UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No.          )

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United Therapeutics Corporation
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About United Therapeutics Our company was founded over 27 years ago with the challenge of finding a way to cure or treat a rare, life-threatening illness suffered by our CEO's daughter. That mission continues today, has grown to encompass a variety of rare diseases, and drives everything that we do. Early on, we developed a roadmap to success based on five strategic objectives:
•Develop the best medicines possible from our intellectual property •Conduct the most insightful clinical trials of our medicines •Achieve superior communication and awareness of our products among physicians •Grow our business to be in the top quintile of our peers •Achieve our goals by doing the right thing and using the highest ethical standards
Our Commitment to Corporate Social Responsibility			AWARDS AND RECOGNITION
		PATIENT-CENTRIC APPROACH The parents of a child with pulmonary arterial hypertension founded United Therapeutics, so we take our commitment to patients personally. Through our relentless pursuit of life-changing therapies, medical devices, and transplantation technologies, and our patient support and assistance programs, we are striving to improve the lives of patients with pulmonary hypertension and other life-threatening diseases.
			Newsweek Magazine's America's Most Responsible Companies 2024
		ENVIRONMENTAL STEWARDSHIP We take sustainability seriously, and we believe that reducing our carbon footprint is a responsibility shared by all. Through our focus on constructing site net zero energy and LEED-certified buildings, we are taking a leadership role in driving the use of sustainable technologies forward.
			Great Places to Work Certified by Fortune Magazine
		OUR PEOPLE We could not have achieved the best year in our company's history without attracting, supporting, and retaining our diverse, hard-working, team-playing employees we call "Unitherians". We have a company-wide minimum living salary, on-site subsidized child care, and a suite of health and wellness benefits to take care of our Unitherians holistically. Our Board and management teams lead our diversity, equity, and inclusion efforts and initiatives.
	Proxy materials or a Notice of Internet Availability are being distributed to shareholders on or about April 29, 2024.

United Therapeutics at a Glance

WHAT IS UNITED THERAPEUTICS?

Founded to save a daughter's life, United Therapeutics is a profitable, 27-year old, unconventional biotechnology company that is

building on its expertise and success developing therapies for pulmonary hypertension (PH) to address other chronic, life-

threatening medical conditions ranging from pulmonary fibrosis to pediatric cancer. We do this through our pursuit of life-changing

therapies, medical devices, organ manufacturing, and transplantation technologies. Our profit margins are among the strongest in

the entire biotechnology industry.

WHAT DID WE DO IN 2023?

We continued to deliver strong operating results from our PH therapies and our pediatric cancer treatment, yielding revenues of

over $2.3 billion and net income of over $980 million. We ended 2023 with a record number of U.S. patients being treated with our

treprostinil-based therapies. Tyvaso DPI®, a novel dry powder inhaler to deliver treprostinil in a simple-to-use device that fits in the

palm of a patient’s hand, grew to become our best-selling product following its commercial launch in 2022. This built on an approval

in 2021 for nebulized Tyvaso® to treat patients with PH due to interstitial lung disease (PH-ILD), following the compelling results of

a clinical study that was published in the New England Journal of Medicine in January 2022. Nebulized Tyvaso and Tyvaso DPI

were the first medicines approved by the U.S. Food and Drug Administration (FDA) to treat this life-threatening disease. All of this

reflects our ongoing commitment to invest in innovative research and development.

We made significant progress toward enrolling our pivotal TETON 1 and TETON 2 clinical trials of nebulized Tyvaso for patients

with idiopathic pulmonary fibrosis (IPF), and launched a new phase 3 study, TETON PPF, of nebulized Tyvaso in patients with

progressive pulmonary fibrosis (PPF). We also continued enrolling our phase 3 ADVANCE OUTCOMES study of ralinepag for

patients with PAH.

We continued to engage with our shareholders—twice reaching out to those that collectively held approximately 70% of our shares

to offer conversations with our Board members—and steadily increased the detailed information we provide about our governance

practices and sustainability efforts.

HOW DID WE DO IN 2023?

Our solid 2023 results are a testament to the value of our focus on being a built-to-last, long-focused, and people-focused company

that prioritizes the interests of patients. We continued our revenue growth trend in 2023, and strong revenues coupled with fiscally

responsible budgeting generated substantial free cash flow, which contributed to our strong financial condition, including

approximately $4.9 billion in cash, cash equivalents, and marketable securities as of December 31, 2023 (approximately

$4.2 billion net of $700 million in indebtedness).

Finally, we continued our leadership as a Delaware public benefit corporation (PBC) with the publication of our second Corporate

Responsibility and Public Benefit Report. Converting to a PBC in 2021 aligned our charter with our longstanding values and

operating model.

WHERE ARE WE HEADED?

Following the 2022 launch of Tyvaso DPI and the 2021 launches of nebulized Tyvaso in PH-ILD and the Remunity Pump for

Remodulin, we expect to continue to grow revenue from our treprostinil-based therapies through new indications and new delivery

devices. We are also working on entirely new therapies to treat pulmonary arterial hypertension (PAH) and other rare diseases that

we hope to launch over the next several years. Longer term, we have set the ambitious goal of addressing the acute shortage of

transplantable organs through our innovative organ manufacturing programs, including ex-vivo lung perfusion (EVLP),

xenotransplantation, regenerative medicine, and organ printing. In 2023, we significantly expanded our portfolio of organ

manufacturing technologies by acquiring IVIVA Medical, Inc. and Miromatrix Medical Inc. in October and December, respectively.

We are striving toward our goal of achieving an annual revenue run rate of $4 billion by mid-decade. We expect this growth to

come from our ongoing commercial programs. In addition, we have five registration-phase studies underway:

•TETON 1 and TETON 2 evaluating nebulized Tyvaso in IPF

•TETON PPF evaluating nebulized Tyvaso in PPF

•ADVANCE OUTCOMES evaluating ralinepag in PAH

•Our phase 3 program evaluating the Centralized Lung Evaluation System (CLES) for EVLP

2024 Proxy Statement 1

UNITED THERAPEUTICS CORPORATION

NOTICE OF 2024 ANNUAL MEETING OF SHAREHOLDERS

	DATE AND TIME		LOCATION		WHO CAN VOTE
Wednesday, June 26, 2024 10:30 a.m. Eastern Time		virtualshareholdermeeting.com/ UTHR2024		Shareholders as of April 29, 2024 (the Record Date) are entitled to notice of, and to vote at, our 2024 Annual Meeting of Shareholders

Voting Items

Company Proposals		Board Vote Recommendation	For Further Details
1	Election of the twelve directors named in this Proxy Statement	“FOR” each director nominee	Page 18
2	Advisory resolution to approve executive compensation	“FOR”	Page 41
3	Approval of the amendment and restatement of the United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan	“FOR”	Page 76
4	Ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for 2024	“FOR”	Page 86

Shareholders will also consider and act upon such other business as may properly come before the Annual Meeting of Shareholders and

any adjournment or postponement thereof. Proxy materials or a Notice of Internet Availability are being distributed to shareholders on or

about April 29, 2024. This year’s Annual Meeting will be conducted solely virtually via live audio webcast. To attend the meeting online,

vote your shares electronically, or submit questions, go to the website listed above. The Annual Meeting will begin at 10:30 a.m. Eastern

Time on Wednesday, June 26, 2024, and you are encouraged to log in early to avoid any delay due to technical issues. Please review this

Proxy Statement for additional information. Whether or not you expect to attend the meeting virtually, you are requested to vote your

shares as promptly as possible so that your shares are represented at the meeting. All shareholders are extended a cordial invitation to

attend this virtual meeting. Our list of shareholders as of the Record Date will also be available for inspection for the ten days prior to the

Annual Meeting. To inspect the list, please contact our investor relations department using the form at https://ir.unither.com/contact-ir.

By Order of the Board of Directors,

PAUL A. MAHON

Corporate Secretary

April 29, 2024

How to Vote

	INTERNET		TELEPHONE		MAIL
Before the meeting, go to proxyvote.com During the meeting, go to virtualshareholdermeeting.com/UTHR2024		(800) 690-6903		Mark, sign, date, and promptly mail the enclosed proxy card in the postage-paid envelope

Important Notice Regarding the Availability of Proxy Materials for United Therapeutics Corporation’s 2024 Annual Meeting

of Shareholders to Be Held on Wednesday, June 26, 2024: United Therapeutics Corporation’s Proxy Statement and Annual

Report on Form 10-K are available at: ir.unither.com/annual-and-proxy

2 United Therapeutics, a public benefit corporation

TABLE OF CONTENTS

UNITED THERAPEUTICS AT A GLANCE	1
NOTICE OF 2024 ANNUAL MEETING OF SHAREHOLDERS	2
BUSINESS OVERVIEW	6
Our Business	6
2023 Performance in Review	9
CORPORATE RESPONSIBILITY	10
Mission and Unitherian Culture	10
Diversity, Equity, and Inclusion	11
Creating a Sustainable Public Benefit Corporation	12
PROXY SUMMARY	13
Voting Matters	13
Governance Highlights	14
Executive Compensation Highlights	16
OUR CORPORATE GOVERNANCE	18
PROPOSAL 1: Election of Directors	18
Selecting Directors	18
How We Select Our Director Nominees	19
Board Diversity and Skills	20
Proxy Access	22
Majority Voting	22
Policy on Overboarding	22
Board Declassification	22
Stock Ownership Guidelines	22
Board of Directors and Nominees	22
Nominees for Election at our 2024 Annual Meeting of Shareholders	23
Director Independence	31
Board Structure	31
Board Leadership	31
Committees of our Board of Directors	32
Corporate Governance Guidelines and Committee Charters	33
Board Roles and Responsibilities	34
Risk Oversight	34
Shareholder Engagement	36
Board Education	37
Board Meetings and Board Member Attendance at our Annual Meetings of Shareholders	37
Shareholder Communication with Directors	37
Non-Employee Director Compensation	37
Overview	37
Equity-Based Awards	38
2023 Non-Employee Director Compensation	39

2024 Proxy Statement 3

EXECUTIVE COMPENSATION	41
PROPOSAL 2: Advisory Resolution to Approve Executive Compensation	41
Compensation Discussion and Analysis	42
Overview	42
Our Named Executive Officers	43
2023 Performance Highlights	44
2023 Shareholder Outreach	44
Overview of our 2023 Executive Compensation Program	45
Pay Element Overview	46
2023 Compensation Decisions	47
2023 Compensation Program Design	56
Key Governance Features of our Executive Compensation Program	59
Other Executive Compensation Policies and Practices	59
Compensation Committee Report	61
Compensation Tables	62
Summary Compensation Table	62
Grants of Plan-Based Awards in 2023	63
Narratives to Summary Compensation Table and Grants of Plan-Based Awards in 2023 Table	64
Outstanding Equity Awards at 2023 Fiscal Year-End	66
Option Exercises and Stock Vested in 2023	68
Pension Benefits in 2023	68
Supplemental Executive Retirement Plan	69
Potential Payments Upon Termination or Change in Control	70
Pay Versus Performance	72
Pay Ratio	75
PROPOSAL 3: Approval of The Amendment and Restatement of The United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan	76
AUDIT MATTERS	86
PROPOSAL 4: Ratification of The Appointment of Ernst & Young LLP as United Therapeutics Corporation’s Independent Registered Public Accounting Firm for 2024	86
Report of our Audit Committee	86
Principal Accountant Fees and Services	87
Policy on Audit Committee Pre-Approval of Audit Services and Permissible Non-Audit Services of our Independent Auditors	88
OTHER MATTERS	88
Certain Relationships and Related Party Transactions	88
Beneficial Ownership of Common Stock	89
Delinquent Section 16(a) Reports	91
Shareholder Proposals and Director Nominations	91
Other Business	92
Shareholders Sharing the Same Address	92
Annual Report	92
INFORMATION ABOUT THE MEETING, VOTING, AND PROXIES	93
Attending the Annual Meeting	93
General	93
Record Date and Outstanding Shares	93
Internet Availability of Proxy Materials	94
Solicitation	94
Voting Rights and Quorum	94
Proxy	94
ANNEX A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan	A-1
ANNEX B - Non-GAAP Financial Information	B-1

Table of Contents

4 United Therapeutics, a public benefit corporation

FORWARD-LOOKING STATEMENTS

This Proxy Statement contains forward-looking statements made pursuant to the safe harbor provisions of Section 21E of the Securities

Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995 (PSLRA). These statements, which are based on our

beliefs and expectations as to future outcomes, include, among others, statements about our future operating results, business plans,

objectives, pipeline advancements, benefits of our products, and any other statements that contain the words believe, seek, expect,

anticipate, forecast, project, intend, estimate, should, could, may, will, plan, or similar expressions, and any other statements

contained or incorporated by reference into this Proxy Statement that are not historical facts. These forward-looking statements are subject

to certain risks and uncertainties, such as those described in our periodic reports filed with the Securities and Exchange Commission

(SEC), that could cause actual results to differ materially from anticipated results. These statements may also be based on standards for

measuring progress that are still developing and on assumptions that are subject to change in the future. Consequently, such

forward-looking statements are qualified by the cautionary statements, cautionary language, and risk factors set forth in our periodic

reports and documents filed with the SEC, including our most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and

Current Reports on Form 8-K. We claim the protection of the safe harbor contained in the PSLRA for forward-looking statements. Our

forward-looking statements speak only as of the date of this Proxy Statement or as of the date they are made, and we assume no

obligation to update or revise the information contained in this Proxy Statement whether as a result of new information, future events, or

any other reason. Our corporate responsibility-related goals are aspirational and may change. Statements regarding our goals are not

guarantees or promises that they will be met. The inclusion of information in our Corporate Responsibility and Public Benefit Report should

not be construed as a characterization of the materiality or financial impact of that information with respect to us or for purposes of any of

our SEC filings.

WEBSITE REFERENCES

Website references included throughout this Proxy Statement are provided for convenience. The content on the referenced websites are

not incorporated herein and are not part of this Proxy Statement.

Table of Contents

2024 Proxy Statement 5

BUSINESS OVERVIEW

Our Business

We market five products for pulmonary hypertension (PH) and one product for pediatric high-risk neuroblastoma (NB). One of our PH

products, nebulized Tyvaso®, was approved in 2021 to treat pulmonary hypertension associated with interstitial lung disease (PH-ILD),

making it the first approved therapy to treat this life-threatening disease that we believe impacts at least 30,000 patients in the United

States. In 2022, we also launched a new version of this therapy, Tyvaso DPI®, which has quickly become our best-selling product.

PH Portfolio				NB Product

Continued Innovation Leads to Revenue Growth

Four of our PH products are prostacyclin analogues based on the molecule treprostinil: nebulized Tyvaso and Tyvaso DPI (inhaled

products) are approved for pulmonary arterial hypertension (PAH) and PH-ILD, Remodulin (delivered parenterally, via intravenous (or

subcutaneous pumps) is approved for PAH, and Orenitram® (an oral tablet) is approved for PAH. Our fifth PH product is Adcirca®, a PDE-5

inhibitor approved for PAH. Our sixth product, Unituxin®, is a monoclonal antibody for treatment of pediatric high-risk NB.

Our total revenues grew 20% in 2023, compared to 2022. Tyvaso revenue (including both nebulized Tyvaso and Tyvaso DPI) grew

41% year-over-year in 2023. Orenitram continued its growth following the FREEDOM-EV label expansion in 2019.

In addition, even with continued generic competition in worldwide markets, Remodulin revenues remained steady. In 2021, we launched

the Remunity Pump for Remodulin, and this product continued to gain traction in the PAH community in 2023. We continue to invest in new

delivery systems to continue to help PAH patients using Remodulin.

We are actively working to improve the delivery systems for treprostinil to enhance convenience, safety, and patient outcomes. We

are also actively studying additional indications for nebulized Tyvaso. We expect these efforts will result in revenue growth for our

treprostinil-based products.

Tyvaso: TETON Studies in Pulmonary Fibrosis

We are conducting three pivotal studies of nebulized Tyvaso in patients with pulmonary fibrosis (PF) called TETON 1, TETON 2, and

TETON PPF. TETON 1 and TETON 2 will evaluate nebulized Tyvaso in idiopathic pulmonary fibrosis (IPF) while TETON PPF will evaluate

nebulized Tyvaso in progressive pulmonary fibrosis (PPF). We believe there are approximately 100,000 IPF patients and up to 60,000 PPF

patients in the United States. Presently, treatment options for IPF and PPF patients are extremely limited.

Tyvaso DPI

In May 2022, we gained FDA approval for Tyvaso DPI. Tyvaso DPI is a dry powder formulation of treprostinil for the treatment of PAH and

PH-ILD, and was developed under a license and collaboration agreement with MannKind Corporation. We believe this product, which is a

small, pocket-sized inhaler that does not need electricity, has significant convenience advantages over current inhaled prostacyclin

alternatives. It has already become our best-selling therapy. Approval of Tyvaso DPI was based on pivotal development studies that

demonstrated biocomparability between Tyvaso DPI and nebulized Tyvaso Inhalation Solution.

6 United Therapeutics, a public benefit corporation

United Therapeutics Treprostinil Historical Annual Net Sales

n Remodulin n Tyvaso DPI n Nebulized Tyvaso n Orenitram

In the chart above, Remodulin revenues include both drug product and infusion devices, such as the Remunity Pump, and revenues for

Tyvaso DPI and nebulized Tyvaso include the drug product and the respective inhalation devices.

We’re Moving Beyond Treprostinil…

We believe that treprostinil will be one of the standards of care in PH for some time to come and anticipate significant growth through label

expansions and new delivery devices. In addition, we are working on programs beyond treprostinil that we think could have an outsized

impact on patients with PH and other lung diseases. For example, we are developing ralinepag, which is a next-generation, oral, selective,

and potent prostacyclin receptor agonist. We are studying ralinepag in a registration-phase clinical trial of PAH patients called ADVANCE

OUTCOMES. We believe ralinepag’s once-daily dosing will make it highly competitive with the existing approved oral prostacyclin agonist,

selexipag, which is a competitor’s product that generated U.S. revenues of approximately $1.3 billion in 2023.

…and Seeking a Cure

The ultimate solution for many patients with PH and many other life-threatening diseases is a cure through organ transplantation.

Each year, end-stage organ failure kills millions of people. A significant number of these patients could have benefited from an organ

transplant. Unfortunately, the number of usable, donated organs available for transplantation has not grown significantly over the past half

century, while the need has soared. Our long-term goals are aimed at addressing this shortage. With advances in technology, we believe

that creating an unlimited supply of tolerable manufactured organs is now principally an engineering challenge, and we are dedicated to

finding engineering solutions.

We are heavily engaged in research and development of a number of organ transplantation-related technologies including regenerative

medicine, organ bio-printing, xenotransplantation, bio-artificial organs, and ex vivo lung perfusion (EVLP).

Several key achievements in our organ manufacturing program include:

•First and Second Successful Xenotransplantations of a Porcine Heart: In January 2022, University of Maryland School of

Medicine surgeons successfully transplanted our experimental, genetically-modified UHeart™ into a living human under an expanded

access authorization by the FDA. The patient ultimately survived for two months following the UHeart transplantation. In June 2022,

data from this procedure were published in the New England Journal of Medicine. In September 2023, the same surgeons

successfully transplanted a second UHeart into another living human. Data from this procedure is expected to be published in 2024.

Business Overview

2024 Proxy Statement 7

•Successful UThymoKidney and UKidney Tests in Preclinical Human Models: In September 2021, surgeons at New York

University (NYU) and University of Alabama Birmingham (UAB) tested UThymoKidneys™ and UKidneys™ from our genetically

modified pigs in brain-dead recipients, providing preclinical evidence that genetically modified pig organs could transcend the most

proximate immunological barriers to xenotransplantation. Results of the UAB experiment were published in the American Journal of

Transplantation in January 2022, and results of the NYU experiments were published in the New England Journal of Medicine in

May 2022. In 2023, researchers at NYU conducted a 61-day UThymoKidney study in a brain-dead recipient; publication of data

from this procedure is expected in 2024.

•ULobe™: The ULobe is a development-stage engineered lung lobe made using a porcine lung scaffold that is decellularized and then

re-cellularized with cells from a human donor other than the recipient (also called “allogeneic” cells). In 2023, our Regenerative

Medicine Laboratory in Research Triangle Park, North Carolina produced 450 decellularized lung scaffolds, 220 recellularized lungs,

and 1.7 trillion human cells for use in recellularization.

•ULung™: The ULung is a development-stage engineered lung composed of a 3-D printed lung scaffold cellularized with either

allogeneic human lung cells, or the patient’s own cells (known as “autologous” cells), with the goal of reducing or eliminating the need

for immunosuppression. The lung scaffold used in the ULung is printed using 3-D printers being developed in collaboration with 3D

Systems, Inc. Our Organ Manufacturing Group located in Manchester, New Hampshire, has achieved recognition for developing the

world’s most complex 3-D printed object. Its lung scaffold designs consist of a record 44 trillion voxels that lay out 4,000 kilometers of

pulmonary capillaries and 200 million alveoli, which demonstrate gas exchange in preclinical models. Under our agreement with 3D

Systems, we also have the exclusive right to develop additional human solid organs using 3D Systems’ printing technology.

•Miromatrix Medical: In December 2023, we completed the acquisition of Miromatrix Medical Inc. (Miromatrix), a company based in

Minnesota, focused on the development of new technologies for generating manufactured kidneys and livers composed of human

primary cells. The Miromatrix external liver assist product, called miroliverELAP®, uses a decellularized porcine liver matrix that has

been seeded with human-derived cells and an extracorporeal blood circuit to maintain liver support in patients experiencing acute liver

failure. In January 2024, the FDA cleared the Miromatrix IND for miroliverELAP, and we are planning to commence enrollment of a

phase 1 study in patients with acute liver failure in 2024. We expect this study will be the first human clinical trial of a manufactured

organ. Miromatrix is also developing miroliver®, a fully-implantable manufactured liver product, and mirokidney®, a fully implantable

manufactured kidney product, both of which are based on decellularized porcine organ scaffolds that have been reseeded with

human-derived cells.

•IVIVA Medical: In October 2023, we completed the acquisition of IVIVA Medical, Inc. (IVIVA), a preclinical stage company based in

Massachusetts, focused on bio-artificial manufactured kidney products. IVIVA’s preclinical implantable kidney product uses

autologous cells to mimic important physiological functions of native kidneys in recipients to support their native kidney function. The

product is designed to replace the need for external kidney dialysis, without the need for immunosuppression.

•EVLP: As of March 1, 2024, over 400 patients have received lung transplants following the use of our centralized EVLP service.

EVLP technology increases the number of transplantable lungs by giving surgeons the ability to assess the function of marginal

lungs to determine if the lungs are suitable for transplantation. This allows for the use of lungs that would have otherwise not

been transplanted.

