
Research and development
Share-based compensation (benefit) expense related to outstanding awards
Share-based compensation expense (benefit) before taxes	11,790,000	(22,969,000)	14,932,000	(17,877,000)
Selling, general and administrative
Share-based compensation (benefit) expense related to outstanding awards
Share-based compensation expense (benefit) before taxes	14,404,000	(24,143,000)	18,061,000	(20,031,000)
Cost of product sales
Share-based compensation (benefit) expense related to outstanding awards
Share-based compensation expense (benefit) before taxes	$ 865,000	$ (529,000)	$ 1,143,000	$ (529,000)