Share Tracking Award Plans (Tables) (Share tracking award plans (STAP))

9 Months Ended

Sep. 30, 2012

Share tracking award plans (STAP)

Awards granted under the STAP

Summary of assumptions to estimate the fair value of share tracking awards

	September 30, 2012		September 30, 2011
Expected volatility	35.8	%	46.6	%
Risk-free interest rate	0.5	%	0.6	%
Expected term of awards (in years)	3.9		4.1
Expected forfeiture rate	7.0	%	6.8	%
Expected dividend yield	0.0	%	0.0	%

Summary of activity and status of STAP awards

	Number of Awards		Weighted- Average Exercise Price		Weighted Average Remaining Contractual Term (in Years)	Aggregate Intrinsic Value (in Thousands)
Outstanding at January 1, 2012	7,795,000		$	45.90
Granted	1,833,353		48.01
Exercised	(1,190,869	)	29.02
Forfeited	(246,961	)	53.89
Outstanding at September 30, 2012	8,190,523		$	48.59	7.5	$	75,018
Exercisable at September 30, 2012	4,278,314		$	42.96	6.9	$	58,512
Expected to vest at September 30, 2012	3,311,741		$	53.59	8.8	$	15,391

Share-based compensation expense (benefit) relating to the STAP

	Three Months Ended September 30,						Nine Months Ended September 30,
	2012			2011			2012			2011
Research and development	$	11,790		$	(22,969	)	$	14,932		$	(17,877	)
Selling, general and administrative	14,404			(24,143		)	18,061			(20,031		)
Cost of product sales	865			(529		)	1,143			(529		)
Share-based compensation expense (benefit) before taxes	27,059			(47,641		)	34,136			(38,437		)
Related income tax (benefit) expense	(9,909		)	17,613			(12,501		)	14,210
Share-based compensation expense (benefit), net of taxes (1)	$	17,150		$	(30,028	)	$	21,635		$	(24,227	)
Share-based compensation capitalized as part of inventory	$	462		$	(812	)	$	608		$	(458	)

(1)Share-based compensation benefit for the three and nine months ended September 30, 2011 resulted from the decrease in the fair value of STAP awards as a result of the decline in the price of our common stock at September 30, 2011.