Business Overview

8 United Therapeutics, a public benefit corporation

2023 Performance in Review

ü CONTINUED STRONG REVENUE PERFORMANCE

•Revenue grew 20% in 2023 compared to 2022

•Total revenues reached an all-time high

•The number of U.S. patients on our treprostinil-based

therapies reached an all-time high

•Tyvaso revenue grew by 41% in 2023 compared to 2022,

driven by the PH-ILD label expansion and the commercial

launch of Tyvaso DPI in June 2022

ü INDUSTRY-LEADING PROFITABILITY

•Net income exceeded $980.0 million in 2023

•Net income margin was 42% and EBITDASO margin* was

54% in 2023, compared to -40% average net income margin

and -11% average EBITDASO margin* for our compensation

peer group**

•Approximately $2.0 million in revenue per employee in 2023,

which ranks highest among the 25 companies in our

compensation peer group

ü CONTINUED INNOVATION AND R&D PROGRESS

•Continued progress on four registration-phase studies:

TETON 1, TETON 2, TETON PPF, and CLES

•Initiation of the TETON PPF study of nebulized Tyvaso

in PPF

•Acquisitions of Miromatrix Medical and IVIVA Medical, adding

additional organ development technologies to our

development portfolio

ü STRONG BALANCE SHEET POISED FOR FUTURE INVESTMENT

•$4.9 billion in cash, cash equivalents, and marketable

investments as of December 31, 2023

•$700 million in debt outstanding as of December 31, 2023

•Strong balance sheet well-positioned to endure economic

instability, and pursue strategic R&D and

business development

*EBITDASO margin is a non-GAAP measure. A reconciliation of this non-GAAP measure and other information relating to this measure can be

found in Annex B to this Proxy Statement.

**For a description of our compensation peer group, see Executive Compensation—Compensation Discussion and Analysis—2023

Compensation Design—Compensation Peer Group.

Business Overview

2024 Proxy Statement 9

CORPORATE RESPONSIBILITY

Mission and Unitherian Culture

At United Therapeutics, we are crystal clear about our purpose and talk about it often—developing innovative therapies for unmet needs,

with the ultimate objective of finding a cure for end-stage organ diseases by creating an unlimited supply of tolerable, transplantable

organs. We maintain a vibrant, entrepreneurial culture, instilling our employees with a sense of ownership and meaning that we believe

gives us a competitive advantage in achieving our mission.

Our Patients

Innovation: We provided the porcine heart (UHeart) that University of Maryland School of Medicine surgeons successfully transplanted

into a living human in 2023, and we provided the xenokidney and thymus (UThymoKidney) that researchers at NYU transplanted into a

deceased human donor to complete a pre-clinical 61-day study in 2023.

Patient Safety: More than 1,700 volunteers participated in our 10 ongoing clinical trials in 2023. We are subject to external audits by

health authorities who verify that we are complying with applicable laws, regulations, and ethical standards. No regulatory inspections of

our clinical trials resulted in required, voluntary, or official actions or monetary fines in 2023.

Patient Support, Education, and Financial Assistance: We launched our first copay assistance care program for patients taking Adcirca

in 2010 and have supported over 32,000 patients over the course of their treatment since then. We provide generous patient access

programs, provide a patient assistance program for all products, and in 2023, we rolled out a $0 co-pay card for PH products for

eligible patients.

Supply Chain Reliability and Inventory: We maintain a rigorous GxP Quality & Compliance program covering those aspects of our

supply chain that could impact the quality and safety of our products. We use more than 600 pre-qualified raw material vendors and service

providers to support clinical and commercial business operations. We also maintain, at a minimum, a two-year inventory of Tyvaso

(nebulized only), Remodulin, and Orenitram based on expected demand, and we contract with third-party contract manufacturers to

supplement our capacity for some products in order to mitigate the risk that we might not be able to manufacture internally sufficient

quantities to meet patient demand.

Our People

Diversity & Inclusion: We are fully committed to diversity, equity, and inclusion, and continuing to live our values of DEI being in our DNA

— see details below.

Engagement: Recent surveys showed that 95% of participating Unitherians said that United Therapeutics is a Great Place to Work,

and our voluntary turnover remains among the lowest relative to peers in the life sciences, biotech, and pharma industries at 5.0%

compared to the industry average of 13.5% (based on June 1, 2022 through June 1, 2023 data from Aon/Radford’s Turnover Study for the

Life Sciences/Biotech/Pharma Sector, published December 2023).

People Programs: Our people programs are designed to demonstrate how much we value our Unitherians, and to enable all Unitherians

to participate in our financial success. For example, all full-time domestic Unitherians have cash compensation targets of at least $75,000

annually (base salary + bonus target). We also provide meaningful opportunities for employees to share in our success by making every

full-time Unitherian a shareholder through our long-term incentive compensation programs. In 2023, we expanded several benefits

including providing access to medical, dental, and vision benefits to part-time Unitherians, increasing the value of our adoption assistance

program and expanding that program to include surrogacy benefits. We offer other market-leading benefit programs and provide access to

a variety of health and wellness facilities and programs, such as on-site childcare centers and state-of-the-art fitness centers, along with

access to 24/7 employee assistance programs.

Safe Work Environment: We had 11 OSHA recordable incidents for our U.S. operations in 2023, with an overall incidence rate of 1.2 per

100 full-time workers. This is below the average incidence rate of 1.6 recordable cases per 100 full-time workers for the pharmaceutical

preparation manufacturing industry (based on the most current U.S. Bureau of Labor Statistics Injuries, Illnesses, and Fatalities industry

average data).

10 United Therapeutics, a public benefit corporation

Our Presence

Environmental Stewardship: We secured LEED Gold certification for a new facility in 2023, bringing our LEED certified portfolio to four

properties representing about 26% of our total square footage. This includes our Phase 5 cold storage distribution center designed for site

net zero energy operations and opened for business in 2023, which is the first of its kind.

Historical Environmental Data: We continued to make progress in quantifying our environmental footprint of our Scope 1 and Scope 2

greenhouse gas emissions. As we expand our sustainability reporting efforts, we remain committed to taking steps to help mitigate our

environmental impacts and enhance our disclosures.

Our Community Programs: We continued to sponsor Community Service Days through which Unitherians engaged in activities such as

school beautification projects, helping with food preparation and serving meals to those in need, and participating in Women's House Build

projects with Habitat for Humanity. We also continued to sponsor STEM-related efforts such as the Maryland STEM Festival and Nvolve to

provide scholarship for Women in STEM fields, and we continued our commitment to sponsor organizations working to advance Diversity,

Equity, and Inclusion (DEI) by giving to the following organizations: Asian Americans Advancing Justice, The ARC, The Trevor Project, the

Thurgood Marshall College Fund, and the Lulac National Education Service Center.

Our Principles

Ethics & Compliance: Our Compliance Principles, based on our key tenet of "Do the Right Thing," outline how we expect all Unitherians

to conduct themselves. 100% of our Unitherians are trained annually on our Code of Conduct.

For more details about our commitment to Corporate Responsibility, download our latest Corporate Responsibility and Public Benefit report

at corporateresponsibility.unither.com. The information on our corporate responsibility website and in our Corporate Responsibility and

Public Benefit reports are not incorporated by reference into, and do not form part of, this Proxy Statement.

Diversity, Equity, and Inclusion

Throughout 2023, we remained steadfast in our commitment to advancing DEI both at the Board level and across our organization. Since

establishing our DEI plan and framework in 2020, we have recognized the transformative power of DEI in driving innovation, nurturing

creativity, and cultivating a workplace where every individual feels valued and empowered.

In 2023, our focus remained on embedding DEI principles into the fabric of our organizational culture. We continued our efforts by

prioritizing ongoing education and training initiatives aimed at enhancing awareness and understanding of DEI issues among our

employees. As part of this effort, we launched company-wide activities centered around the theme of Allyship. The majority of our team

members actively participated in our DEI training, "Bystander Awareness and Prevention." By investing in these initiatives, we are not only

fostering a more inclusive environment but also equipping our employees with the tools and knowledge needed to actively contribute to our

collective DEI goals. Our ongoing dedication to DEI ensures that it remains a core element of our everyday operations, driving positive

change and reinforcing our commitment to excellence.

Our Inclusion Advisory Group and DEI Executive Council, overseen by our Chief People Officer, regularly convened to guide and monitor

our ongoing DEI efforts throughout 2023. Their collaborative efforts were instrumental in achieving significant milestones. They provided

invaluable support to our Employee Resource Groups (ERGs), including our Inspire Women’s Group, UT’s Black Affinity Organization, and

oUT & PROUD, our LGBTQ+ ERG. These ERGs spearheaded initiatives such as speaker programs, employee panel discussions, and

mentorship programs for our 2023 intern cohort, fostering awareness and facilitating connections among Unitherians across various

regions and roles. Furthermore, we launched a formal mentorship program and emerging leader initiative. Continuously enhancing our

recruitment diversity outreach and communication strategies remained a focus, demonstrating our ongoing commitment to inclusivity and

representation.

All Unitherians    Management

Corporate Responsibility

2024 Proxy Statement 11

Creating a Sustainable Public Benefit Corporation

In 2021, our shareholders overwhelmingly approved the conversion of our company from a traditional Delaware corporation into a

Delaware PBC. This change aligned our legal form with our longstanding commitment to serve our patients, and we continue to believe it

will: (1) enhance our ability to recruit and retain top talent; (2) reinforce our standing and credibility with regulators and stakeholders; (3)

attract more of the rapidly growing pools of duration, impact, and Environmental, Social and Governance (ESG)-screened capital; and (4)

enhance our ability to create excellent and sustainable value for our shareholders. With our PBC conversion, we became the first

publicly-traded biopharmaceutical company organized as a PBC.

The fiduciaries of a PBC must identify the specific public benefit purpose they will pursue alongside their creation of shareholder value.

They must also report on their promotion of this specific public benefit purpose. Our PBC purpose is to provide a brighter future for

patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of

transplantable organs.

Our shareholders have expressed a keen interest in learning how United Therapeutics is working to create a sustainable company and to

address our ESG objectives, and we are steadily increasing the amount and granularity of our disclosures to meet this interest.

See corporateresponsibility.unither.com. As a PBC we are required to report on our progress toward fulfilling our PBC mission, which we

believe further enhances our disclosures and relationships with employees, patients, shareholders, and other stakeholders.

What is a Public Benefit Corporation?

A Delaware PBC is a for-profit corporation. There are two primary differences between a PBC and a traditional Delaware

for-profit corporation:

•A corporation organized as a Delaware PBC identifies in its certificate of incorporation one or more specific public benefits that it

will seek to promote in addition to shareholders' financial interests. The public benefits are actions or goals that are intended to

have positive effects on a category of persons, entities, interests, or communities.

•In making decisions, directors of a PBC have an obligation to balance the financial interests of shareholders, the interests of

stakeholders materially affected by the PBC’s conduct, and pursuit of the corporation’s public benefit purpose.

A Delaware PBC must also provide its shareholders with a statement, at least every other year, as to the PBC’s assessment of

the success of its efforts to promote its public benefit purpose and the best interests of those materially affected by the PBC's

conduct. We plan to continue to provide this update annually with our Corporate Responsibility and Public Benefit Report.

Corporate Responsibility

12 United Therapeutics, a public benefit corporation

PROXY SUMMARY

Voting Matters

Shareholders will be asked to vote on the following matters at the Annual Meeting:

1 Election of Directors

This year at our Annual Meeting, Mr. Christopher Causey, Professor Raymond Dwek, Mr. Richard Giltner, Mr. Ray Kurzweil, Ms. Jan

Malcolm, Dr. Linda Maxwell, Professor Nilda Mesa, Dr. Judy Olian, Dr. Martine Rothblatt, Mr. Christopher Patusky, Dr. Louis Sullivan,

and Gov. Tommy Thompson are nominees for election as directors to serve one-year terms until our 2025 Annual Meeting of

Shareholders or until their successors are duly elected and qualified or their office is otherwise vacated.

Our Board recommends a vote FOR each director nominee. See page 18

2 Advisory Resolution to Approve Executive Compensation

We are asking our shareholders to vote on an advisory resolution, commonly known as a “Say-on-Pay” proposal, to approve executive

compensation as reported in this Proxy Statement.

Our Board recommends a vote FOR this proposal. See page 41

3 Approval of the Amendment and Restatement of The United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan (the Plan)

The Amendment and Restatement makes the following key changes to the Plan:

•Increases the maximum number of shares of our common stock that may be issued under the Plan by 1,320,000 shares

•Extends the expiration date of the Plan to April 25, 2034

Our Board recommends a vote FOR this proposal. See page 76

4 Ratification of the Appointment of Ernst & Young LLP as United Therapeutics Corporation’s Independent Registered Public Accounting Firm for 2024

The Audit Committee of our Board has appointed Ernst & Young LLP as our independent registered public accounting firm for the year

2024. We ask that our shareholders vote to ratify this appointment.

Our Board recommends a vote FOR this proposal. See page 86

2024 Proxy Statement 13

Governance Highlights

Current Board of Directors

					Director Since	Committee Membership
	Name and Primary Occupation			Age		AC	CC	NGC
		Christopher Causey, M.B.A.	IND	61	2003	•
		Former Consultant and Healthcare Executive
		Raymond Dwek, C.B.E., F.R.S.	IND	82	2002		•
		Emeritus Director of the Glycobiology Institute, University of Oxford
		Richard Giltner	IND	60	2009			•
		Former Portfolio Manager, Lyxor Asset Management
		Katherine Klein, Ph.D.*	IND	67	2014
		Professor of Management, The Wharton School Former Vice Dean, Wharton Social Impact Initiative
		Ray Kurzweil	IND	76	2002
		Principal Researcher and AI Visionary, Google
		Linda Maxwell, M.D., M.B.A.	IND	50	2020	•
		Surgeon Operating Partner, DCVC
		Nilda Mesa, J.D.	IND	64	2018		•	•
		Adjunct Professor, Columbia University Former Director, NYC Mayor’s Office of Sustainability
		Judy Olian, Ph.D.	IND	72	2015	•
		President, Quinnipiac University Former Dean, UCLA Anderson School of Management
		Christopher Patusky, J.D., M.G.A.	IND	60	2002			•
		Founder, Patusky Associates, LLC Vice Chair and Lead Independent Director, United Therapeutics
		Martine Rothblatt, Ph.D., J.D., M.B.A.		69	1996
		Founder, Chairperson, and Chief Executive Officer, United Therapeutics
		Louis Sullivan, M.D.	IND	90	2002		•	•
		President Emeritus, Morehouse School of Medicine Former Secretary, U.S. Department of Health and Human Services
		Governor Tommy Thompson, J.D.	IND	82	2010	•
		Former Governor of Wisconsin Former Secretary, U.S. Department of Health and Human Services

AC – Audit Committee	•	Member
CC – Compensation Committee		Chair
NGC – Nominating and Governance Committee
	IND	Independent
*   Professor Klein's term will expire at the 2024 Annual Meeting. She is not standing for re-election.

Proxy Summary

14 United Therapeutics, a public benefit corporation

Board Snapshot*

Independence Diversity

	Public Company Board Experience (non-UT)
		6/12
	Executive Management Experience
		9/12
	Financial Acumen
		11/12
	Legal
		4/12
	Government / Regulatory Experience
		6/12

	International
		7/12
	Science / Medicine
		6/12
	Healthcare Industry Experience
		8/12
	Environmental, Social, and Governance
		10/12

*Data reflects Board nominees.

Our Governance Best Practices

We have taken great strides over recent years to implement best corporate governance practices, often acting ahead of the curve in terms

of our industry peers and the Russell 3000.

ü MAJORITY VOTING

In 2015, we adopted a majority

voting standard with a director

resignation policy.

ü BOARD DESTAGGERING

In 2020, we amended our Certificate

of Incorporation to commence a

destaggering process. At our 2023 Annual

Meeting, all of our directors stood for

re-election for one-year terms, thereby

completing the destaggering process.

ü DIVERSITY AND REFRESHMENT

Diversity and refreshment are also key

areas of focus where we are largely in line

with our peers or ahead of the curve. For

example, 42% of our Board are women.

Since 2014, we have added four new

directors (five if Ms. Malcolm is elected to

our Board), all of whom are women and two

of whom self-identify as racially/ethnically

diverse.

ü PROXY ACCESS

In 2015, we adopted a market-standard

form of proxy access.

ü SHAREHOLDER FEEDBACK

Our Compensation and Nominating and

Governance Committees take shareholder

feedback on executive compensation and

corporate governance seriously—we have

made numerous changes in direct

response to shareholder feedback.

ü ENHANCED DISCLOSURE

In 2022, we issued our third annual

corporate responsibility report, containing

our first public benefit report, and

expanding our ESG disclosures. In the

2022 Proxy Statement, we began providing

enhanced disclosure regarding our Board's

skills and diversity.

Proxy Summary

2024 Proxy Statement 15

Executive Compensation Highlights

Total Compensation Mix—Pay for Performance

United Therapeutics has a strong pay-for-performance philosophy, as a substantial majority of pay for our Chief Executive Officer and

other Named Executive Officers (NEOs) (as defined below under Compensation Discussion and Analysis—Our Named Executive

Officers) is performance-based and at-risk, based on individual and company performance.

Our executive compensation program is rooted in our pay-for-performance philosophy, aligning our leadership around executing against

our short, medium and long-term objectives and maintaining a synergistic connection with our PBC purpose of providing a brighter future

for patients. Our pay-for-performance philosophy is reflected in both our short-term and long-term incentive compensation programs.

Our 2023 performance drove home the strength of our executive compensation programs—we exceeded our revenue target and our

patient target (reaching more patients than ever before with our products), maintained top quintile profitability, made substantial progress

on critical R&D programs, and delivered an uninterrupted supply of medicines to our patients.

The following charts illustrate the extent to which pay for our Chief Executive Officer and our other NEOs is “at risk”, meaning payout levels

are based entirely on performance due to the use of performance targets. For each chart, the amounts shown represent 2023 base salary

(on an annualized basis, following the March 2023 salary increases), 2023 target cash bonus opportunity, and the target equity value of the

2023 equity grant. Notably, over 90% of our CEO's pay, and 83% of our other NEOs' pay, is performance-based.

2023 CEO and Other NEOs Pay Mix
CEO
Other NEOs

2023 Equity Award to NEOs is 100% Performance-Based

In March of 2023, we granted an annual equity award to each of our NEOs, following the conclusion of the four-year compensation period

covered by the equity grant awarded in 2019 (which was granted instead of annual equity awards for the performance years 2019 through

2022). The terms of these 2023 NEO awards met or exceeded each of the commitments we made to shareholders following the 2019

grant. In particular, our 2023 NEO equity awards have the following features:

•The award was part of our annual program, consistent with our commitment to shareholders (i.e., not a front-loaded grant).

•100% of the award was performance-based.

•The award was comprised of performance stock units and performance stock options.

•The performance metrics for these awards are based on (1) revenue growth over a three-year performance period; (2) cash profit

margin performance over a three-year performance period; and (3) research and development achievements over a three-year

performance period.

The 2023 equity award to NEOs features "cliff-vesting" at the end of the three-year performance period (2023 through 2025) and was

delivered as follows:

•Performance Stock Options. 50% of each NEO’s equity award for 2023 was granted in the form of performance stock options,

which will vest based on the achievement of certain three-year cash profit margin objectives. The use of performance stock options

provides our team with a strong incentive to deliver both against the performance conditions set forth, but also pursue growth that

would result in stock price appreciation over the long-term.

•Performance Stock Units. 50% of each NEO’s equity award for 2023 was granted in the form of performance stock units, which will

vest based on the achievement of three-year revenue growth objectives and the achievement of certain R&D milestones. The use of

performance stock units aligns executive and shareholder interest, balancing incentives between sustained revenue growth and

achieving R&D milestones.

2023 Highlight: While compensation paid to our Chief Executive Officer in 2023 as reported in the Summary Compensation Table

increased by more than 200% as compared to 2022, this was a by-product of our return to an annual equity award cycle. 2023

was the first year our CEO received an equity award since 2019.

Proxy Summary

16 United Therapeutics, a public benefit corporation

Incentivizing and Rewarding Revenue Growth

We continue to set robust goals under our annual Company-Wide Milestone Program, which governs short-term cash bonuses for our

NEOs. As one example, the chart below shows our revenue targets for the past three years and our actual revenue performance each

year. For 2023, our revenue threshold was set above prior-year performance, and our revenue target was set to incentivize significant

year-over-year revenue growth. Our Compensation Committee also reviews analyst consensus revenue estimates in setting our

revenue targets.

*(+/-5%).

Proxy Summary

2024 Proxy Statement 17

OUR CORPORATE GOVERNANCE

1 Election of Directors

Our Board consists of twelve members. This year at our Annual Meeting, the following individuals, each of whom is a current director, have

been re-nominated for election as director to serve one-year terms until our 2025 Annual Meeting of Shareholders: Mr. Christopher

Causey, Professor Raymond Dwek, Mr. Richard Giltner, Mr. Ray Kurzweil, Dr. Linda Maxwell, Professor Nilda Mesa, Dr. Judy Olian,

Mr. Christopher Patusky, Dr. Martine Rothblatt, Dr. Louis Sullivan, and Governor Tommy Thompson. Each of these directors was

previously elected by shareholders at our 2023 Annual Meeting to serve one-year terms. In addition, a new director candidate, Jan

Malcolm, has been nominated to serve a one-year term until our 2025 Annual Meeting of Shareholders. Ms. Malcolm was recommended

by one of our existing independent Board members. Professor Katherine Klein's term will expire at the Annual Meeting.

Directors are elected by a majority of votes cast at our Annual Meeting in an uncontested election, such as this one. A majority of

votes cast means that the number of votes cast for the director nominee’s election must exceed the number of votes cast against that

director nominee’s election. Broker non-votes and abstentions are not considered votes cast and therefore have no impact on the election

of directors. Cumulative voting is not permitted in the election of directors. Proxies may not be voted for more than twelve nominees. Each

of our director nominees has consented to be named in this Proxy Statement and to continue to serve on our Board of Directors, if elected.

We do not anticipate that any nominee will become unable or unwilling to accept their nomination or election. If such an event should

occur, the persons named on the proxy card intend to vote for the election of such other person as is selected by our Board in such

nominee’s stead. In the alternative, the persons named on the proxy card may simply vote for the remaining nominees, leaving a vacancy

that may be filled at a later date by our Board of Directors, or our Board of Directors may reduce the size of our Board.

Our Board of Directors recommends that you vote FOR the election of each of the nominees.

Selecting Directors

We believe that our directors should possess the highest personal and professional ethics, integrity, and values, and should be committed

to representing the best interests of our shareholders and other stakeholders. We also endeavor to have a Board of Directors that, as a

whole, represents a range of experiences in business, government, education, and technology and in other areas that are relevant to our

business activities. As reflected in our Corporate Governance Guidelines, our Board and our Nominating and Governance Committee seek

to achieve a diversity of occupational and personal backgrounds on the Board, including with respect to gender and racial/ethnic diversity,

and actively include women and racially/ethnically diverse candidates in the pool from which Board nominees are chosen and instruct any

search firm the Nominating and Governance Committee engages to do so as well. We assess the effectiveness of our efforts in this

respect during the annual Board and Board committee evaluation process coordinated by our Nominating and Governance Committee. In

addition, our Nominating and Governance Committee seeks to recommend director candidates who will enhance the quality of our Board’s

deliberations and decisions, take their duties seriously, and promote the values and ethics to which we subscribe. Our Board also believes

there are certain attributes every director should possess, which are described in the How We Select Our Director Nominees section

below. In evaluating incumbent directors for re-nomination to our Board, the members of our Nominating and Governance Committee

consider a variety of factors. These include each director’s independence, financial literacy, personal and professional accomplishments,

tenure on and contributions to our Board, and experience in light of our business goals.

Board Evaluation and Refreshment

Our Nominating and Governance Committee oversees efforts to evaluate the effectiveness of our Board and its Committees. Each

Committee conducts an annual self-evaluation, and our full Board conducts an annual self-evaluation during an executive session of

independent directors without management present. Our Nominating and Governance Committee leads the process of evaluating

the performance of our Board, and taking steps to ensure new voices are brought in periodically to refresh our Board. Among other things,

the tenure of our existing directors is considered during the re-nomination process. While several of our directors have relatively long

tenures, we value their long-term perspectives, particularly given the lengthy nature of our business plans, including our research and

development programs. As a result, our refreshment process is focused on bringing on new directors every few years, as opposed to

focusing on arbitrary retirement requirements. We have engaged with shareholders regarding our board refreshment process and received

favorable feedback. This year, our refreshment efforts have resulted in the nomination of a new director candidate, Ms. Malcolm, to replace

Professor Klein.

18 United Therapeutics, a public benefit corporation

How We Select Our Director Nominees

Succession Planning

Our Nominating and Governance Committee considers current and long-term needs of our evolving business and seeks potential director

candidates in light of emerging needs, our current Board structure, tenure, skills, diversity, and experience.

Identification of Candidates

Our Nominating and Governance Committee engages in a search process for candidates, led by its Chair, and actively includes women

and racially/ethnically diverse candidates in the candidate pool and instruct any search firm it engages to do so as well.

Our Nominating and Governance Committee considers candidates recommended by members of our Board, executive officers,

shareholders, and other sources, and evaluates shareholder nominees using the same criteria as it uses to evaluate all other candidates.

A shareholder who wishes to recommend a prospective nominee for our Nominating and Governance Committee’s consideration should

submit the candidate’s name and qualifications to our Corporate Secretary at the address set forth under Shareholder Communication

with Directors below.

Qualifications Sought

To be considered, each director candidate must meet the following minimum criteria:

•Personal and professional integrity

•A record of exceptional ability and judgment

•Ability and willingness to participate fully and work constructively in Board activities, including active participation in meetings of our

Board and any committees to which they are assigned

•Interest, capacity, and willingness, in conjunction with the other members of our Board, to serve the interests of our shareholders

•Reasonable knowledge of our field of operations, as well as familiarity with the principles of good corporate governance

•Expertise needed to serve on one or more committees of our Board

•Independence, including the absence of any personal or professional relationships that would adversely affect the candidate's ability

to serve our best interests and those of our shareholders

In addition, our Nominating and Governance Committee is interested in candidates who possess the following skills:

•The ability to contribute to the variety of opinions, perspectives, personal and professional experiences and backgrounds, as well as

other characteristics that differ among members of our Board

•A desire to contribute positively to the existing tone and collaborative culture among our Board members

•Professional and personal experiences and expertise relevant to achievement of our strategic objectives

Meeting with Candidates

Once our Nominating and Governance Committee identifies a potential director nominee, it screens the candidate, performs reference

checks, and conducts interviews with the assistance of our General Counsel and our Chairperson and Chief Executive Officer.

If the outcome of that process is favorable, our Nominating and Governance Committee may recommend the candidate to our Board for

consideration.

Decision and Nomination

Our Nominating and Governance Committee recommends, and our full Board approves, the director candidates who are best qualified to

serve the interest of our shareholders. Our Nominating and Governance Committee’s evaluation of director nominees considers their ability

to contribute these qualities and skills to our Board.

Election

Each year, shareholders consider and elect directors at our Annual Meeting of Shareholders. In addition, our Board may appoint directors

to fill vacancies upon the recommendation of our Nominating and Governance Committee during the year.

Our Corporate Governance

2024 Proxy Statement 19

Re-Nomination Process

Our Nominating and Governance Committee appreciates the importance of critically evaluating individual directors and their

contributions to our Board in connection with re-nomination decisions.

In considering whether to recommend re-nomination of a director for election at our Annual Meeting, our Nominating and Governance

Committee conducts a detailed review, considering factors such as:

•The extent to which the director’s judgment, skills, qualifications, and experience (including those gained due to tenure on our

Board) continue to contribute to our Board’s success

•Attendance and participation at, and preparation for, Board and committee meetings

•Independence

•Shareholder feedback, including the support received by those director nominees elected at our most recent Annual Meeting

•Outside board and other affiliations, including any actual or perceived conflicts of interest

•The extent to which the director continues to contribute to our Board’s diversity

Board Diversity and Skills

We believe it is important that our Board is composed of individuals reflecting the diversity represented by our employees, our patients, and

our communities. In recent years, our Nominating and Governance Committee has taken this priority to heart in its nominations process,

and the diversity of our Board has grown significantly. Below, we provide details concerning the diversity and skill set of our

Board nominees.

Knowledge, Skills and Experience

Public Board Experience*

l

l

l

l

l

l

Executive Management Experience

l

l

l

l

l

l

l

l

l

Financial Acumen

l

l

l

l

l

l

l

l

l

l

l

Legal

l

l

l

l

Government / Regulatory Experience

l

l

l

l

l

l

International

l

l

l

l

l

l

l

Science / Medicine

l

l

l

l

l

l

Healthcare Industry Experience

l

l

l

l

l

l

l

l

Environmental, Social, and Governance

l

l

l

l

l

l

l

l

l

l

Gender

Male

l

l

l

l

l

l

l

Female

l

l

l

l

l

Race / Ethnicity

African American or Black

l

l

Alaskan Native or American Indian

Asian

Hispanic or Latinx

l

Native Hawaiian or Pacific Islander

White

l

l

l

l

l

l

l

l

l

l

l

LGBTQ+

l

l

*Denotes experience serving on the board of directors of one or more public companies other than United Therapeutics

Our Corporate Governance

20 United Therapeutics, a public benefit corporation

	Public Company Board Experience (non-UT)			International
		6/12			7/12
	Executive Management Experience			Science / Medicine
		9/12			6/12
	Financial Acumen			Healthcare Industry Experience
		11/12			8/12
	Legal			Environmental, Social, and Governance
		4/12			10/12
	Government / Regulatory Experience
		6/12

Board Skill	Why This Skill is Important to Our Board
Public Company Board Experience	Public companies face heightened public scrutiny and legal, regulatory, and accounting requirements unlike those faced by private companies.
Executive Management Experience	Management of large organizations such as United Therapeutics can be extremely complex and challenging, and experience with executive management can help provide the context needed for overseeing our executive officers.
Financial Acumen	It is extremely important that we manage our company in a fiscally conservative manner, and present our financial results in a clear, accurate, and reliable manner, navigating the complexity of evolving accounting standards and regulatory requirements.
Legal	In our business we encounter extremely complex legal issues and challenges, including threatened and actual litigation, and compliance with a myriad of laws and regulations.
Government / Regulatory Experience	There are fewer industries more heavily regulated than the biopharmaceutical and medical device industries. Regulatory expertise helps ensure appropriate oversight of our compliance and regulatory functions, which are critical to our success.
International	While most of our operations are U.S.-based, we conduct clinical trials and commercial distribution of our products worldwide.
Science / Medicine	Our success is heavily dependent on our ability to successfully conduct insightful research and development efforts often involving cutting-edge technologies, and to manufacture our products using highly complex technologies.
Healthcare Industry Experience	The healthcare sector presents unique challenges, and given our patient-centric mission experience in the healthcare field is extremely valuable.
Environmental, Social, and Governance	We believe that ESG issues present important challenges, as well as the opportunity to build sustainable value for shareholders and other key stakeholders. We are committed to fulfilling our PBC purpose, while also delivering excellent financial performance for our shareholders.

The following chart provides diversity information related to our current Board members in accordance with Nasdaq requirements.

Board Diversity Matrix (as of April 29, 2024)
Total Number of Directors			12
Part I: Gender Identity	Male	Female		Non-Binary	Did Not Disclose
Directors	7	5		0	0
Part II: Demographic Background
African American or Black	1	1		0	0
Alaskan Native or American Indian	0	0		0	0
Asian	0	0		0	0
Hispanic or Latinx	0	1		0	0
Native Hawaiian or Pacific Islander	0	0		0	0
White	6	5		0	0
Two or More Races or Ethnicities	0	2		0	0
LGBTQ+			1
Did Not Disclose Demographic Background			0

Our Corporate Governance

2024 Proxy Statement 21

Proxy Access

We amended our bylaws in 2015 to implement proxy access, which allows shareholders to nominate and include in our Proxy Statement

their own director nominees, provided that the shareholder(s) and the nominee(s) satisfy the requirements in our bylaws. Our Board

carefully considered feedback we received from our shareholders in creating a thoughtfully designed and balanced approach to proxy

access that mitigates the risk of abuse and protects the interests of all of our shareholders, while affording a meaningful proxy access right.

Shareholders who wish to nominate directors for inclusion in our Proxy Statement in accordance with the procedures in our bylaws should

follow the instructions under Other Matters—Shareholder Proposals and Director Nominations in this Proxy Statement.

Majority Voting

In June 2015, as part of our Board’s ongoing review of our corporate governance policies, we amended our bylaws to provide that director

nominees are elected by a majority of votes cast in uncontested director elections. A majority of votes cast means that the number of votes

cast for the director nominee’s election must exceed the number of votes cast against that director nominee’s election. In connection with

this bylaw amendment, our Board also adopted the director resignation policy set forth in our Corporate Governance Guidelines, providing

that any director who is not elected by a majority of the votes cast is expected to tender their resignation to our Nominating and

Governance Committee. Our Nominating and Governance Committee will recommend to our Board whether to accept or reject the

resignation offer, or whether other action should be taken, considering all factors that our Nominating and Governance Committee believes

are relevant. Our Board will act on our Nominating and Governance Committee’s recommendation within 90 days following certification of

the election results. Any director who tenders their resignation pursuant to our director resignation policy will not participate in the

proceedings of either our Nominating and Governance Committee or our Board with respect to their own resignation offer.

Policy on Overboarding

In 2020, we updated our Corporate Governance Guidelines to reduce our overboarding limit, such that directors are not permitted to serve

on more than four public company boards (including our Board). This limit is below the limit of five boards contained in the guidelines of

major proxy advisory firms, and satisfies the proxy voting criteria of our largest shareholders. In fact, this action was taken in direct

response to feedback received during our shareholder outreach process in 2019. All of our directors satisfy our current

overboarding policy.

Board Declassification

At our 2020 Annual Meeting of Shareholders, our shareholders approved an amendment to our Amended and Restated Certificate

of Incorporation to eliminate the classification of our Board. As a result, the classified nature of our Board was phased out, and the

declassification was completed at our 2023 Annual Meeting when our entire Board was nominated for election to one-year terms.

Stock Ownership Guidelines

In 2011, our Board adopted Stock Ownership Guidelines applicable to our directors and our NEOs in order to further align the financial

interests of our directors and NEOs with those of our shareholders, to foster a long-term management orientation, and to promote sound

corporate governance. For non-employee members of our Board, our Stock Ownership Guidelines provide an ownership target equal to

the lesser of 5,000 shares or a value equivalent to five times the annual cash Board retainer. The policy includes procedures for granting

exemptions in the case of hardship. Our Nominating and Governance Committee oversees this policy and receives an annual compliance

report. As of its most recent review in March 2024, all of our non-employee directors were in compliance with these guidelines. Ownership

targets for our NEOs (including those serving on our Board) are described below under Executive Compensation—Key Governance

Features of our Executive Compensation Program—Other Executive Compensation Policies and Practices—Stock

Ownership Guidelines.

Board of Directors and Nominees

The following presents information concerning persons nominated for election as directors at our Annual Meeting, including their age as of

the date of this Proxy Statement, membership on committees of our Board, principal occupations or affiliations during the last five years or

more, director qualifications, and certain other directorships held. For additional information concerning the director nominees, including

stock ownership and compensation, see the section entitled Non-Employee Director Compensation and the Other Matters—Beneficial

Ownership of Common Stock table below.

Our Corporate Governance

22 United Therapeutics, a public benefit corporation

Nominees for Election at our 2024 Annual Meeting of Shareholders

Mr. Causey, Professor Dwek, Mr. Giltner, Mr. Kurzweil, Dr. Maxwell, Professor Mesa, Dr. Olian, Mr. Patusky, Dr. Rothblatt, Dr. Sullivan,

and Governor Thompson were each previously elected by shareholders at our 2023 Annual Meeting to serve a one-year term.

Ms. Malcolm has been nominated as a new director candidate. All twelve of our director-nominees have been nominated for election at our

2024 Annual Meeting to serve a one-year term.

	Christopher Causey, M.B.A.
	Age: 61 Director Since: 2003	Committees: Nominating and Governance (Chair) Audit

Background

Mr. Causey served as the Principal of the Causey Consortium, a professional services organization providing business strategy and

marketing counsel to the healthcare industry, from 2002 until his retirement in 2021. Previously, Mr. Causey served as a senior marketing

officer for a variety of healthcare companies. From 2001 to 2002, Mr. Causey served as Chief Marketing Officer for Definity Health

Incorporated. He was also a member of the board of directors of Data Sciences International, Inc., a private company that develops

wireless physiological monitoring solutions, from 2008 to 2013. Mr. Causey currently serves on the Board of Trustees of The College of

Wooster. Mr. Causey received his bachelor's degree in psychology from The College of Wooster, and his M.B.A. from The George

Washington University.

Director Qualifications

Drawing upon nearly 30 years of experience in strategic planning and marketing for health care delivery, financing, and biotechnology

organizations, including as Principal of Causey Consortium, Mr. Causey brings to our Board substantial experience in the health care and

biotech industries. Our Board benefits from Mr. Causey’s extensive leadership experience as a senior health care marketing executive. Our

Board has determined that Mr. Causey meets the financial sophistication requirements of Nasdaq’s listing standards for Audit

Committee members.

	Raymond Dwek, C.B.E., F.R.S.
	Age: 82 Director Since: 2002	Committees: Compensation

Background

Professor Dwek is a Fellow of the Royal Society, London, and served as Director of the Glycobiology Institute at the University of Oxford

from 1988 to 2021. He also served as Professor of Glycobiology at the University of Oxford from 1988 through 2009, and currently serves

as Professor Emeritus. He was President of the Institute of Biology (a professional organization) from 2008 through 2010. From 2000 to

2006, Professor Dwek served as head of the Department of Biochemistry at the University of Oxford. Professor Dwek has been serving in

various positions at the University of Oxford since 1966. In 1988, Professor Dwek was the scientific founder of Oxford GlycoSciences PLC,

which was publicly-traded on the London Stock Exchange and Nasdaq, and he served as a member of its board of directors until its sale in

2003. The company, in collaboration with Professor Dwek's Glycobiology Institute, successfully developed an FDA-approved treatment for

Gaucher disease. He was the 2007 Kluge Chair of Technology and Society at the U.S. Library of Congress. Professor Dwek is the founder

of glycobiology, the study of the structure, biosynthesis, and biology of sugar chains attached to proteins. Professor Dwek studied

Chemistry at Manchester University. After completing his M.Sc., he pursued a DPhil in Chemistry. He holds a D.Sc and M.A from Oxford

University. He has been elected Fellow of the Royal Society (FRS), Fellow of the Royal Society of Chemistry (FRSC), and an Honorary

Fellow Royal Institute of Physicians (Hon FRCP), and was awarded the Commander of the Order of the British Empire (CBE) honour, as

well as the Romanian Order of Merit. He has been awarded honorary degrees from numerous universities worldwide.

Director Qualifications

Professor Dwek has extensive scientific experience as both the head of the Department of Biochemistry at the University of Oxford, one of

the world’s largest biochemistry departments, and as a biotechnology innovator at organizations such as the Glycobiology Institute and

Oxford GlycoSciences PLC. In evaluating existing and potential new programs, our Board benefits from his scientific insight and

experience in pharmaceutical research and development.

Our Corporate Governance

2024 Proxy Statement 23

	Richard Giltner
	Age: 60 Director Since: 2009	Committees: Audit (Chair) Nominating and Governance

Background

From 2009 until his retirement in 2010, Mr. Giltner was a portfolio manager at Lyxor Asset Management, an asset management group at

the French bank Société Générale. From 2006 until 2009, he served as a managing director of Société Générale Asset Management, an

international fund management firm, and head of the European office for its fund of hedge funds group. From 2003 to 2006, Mr. Giltner was

the global head of foreign exchange options for the investment banking arm of Société Générale. He also held various other managerial

positions within Société Générale from 1991 until 2003. Mr. Giltner has been a private investor since his retirement from Société Générale

in 2010. Mr. Giltner received his bachelor's degree from Northwestern University.

Director Qualifications

Mr. Giltner brings to our Board decades of experience in the financial sector, including international financial markets, financial derivatives,

alternative investments, and asset management. As our business continues to grow and expand, our Board benefits from Mr. Giltner’s

global business and financial experience and his perspective as an institutional investor, as well as his leadership experience in

international finance from his service in various management roles at Société Générale. Our Board has determined that Mr. Giltner is an

audit committee financial expert as defined under the rules and regulations of the SEC and meets the financial sophistication requirements

of Nasdaq’s listing standards for Audit Committee members.

	Ray Kurzweil
	Age: 76 Director Since: 2002	Committees: None

Background

Mr. Kurzweil is an inventor, entrepreneur, and author, and has created several important technologies in the artificial intelligence field. He

has received the National Medal of Technology, the MIT Lemelson Prize, twenty-one honorary doctorates, a Grammy award for his

contributions to music technology, and honors from three U.S. Presidents. In 2002, Mr. Kurzweil was inducted into the National Inventors

Hall of Fame. Since 1995, Mr. Kurzweil has served as the Chief Executive Officer of Kurzweil Technologies, Inc., a technology

development firm. Since January 2013, he has also served as a Director of Engineering and currently serves as Principal Researcher and

AI Visionary for Google, a global technology and Internet search company. Mr. Kurzweil previously served on the boards of directors of

Inforte Corp. and Medical Manager Corporation, both of which were publicly-traded. Mr. Kurzweil has a B.S. in Computer Science and

Literature from the Massachusetts Institute of Technology.

Director Qualifications

Mr. Kurzweil brings to our Board extensive technological experience as an inventor and technology developer. His technical experience in

the areas of artificial intelligence, telemedicine, and pharmaceutical research and development, and his experience in building businesses

around his inventions, provide our Board with perspective in evaluating current and proposed technologies and business opportunities. In

particular, Mr. Kurzweil has over 60 years of experience in the field of artificial intelligence, and has brought many artificial intelligence-

related inventions to market. Artificial intelligence technologies are becoming increasingly important in the field of medicine, making

Mr. Kurzweil's expertise highly valuable to United Therapeutics. Mr. Kurzweil also brings to our Board substantial corporate leadership

experience from his role as Chief Executive Officer of Kurzweil Technologies, Inc., as well as public company governance experience

through previous directorships.

Our Corporate Governance

24 United Therapeutics, a public benefit corporation

	Jan Malcolm
	Age: 67 Director Since: N/A	Committees: None

Background

Ms. Malcolm is an accomplished leader in health policy, public health, and health care finance and delivery. She has demonstrated a

career-long dedication to improving the health of the public and the care of complex populations. Twice Minnesota’s Commissioner of

Health under three governors representing two political parties (from 1999-2003 and from 2018 until her retirement in January 2023), Ms.

Malcolm earned a national reputation as one of the first health care leaders to highlight health disparities and the impact of social

determinants of health. As Health Commissioner during the COVID-19 pandemic, she also played an instrumental and visible role in

educating the public, creating dynamic and user-friendly systems for sharing COVID-19 data with the people of Minnesota, and rapidly

expanding testing capacity. Prior to the COVID-19 pandemic, the Minnesota Department of Health had a budget of over $600 million per

year from all funding sources, and employed over 1,500 highly professional staff. During the pandemic the budget and staffing more than

doubled with federal funds, staff re-deployments, and temporary contractors. In recognition of her many accomplishments, in

February 2024 the American Medical Association (AMA) presented Ms. Malcolm with the AMA Award for Outstanding

Government Service.

Prior to being re-appointed Commissioner in 2018, Ms. Malcolm was an adjunct faculty member at the University of Minnesota School of

Public Health, where she co-directed a national research and leadership development program funded by the Robert Wood Johnson

Foundation. Ms. Malcolm also served as vice president of the Allina Health system from 1994 to 1999 and 2013 to 2016, with

responsibilities spanning corporate communications, public affairs, government relations, health policy, community relations, and

philanthropy. From 2005 to 2013, she served as CEO of the Courage Center, a leading provider of rehabilitation and health services for

people with disabilities serving over 12,000 patients annually. Ms. Malcolm received a bachelor’s degree in philosophy and psychology

from Dartmouth College.

Director Qualifications

If elected to our Board, Ms. Malcolm’s deep public health and government relations experience will be invaluable as we tackle the diverse

array of challenges we will face in our efforts to revolutionize the treatment of end-stage organ disease through the development,

commercialization, and distribution of manufactured organs. Through her experiences as Commissioner of Health for the State of

Minnesota and as CEO of the Courage Center, she also has hands-on operational experience managing complex organizations, which we

believe will give her valuable practical insights in guiding our company. Finally, her focus on healthcare equity matters aligns with our

public benefit purpose of bringing a brighter future to patients, regardless of their financial resources.

Our Corporate Governance

2024 Proxy Statement 25

	Linda Maxwell, M.D., M.B.A.
	Age: 50 Director Since: 2020	Committees: Audit

Background

Dr. Maxwell is an experienced physician-surgeon, an educator, a published scientific author, and a health technology entrepreneur and

innovator. She began her professional career in 2006 as an academic ENT surgeon. Most recently in March 2021, she joined DCVC, a

Silicon Valley venture capital firm, as an Operating Partner where she focuses on portfolio company governance and due diligence.

From 2015 through January 2024, Dr. Maxwell was an Adjunct Professor of Surgery at the University of Toronto, a public university,

Distinguished Visiting Professor at Toronto Metropolitan University (formerly known as Ryerson), a public university, and Associate

Scientist at the Li Ka Shing Knowledge Institute in Toronto, a research and educational center. She served as Founding and Executive

Director of the Biomedical Zone in 2015, Canada's only hospital-embedded, physician-led business incubator for emerging health

technology companies. In that capacity, she guided a wide variety of startup companies through clinical development, capitalization,

and commercialization.

From 2013 to 2014, Dr. Maxwell managed a life sciences tech transfer portfolio at the University of Oxford and the UK National Health

Service, executing patent strategy, spin-out company formation, and early-stage capital raising. She has also served as a healthcare

innovation expert to various Canadian federal, provincial, and local government entities, as a member of the Department Audit Committee

of the Public Health Agency of Canada, and as an advisor to the Canadian Medical Association and the Canadian Space Agency.

She is a graduate of Harvard College and Yale Medical School, and holds an MBA from Oxford University. Dr. Maxwell completed surgical

training at the University of Toronto and is double board certified in Otolaryngology-Head Neck Surgery and Facial Plastic Reconstructive

Surgery. She holds an ICD.D designation, awarded by the Institute of Corporate Directors, University of Toronto, School of Management.

She is a member of NACD and completed the Diligent Climate Leadership Certificate in 2022.

She previously served as a member of the board of directors of Profound Medical Inc., a publicly-traded company.

Other Current Public Company Board

•ImmunityBio, Inc.

Director Qualifications

Dr. Maxwell brings to our Board important expertise as a medical doctor, as a health technology entrepreneur and innovator, and as

an expert in corporate governance. Her experience in guiding emerging health technology companies through clinical development and

commercialization is highly valued to an entrepreneurial biotech company like United Therapeutics. In addition, our Canadian operations

have become increasingly important in recent years, so Dr. Maxwell's knowledge of the Canadian regulatory environment is very valuable

to us. Our Board has determined that Dr. Maxwell meets the financial sophistication requirements of Nasdaq's listing standards for Audit

Committee members.

Our Corporate Governance

26 United Therapeutics, a public benefit corporation

	Nilda Mesa, J.D.
	Age: 64 Director Since: 2018	Committees: Compensation Nominating and Governance

Background

Professor Mesa has had a long and innovative career in environment, energy, and sustainability at the city, state, national, and global

levels, and now writes and presents extensively on climate, energy, equity, and urban systems relating to them. From 2014 to 2016,

Professor Mesa served as Director of the New York City Mayor’s Office of Sustainability, where she led the pathbreaking OneNYC

long-term sustainability plan for the city. As chief sustainability officer for New York City, she oversaw programs in climate, energy,

sustainability, air quality and public health, waste, green buildings, transportation, public education, and other initiatives. In 2016, she

returned to Columbia University, where she had previously served, as an adjunct professor at the School of International and Public Affairs,

as well as Director of the Urban Sustainability and Equity Planning Program with Columbia’s Center for Sustainable Urban Development at

the Earth Institute. She was also Adjunct Professor in the Graduate School of Architecture, Planning, and Preservation. In 2006, she

founded Columbia’s Office of Environmental Stewardship, one of the first in the United States for a university. She also served as Chief

Administrative Officer at the Columbia Journalism School from 2012 to 2014. Before joining Columbia, Professor Mesa served in

environmental leadership roles at the White House Council on Environmental Quality, the U.S. Air Force, the U.S. Environmental

Protection Agency, and the California Attorney General’s office, and practiced law in both the public and private sectors. Her work has

involved extensive international experience, including most recently a 2018 to 2021 appointment as a visiting professor and lecturer at the

Paris School of International Affairs at SciencesPo (Paris Institute of Political Studies), an international research university in France. She

is the co-author of Collaborating for Climate Resilience (Routledge, 2021), and a contributor to Smarter New York City: How City Agencies

Innovate (Columbia University Press, 2019). She is a graduate of Harvard Law School and Northwestern University.

Director Qualifications

Professor Mesa brings to our Board extensive executive leadership experience, particularly in the area of environmental stewardship,

energy, and sustainability. As we continue to operate and grow our business in an environmentally sustainable fashion, we expect

Professor Mesa’s insights to be extremely valuable. In addition, our Board benefits from her experience working in a variety of scientific,

academic, government, legal, and international settings.

Our Corporate Governance

2024 Proxy Statement 27

	Judy Olian, Ph.D.
	Age: 72 Director Since: 2015	Committees: Audit

Background

Dr. Olian has served as President of Quinnipiac University, a private university, since July 2018. Previously, she served as dean of the

UCLA Anderson School of Management and the John E. Anderson Chair in Management from 2006 to 2018. Her research and business

expertise centers on aligning organizational strategies and design with human resource systems and incentives, and managing top

management teams. She began her UCLA appointment after serving as dean and professor of management at the Smeal College of

Business Administration at Pennsylvania State University. Earlier, she served in various faculty and executive roles at the University of

Maryland and its Robert H. Smith School of Business. Dr. Olian serves or has been a member of various advisory boards (including the

U.S. Studies Centre at the University of Sydney, Peking University Business School’s International Advisory Board, the Connecticut

Governor’s Workforce Council, the Business-Higher Education Forum, New Haven Promise, and Catalyst, a leading global think tank for

women in business) and served as Chair of the Loeb Awards for Business Journalism. In 2024, she was appointed by the Governor of

Connecticut to co-chair AdvanceCT, a public private entity that attracts and retains businesses in the state, and since 2022 she has served

on the board of Hartford Healthcare, the largest healthcare system in Connecticut. Born and raised in Australia, Dr. Olian received her B.S.

in Psychology from the Hebrew University, Jerusalem and her M.S. and Ph.D. in Industrial Relations from the University of Wisconsin,

Madison. She was the Chair of AACSB International, the premier thought leadership and accreditation organization for leading global

business schools, and currently serves on the board of directors of Ares Management, L.P., a publicly-traded global alternative asset

management firm, and Mattel, Inc., a publicly-traded multinational toy manufacturing company.

Other Current Public Company Boards

•Ares Management, L.P.

•Mattel, Inc.

Director Qualifications

As the president of a prestigious university and former dean of one of the world’s leading business schools, Dr. Olian brings valuable

expertise in managing and leading a large organization. Her academic expertise, which centers on the alignment of organizational

strategies with human resource systems and incentives, provides valuable insight to a growing biotech company like United Therapeutics.

In addition, her service as a director of Ares Management and Mattel provides valuable public company board experience. Our Board has

determined that Dr. Olian meets the financial sophistication requirements of Nasdaq’s listing standards for Audit Committee members.

Our Corporate Governance

28 United Therapeutics, a public benefit corporation

	Christopher Patusky, J.D., M.G.A.
	Age: 60 Director Since: 2002 Vice Chair of the Board Lead Independent Director	Committees: Compensation (Chair) Nominating and Governance

Background

Mr. Patusky has 35 years of experience in the private, public, and non-profit sectors. After graduating from Harvard Law School, he

practiced law from 1988 to 2000, focusing on litigation, intellectual property, and business startups. His legal work included co-leading a

team that obtained the first approval from the Federal Communications Commission and the United Nations' International

Telecommunications Union of the use of stratospheric stations for delivery of telecommunication services worldwide. After receiving a

master’s degree in governmental administration from the University of Pennsylvania in 2001, Mr. Patusky served from 2002 to 2007

as Executive Director and faculty member at the University of Pennsylvania’s Fels Institute of Government where he directed the

implementation of an innovative performance management system for the 270 schools of the Philadelphia School District, which was

recognized by the IBM Business of Government awards program. From 2007 to 2011, Mr. Patusky was the Real Estate Director for the

Maryland Department of Transportation with oversight responsibility for real estate policy for all modes of transportation, service on the

department's sustainability committee and implementation of the Governor's Transit Oriented Development (TOD) program, including the

drafting and passage of Maryland's first of kind TOD law. Since 2012, Mr. Patusky has served as the founding principal of Patusky

Associates, LLC, which serves as a personal investment vehicle, and as an executive manager of Slater Run Vineyards, LLC, his family’s

farm-based vineyard and winery. Mr. Patusky received a bachelor of science in history and political science from Northwestern University.

Director Qualifications

Mr. Patusky brings to our Board extensive legal, regulatory, business, governance, financial, and international experience from his varied

career. Our Board has determined that Mr. Patusky meets the financial sophistication requirements of Nasdaq’s listing standards for Audit

Committee members.

	Martine Rothblatt, Ph.D., J.D., M.B.A.
	Age: 69 Director Since: 1996 Chairperson of the Board Chief Executive Officer	Committees: None

Background

Dr. Rothblatt founded United Therapeutics in 1996 and has served as Chairperson and Chief Executive Officer since its inception.

Previously, she created the satellite radio company SiriusXM. She is a co-inventor on nine U.S. patents, with additional patents pending.

Her pioneering book, Your Life or Mine: How Geoethics Can Resolve the Conflict Between Private and Public Interests in

Xenotransplantation, anticipated the need both for global virus bio-surveillance and a greatly expanded supply of transplantable organs.

Dr. Rothblatt has also analyzed the socio-ethical issues of human-like cyber competencies, as are emerging from large language models,

in her 2014 book Virtually Human.

Director Qualifications

Dr. Rothblatt brings to our Board extensive leadership and business experience at technology companies, as well as in depth knowledge of

our company from her service as our founder, Chairperson, and Chief Executive Officer. She also has substantial knowledge of medical

ethics, having obtained her Ph.D. in medical ethics from the University of London.

Our Corporate Governance

2024 Proxy Statement 29

	Louis Sullivan, M.D.
	Age: 90 Director Since: 2002	Committees: Compensation Nominating and Governance

Background

Dr. Sullivan was the founding President of Morehouse School of Medicine, from 1981 to 1989, served as President again from 1993

to 2002, and has served as President Emeritus since 2002. Dr. Sullivan was also one of the founders and served as Chair of Medical

Education for South African Blacks, Inc., a member of the National Executive Council for the Boy Scouts of America, and a member of the

Board of Trustees of Little League of America. Dr. Sullivan served as Secretary of the U.S. Department of Health and Human Services

from 1989 to 1993. He is a physician certified in internal medicine with a sub-specialty certification in hematology. Dr. Sullivan currently

serves on the board of directors of Emergent BioSolutions, Inc. (since 2005), a publicly-traded company. He also serves as Co-Chair of the

Henry Schein Cares Foundation. Dr. Sullivan previously served on the boards of directors of a wide range of public companies, including

General Motors Company, BioSante Pharmaceuticals, Inc., Bristol Myers Squibb Company, Cigna Corporation, 3M Company, Henry

Schein, Inc., Household International (now HSBC), Equifax, and Georgia Pacific Corporation. Dr. Sullivan received his bachelor's degree

from Morehouse College, and his medical degree from Boston University.

Other Current Public Company Board

•Emergent BioSolutions, Inc.

Director Qualifications

Dr. Sullivan brings to our Board extensive experience in the healthcare industry as a public official from his service as Secretary of the U.S.

Department of Health and Human Services, a physician certified in internal medicine, and as President of Morehouse School of Medicine.

He also has substantial public company board experience.

	Tommy Thompson, J.D.
	Age: 82 Director Since: 2010	Committees: Audit

Background

Before entering the private sector in 2005, Governor Thompson enjoyed a long and distinguished career in public service. As Secretary of

the U.S. Department of Health and Human Services from 2001 to 2005, he was a leading advocate for the health and welfare of all

Americans. He also served four terms as Governor of Wisconsin from 1987 to 2001. Governor Thompson served as Interim President of

the University of Wisconsin System from July 2020 through March 2022. Governor Thompson served as a partner at the law firm of

Akin Gump Strauss Hauer & Feld LLP in Washington, D.C. from 2005 until January 2012, and as an Adjunct Senior Advisor from 2017

to 2020. From 2005 to 2009, he also served as the Independent Chair of the Deloitte Center for Health Solutions, which researches and

develops solutions to some of our nation’s most pressing health care and public health related challenges. He currently serves on the

boards of directors of Healthpeak Properties, Inc. and TherapeuticsMD, Inc., each of which is publicly-traded. He resigned as executive

chair of the TherapeuticsMD board in March 2024, and was re-appointed as the non-executive chair of the TherapeuticsMD board.

He previously served on the boards of various other public companies, including AGA Medical Holdings, Inc., Cancer Genetics Inc.,

CareView Communications, Inc., Centene Corporation, CNS Response, Inc., C.R. Bard, Inc., Cytori Therapeutics, Inc., Scilex Holding

Company, Physicians Realty Trust, SpectraScience, Tyme Technologies, Inc., and X Shares Advisors. Governor Thompson earned his

bachelor and juris doctor degrees from the University of Wisconsin–Madison.

Other Current Public Company Boards

•Healthpeak Properties, Inc.

•TherapeuticsMD, Inc.

Director Qualifications

Governor Thompson brings to our Board significant experience in the healthcare industry, both as a public official (former Secretary of the

U.S. Department of Health and Human Services) and in the private sector (Deloitte Center for Health Solutions), as well as public company

board experience and knowledge of legislative affairs. Governor Thompson’s legal experience from his private practice at Akin Gump also

is useful in our Board’s oversight of our legal and regulatory compliance. Our Board has determined that Governor Thompson meets the

financial sophistication requirements of Nasdaq’s listing standards for Audit Committee members.

Our Corporate Governance

30 United Therapeutics, a public benefit corporation

Director Independence

Our Board has made the following independence determinations:

•General Independence: Christopher Causey, Raymond Dwek, Richard Giltner, Katherine Klein, Ray Kurzweil, Jan Malcolm, Linda

Maxwell, Nilda Mesa, Judy Olian, Christopher Patusky, Louis Sullivan, and Tommy Thompson are independent in accordance with the

Nasdaq listing standards

•Management Director: Martine Rothblatt is not independent due to her employment as our Chief Executive Officer

•Audit Committee Standards: Christopher Causey, Richard Giltner, Linda Maxwell, Judy Olian, and Tommy Thompson meet the

heightened independence standards for audit committee members set forth in rules promulgated under the Securities Exchange Act

of 1934, as amended (the Exchange Act)

•Compensation Committee Standards: Raymond Dwek, Nilda Mesa, Christopher Patusky, and Louis Sullivan meet the heightened

independence standards for compensation committee members under the Nasdaq listing standards

•Nominating and Governance Committee Standards: Christopher Causey, Richard Giltner, Nilda Mesa, Christopher Patusky, and

Louis Sullivan meet the independence standards for nominating committee members under the Nasdaq listing standards

Board Structure

Board Leadership

Our Board believes that it is important to evaluate and determine the most appropriate Board leadership structure so that our Board can

both provide effective, independent oversight of management and facilitate its understanding of our business. To carry out this

responsibility, our Corporate Governance Guidelines empower our Board to periodically evaluate and determine the appropriate leadership

structure for our Board. In doing so, our Board has the flexibility to consider our specific circumstances and evolving needs at any

given time.

Our Board has determined that at this time, the leadership structure best suited to support the dynamic demands of our business is to have

Dr. Rothblatt, who founded our company, serve as Chairperson of our Board and Chief Executive Officer, and to appoint a Lead

Independent Director with robust, well-defined responsibilities. Our Board believes that Dr. Rothblatt serving in the combined roles of

Chairperson and Chief Executive Officer provides an efficient and effective leadership model for a growing entrepreneurial company like

ours, as it fosters clear accountability, effective decision-making, and alignment on corporate strategy. In addition, because our Board

works closely with our executive officers and members of senior management, there is a natural synergy in the combined Chairperson and

Chief Executive Officer roles that facilitates our Board’s guidance of management. The Board will continue to monitor the appropriateness

of this structure.

Our Board also believes that independent leadership is an important aspect of our Board’s leadership structure. As a result, the

independent directors on our Board have designated Mr. Patusky as Lead Independent Director.

Lead Independent Director

•Our Lead Independent Director is selected annually by the independent directors.

•Among other responsibilities, our Lead Independent Director:

•coordinates the activities of our independent directors;

•approves Board meeting schedules and agendas;

•chairs all meetings of our Board when the Chairperson is not present, including executive sessions of our independent

directors; and

•serves as principal liaison between our independent directors and our Chairperson and senior management

•Our Lead Independent Director also has the authority to call executive sessions of the independent directors and is available for

consultation and communication with major shareholders.

A more detailed description of the responsibilities of the Lead Independent Director is included in our Corporate Governance Guidelines,

which are available on our website at ir.unither.com/corporate-governance.

Our Corporate Governance

2024 Proxy Statement 31

Committees of our Board of Directors

Our Board has three standing committees. A summary of each committee’s duties and each committee’s current composition can be found

below. Additional detail on each committee’s duties can be found in each committee’s charter. Each committee’s charter provides that it

may delegate responsibilities to subcommittees if it determines such a delegation would be appropriate. Committee charters can be found

on our website at ir.unither.com/corporate-governance.

Audit Committee
Members:	Meetings in 2023: 5
Richard Giltner (Chair), Christopher Causey, Linda Maxwell, Judy Olian, Tommy Thompson Primary Responsibilities •Representing and assisting our Board in its oversight responsibilities regarding our accounting and financial reporting processes, the audits of our financial statements, and system of internal controls over financial reporting, including the integrity of our financial statements, and the qualifications and independence of Ernst & Young LLP, our independent registered public accounting firm •Retaining and terminating our independent auditors •Approving in advance all audit and non-audit services to be performed by our independent auditors •Approving related party transactions •General oversight of risks related to our financial statements, internal controls, financial reporting processes, information technology, cybersecurity, and compliance with federal securities laws For additional information regarding the processes and procedures used by our Audit Committee, see the section entitled Report of our Audit Committee below.

Compensation Committee
Members:	Meetings in 2023: 5
Christopher Patusky (Chair), Raymond Dwek, Nilda Mesa, Louis Sullivan Our Compensation Committee oversees our compensation plans and policies, reviews and approves compensation for our executive officers, oversees the administration of our equity incentive and share tracking awards plans and our Supplemental Executive Retirement Plan, and reviews and approves grants of equity awards to our executive officers and the methodology and formulae for granting stock options and restricted stock units to other employees. Our Compensation Committee may delegate its responsibilities to subcommittees of the Compensation Committee if it determines such delegation would be appropriate. Primary Responsibilities •Creating a system for awarding long-term and short-term performance-oriented incentive compensation to attract and retain senior management, and reviewing our compensation plans to confirm that they are appropriate, competitive, and properly reflect our goals and objectives while managing risk •Assisting our Board in discharging its responsibilities regarding compensation of our executive officers •Establishing and overseeing the administration of our clawback policy, in consultation with our Audit Committee •Evaluating our CEO and setting our CEO's compensation •Overseeing human capital management and diversity, equity, and inclusion matters For additional information regarding the processes and procedures used by our Compensation Committee, see the section entitled Compensation Discussion and Analysis below.

Our Corporate Governance

32 United Therapeutics, a public benefit corporation

Nominating and Governance Committee
Members:	Meetings in 2023: 6
Christopher Causey (Chair), Christopher Patusky, Richard Giltner, Nilda Mesa, Louis Sullivan Primary Responsibilities In addition to the responsibilities described in the section entitled How We Select Our Director Nominees above, our Nominating and Governance Committee’s primary responsibilities include: •Proposing nominees for election to our Board •Proposing nominees to fill vacancies on our Board and newly created directorships •Reviewing candidates for election to our Board recommended to us by our shareholders •Recommending committee membership and committee chairs •Reviewing executive management succession plans •Overseeing the performance and the process for conducting evaluations of the Board and its committees •Evaluating and overseeing issues and developments with respect to corporate governance, and making recommendations to our Board regarding corporate governance •Overseeing our compliance program and our enterprise risk management program •Overseeing our ESG disclosure program, and PBC oversight and reporting •Overseeing company policies and practices regarding political contributions •Overseeing compliance with stock ownership guidelines

Corporate Governance Guidelines and Committee Charters

Upon the recommendation of our Nominating and Governance Committee, our Board maintains Corporate Governance Guidelines as a

framework for the governance of our company. These guidelines are reviewed annually by our Nominating and Governance Committee,

which recommends any changes to be submitted to the full Board for approval. In 2021, we updated our Corporate Governance Guidelines

to, among other things, address PBC-specific obligations, and in 2023, we further updated our Corporate Governance Guidelines to,

among other things, (1) make clear that our Nominating and Governance Committee actively includes women and racially/ethnically

diverse candidates in the pool from which new Board members are chosen (and instructs any search firm the Nominating and Governance

Committee engages to do so); (2) require our Board to conduct an annual self-evaluation to assess the performance the Board and its

committees, overseen by the Nominating and Governance Committee; and (3) following consultations with shareholders, affirmatively state

that we will not, subject to certain limitations, require, without prior shareholder approval, shareholders submitting director nominations or

proposals of other business under the advance notice provisions of our bylaws to disclose the identities of certain holders of economic

interests in such shareholders, plans to nominate candidates to other public company boards of directors, or director nominations or

shareholder proposals privately submitted to other public companies. The foregoing description is qualified in its entirety by reference to

our Corporate Governance Guidelines, which, along with the charter for each Board committee, are available electronically in the

Corporate Governance section of the Investors page of our website, located at ir.unither.com/corporate-governance, or by writing to us

at United Therapeutics Corporation, Attention: Corporate Secretary, 1735 Connecticut Avenue N.W., Washington, D.C. 20009.

Our Corporate Governance

2024 Proxy Statement 33

Board Roles and Responsibilities

Risk Oversight

Our Board is responsible for overseeing the risks facing our company. Our Board works directly with our executive officers and other

members of our senior management team in carrying out its risk oversight function. Our directors take a proactive, interested, and detailed

approach to their service on our Board and set expectations to promote our success through the achievement of business objectives while

maintaining high standards of responsibility and ethics.

BOARD OF DIRECTORS

•At its regularly scheduled meetings, our Board receives reports from our Chairperson and Chief Executive Officer, President and

Chief Operating Officer, Chief Financial Officer, and General Counsel, and may also receive reports from the Committee Chairs,

outside consultants, and other members of senior management, among others. These presentations often include identification and

assessment of risks our company currently faces or may face in the future. On an annual basis, our Board receives presentations

from our Chief Compliance Officer and the head of our Risk Management Department.

•Our Board asks questions, discusses and provides guidance to management on the risks presented, as well as any risks identified by

our Board.

•Our Board implements its risk oversight function both as a whole and through delegation to various committees. These committees

meet regularly and report back to the full Board.

AUDIT COMMITTEE

•Our Audit Committee’s responsibilities include general oversight of our company’s risks related to matters involving or impacting

financial statements, internal controls, federal securities laws, financial reporting processes, information technology, and

cybersecurity. Our Audit Committee coordinates with our Nominating and Governance Committee concerning oversight of risk

assessment and risk management.

COMPENSATION COMMITTEE

•Our Compensation Committee’s duties include overseeing an assessment of the incentives and risks arising from or related to our

compensation policies and practices, including but not limited to those applicable to our executive officers, and evaluating whether

those incentives and risks are appropriate (see Compensation Risk Assessment below).

NOMINATING AND GOVERNANCE COMMITTEE

•Our Nominating and Governance Committee’s responsibilities include oversight of our company’s practices with respect to legal and

regulatory compliance risk, as well as oversight of our enterprise risk management program. Our Chief Compliance Officer regularly

meets with our Nominating and Governance Committee (at least semi-annually) to review the state of our compliance program and

our compliance risk assessment and mitigation plan, and also meets with our full Board on an annual basis. In addition, the head of

our Risk Management Department meets with our Nominating and Governance Committee semi-annually, and with our full Board

annually, to review the top risks identified through our enterprise risk management program, and the effectiveness of our risk

mitigation strategies.

MANAGEMENT

•Our senior management team is responsible for assessing risk on a daily basis. Our Board expects that our senior management

team continually identifies, assesses, and manages the short-term and long-term risks faced by our company. If members of our

senior management team identify risks that are material to United Therapeutics, our Board may convene a special meeting to

discuss, assess, and address such risks.

Our Corporate Governance

34 United Therapeutics, a public benefit corporation

Cybersecurity Risk Oversight

Our Board has delegated the primary responsibility to oversee risks related to cybersecurity matters to our Audit Committee. Our Audit

Committee regularly receives reports and presentations on data privacy and security from senior personnel with responsibility for IT

security, including our Security, Risk and Compliance Director and our Chief Information Officer. We have protocols by which the Incident

Management Team (IMT) escalates certain cybersecurity incidents and, where appropriate, the IMT will notify appropriate stakeholders

and our Audit Committee and provide updates on the status of the incident. For more information on our cybersecurity risk management,

strategy and governance, see “Item 1C. Cybersecurity” of our Annual Report on Form 10-K.

Compensation Risk Assessment

In April 2024, our Compensation Committee reviewed a risk assessment conducted by management and our Compensation Committee’s

independent compensation consultant to determine whether the design of our employee compensation programs and the amounts and

components of employee compensation might create incentives for excessive risk taking by our employees. Based on this review, our

Compensation Committee concluded that the risks arising from our employee compensation programs are not reasonably likely to have a

material adverse effect on our company. Our Compensation Committee believes that our compensation programs encourage employees,

including our executives, to remain focused on an appropriate balance of the short-term and long-term operational and financial goals of

our company, thereby reducing the potential for actions that involve an excessive level of risk. See the section entitled Compensation

Discussion and Analysis below for information regarding certain risk mitigating features of our compensation programs.

Our Corporate Governance

2024 Proxy Statement 35

Shareholder Engagement

How We Engage

Investor Relations and Senior Management We provide investors with many opportunities to provide feedback to our Board and senior management. We participate in investor conferences throughout the year and regularly meet with our shareholders.	Board Involvement Directors regularly and actively engage with our shareholders. For several years, our Compensation Committee Chair has actively sought to engage with our top 25+ shareholders at least once, and usually twice, per year. Our Nominating and Governance Committee Chair also engages with our shareholders on other governance topics.
2023 Engagement We offered to meet with shareholders before our 2023 Annual Meeting, reaching out to 37 of our largest shareholders that collectively held approximately 70% of our outstanding shares. Calls were held with five shareholders (holding approximately 10% of our outstanding shares) where we engaged in dialogue about governance topics, ESG topics along with corporate strategy. We also sought to engage with our shareholders following the 2023 Annual Meeting, again offering to meet with shareholders that collectively held approximately 70% of our outstanding shares (32 of our largest shareholders), and held a discussion with four shareholders (holding approximately 30% of our outstanding shares) that accepted our offer. Those conversations focused on our most recent Corporate Responsibility and PBC Report and other governance topics.
Outcomes from Shareholder Engagement Each year, we consider shareholder feedback carefully, and have modified our governance practices, executive compensation program, and disclosures in light of this feedback. Some of the actions we have taken in response to shareholder feedback over the past several years include: Governance •Adoption of majority voting (2015) •Adoption of proxy access (2015) •Board declassification (2020) •Stricter overboarding limits for directors (2020) •Restrictions on certain advance notice bylaws absent shareholder approval (2023) ESG •Commenced ESG disclosure program, resulting in the creation of our corporate responsibility website and our first annual corporate responsibility report (2020) •Launched effort to become the first-ever public biopharmaceutical company organized as a public benefit corporation (2021) Executive Compensation •Renegotiated our Chief Executive Officer’s employment agreement to eliminate her entitlement to an annual stock option grant based on a market capitalization formula, and to eliminate an excise tax gross-up provision (2015) •Shifted to 100% performance-based equity compensation program for our NEOs (2017) •Reduced annualized total direct compensation for our CEO to approximately the 50th percentile of our peer group (2019) •Reduced compensation for our CEO by 89% in 2020, compared to 2019 (2020); by 92% in 2021, compared to 2019 (2021); and by 88% in 2022, compared to 2019 (2022) •Addressed 2020 Say-on-Pay voting result through responsive changes and disclosures (2021) •Changed design of CEO long-term incentive compensation for 2023 in response to shareholder feedback (2023) Enhanced Disclosure •Complete revamp of our proxy statement, to enhance readability (2020) •Added significant additional disclosure concerning our executive compensation decisions, and how they tie into our business strategy (2020 and 2021) •Enhanced disclosure concerning Board skills and diversity (2021 and 2022)

Our Corporate Governance

36 United Therapeutics, a public benefit corporation

Board Education

Our Board participates in a number of educational activities. Key members of management regularly provide scientific and business

presentations to our Board to increase its understanding of the science behind our pipeline and our business activities. Experts regularly

provide training sessions on key topics, particularly in complex legal, regulatory, and compliance areas. We provide directors memberships

with the National Association of Corporate Directors, and encourage our Board members to take advantage of its numerous educational

resources and programs. We also provide support for directors who wish to attend educational programs they identify that are relevant to

their Board service.

Board Meetings and Board Member Attendance at our Annual Meetings

of Shareholders

Our full Board held four meetings during 2023. In addition, during 2023, our Audit Committee held five meetings, our Compensation

Committee held five meetings, and our Nominating and Governance Committee held six meetings. Every director attended 100% of the

total number of meetings of our Board and the committees on which they served during 2023. In accordance with applicable Nasdaq listing

standards, the independent members of our Board met without management present four times during 2023.

Our Board encourages all of its members to attend our Annual Meeting of Shareholders, although attendance is not mandatory. All of our

directors attended our 2023 Annual Meeting of Shareholders.

Shareholder Communication with Directors

Shareholders are encouraged to address any director communications to our Corporate Secretary by overnight or certified mail, signature

acceptance or return receipt required, at: United Therapeutics Corporation, Attention: Corporate Secretary, 1735 Connecticut Avenue

N.W., Washington, D.C. 20009. Our Corporate Secretary has the authority to disregard or take other reasonable action with respect to any

inappropriate shareholder communications. After confirming the stock ownership of the author of the communication, our Corporate

Secretary will review the appropriateness of a shareholder communication based on the relevance of the communication to Board duties

and responsibilities. If deemed an appropriate communication, our Corporate Secretary will submit the shareholder communication to our

Lead Independent Director, who may share it with our Nominating and Governance Committee or our full Board.

Non-Employee Director Compensation

Overview

In 2023, our non-employee director compensation program was comprised of three main elements:

•an annual cash retainer (payable quarterly) for service as a member of our Board

•additional annual cash retainers (payable quarterly) for service on Board committees and for service as Lead Independent Director

•stock options or restricted stock units (in either case, granted initially upon joining our Board, and thereafter on an annual basis) for

service as a member of our Board

Directors may also be compensated for special assignments from our Board, although no such assignments occurred during 2023.

Employee directors do not receive any compensation for service on our Board in addition to their regular compensation as employees.

Our Compensation Committee generally reviews non-employee director compensation levels approximately once every two years, and

final decisions with respect to any changes in non-employee director compensation levels are made by our Board upon the

recommendation of our Compensation Committee. For 2023, our Compensation Committee’s independent consultant reviewed the market

competitiveness of our non-employee director compensation program relative to our compensation peer group and did not recommend any

changes in compensation levels. Such non-employee director compensation levels were established by our Board in February 2016. The

following table outlines the non-employee director compensation levels in effect for 2023:

Our Corporate Governance

2024 Proxy Statement 37

	Annual Cash		Value of Equity Based Awards(3)
			Initial	Annual
Board Membership		$60,000	$400,000	$400,000
Lead Independent Director(1)		$35,000	$—	$—
Committee Chair(2):
Audit Committee		$25,000	$—	$—
Compensation Committee		$25,000	$—	$—
Nominating and Governance Committee		$25,000	$—	$—
Committee Membership(2):
Audit Committee		$15,000	$—	$—
Compensation Committee		$15,000	$—	$—
Nominating and Governance Committee		$15,000	$—	$—

(1)Compensation for service as Lead Independent Director is paid in addition to amounts paid for membership on our Board and for any

committee chair or membership.

(2)Committee chairs received the compensation indicated for committee chair in lieu of the compensation for committee membership.

Compensation for committee chair and committee membership is paid in addition to amounts paid for Board membership.

(3)Annual awards are generally granted once per year on the date of the first meeting of our Board following our Annual Meeting of Shareholders

or for newly appointed directors, on or shortly following appointment to our Board.

Equity-Based Awards

In 2023, non-employee directors were eligible to receive equity-based awards under the United Therapeutics Corporation Amended and

Restated 2015 Stock Incentive Plan (the 2015 SIP), as follows:

•Form of Awards: Initial grants and annual grants were paid in the form of stock options, restricted stock units (RSUs), or a

combination of the two. For each grant, directors could elect to receive awards in any one of the following forms:

•100% stock options

•100% RSUs

•50% stock options / 50% RSUs

•Value of Awards: The aggregate value of each director’s annual equity-based award was $400,000. The aggregate value of an initial

equity-based award upon joining our Board was $400,000, plus a pro rata portion of the annual equity-based award value based on

the number of months remaining in our Board service year at the date of grant.

•Deferral for RSUs: For directors who elected to receive RSUs, our Compensation Committee has implemented a deferral program

enabling directors to defer delivery of shares of common stock until a date of their choosing following vesting of the RSUs in

accordance with the terms and conditions of the program.

•Calculation Methodology: Our Compensation Committee also sets the methodology for determining the precise numbers of stock

options and/or RSUs for each grant. For the annual grants, which are generally made in June or July of each year, the following

applies (subject to modification by our Compensation Committee in its discretion):

•Stock Options: The number of stock options was calculated by dividing the equity value ($400,000, or $200,000, if the director 

elected to receive 50% stock options and 50% RSUs) by the fair value of each stock option, calculated in accordance with the

Black-Scholes-Merton methodology utilized in calculating share-based compensation for financial reporting purposes.

Black-Scholes-Merton inputs were the same as those used in our most recent Quarterly Report on Form 10-Q, except that the

stock price input was the average closing price of our common stock over a recent time period prior to the date of grant.

•RSUs: The number of RSUs was calculated by dividing the equity value ($400,000, or $200,000, if the director elected to receive

50% stock options and 50% RSUs) by the average closing price of our common stock over a recent time period prior to the date

of grant.

•Rounding: The resulting number of stock options or RSUs, calculated as above, was rounded to the nearest ten shares.

The grant-date fair value of stock options and RSUs reported in the Non-Employee Director Compensation table each year often

varies from the target for each director ($400,000 for 2023), because the methodology used to calculate the number of stock options

and/or RSUs delivered was based on an average stock price over a specified, predetermined one-month period prior to the date of

grant, whereas the amount reported in the table represents the grant date fair value of the stock options and RSUs on the date of

grant. See 2023 Non-Employee Director Compensation below.

Our Corporate Governance

38 United Therapeutics, a public benefit corporation

•Exercise Price: Stock options granted to non-employee directors have an exercise price equal to the closing price of our common

stock as reported on the Nasdaq Global Select Market on the date of grant, or on the preceding trading day if the award is granted on

a date when the Nasdaq is not open.

•Grant Timing:

•The date of grant for a new non-employee director’s initial award, consisting of the initial membership award and a prorated

amount of the annual award for the remainder of the board service year, is the date of a director’s appointment or election to

our Board.

•The date of grant for annual awards is the date of the first meeting of our Board following our Annual Meeting of Shareholders in

the year of grant.

•Vesting: Non-employee director awards granted in 2023 fully vest on the one-year anniversary of the grant date, but only if the

director attends at least 75% of the regularly scheduled meetings of our Board and their committee meetings from the date of grant

until the date of our next Annual Meeting of Shareholders (the Attendance Requirement).

2023 Non-Employee Director Compensation

The following table lists the compensation earned in 2023 by each non-employee director:

Name	Fees Earned or Paid in Cash(1)	Restricted Stock Units(2)		Stock Options(2)		Total
Christopher Causey	$100,000		$—		$381,535		$481,535
Raymond Dwek	$75,000		$—		$381,535		$456,535
Richard Giltner	$100,000		$413,658		$—		$513,658
Katherine Klein(3)	$60,000		$206,829		$190,768		$457,597
Ray Kurzweil	$60,000		$206,829		$190,768		$457,597
Linda Maxwell	$75,000		$—		$381,535		$456,535
Nilda Mesa	$90,000		$206,829		$190,768		$487,597
Judy Olian	$75,000		$413,658		$—		$488,658
Christopher Patusky	$135,000		$206,829		$190,768		$532,597
Louis Sullivan	$90,000		$—		$381,535		$471,535
Tommy Thompson	$75,000		$—		$381,535		$456,535

(1)Includes (as applicable) annual cash retainer and fees for serving on our Board, the committees of our Board, as a committee chair, and as

Lead Independent Director.

(2)On July 13, 2023, each of our non-employee directors was granted stock options and/or RSUs. Each stock option had an exercise price of

$229.81 per share and a grant date fair value of $83.67 per share, and each RSU had a grant date fair value of $229.81 per share. Amounts

shown in these columns represent the aggregate grant date fair value of the stock options and RSUs granted in 2023, which were the only

awards granted to non-employee directors in 2023, computed in accordance with applicable accounting standards. For a discussion of the

valuation assumptions for stock options, see Note 8—Share-Based Compensation to the consolidated financial statements included in our

Annual Report on Form 10-K for the year ended December 31, 2023.

The grant-date fair value of RSUs and stock options presented in this table differs from the $400,000 target for each director due to the

methodology used to calculate the number of RSUs and/or stock options delivered, which was based on an average stock price over a

specified one-month period prior to the date of grant.

(3)Although Professor Klein is not standing for re-election at the 2024 Annual Meeting, she met the Attendance Requirement and on April 24,

2024, the Compensation Committee approved (i) allowing her unvested equity awards to remain outstanding and eligible to vest on the one-

year anniversary of the date of grant notwithstanding that she will not be a member of the Board as of such date; and (ii) the extension of the

term of her stock options until three years following the expiration of her term as director on June 26, 2024 (or, if earlier, the expiration of the

original ten-year term of such stock options).

Our Corporate Governance

2024 Proxy Statement 39

Each non-employee director held the following number of stock options, awards under our 2011 United Therapeutics Corporation Share

Tracking Awards Plan (collectively with its predecessor plan adopted in 2008, the STAP), and RSUs as of December 31, 2023:

Name	Stock Options	STAP Awards	RSUs
Christopher Causey	28,330	—	—
Raymond Dwek	19,560	10,000	—
Richard Giltner	15,000	10,000	1,800
Katherine Klein	68,240	29,375	900
Ray Kurzweil	48,210	15,000	900
Linda Maxwell	34,670	—	—
Nilda Mesa	26,030	—	900
Judy Olian	19,620	—	1,800
Christopher Patusky	58,540	—	900
Louis Sullivan	30,440	—	—
Tommy Thompson(1)	56,790	13,000	880

(1)Governor Thompson's 880 RSU awards vested on July 7, 2023; however, receipt of shares was deferred to July 8, 2026.

Our Corporate Governance

40 United Therapeutics, a public benefit corporation

EXECUTIVE COMPENSATION

2 Advisory Resolution to Approve Executive Compensation

We are asking our shareholders to vote on an advisory resolution, commonly known as a “Say-on-Pay” proposal, to approve executive

compensation as reported in this Proxy Statement. Our Compensation Committee, which is responsible for designing and administering

our executive compensation program, has designed our executive compensation program to provide a competitive and internally equitable

compensation and benefits package that reflects company performance, job complexity, and the value provided, while also promoting long

term retention, motivation, and alignment with the long-term interests of our shareholders.

As described elsewhere in this Proxy Statement, we have evolved our compensation practices significantly in recent years, in large part in

response to shareholder feedback. We were therefore very pleased with the overwhelming shareholder support received for our 2023

Say-on-Pay proposal.

In connection with your vote on this proposal, we urge you to read the Compensation Discussion and Analysis section of this Proxy

Statement, the Summary Compensation Table, and other related compensation tables and narratives that follow, which provide detailed

information on the compensation of our NEOs. Our Compensation Committee and our Board of Directors believe that the policies and

procedures articulated in these sections of this Proxy Statement are effective in achieving our goals, and that the compensation of our

NEOs reported in this Proxy Statement has supported and contributed to both our recent and long-term success.

In accordance with Section 14A of the Exchange Act, and as a matter of good corporate governance, we are asking shareholders to

approve the following advisory resolution at the Annual Meeting:

RESOLVED, that the shareholders of United Therapeutics Corporation (our “Company”) approve, on an

advisory basis, the compensation of our Company’s Named Executive Officers disclosed in the Compensation

Discussion and Analysis, the Summary Compensation Table and the related compensation tables, notes and

narrative in the Proxy Statement for our Company’s 2024 Annual Meeting of Shareholders.

This advisory resolution is not binding on our Board of Directors. Although non-binding, our Board and our Compensation Committee will

review and consider the voting results when making future decisions regarding our executive compensation program. Based on the results

of our 2023 shareholder advisory vote on the preferred frequency of holding future advisory votes to approve executive compensation, our

Board of Directors has adopted a policy providing for an annual advisory resolution to approve executive compensation. Unless our Board

modifies its policy on the frequency of future “Say-on-Pay” advisory votes, the next “Say-on-Pay” advisory vote will be held at our 2025

Annual Meeting of Shareholders. Approval of this proposal requires the affirmative vote of the holders of a majority of the voting

power of all shares of stock entitled to vote thereon, present in person or by proxy, at our Annual Meeting. Abstentions have the

same effect as an “against” vote. Broker non-votes, if any, have no impact on the vote.

Our Board of Directors recommends that you vote FOR the advisory resolution to approve executive compensation.

2024 Proxy Statement 41

Compensation Discussion and Analysis

This Compensation Discussion and Analysis describes the compensation objectives and policies set by our Compensation Committee

for our NEOs, including executive pay decisions and processes and all elements of our executive compensation program. In this

Compensation Discussion and Analysis and elsewhere in this Proxy Statement, the term Compensation Committee refers to the

Compensation Committee of our Board of Directors, and the terms we and our refer to United Therapeutics.

Overview

Below is a summary of introductory highlights regarding key 2023 compensation outcomes, performance metrics, and other achievements.

ü INDUSTRY-LEADING PROFITABILITY

•42% net income margin, 54% EBITDASO margin*

•$2.0 million revenue per employee, the highest in our

compensation peer group

ü CONTINUED REVENUE GROWTH TRAJECTORY

•20% increase in revenue overall in 2023 compared to 2022

•41% growth for total Tyvaso revenues (nebulized Tyvaso and

Tyvaso DPI) in 2023 compared to 2022

•Record number of U.S. treprostinil patients on therapy at

year-end 2023

ü ROBUST SUPPLY CHAIN

•Supplied patients Tyvaso DPI, which has grown to become

our best-selling product

•Opened first-ever cGMP warehouse designed to be net-zero

operational carbon

•Maintained two-year inventory of nebulized Tyvaso,

Remodulin, and Orenitram

ü PIPELINE EXECUTION

•Progressed TETON 1, TETON 2, and ADVANCE

OUTCOMES studies

•Launched phase 3 TETON PPF study of nebulized Tyvaso

in PPF

•Augmented organ manufacturing programs through

acquisitions of IVIVA and Miromatrix

*EBITDASO margin is a non-GAAP measure. A reconciliation of this non-GAAP measure and other information relating to this measure can be

found in Annex B to this Proxy Statement.

CEO Compensation at a Glance

•Our CEO's target total direct compensation is predominantly at-risk and performance-based (90.6%)

•2023 total target direct compensation was at the 50th percentile, which means her opportunities for above target pay were tied to

above target performance

•During 2023, our CEO received:

•A market and performance-based increase in base salary of 6.0%, following several years of modest increases

•No change in cash incentive target or maximum potential payout, as a percentage of salary

•Her first long-term incentive equity award since 2019, which was delivered in the form of 100% performance-based equity grants.

These awards were comprised of both performance-based stock options and performance-based stock units, with multiple

performance criteria.

Shareholder Engagement

•Extensive shareholder outreach before and after the 2023 Annual Meeting (reached out to holders of ~70% of our outstanding shares)

•Met commitment made to shareholders not to make any additional NEO equity awards until 2023

•2023 equity awards to NEOs are aligned with all commitments made to shareholders in 2021—and they are 100%

performance-based, exceeding our commitment that the 2023 equity awards would be at least 50% performance-based

Executive Compensation

42 United Therapeutics, a public benefit corporation

Our Named Executive Officers

Our 2023 Named Executive Officers (or NEOs) are:

  Martine Rothblatt, Ph.D., J.D., M.B.A. 69, Founder, Chairperson, Chief Executive Officer, and Director

Dr. Rothblatt founded United Therapeutics in 1996 and has served as Chairperson and Chief Executive Officer since its inception.

Previously, she created the satellite radio company SiriusXM. She is an inventor or co‑inventor on nine U.S. patents, with additional

applications pending. Her pioneering book, Your Life or Mine: How Geoethics Can Resolve the Conflict Between Private and Public

Interests in Xenotransplantation, anticipated the need both for global virus bio-surveillance and a greatly expanded supply of transplantable

organs. Dr. Rothblatt has also analyzed the socio-ethical issues of human-like cyber competencies, as are emerging from large language

models, in her 2014 book Virtually Human.

  Michael Benkowitz 52, President and Chief Operating Officer

Mr. Benkowitz joined United Therapeutics in 2011 as our Executive Vice President, Organizational Development, and was promoted to

President and Chief Operating Officer in 2016. He is responsible for all of our commercial, medical affairs, and corporate compliance

activities, most company-wide administrative functions, including human resources and information technology, many of our business

development efforts, and several of our key business alliances and partnerships.

  James C. Edgemond 57, Chief Financial Officer and Treasurer

Mr. Edgemond joined United Therapeutics in January 2013 as Treasurer and Vice President, Strategic Financial Planning. Mr. Edgemond

was promoted to Chief Financial Officer and Treasurer in March 2015. Prior to joining United Therapeutics, he was Vice President,

Corporate Controller, and Treasurer of Clark Construction Group from 2008 through January 2013. He also served in a variety of roles at

The Corporate Executive Board Company from 1998 to 2008, including as Executive Director, Finance from 2005 to 2008. He began his

career as a public accountant at KPMG Peat Marwick LLP, from 1990 through 1998, where he served in a variety of roles, including as a

Senior Manager prior to his departure.

  Paul A. Mahon, J.D. 60, Executive Vice President, General Counsel, and Corporate Secretary

Mr. Mahon has served as General Counsel and Corporate Secretary of United Therapeutics since its inception in 1996. In 2001,

Mr. Mahon joined United Therapeutics full-time as Senior Vice President, General Counsel and Corporate Secretary. In 2003, Mr. Mahon

was promoted to Executive Vice President, General Counsel, and Corporate Secretary. Prior to 2001, he served United Therapeutics,

beginning with its formation in 1996, in his capacity as principal and managing partner of a law firm specializing in technology and

media law.

Executive Compensation

2024 Proxy Statement 43

2023 Performance Highlights

2023 continued the strategic transformation for United Therapeutics with several important milestones for our patients and our

shareholders, including:

$2.3 billion in revenues, continuing a trend of double-digit percent revenue growth ~$2.0 million in revenue per employee, which ranked highest out of companies in our compensation peer group	We advanced our key pipeline programs during 2023, including: •TETON 1 and TETON 2 studies of nebulized Tyvaso in IPF •TETON PPF study of nebulized Tyvaso in PPF •ADVANCE OUTCOMES study of ralinepag in PAH •Phase 3 study of CLES EVLP service •ARTISAN, a phase 4 study to evaluate early and rapid treprostinil therapy in PAH
We reached record numbers of PH patients in the United States being treated with our treprostinil-based therapies— once again reaching more patients than ever before

2023 Shareholder Outreach

At our 2023 Annual Meeting, our shareholders overwhelmingly approved our Say-on-Pay proposal, with over 97% of the votes cast in favor

of the proposal. We therefore did not make any changes to our compensation programs directly as a result of our 2023 Say-on-Pay vote.

In the spring of 2023, we reached out to 37 shareholders that collectively held approximately 70% of our outstanding shares. Calls were

held with five shareholders (collectively holding approximately 10% of our outstanding shares) where we engaged in dialogue about

governance topics, ESG topics, and corporate strategy.

Following our 2023 Annual Meeting, we also offered to engage with shareholders that collectively held approximately 70% of our

outstanding shares (32 shareholders), and held a discussion with four shareholders (collectively holding approximately 30% of our

outstanding shares) that accepted our offer. These conversations focused on our most recent Corporate Responsibility and PBC Report

and other governance topics.

Meetings with shareholders in 2023 were led by Christopher Patusky, our Lead Independent Director and Compensation Committee Chair,

with participation from Christopher Causey, our Nominating and Governance Committee Chair. Where appropriate, participants also

included representatives of our human resources, investor relations, and legal departments. The purpose of these meetings was to gather

feedback regarding our executive compensation and corporate governance policies and our 2023 Corporate Responsibility and

PBC Report.

Executive Compensation

44 United Therapeutics, a public benefit corporation

Overview of our 2023 Executive Compensation Program

Compensation Program Objectives

Our executive compensation program is designed to retain and motivate our executive team, while achieving four critical objectives:

pay-for-performance (with at-risk pay representing approximately 90.6% of overall Chief Executive Officer pay and approximately 83.0% of

our other NEOs’ pay); incentivize alignment with shareholder interests based on delivering operating performance and stock appreciation;

balancing incentives over the short-term and long-term; and market competitiveness.

Sustainable, Long-Term Shareholder Value Creation
Pay-for-Performance	Shareholder Alignment	Balance Short- and Long-Term Perspectives	Market Competitiveness

Pay Program Elements

We accomplish these objectives through the following compensation elements, as summarized below:

	Objective
Compensation Element	Pay-for- Performance	Shareholder Alignment	Balance Short- and Long-Term Perspectives	Market Competitiveness
Base Salary				ü
Cash Incentive Awards	ü	ü	ü	ü
Long-Term Incentives (Stock Options and Stock Units)	ü	ü	ü	ü
Benefits / Perquisites				ü
Supplemental Executive Retirement Plan			ü
Severance / Change-of-Control Benefits			ü	ü
Stock Ownership Guidelines		ü	ü	ü

Executive Compensation

2024 Proxy Statement 45

Pay Element Overview

Our compensation program is comprised of three elements: base salary, annual short-term incentive (cash bonus), and a long-term

incentive program. A significant portion of target total direct compensation (TDC) for our CEO and other NEOs is structured as “at risk”

compensation, comprised of the annual short-term incentive cash bonus and long-term incentives delivered as a mix of performance stock

options and performance stock units.

		Element / Percent of TDC		Why We Pay This Element	Key Characteristics	How We Determine Amount
		Base Salary		•Provides market competitive levels of fixed pay to attract and retain our NEOs	•Cash •Annual	•Market rate, internal pay equity, experience and critical skills, expertise, scope of responsibility, and sustained performance
		CEO	Other NEOs
		Cash Bonus		•Provides competitive incentives to achieve difficult, annual performance goals •Pay-for-performance •Shareholder alignment •Strategic alignment balancing a focus on patients through manufacturing and inventory performance, and advancement of clinical programs with driving revenue and profitability	•Cash •Performance-based •Annual	•50% Financial •25% Cash Profits •25% Revenues •50% Operational •25% Manufacturing •25% R&D •Payout 0-300% of target based on above target revenue and cash profit margin performance, and achieving patient growth goals
		CEO	Other NEOs
		Equity Award		•Strategic alignment incentivizing achievement of objectives over the performance period •Pay-for-performance alignment •Shareholder alignment, focused on value creation over time •Retention element	•At-risk •Performance-based •50% of 2023 equity award delivered as performance stock options, which vest based on performance goals set at the beginning of the three- year performance period. Further, shareholder alignment is deepened since any options that vest will only have value if our stock price increases after grant •50% of 2023 equity award delivered as performance stock units, which vest based on attainment of performance goals set at the beginning of the three-year performance period •"Cliff-vest" at the end of the three-year performance period	•Market rate, internal pay equity, experience and critical skills, expertise, scope of responsibility, and sustained performance
		CEO	Other NEOs

Executive Compensation

46 United Therapeutics, a public benefit corporation

The following charts illustrate the extent to which pay for our Chief Executive Officer and our other NEOs is at risk, as payout levels are

based entirely on performance. For each chart, the amounts shown represent 2023 base salary (on an annualized basis, following the

March 2023 salary increases), 2023 target cash bonus, and the target equity value of the long-term incentive awards granted in

March 2023, which were granted 50% in the form of performance stock options and 50% in the form of performance stock units.

CEO Target Pay Mix	Other NEO Target Pay Mix

2023 Compensation Decisions

Summary of 2023 Compensation

The components of our NEOs’ target total direct compensation are base salary and variable compensation, including cash incentives and

long-term incentive compensation in the form of performance stock options and performance stock units. In 2023, we kept and exceeded

our commitment to shareholders, granting long-term equity incentive awards to our CEO and other NEOs for the first time since

2019 and designing an award that is 100% performance-based, comprised of different equity vehicles, and using multiple

performance criteria for vesting over a three-year performance period.

Summary of 2023 Target Total Direct Compensation

NEO	2023 Base Salary(1)	% Increase Over 2022 Base Salary	2023 Cash Incentive Bonus Target as % of Base Salary	Change in Cash Incentive Bonus Target %(2)	2023 Long-Term Incentive Award Target(3)		2023 Total Target Direct Compensation
Martine Rothblatt	$1,500,000	6.0%	125%	—%		$12,500,000		$15,875,000
James Edgemond	$800,000	6.7%	75%	—%		$3,500,000		$4,900,000
Michael Benkowitz	$1,130,000	15.3%	85%	—%		$6,000,000		$8,090,500
Paul Mahon	$940,000	—%	70%	7.7%		$3,000,000		$4,598,000

(1)Reflects increases in annual base salaries effective March 5, 2023 and first reflected in pay on March 24, 2023.

(2)Represents the difference in cash incentive award target as a percentage of salary between 2022 and 2023.

(3)Reflects the target equity value awarded to NEOs in March 2023.

Base Salary

Base salary is the only fixed element of the compensation packages for our NEOs. Our Compensation Committee reviews and establishes

base salary levels for our NEOs each year taking into consideration one or more of the following factors, depending on the circumstances:

(1) a qualitative evaluation of individual performance, responsibility and experience, including contribution to the advancement of corporate

objectives, impact on financial results, and strategic accomplishments; (2) our overall performance, financial condition, and prospects;

(3) the annual compensation received by executives holding comparable positions at our peers; and (4) the input of our Chief Executive

Officer (in the case of the other NEOs). Base salaries are also typically reviewed when there is a material change in the executive’s

responsibilities during the year.

In early 2023, our Compensation Committee approved salary increases for our NEOs, as shown in the table above, effective

March 5, 2023. Salary increases were determined based on a review of competitive pay positioning, taking into consideration a number of

factors, including internal pay equity among NEOs.

Executive Compensation

2024 Proxy Statement 47

Cash Incentive Award Program

Each year, our Compensation Committee establishes cash incentive award targets for each of our NEOs, taking into consideration the

same factors it uses to determine base salaries. For 2023, our Compensation Committee established cash incentive award targets for our

NEOs as a percentage of base salary, at the levels shown in the Summary of 2023 Target Total Direct Compensation table above.

There was no change to cash incentive targets for our CEO from 2022 to 2023, and a modest change to the cash incentive target for one

of our NEOs, our EVP and General Counsel, from 2022 to 2023, increasing from 65% of base pay to 70% of base pay.

These stated incentive targets are comparable to those of executives holding similar roles and levels of responsibility at our peer

group companies. Cash incentives are earned for achieving our Company-Wide Milestones (described below) and three of our four

Milestones are subject to a threshold, or minimum, level of performance before earning credit for those Milestones. We believe that by

setting a threshold level of performance as well as a maximum under the plan we have aligned these policies with market norms and have

also responded to feedback from our shareholders.

Each of our NEOs had the opportunity to earn up to 300% of their respective target cash incentive award for 2023, based on above target

performance on our cash profit and revenue-based Milestones (i.e. the Financial Multiplier), and performance against our Patient Multiplier.

The Financial Multiplier and the Patient Multiplier bring forward the strength of our pay-for-performance philosophy and our PBC purpose,

creating a balanced metric that synergistically balances our goal of reaching more patients, with our revenue and profitability objectives -

aligning our compensation programs with both shareholder and patient interest.

2023 Company-Wide Milestone Program

The Milestones (or performance goals) under our 2023 Company-Wide Milestone Program are intended to create company-wide

incentives relating to significant corporate objectives, falling into two categories: (1) financial metrics, consisting of revenue and profitability

targets; and (2) operational metrics, tied to manufacturing and research and development (R&D) objectives. Our Compensation Committee

approved the specific goals and weightings based on management input at the beginning of the year and a desire to reflect core

performance measures and priorities for the business for the fiscal year, including our commitment to compliance, and to set goals that

translate most directly into short-, medium- and long-term value growth.

The goal-setting process for 2023 was rigorous, involving lengthy discussions and a review of multiple data points, including analyst

consensus, product expectations, and overall market potential. The Milestone performance targets are difficult to meet and require

significant leadership and execution excellence on the part of our NEOs. Based on these factors, our Compensation Committee

established the following Company-Wide Milestones and weightings for 2023:

2023 Company-Wide Milestones	Weighting
Milestone 1—Financial Performance-Cash Profits*: Achieve cash profits in the top quintile of our peer group as measured by a 50% cash profit margin	25%
Milestone 2—Financial Performance-Revenue: Superior financial performance as evidenced by achieving the net revenues for 2023 included in our long-range business plan (a target of $2.2 billion)	25%
Milestone 3—Manufacturing: Adequate manufacturing capabilities, evidenced by a two-year inventory of Remodulin, Tyvaso (nebulized), and Orenitram finished drug product and passing all GMP-related FDA inspections at our facilities without any issues that prevent the use or approval of any of our drug products	25%
Milestone 4—Research & Development: Conduct insightful research and development programs, taking into account regulatory approvals, label extensions and the quantity and quality of trials that support our business goals	25%

*Cash profit margin is defined as cash profit divided by net revenues. Cash profit is defined as net income for 2023 as reported in our Annual

Report on Form 10-K for the year ended December 31, 2023, adjusted to add the following expenses, net of relevant benefits (or subtracted,

to the extent the expense item is a net benefit):

•Interest expense

•Non-cash charges (including, without limitation, amortization, and depreciation)

•Tax expense (including penalties and interest) and expenses associated with the branded prescription drug fee

•Extraordinary, non-recurring and unusual items (including without limitation, license fees, Milestone payments, gains/losses on

acquisition/disposal of assets, asset impairments, restructuring costs, foreign currency adjustments, and discontinued operations)

•Legal expenses related to (1) intellectual property prosecution and defense; (2) litigation and government investigation and enforcement

proceedings; and (3) amounts paid to settle/resolve legal disputes, litigation and government investigations and enforcement proceedings

•Share-based compensation expense

Executive Compensation

48 United Therapeutics, a public benefit corporation

Our Compensation Committee carefully crafted these Milestones, which represent rigorous, objective standards by which to measure

company and executive officer performance. Our Compensation Committee believes that all four Milestones are strategically important to

our continued success and therefore should be weighted equally in determining incentive awards. Cash profits and revenue objectives are

important to maintaining industry-leading financial performance. Our 2023 goals are tied to our long-term strategic objectives, which

include aggressive revenue targets over near-term, medium-term, and long-term time horizons, and are designed to achieve profitability at

the top quintile of our peers. Our financial performance goal was established based on many factors, including market opportunity for each

product, analyst expectations, and historical individual product performance. Our Compensation Committee also considered the continued

impact of generic competition for Adcirca and Remodulin in setting revenue goals. Our total revenue goal for 2023 was set at $2.2 billion,

which was well above our 2022 actual revenue performance and set to incentivize significant year-over-year revenue growth. In fact, our

threshold level of revenue performance for 2023 was set at $2.05 billion, which was also above our 2022 actual revenue performance. This

meant our executives would not receive any bonus from revenue performance in 2023 unless our revenues exceeded 2022 actual

revenue performance. Additionally, as a condition to receiving any credit for the Patient Multiplier, as described below, we were also

required to achieve revenue performance of at least 95% of target, therefore exceeding actual 2022 revenue and creating the balance

between our financial and patient metrics/performance goals. Our cash profit margin performance Milestone is set at a very high bar,

incentivizing top-quintile performance relative to our peers and thoughtful and disciplined budget and spend management. Our

manufacturing Milestone is intended to incentivize a continuous supply of our treprostinil-based therapies, which generate the vast majority

of our revenues. Our R&D Milestone was intended to drive a robust pipeline of products capable of delivering future revenues sufficient to

drive industry-leading growth.

The details of our framework for determining 2023 Milestone performance are provided below. As a general matter, under the terms of our

Company-Wide Milestone Program, our Compensation Committee has the authority to exercise negative (downward) discretion in the

event of partial attainment under any of the Milestones. The financial targets (cash profits and revenues) are set considering the market

opportunity for our existing products, potential entrance of generic competition into the market during the performance period, analyst

expectations, and our broader business plans.

Financial Performance—Cash Profit Margin

Below Threshold 0% credit	At Threshold 50% credit	Target 100% credit	Stretch/Maximum 125% credit*

Financial Performance—Revenues

Below Threshold 0% credit	At Threshold 50% credit	Target 100% credit	Stretch/Maximum 125% credit*

*Stretch goal to provide additional credit for above profit performance is applied as discussed under Financial Multiplier below.

Manufacturing

We award pro rata credit based on the number of quarters for which: (1) pre-specified inventory levels are achieved (i.e., two-year supply

of Orenitram, Remodulin, and nebulized Tyvaso); and (2) we pass any GMP-related FDA inspections at our facilities without any issues

that prevent the use or approval of any of our drug products. Meeting the goals for a minimum of two quarters is a threshold condition for

any credit under this Milestone. Achievement of this Milestone requires operational and manufacturing excellence across multiple

interrelated functions, and supports our mission of providing a stable supply of our therapies to our patients that can withstand supply chain

disruptions, pandemics, and other challenges.

Research & Development

Performance under the R&D Milestone is based on a system of R&D points, where expected points (i.e., the goal) are determined at the

beginning of the year based on our pipeline, and progress is measured at the end of the year.

Award pro rata credit	100% credit (at target)
< 100% of Goal	100%+ of Goal

Executive Compensation

2024 Proxy Statement 49

Financial Multiplier

For 2023, above-target cash incentive awards were possible (up to 150% of target) through the application of a Financial Multiplier, which

is based only on the achievement of financial performance against the pre-established revenue and cash profit margin target and stretch/

maximum goals, as follows:

	Range (Target to Stretch/Maximum)
Cash Profit Margin Performance	50%	55%
Revenue Performance	2.2 billion	2.35 billion
Multiplier for each Metric*	0%	25%

*The Financial Multiplier is calculated independently for each metric, using linear interpolation between performance levels. Aggregate multiplier

of up to 50% is applied to the entirety of the Milestone program attainment after determining individual performance for each

individual Milestone.

Patient Multiplier

In 2022, we added the Patient Multiplier as an additional modifier that applies to cash incentive targets after Milestone attainment and is in

addition to the Financial Multiplier, in determining final cash incentive awards. The Patient Multiplier aligns with both our pay-for-

performance philosophy and our patient-focused public benefit purpose, and is based on the achievement of a pre-established patient

growth target. This added modifier balances our revenue and profitability goals, intending to incentivize reaching additional patients with

our therapies, while maintaining focus on our rigorous revenue and cash profit goals for 2023, including a requirement that we achieve a

minimum revenue of $2.09 billion before the Patient Multiplier could be applied. For 2023, the patient threshold/target and stretch/max goal

was determined by considering the number of patients on our therapies at the end of 2022, and the number of patients we would need to

add to our therapies in 2023 in order to achieve our long-term objectives. The goal, and associated multiplier, was set as follows:

	Range (Threshold/Target to Stretch/Maximum)
Patient Goal	14,000	15,000
Multiplier*	0%	100%

*The Patient Multiplier is calculated using linear interpolation between performance levels. A multiplier of up to 100% is applied to the entirety of

the Milestone program attainment and Financial Multiplier.

Executive Compensation

50 United Therapeutics, a public benefit corporation

2023 Milestone and Patient Multiplier Performance

For 2023, our Compensation Committee determined that 100% of the Milestones were achieved, plus an additional 21% multiplier for

exceeding our revenue target (but not reaching our maximum), and above-maximum performance under our cash profit Milestone.

Additionally, our Compensation Committee determined that our Patient Multiplier was achieved at 152%, and would apply to the

determination of the final bonus award for our NEOs, as we exceeded the target number of patients on our therapies in 2023. Performance

attainment is shown below:

Milestone	Performance	Attainment Level % (A)	Weighting (B)	% of Award Earned (A × B)
1 (Cash Profit Margin)		100%	25%	25%
	2023 cash profit margin was 61%, representing 122% performance against the target of 50%. Because performance also exceeded the maximum 55% threshold, the full milestone achievement was awarded including a 25% financial multiplier.
2 (Revenue)		100%	25%	25%
	2023 net revenues were $2.33 billion, exceeding our target of $2.2 billion. Because performance exceeded target, full milestone achievement was awarded and a 21% financial multiplier.
3 (Mfg)	Maintained greater than two-year inventory of all strengths of Remodulin, nebulized Tyvaso, and Orenitram and passed all FDA inspections at our facilities without any issues that prevent the use or approval of any of our drug products. Full Milestone achievement was awarded.	100%	25%	25%
4 (R&D)	Achieved 32 R&D points against a goal of 25 (details provided below).	100%	25%	25%
	Total Milestone Attainment			100%
Financial Multiplier	Cash profit performance exceeded maximum at 61% (25% financial multiplier) and revenue performance exceeded target but did not achieve maximum performance (21% financial multiplier) resulting in total Financial Multiplier of 146%.			146%
Milestone Attainment x Financial Multiplier				146%
Patient Multiplier
	We completed 2023 with 14,517 patients on our therapies, exceeding our threshold/ target of 14,000 patients, resulting in a 152% Patient Multiplier to be awarded.			152%
Total	Milestone Attainment x Financial Multiplier x Patient Multiplier			222%

Executive Compensation

2024 Proxy Statement 51

A word about our financial performance goals

•Revenue. Our revenue goal for 2023 was set well above actual 2022 revenue performance. In fact, the 2023 revenue goal threshold,

set at $2.05 billion, was set above our 2022 revenue performance and was a minimum level of revenue performance required before

our Patient Multiplier would apply. As a result, our NEOs would not receive any bonus for 2023 revenue performance, and would not

have the opportunity for above target bonus awards based on performance against our patient multiplier, unless our revenues were

higher in 2023 than in 2022. In 2023, amid lingering challenges navigating the ongoing impact of the COVID-19 pandemic, and

continuing pressure from generic competition for both Adcirca and Remodulin, our team stepped up with innovation and

determination, achieving more than a 20% increase in revenues over 2022.

*(+/-5%)

•Cash Profit. We have always focused on market- and peer-leading profitability, which enables us to maintain a healthy balance

sheet to support long-term business continuity to endure disruptions created by pandemics and other events outside our control. Our

cash profit margin is a somewhat unique metric, in that it is designed to ensure we adhere closely to a carefully-crafted budgeting

algorithm whereby our cash budget each year is set at no more than 50 percent of the prior year’s net revenue. This algorithm helps

ensure a disciplined approach to setting R&D and other priorities at our company. This correlates to our 50 percent cash profit

margin goal set for 2023. This budgeting algorithm has historically led to top-quintile profitability. For comparative purposes, we have

included the chart below to show how our budget discipline translated into top-quintile profitability in 2023. Because not all

companies report the same non-GAAP financial measures, the chart below shows how our cash profit performance led to top-quintile

performance in 2023 based on a uniform profitability metric: EBITDASO margin, or earnings before interest, taxes, depreciation,

amortization, and share-based compensation expense, divided by revenues. In 2023, we had the highest EBITDASO margin in our

peer group. The chart below shows EBITDASO margin for all companies within our compensation peer group except for four

companies who were acquired, filed for bankruptcy or were taken private in 2023. We also excluded one peer company from the

chart below that in 2023 recorded a one-time full valuation allowance on it's U.S. federal and state deferred tax assets, which

resulted in a significant income tax expense and high effective tax rate and an EBITDASO margin of 256%. Additionally,

eight companies whose EBITDASO margin was a negative number are displayed below as 0%.

Executive Compensation

52 United Therapeutics, a public benefit corporation

Additional detail regarding our R&D performance

In evaluating performance under Milestone 4 (Research and Development), our Compensation Committee reviewed the clinical and

registration-stage products being developed within our pipeline, the unmet medical needs they are intended to address, and the

significance of potential revenues if approved. For 2023, we measured performance against our R&D milestone by awarding a set number

of points for each accomplishment (eight points for each approval or label expansion, four points for each phase 3 or phase 4 study

commenced or progressed, two points for each phase 1 or phase 2 study commenced or progressed, and one point for each IND filed on a

new product candidate or indication). The following is a list of these programs, several of which represent multi-billion-dollar revenue

opportunities:

•FDA Approvals: N/A

•Late-Stage Clinical Programs: 28 points awarded for progressing seven registration-stage programs, listed below:

•TETON 1, a phase 3 study of nebulized Tyvaso for idiopathic pulmonary fibrosis (U.S. and Canada)

•TETON 2, a phase 3 study of nebulized Tyvaso for idiopathic pulmonary fibrosis (outside U.S. and Canada)

•TETON PPF, a phase 3 study of nebulized Tyvaso for progressive pulmonary fibrosis

•ADVANCE OUTCOMES, a phase 3 event-based study of ralinepag in PAH patients

•Registration study of ex-vivo lung perfusion technology to increase the utilization of donated lungs for transplantation

•ARTISAN, a phase 4 study to evaluate early and rapid treprostinil therapy in PAH patients

•SAPPHIRE, a registration study of gene therapy product called Aurora-GT in PAH patients

•Earlier-Stage Clinical Program: Four points awarded for progressing two early-stage development programs:

•XenoKidney™, a preclinical study evaluating the safety and efficacy of XenoKidneys

•XenoHeart™, a preclinical study evaluating the safety and efficacy of XenoHearts

•New Product Candidates: N/A

Executive Compensation

2024 Proxy Statement 53

2023 Cash Incentive Awards under our Company-Wide Milestone Program

The cash incentive awards earned by our NEOs and approved by our Compensation Committee for the 2023 performance year were as

follows:

NEO	2023 Base Salary (A)		2023 Cash Incentive Award Target as % of Base Salary (B)	2023 Milestone Attainment (C)	2023 Financial Multiplier (D)	2023 Patient Multiplier (E)	Total Cash Incentive Bonus Earned (A × B x C x D x E)
Martine Rothblatt		$1,500,000	125%	100%	146%	152%		$4,161,000
James Edgemond		$800,000	75%	100%	146%	152%		$1,331,520
Michael Benkowitz		$1,130,000	85%	100%	146%	152%		$2,131,542
Paul Mahon		$940,000	70%	100%	146%	152%		$1,460,234

Long-Term Incentive Compensation

Long-term incentive compensation, or equity awards, are a critical component of our NEOs' total compensation. They serve to align

executive and shareholder interests, foster an ownership culture which is reinforced by our stock ownership guidelines, and provide a

powerful tool in attracting and retaining our critical executive talent. These awards represent the largest proportion of compensation for our

NEOs, representing 78.8% of our CEO's total target compensation, and 70.2% of average total target compensation for our other NEOs.

In March of 2023, we granted an annual equity award to our NEOs, following the conclusion of the four-year equity grant awarded in 2019

(which was granted instead of annual equity awards for the performance years 2019 through 2022). The design of these 2023 NEO awards

met or exceeded each of the commitments we made to shareholders. In particular, our 2023 NEO equity awards had the following

features:

•The award was part of our annual program, consistent with our commitment to shareholders (i.e., not a front-loaded grant).

•100% of the award was performance-based.

•The award was comprised of performance stock units and performance stock options.

•The performance metrics for these awards are based on (1) revenue growth over a three-year performance period; (2) cash profit

margin performance over a three-year performance period; and (3) research and development achievements over a three-year

performance period.

Long-Term Incentive Equity Award Mix

As committed to shareholders in 2021, the 2023 equity award made to NEOs was comprised of a mix of both performance stock options

and performance shares.

•Performance Stock Options ("PSOs"). 50% of each NEO’s equity award for 2023 was granted as performance stock options, which

will vest only if we achieve three-year cash profit margin objectives. The use of performance stock options provides our team with a

strong incentive to deliver both against the performance conditions set forth, but also incentivize sustained growth that would result in

stock price appreciation over the long-term.

•Performance Stock Units ("PSUs"). 50% of each NEO’s equity award for 2023 was granted as performance stock units, half of

which will vest based on the achievement of three-year revenue growth objectives; and the other half will vest based on the

achievement of certain R&D milestones. The use of performance stock units aligns executive and shareholder interests, while

balancing incentives between sustained revenue growth and achieving R&D milestones.

Executive Compensation

54 United Therapeutics, a public benefit corporation

2023 Long-Term Incentive Awards

2023 Equity Awards

		Target Value and Target # of PSOs and PSUs Granted
		PSOs		PSUs
Named Executive Officer	Total Target Equity Value Awarded	PSOs Target Value ($)	# of PSOs granted at target	PSUs Target Value ($)	# of PSUs - Revenue Growth granted at target	# of PSUs - R&D Milestones granted at target
Martine Rothblatt	$12,500,000	$6,250,000	69,240	$6,250,000	12,360	12,360
James Edgemond	$3,500,000	$1,750,000	19,390	$1,750,000	3,460	3,460
Michael Benkowitz	$6,000,000	$3,000,000	33,240	$3,000,000	5,930	5,930
Paul Mahon	$3,000,000	$1,500,000	16,620	$1,500,000	2,965	2,965

The above represent the target equity value awarded, and the number of PSOs and PSUs granted at target performance. The actual number

of PSOs and PSUs granted on March 15, 2023 were 300% of target, representing the maximum performance vesting possible against the

performance conditions set over the three-year performance period, though, depending on the achievement of the performance goals, between 0%

and 300% of the target award will vest. Details can be found below under Grants of Plan-Based Awards in 2023. The value displayed in this chart

is the target value of the award at the time of approval; the actual grant date fair value will differ and is detailed in the Summary

Compensation Table.

The 2023 performance-based equity awards will vest at the end of the three-year performance period (January 1, 2023-

December 31, 2025), i.e. "cliff-vest", based on the following performance conditions:

2023 Equity Awards: 2023-2025 Performance Period Goals

Our Compensation Committee designed the 2023 equity awards to drive and reward performance across three key objectives over a three-

year performance period (2023-2025), as described below:

•50% of the award was granted in the form of PSOs with vesting criteria designed to incentivize top quintile profitability, measured

by the average of our cash profit margin (cash profit for that year, divided by net revenue for that year) over the three-year

performance period.

•25% of the award was granted in the form of PSUs with vesting criteria designed to incentivize sustained, robust revenue growth,

measured by the average year-over-year revenue growth across the three-year performance period. For a given year, revenue growth

equals the percentage change in revenue, as compared to the prior year.

•25% of the award was granted in the form of PSUs with vesting criteria designed to incentivize R&D progress, measured by specific,

objective clinical development achievements by the end of the three-year performance period that are designed to lead to additional

long-term revenue growth and revenue diversification.

For each performance condition, threshold, target, stretch and maximum levels of performance were set, with performance vesting ranging

from 0%-300% of target to be determined at the end of the performance period. We are not disclosing the specific average cash profit

margin, average revenue growth, or R&D target goals at this time due to potential competitive harm, but when setting the target goals the

Compensation Committee believed they were challenging and will require substantial performance to achieve.

While compensation paid to our CEO in 2023 as reported in the Summary Compensation Table increased by more than 200%

as compared to 2022, this was a by-product of our return to an annual equity award cycle. 2023 was the first year our CEO

received an equity award since 2019.

Executive Compensation

2024 Proxy Statement 55

2023 Compensation Program Design

Roles of Management, Compensation Committee, and Compensation Consultant

Role of Our Compensation Committee and Management

Our Compensation Committee is composed entirely of independent directors, as defined by Rule 6505(a)(2) of the Nasdaq listing

standards. Our Compensation Committee meets as often as it determines necessary to carry out its duties and responsibilities through

regularly scheduled meetings and, if necessary, special meetings. Our Compensation Committee also has the authority to take certain

actions by written consent of all members. In 2023, our Compensation Committee met five times. Our Compensation Committee reviews

and oversees our compensation policies, plans, and programs and reviews and determines the compensation to be paid to our NEOs, with

the input and advice from its independent compensation consultant. Our Compensation Committee also considers the input of our Chief

Executive Officer in making compensation decisions related to our other NEOs.

Role of Independent Compensation Consultant

Our Compensation Committee has the authority to engage advisors to assist it in carrying out its responsibilities. In accordance with this

authority, our Compensation Committee directly engaged Aon's Human Capital Solutions practice, a division of Aon plc (Aon) as its

compensation consultant during 2023 to provide advice to our Compensation Committee on our executive and non-employee director

compensation practices and policies. Our Compensation Committee, in its discretion, may replace its independent compensation

consultant or hire additional consultants at any time. Aon performed additional services during 2023, namely consulting services for non-

executive employee compensation matters and broad-based compensation survey data, and was paid fees for these services totaling

approximately $18,350. In addition, Aon affiliates (Aon plc and its related entities) performed actuarial services relating to our SERP,

insurance advisory services, and retirement plan advisory services, along with risk management consulting and insurance brokerage

services for United Therapeutics during 2023, for which we paid approximately $772,977 during 2023. Additional insurance premiums and

related fees were paid to Aon plc and passed through to insurance companies not affiliated with Aon plc. Our Compensation Committee

approved these services and determined that they did not impair Aon’s independence. Our Compensation Committee considered the

independence of Aon in light of SEC rules regarding conflicts of interest involving compensation consultants and Nasdaq listing standards

regarding compensation consultant independence. Based on its review, our Compensation Committee determined that Aon was

independent, and that Aon's work did not raise any conflicts of interest. In making the foregoing determination, our Compensation

Committee considered the following six factors, as well as other factors it deemed relevant: (1) the provision of other services to us by Aon;

(2) the amount of fees Aon received from us, as a percentage of Aon's total revenue; (3) the policies and procedures of Aon that are

designed to prevent conflicts of interest; (4) the absence of any business or personal relationships of the Aon consultants with any member

of our Compensation Committee; (5) the absence of any United Therapeutics stock owned by the Aon consultants performing services for

our Compensation Committee; and (6) the absence of any business or personal relationships of the Aon consultants or Aon itself with any

of our executive officers. During 2023, we paid Aon $377,187 in fees for determining or recommending the amount and form of

compensation to our directors and executive officers.

Our Compensation Committee engaged Aon during 2023 to review and advise our Compensation Committee on all principal aspects of

executive and non-employee director compensation. This included base salaries, cash incentive awards, and long-term incentive awards

for our executive officers. Aon performed the following tasks for our Compensation Committee in 2023, among others:

•Reviewing and advising on the structure of our compensation arrangements for our Chief Executive Officer and our other NEOs

•Reviewing and advising on the structure of our compensation arrangements for our non-employee directors

•Providing recommendations regarding the composition of our peer group

•Analyzing publicly available proxy data for companies within our peer group and survey data relating to executive compensation

•Conducting pay and performance analyses relative to our peer group

•Updating our Compensation Committee on industry trends and best practices with respect to executive long-term incentive

compensation program design, including types of long-term incentive compensation awards, size of long-term incentive

compensation grants, and aggregate long-term incentive compensation grant usage

•Reviewing our equity incentive awards against our design/cost targets and against industry norms

•Reviewing the Compensation Discussion and Analysis and other compensation-related disclosures in this Proxy Statement

•Advising our Compensation Committee in connection with its risk assessment relating to our compensation programs

•Preparing for shareholder engagement sessions

•Working on special or ad hoc projects for, or at the request of, our Compensation Committee as they arose

In the course of fulfilling these responsibilities, Aon regularly communicated with our Compensation Committee Chair outside of and prior

to most Compensation Committee meetings. Our Compensation Committee regularly invites its independent compensation consultant to

attend its meetings. In 2023, Aon representatives attended each of our Compensation Committee’s five meetings.

Executive Compensation

56 United Therapeutics, a public benefit corporation

While our Compensation Committee considered its independent consultant’s recommendations in 2023, our Compensation Committee’s

decisions, including the specific amounts paid to our executive officers and directors, were its own and may reflect factors and

considerations in addition to the information and recommendations provided by its independent consultant.

Compensation Peer Group

On an annual basis, our Compensation Committee reviews NEO compensation levels relative to a peer group of industry and labor market

competitors. For 2023, we defined our peer group as the top 25 companies other than United Therapeutics, ranked by revenue, in the

Nasdaq Biotechnology Index, which is consistent with the peer group selection methodology used for 2022. Our 2023 peer group was

selected in July 2022, and was used to develop market data as an input into our compensation program for 2023. This peer group includes

only companies that are U.S.-based or based in jurisdictions with similar compensation disclosure requirements as U.S. companies, and

excludes companies with no product revenues (e.g., companies whose revenues consist of royalties) and companies with a business focus

dissimilar from ours (e.g., companies focused on animal health products). Our methodology for selecting compensation peers uses an

objective metric, which our Compensation Committee believes results in a peer group that includes biopharmaceutical and biotechnology

companies that are similar to us in terms of financial performance, shareholder value creation, and drug development and

commercialization, and generally reflects the universe of companies from which we recruit, and against which we retain, executive talent.

Each year, a number of peers are added or removed from the list and replaced with other companies for various reasons, including merger

and acquisition activities. We have provided below for reference the profile of our compensation peer group for 2023, showing changes

made from our 2022 peer group. For clarity, the 2022 peer group was selected in 2021 and used for setting 2022 compensation policies.

The 2023 peer group was selected in 2022 and used for setting 2023 compensation policies.

2022 PEER GROUP			ADDITIONS FOR 2023
Alexion Pharmaceuticals	Incyte		Alnylam Pharmaceuticals	Novavax
Alkermes	Ionis Pharmaceuticals		CRISPR Therapeutics	Viatris
Amarin	Jazz Pharmaceuticals		Maraval Life Sciences	Vir Biotechnology
Amgen	Moderna
BeiGene	Myriad Genetics
Biogen	Neurocrine Biosciences		DELETIONS FOR 2023
BioMarin Pharmaceutical	Opko Health		Alexion Pharmaceuticals	Myriad Genetics
Blueprint Medicines	PRA Health Sciences		Amarin	OPKO Health
Endo International	Regeneron		Blueprint Medicines	PRA Health Sciences
Exelixis	Seattle Genetics
Gilead Sciences	Syneos Health
Horizon Therapeutics	Vertex
Illumina

2023 PEER GROUP
Alkermes	Endo International	Jazz Pharmaceuticals	Syneos Health
Alnylam Pharmaceuticals	Exelixis	Maraval Life Sciences	Vertex Pharmaceuticals
Amgen	Gilead Sciences	Moderna	Viatris
BeiGene	Horizon Therapeutics	Neurocrine Biosciences	Vir Biotechnology
Biogen	Illumina	Novavax
BioMarin Pharmaceuticals	Incyte	Regeneron Pharmaceuticals
CRISPR Therapeutics	Ionis Pharmaceuticals	Seattle Genetics

Executive Compensation

2024 Proxy Statement 57

The following chart shows how United Therapeutics ranks within its 2023 peer group on a variety of metrics. These metrics were based on

available data at the time the peer group was approved, generally reflecting the trailing twelve-month period ending March 31, 2022.

	United Therapeutics ($ in millions)	Percentile	Rank
Revenue	$1,768.3		16th of 26
Operating Income	$908.7		9th of 26
Adjusted Operating Income(1)	$909.3		10th of 26
Net Income	$687.4		11th of 26
Return on Invested Capital	12.3%		8th of 26
Return on Equity	18.0%		10th of 26
Return on Assets(1)	11.4%		6th of 26
Market Cap Per Employee(2)	$8.9		9th of 26
Revenue Per Employee	$1.8		8th of 26

(1)Adjusted Operating Income is a non-GAAP figure, which in the case of United Therapeutics was calculated by adjusting operating income (the

most closely comparable GAAP figure) to (i) add back $2.2 million of property, plant, and equipment (PP&E) impairments and (ii) deduct $1.6

million of SERP-related expenses. We do not use Adjusted Operating Income for operational purposes, but we do think it provides our

Compensation Committee and our shareholders useful information in evaluating the reasonableness of our peer group selection criteria.

Return on Assets has been calculated using Adjusted Operating Income.

(2)Market capitalization per employee as of March 31, 2022.

Our Compensation Committee’s approach to peer group selection is to apply an objective external measure for selecting companies. This

results in a number of peers being larger than United Therapeutics based on revenue as well as a number of peers being smaller. Our goal

each year is to place our company within the peer group statistics of the 25th to 75th percentile for revenue as close to the median as

possible while managing changes each year due to sector volatility, industry consolidation, and differences in business and organization

models. Furthermore, our Compensation Committee views it as critical to measure ourselves against industry-leading peers (including

those that are both larger and smaller than we are) because, in addition to being companies with which we compete for talent, many of

these larger and smaller companies are also our business competitors. We believe this approach results in a peer group that reflects

companies of similar scope and complexity to ours.

Executive Compensation

58 United Therapeutics, a public benefit corporation

Key Governance Features of our Executive

Compensation Program

Our Compensation Committee periodically assesses the effectiveness of our compensation policies and practices in achieving its

pay-for-performance objective while aligning the interests of executive officers with those of shareholders, balancing short-term and

long-term elements, and maintaining market competitiveness. Our Compensation Committee also reviews risk mitigation and governance

items, which are designed to help ensure that our compensation programs are functioning to achieve such objectives. In conjunction with

this assessment and review, we have adopted the following best practices:

ü     WHAT WE DO

•Design our executive compensation program to align

pay and performance

•Maintain an appropriate balance between short-term and

long-term compensation, which discourages short-term risk

taking at the expense of long-term results

•Grant performance-based long-term incentive awards with

multi-year metrics

•Review tally sheets for each executive to provide a holistic

view of executive compensation

•Maintain stock ownership guidelines to align executive

officer and share ownership with that of our directors and

our shareholders

•Prohibit hedging and pledging by executives and directors*

•Employ a compensation recovery, or clawback, policy

•Conduct annual risk assessments of our compensation

policies and practices

•Hold Compensation Committee executive sessions

without management

•Engage an independent compensation consultant who

reports directly to our Compensation Committee

û     WHAT WE DON’T DO

•No backdating of stock options

•No repricing of stock options without shareholder approval

•No liberal share recycling under 2015 Stock Incentive Plan

•No vesting prior to the first anniversary of grant, subject to

limited exceptions

•No discounted or reloaded stock options

•No excessive perquisites

•No excise tax gross ups

•No guaranteed bonus payments

*Pursuant to our insider trading policy, directors, officers, and employees are prohibited from purchasing our securities on margin, engaging in

“short” sales of our common stock, or buying or selling puts, calls, futures contracts, or other forms of derivative securities relating to our

securities. In addition, our Board has adopted a policy prohibiting our directors and executive officers from pledging of shares of our

common stock.

Other Executive Compensation Policies and Practices

Equity Incentive Awards Grant Timing Policy

Our equity incentive award grant timing is designed so that equity-based awards are granted after the market has had an opportunity to

react to our announcement of annual earnings. As such, as a general matter, equity-based awards to our employees and NEOs are

typically granted on March 15th each calendar year (or the preceding trading day if markets are not open on March 15th). We also believe

this timing helps us avoid broad internal communication of highly confidential financial results prior to public announcement of our annual

financial results. Our Compensation Committee may also approve equity-based awards at other times, in connection with significant

personnel events, such as new hire, promotion, new directorship, achievement of a significant corporate objective, or appointment to a

Board committee. In addition, our Compensation Committee has the flexibility to grant awards on the 15th day of any month (or the

preceding trading day if markets are not open on the 15th).

All equity incentive awards granted to our NEOs and other employees have an exercise price equal to at least the closing price of our

common stock on the Nasdaq on the date of grant or, if the award is granted on a date when the Nasdaq is not open, an exercise price

equal to at least the closing price of our common stock on the Nasdaq on the preceding trading day.

Executive Compensation

2024 Proxy Statement 59

Benefits and Perquisites

The benefits offered to our NEOs are substantially the same as those offered to all employees, with the exception of the supplemental

executive retirement plan (SERP) discussed in the section entitled Supplemental Executive Retirement Plan below. We provide a tax-

qualified retirement plan (a 401(k) plan) and medical and other benefits to executives that are generally available to other full-time

employees. Under our 401(k) plan, all employees are permitted to contribute up to the maximum amount allowable under applicable law

(i.e., $22,500 in 2023 or $30,000 for eligible participants who are age 50 or older). We make matching contributions equal to 40% of

eligible employee contributions with such matching contributions vesting 33 1/3% per year based on years of service, not the amount of

time an employee has participated in the 401(k) plan. Therefore, once an employee completes three years of service, their account is fully

vested, and any future matching funds will vest immediately. The 401(k) plan and other generally available benefits programs allow us to

remain competitive for executive talent. We also provide limited perquisites to our NEOs, including participation in either our vehicle lease

program, which covers the monthly lease payment and cost of insurance and maintenance on vehicles, or a monthly car allowance of

$1,300. Our Compensation Committee believes that the availability of these benefit programs generally enhances executive recruitment,

retention, productivity, and loyalty to us.

For additional details on certain benefits and perquisites received by our NEOs, see the Summary Compensation Table below.

Supplemental Executive Retirement Plan

We maintain our SERP for select executives to enhance the long-term retention of individuals who have been and will continue to be vital

to our success. Currently, only our NEOs and one other member of senior management participate in the SERP. The SERP provides

participants with a lifetime annual payment after retirement (or at their election, a lump-sum payment) of up to 100% of final average

three-year gross salary less estimated social security benefit, provided that they are employed by us or one of our affiliates until age 60.

Participants in the SERP are prohibited from competing with us or soliciting our employees for a period of twelve months following their

termination of employment or, if earlier, upon attainment of age 65. Violation of this covenant will result in forfeiture of all benefits under

the SERP.

Additional details regarding the SERP, including provisions in connection with a participant’s death or disability or change in control, are

provided under the Pension Benefits in 2023 table below.

Post-Employment Obligations to Named Executive Officers

Each of our NEOs is eligible for certain severance payments in the event their employment terminates under specified circumstances,

including in connection with a change in control, as provided in their employment agreements as well as the terms of the SERP, the 1997

United Therapeutics Corporation Amended and Restated Equity Incentive Plan (EIP), the 2015 SIP, and the STAP. These payments vary

based on the type of termination but may include cash severance, stock option and STAP vesting acceleration, SERP vesting acceleration,

and/or continuation of health and other benefits.

Our Compensation Committee approved these arrangements in order to promote the loyalty and productivity of our NEOs and to align

executive and shareholder interests by enabling executives to consider corporate transactions that are in the best interests of our

shareholders and our other constituents without undue concern about whether the transaction may jeopardize their employment. Our

Compensation Committee wants our NEOs to be free to think creatively and promote the best interests of our company without worrying

about the impact of those decisions on their employment.

Details regarding severance and change in control arrangements for our NEOs are contained in the text following the Potential Payments

Upon Termination or Change in Control table below.

Stock Ownership Guidelines

As noted above under Our Corporate Governance—Selecting Directors—Stock Ownership Guidelines, in 2011, our Board adopted

Stock Ownership Guidelines in order to further align the financial interests of our directors and NEOs with those of our shareholders, to

foster a long-term management orientation, and to promote sound corporate governance. Our Stock Ownership Guidelines set targets for

each NEO according to the lesser of a multiple of base salary or fixed number of shares of common stock as follows:

Title of NEO	Ownership Target
Chairperson and Chief Executive Officer	Lesser of 6x base salary or 100,000 shares
President and Chief Operating Officer	Lesser of 3x base salary or 30,000 shares
Chief Financial Officer and Treasurer	Lesser of 3x base salary or 20,000 shares
Executive Vice President and General Counsel	Lesser of 3x base salary or 30,000 shares

The policy provides procedures for granting exemptions in the case of hardship. Our Nominating and Governance Committee oversees this

policy and receives an annual compliance report. As of its most recent review in March 2024, all of our NEOs were in compliance with

these guidelines.

Executive Compensation

60 United Therapeutics, a public benefit corporation

Clawback Policy

In July of 2023, we adopted a clawback policy intended to comply with the requirements of Nasdaq Listing Standard 5608 implementing

Rule 10D-1 under the Exchange Act. In the event we are required to prepare an accounting restatement of our financial statements due to

material non-compliance with any financial reporting requirement under the federal securities laws, our company will recover, on a

reasonably prompt basis, the excess incentive-based compensation received by any covered executive, including our NEOs, during the

prior three fiscal years that exceeds the amount that the executive otherwise would have received had the incentive-based compensation

been determined based on the restated financial statements.

Policy Regarding Tax Deductibility of Executive Compensation

Under Section 162(m) of the Internal Revenue Code (the Code), a limitation exists on the deductibility of compensation paid to certain

"covered employees", including all of our NEOs, in excess of $1 million per year and thus, we are unable to deduct compensation payable

to NEOs in excess of such limit.

While our Compensation Committee considers the impact of this tax treatment, the primary factor influencing program design is the support

of our business objectives. Accordingly, our Compensation Committee retains flexibility to structure our compensation programs in a

manner that is not tax-deductible in order to achieve a strategic result that our Compensation Committee determines to be

more appropriate.

Compensation Committee Report

The Compensation Committee of our Board of Directors has reviewed and discussed the Compensation Discussion and Analysis

contained within this Proxy Statement with management and, based on such review and discussions, our Compensation Committee

recommended to our Board of Directors that the Compensation Discussion and Analysis be included in this Proxy Statement and

incorporated into United Therapeutics’ Annual Report on Form 10-K for the year ended December 31, 2023.

Submitted by the Compensation Committee:

CHRISTOPHER PATUSKY (Chair)

RAYMOND DWEK

NILDA MESA

LOUIS SULLIVAN

Executive Compensation

2024 Proxy Statement 61

Compensation Tables

Summary Compensation Table

The following table shows compensation information for 2021, 2022, and 2023 for our NEOs, calculated in accordance with

SEC regulations.

Name and Principal Position	Year	Salary(1) ($)		Restricted Stock Units(2) ($)	Stock Options(2) ($)	Non-Equity Incentive Plan Compensation(3) ($)	Change in Pension Value and Nonqualified Deferred Compensation Earnings(4) ($)	All Other Compensation(5) ($)	Total ($)
Martine Rothblatt Chairperson and Chief Executive Officer	2023	1,476,379	(6)	5,376,600	5,926,252	4,161,000	—	17,826	16,958,057
	2022	1,402,290	(6)	—	—	3,909,114	—	10,800	5,322,204
	2021	1,367,858	(6)	—	—	2,132,813	—	10,400	3,511,071
James Edgemond Chief Financial Officer and Treasurer	2023	790,385		1,505,100	1,659,590	1,331,520	741,821	26,068	6,054,484
	2022	745,192		—	—	1,243,181	—	17,411	2,005,784
	2021	721,154		—	—	679,688	481,573	20,800	1,903,215
Michael Benkowitz President and Chief Operating Officer	2023	1,101,154		2,579,550	2,845,012	2,131,542	1,125,721	23,572	9,806,551
	2022	973,269		—	—	1,841,013	—	14,153	2,828,435
	2021	940,385		—	—	1,004,063	355,353	16,691	2,316,492
Paul Mahon Executive Vice President and General Counsel	2023	940,000		1,289,775	1,422,506	1,460,234	—	41,086	5,153,601
	2022	934,231		—	—	1,350,371	—	24,600	2,309,202
	2021	905,385		—	—	739,375	—	22,400	1,667,160

(1)Increases in base salaries for each of our NEOs became effective on February 22, 2021, March 6, 2022, and March 5, 2023.

(2)No equity awards were granted to our NEOs during the 2021-2022 period. In March 2023, we issued stock options and restricted stock units

(RSUs) with vesting conditions tied to the achievement of specified performance criteria through the end of 2025. Amounts shown represent

the aggregate grant date fair value of stock options and RSUs computed in accordance with applicable accounting standards. For a discussion

of valuation assumptions for stock options see Note 8—Share-Based Compensation to the consolidated financial statements included in our

Annual Report on Form 10-K for the year ended December 31, 2023. The value of stock option awards with performance conditions are

reported at target, calculated using the Black-Scholes-Merton value in accordance with GAAP. The value of RSU awards with performance

conditions are reported at target, calculated using the stock price on the date of grant. For both the stock options and the RSUs, the number of

shares earned may exceed target for "stretch" performance, up to a maximum number of shares. If the maximum number of shares were

used, the grant date fair value would be as follows:

Name	Type of Equity Award	Number of Shares (at target)	Grant-Date Fair Value (at target)	Number of Shares (at maximum)	Grant-Date Fair Value (at maximum)
Martine Rothblatt	Stock Options	69,240	$5,926,252	207,720		$17,778,755
	RSUs	24,720	$5,376,600	74,160		$16,129,800
James Edgemond	Stock Options	19,390	$1,659,590	58,170		$4,978,770
	RSUs	6,920	$1,505,100	20,760		$4,515,300
Michael Benkowitz	Stock Options	33,240	$2,845,012	99,720		$8,535,035
	RSUs	11,860	$2,579,550	35,580		$7,738,650
Paul Mahon	Stock Options	16,620	$1,422,506	49,860		$4,267,517
	RSUs	5,930	$1,289,775	17,790		$3,869,325

(3)Amounts shown for each year represent the total cash awards earned by each NEO under our Company-Wide Milestone Program for

the respective year, although the awards were not paid until March of the following year. The payouts were determined based on our

attainment of specific, pre-established performance metrics. For example, the amounts reported for 2023 reflect cash earned in respect of

2023 performance but paid in March 2024. In addition, amounts shown for 2023 and 2022 reflect the Patient Multiplier, which did not exist in

2021. For information on the amounts earned for 2023, see the section entitled Cash Incentive Award Program in the Compensation

Discussion and Analysis above.

(4)Amounts shown represent the change in the actuarial present value of retirement benefits under the SERP, calculated in accordance with

GAAP under SEC requirements. The assumptions used in calculating the change in the actuarial present value of SERP benefits are

described in the footnotes to the Pension Benefits in 2023 table below. The change in pension value from year to year as reported in

the table will vary based on these assumptions and may not represent the value that a NEO will accrue or receive under the SERP. For

Dr. Rothblatt and Mr. Mahon, the value in the table is reported as zero in accordance with SEC rules. The actual change for Dr. Rothblatt was

($636,567) and for Mr. Mahon was ($263,584).

Executive Compensation

62 United Therapeutics, a public benefit corporation

(5)The amounts shown represent the aggregate incremental cost that can be attributed to lease payments made on vehicles used by a NEO or

for monthly automobile allowances, travel expenses for family members to our functions (collectively, the perquisites), and “matching

contributions” under our 401(k) Plan equal to 40% of each participant’s qualifying salary contributions. The 2023 amounts shown include a

401(k) match of $12,000 for each of Dr. Rothblatt, Mr. Edgemond, Mr. Benkowitz, and Mr. Mahon. Additionally, the 2023 amounts include

personal usage of a company leased vehicle of $10,108 and $6,291 for Mr. Edgemond and Mr. Benkowitz, respectively, and a car allowance

of $15,600 for Mr. Mahon. The 2023 amounts also include travel expenses for family members of $5,826, $3,960, $5,281, and $13,486 for

Dr. Rothblatt, Mr. Edgemond, Mr. Benkowitz, and Mr. Mahon, respectively.

(6)Our Canadian subsidiary paid a portion of Dr. Rothblatt’s total base salary in Canadian dollars. The value of this portion in U.S. dollars has

been estimated for the purposes of disclosure by using the average exchange rate for each respective year. In 2021, 2022, and 2023, our

Canadian subsidiary paid the equivalent of US$238,274, US$271,773, and US$171,237 of Dr. Rothblatt’s total base salary, respectively.

Grants of Plan-Based Awards in 2023

			Estimated Future Payouts Under Non-Equity Incentive Plan Awards			Estimated Future Payouts Under Equity Incentive Plan Awards			Exercise or Base Price of Stock Option Awards ($/Sh)		Grant Date Fair Value of Stock Option Awards and RSU Awards(5) ($)
Name	Grant Date		Threshold(4) ($)	Target(4) ($)	Maximum(4) ($)	Threshold (#)	Target (#)	Maximum (#)
Martine Rothblatt	3/15/2023	(1)				34,620	69,240	207,720		$85.59	5,926,252
	3/15/2023	(2)				6,180	12,360	37,080			2,688,300
	3/15/2023	(3)				6,180	12,360	37,080			2,688,300
	N/A	(4)	703,125	1,875,000	5,625,000
James Edgemond	3/15/2023	(1)				9,695	19,390	58,170		$85.59	1,659,590
	3/15/2023	(2)				1,730	3,460	10,380			752,550
	3/15/2023	(3)				1,730	3,460	10,380			752,550
	N/A	(4)	225,000	600,000	1,800,000
Michael Benkowitz	3/15/2023	(1)				16,620	33,240	99,720		$85.59	2,845,012
	3/15/2023	(2)				2,965	5,930	17,790			1,289,775
	3/15/2023	(3)				2,965	5,930	17,790			1,289,775
	N/A	(4)	360,188	960,500	2,881,500
Paul Mahon	3/15/2023	(1)				8,310	16,620	49,860		$85.59	1,422,506
	3/15/2023	(2)				1,483	2,965	8,895			644,888
	3/15/2023	(3)				1,483	2,965	8,895			644,888
	N/A	(4)	246,750	658,000	1,974,000

(1)This award of stock options is part of the NEO's 2023 equity incentive award opportunity. These stock options are subject to a three-year

performance period (2023-2025) tied to average cash profits margin. To the extent earned, these stock options cliff vest at the end of the

three-year period.

(2)This award of RSUs is part of the NEO's 2023 equity incentive award opportunity. These RSUs are subject to a three-year performance period

(2023-2025) tied to revenue growth. To the extent earned, these RSUs cliff vest at the end of the three-year period.

(3)This award of RSUs is part of the NEO's 2023 equity incentive award opportunity. These RSUs are subject to a three-year performance period

(2023-2025) tied to clinical developments. To the extent earned, these RSUs cliff vest at the end of the three-year period.

(4)Actual cash incentive awards earned under the program in 2023 are reported in the Summary Compensation Table under the column

entitled “Non-Equity Incentive Plan Compensation.” While there are threshold performance criteria and payout levels for 75% of the cash

incentive program (based on the Milestones related to cash profits, revenues, and manufacturing), the R&D Milestone does not contain

threshold / minimum performance criteria. The amount reported under the column entitled "Threshold" shows the amount that would be earned

if no credit was awarded under the R&D Milestone and the remaining three Milestones were achieved at threshold / minimum levels.

(5)The grant date fair value of stock options and RSUs is generally the amount that we will recognize as an expense over the award's vesting

period assuming target performance levels, computed in accordance with applicable accounting standards.

Executive Compensation

2024 Proxy Statement 63

Narratives to Summary Compensation Table and Grants of Plan-Based

Awards in 2023 Table

Named Executive Officer Employment Agreements

The material terms of each NEO’s employment agreement are described below.

Dr. Rothblatt

In April 1999, we entered into an employment agreement with Dr. Rothblatt. This agreement was amended from time to time and we

entered into an Amended and Restated Executive Employment Agreement with Dr. Rothblatt effective January 1, 2009, in order to clarify

the effectiveness of certain prior amendments, and to make other immaterial amendments. This agreement was further amended effective

January 1, 2015, to remove her entitlement to an annual grant of stock options based on a market capitalization growth formula and to

provide us flexibility to grant her incentive-based compensation in a variety of forms at our Compensation Committee’s discretion. The

amendment also eliminated Dr. Rothblatt’s right to an Internal Revenue Code Section 280G excise tax gross up payment, among

other changes.

Dr. Rothblatt’s employment agreement provides for an initial five-year term, which is automatically extended for an additional year at the

end of each year unless either party gives at least six months’ notice of termination. If either party provided such a notice of termination, it

would result in a four-year remaining term. We note that this rolling five-year term has no bearing on potential severance payments upon

termination, which are described under Potential Payments Upon Termination or Change in Control.

Dr. Rothblatt’s compensation in 2023 was paid pursuant to this employment agreement, which entitles her to a minimum base salary of

$180,000, annual cash and long-term incentive compensation, and participation in employee benefits generally available to other

executives. The level of Dr. Rothblatt’s base salary is subject to annual review and increase by our Compensation Committee. Her annual

salary was reviewed in early 2023, and beginning March 5, 2023, was set at $1,500,000. Her employment agreement also requires us to

pay the cost of leasing, maintaining, and insuring an automobile for Dr. Rothblatt.

Dr. Rothblatt’s employment agreement prohibits her from engaging in activities competitive with us for five years following her last receipt

of compensation from us. She is also subject to a permanent confidentiality obligation. For information regarding severance and change in

control arrangements for Dr. Rothblatt, see the text following the Potential Payments Upon Termination or Change in Control

table below.

Mr. Edgemond, Mr. Benkowitz, and Mr. Mahon

We have entered into employment agreements with each of Messrs. Edgemond, Benkowitz, and Mahon. The agreement for Mr. Mahon

provides for an initial five-year term, which is automatically extended for an additional year at the end of each year. Either party may

terminate the agreement a certain time period prior to an annual renewal, which would result in a four-year remaining term. The

agreements for Messrs. Benkowitz and Edgemond provide an initial term of three years, following which the agreement continues from

year to year for one-year terms unless either party provides written notice to terminate a certain time period prior to the end of the then

current term. Each employment agreement provides for an annual minimum base salary, which is subject to annual review and increase by

our Compensation Committee. Annual salaries for each of these executives were reviewed in early 2023, with raises becoming effective

March 5, 2023. The following table outlines these details for each executive:

Name	Month/Year of Agreement	Minimum Base Salary under Agreement		Base Salary as of March 5, 2023
James Edgemond	March 2015		$400,000		$800,000
Michael Benkowitz	June 2016		$650,000		$1,130,000
Paul Mahon	June 2001		$300,000		$940,000

Under these agreements, each executive is eligible to participate in our broad-based employee benefit plans. In accordance with our

executive automobile policy, Messrs. Edgemond, Benkowitz, and Mahon each receives either a monthly car allowance of $1,300 per

month or the use of a company owned or leased vehicle.

Each of these employment agreements prohibits the executive from accepting employment, consultancy, or any other business

relationships with an entity that directly competes with us or from engaging in the solicitation of our employees on behalf of a competitor for

a period of time following his last receipt of compensation from us (two years in the case of Mr. Mahon and one year in the case of

Mr. Edgemond and Mr. Benkowitz). Each agreement includes an obligation of confidentiality for three years after termination of the

executive’s employment.

Executive Compensation

64 United Therapeutics, a public benefit corporation

Messrs. Edgemond and Benkowitz are each party to a change in control severance agreement providing benefits in the event of his

termination following a change in control. In particular, these benefits include a cash severance payment equal to two times base salary,

plus two times the highest of (1) the cash incentive award paid to the individual for the year immediately preceding the year in which the

change in control occurs; (2) the cash incentive award payable to the individual for the year immediately preceding the year in which the

termination of employment occurs; or (3) the individual’s annual target cash incentive award. This cash severance would become payable

in lieu of any severance payment under the respective employment agreements unless severance under the employment agreement would

result in a greater benefit. The change in control severance agreement also provides for continuation of medical benefits for 24 months

following termination, and outplacement benefits with a value of $10,000.

For further information regarding severance and change in control arrangements for these NEOs, see the text following the Potential

Payments Upon Termination or Change in Control table below.

Summary of Terms of Plan-Based Awards

Stock Options and RSUs under the 2015 SIP

In March 2023, our NEOs were granted stock options and RSUs under our 2015 SIP. No equity-based awards were granted to our NEOs

in 2021 or 2022.

Stock options and RSUs granted under the 2015 SIP in 2023 cliff vest on the third anniversary of the date of grant to the extent earned

based on a three-year performance period (each stock option award's performance is tied to average cash profits margin, one of the RSU

award's performance is tied to revenue growth, and the other RSU award's performance is tied to research and development

achievements). Each stock option award has an expiration date of the tenth anniversary of the date of grant. For information regarding

acceleration of vesting upon certain employment termination events, see the text following the Potential Payments Upon Termination or

Change in Control table below.

Executive Compensation

2024 Proxy Statement 65

Outstanding Equity Awards at 2023 Fiscal Year-End

The following table sets forth information regarding unexercised stock options, STAP awards, or RSU awards held by each of our NEOs as

of December 31, 2023.

			Option Awards					Stock Awards
Name and Grant Date	Award Type		Number of Securities Underlying Unexercised Options or STAP Awards		Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options (#)	Option or STAP Award Exercise Price ($)	Option or STAP Award Expiration Date	Equity Incentive Plan Awards: Number of Unearned and Unvested RSUs (#)	Equity Incentive Plan Awards: Market or Payout Value of Unearned and Unvested RSUs ($)(12)
			Exercisable (#)	Unexercisable (#)
Martine Rothblatt
12/31/2014	Stock Option	(1)	723,869	—	—	129.49	12/31/2024	—	—
03/15/2016	Stock Option	(2)	294,000	—	—	120.26	03/15/2026	—	—
03/15/2017	Stock Option	(3)	240,000	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	100,000	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(6)	150,288	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	244,122	—	—	146.03	03/15/2027	—	—
03/15/2018	Stock Option	(5)	285,103	—	—	111.00	03/15/2028	—	—
03/15/2018	Stock Option	(6)	213,827	—	—	111.00	03/15/2028	—	—
03/15/2019	Stock Option	(7)	500,000	—	—	135.42	03/15/2027	—	—
03/15/2019	Stock Option	(8)	500,000	—	—	117.76	03/15/2027	—	—
03/15/2023	Stock Option	(9)	—	—	207,720	217.50	03/15/2033	—	—
03/15/2023	RSU	(10)	—	—	—	—	—	37,080	8,153,521
03/15/2023	RSU	(11)	—	—	—	—	—	37,080	8,153,521
James Edgemond
03/13/2015	STAP Award	(2)	25,000	—	—	163.30	03/13/2025	—	—
03/13/2015	STAP Award	(2)	15,160	—	—	163.30	03/13/2025	—	—
03/15/2016	Stock Option	(2)	49,000	—	—	120.26	03/15/2026	—	—
03/15/2017	Stock Option	(3)	45,000	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	18,750	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(6)	32,205	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	52,312	—	—	146.03	03/15/2027	—	—
03/15/2018	Stock Option	(5)	75,349	—	—	111.00	03/15/2028	—	—
03/15/2018	Stock Option	(6)	56,512	—	—	111.00	03/15/2028	—	—
03/15/2019	Stock Option	(7)	162,500	—	—	135.42	03/15/2027	—	—
03/15/2019	Stock Option	(8)	162,500	—	—	117.76	03/15/2027	—	—
03/15/2023	Stock Option	(9)	—	—	58,170	217.50	03/15/2033	—	—
03/15/2023	RSU	(10)	—	—	—	—	—	10,380	2,282,458
03/15/2023	RSU	(11)	—	—	—	—	—	10,380	2,282,458
Michael Benkowitz
03/13/2015	STAP Award	(2)	32,200	—	—	163.30	03/13/2025	—	—
03/15/2016	Stock Option	(2)	39,200	—	—	120.26	03/15/2026	—	—
06/24/2016	Stock Option	(2)	52,500	—	—	102.11	06/24/2026	—	—
03/15/2017	Stock Option	(3)	63,000	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	26,250	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(6)	42,940	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	69,750	—	—	146.03	03/15/2027	—	—
03/15/2018	Stock Option	(5)	85,531	—	—	111.00	03/15/2028	—	—
03/15/2018	Stock Option	(6)	64,148	—	—	111.00	03/15/2028	—	—
03/15/2019	Stock Option	(7)	187,500	—	—	135.42	03/15/2027	—	—
03/15/2019	Stock Option	(8)	187,500	—	—	117.76	03/15/2027	—	—
03/15/2023	Stock Option	(9)	—	—	99,720	217.50	03/15/2033	—	—
03/15/2023	RSU	(10)	—	—	—	—	—	17,790	3,911,843
03/15/2023	RSU	(11)	—	—	—	—	—	17,790	3,911,843

Executive Compensation

66 United Therapeutics, a public benefit corporation

			Option Awards					Stock Awards
Name and Grant Date	Award Type		Number of Securities Underlying Unexercised Options or STAP Awards		Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options (#)	Option or STAP Award Exercise Price ($)	Option or STAP Award Expiration Date	Equity Incentive Plan Awards: Number of Unearned and Unvested RSUs (#)	Equity Incentive Plan Awards: Market or Payout Value of Unearned and Unvested RSUs ($)(12)
			Exercisable (#)	Unexercisable (#)
Paul Mahon
03/13/2015	STAP Award	(2)	116,250	—	—	163.30	03/13/2025	—	—
03/15/2017	Stock Option	(3)	75,000	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	31,250	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(6)	42,940	—	—	146.03	03/15/2027	—	—
03/15/2017	Stock Option	(4)	69,750	—	—	146.03	03/15/2027	—	—
03/15/2019	Stock Option	(7)	150,000	—	—	135.42	03/15/2027	—	—
03/15/2019	Stock Option	(8)	90,000	—	—	117.76	03/15/2027	—	—
03/15/2023	Stock Option	(9)	—	—	49,860	217.50	03/15/2033	—	—
03/15/2023	RSU	(10)	—	—	—	—	—	8,895	1,955,922
03/15/2023	RSU	(11)	—	—	—	—	—	8,895	1,955,922

(1)These stock options were fully vested upon grant pursuant to Dr. Rothblatt’s employment agreement.

(2)These stock options or STAP awards vested in one-fourth increments on each of the first four anniversaries of the date of grant.

(3)These stock options vested in one-third increments on each of the first three anniversaries of the date of grant.

(4)These stock options were subject to a three-year (2017-2019) performance threshold tied to average cash profits margin. These stock options

were fully earned as of December 31, 2019 and vested at March 15, 2020.

(5)These stock options were subject to a three-year (2018-2020) performance threshold tied to average cash profits margin. These stock options

were fully earned as of December 31, 2020 and vested at March 15, 2021.

(6)These stock options were subject to a one-year performance threshold tied to Company-Wide Milestone Performance. Once earned, shares

vested in equal installments over a three-year period. The number of shares shown reflects the number of shares earned based on

actual performance.

(7)These stock options fully vested (100%) on the fourth anniversary of the date of grant.

(8)These stock options vested in one-third increments on the second, third, and fourth anniversaries of the date of grant.

(9)These stock options are subject to a three-year performance period (2023-2025) tied to average cash profits margin. To the extent earned,

these stock options cliff vest at the end of the three-year period. The number of shares shown is at "maximum". The number of shares that are

ultimately earned may be lower, depending on performance over the relevant three-year period.

(10)These RSUs are subject to a three-year performance period (2023-2025) tied to revenue growth. To the extent earned, these RSUs cliff vest

at the end of the three-year period. The number of shares shown is at "maximum". The number of shares that are ultimately earned may be

lower, depending on performance over the relevant three-year period.

(11)These RSUs are subject to a three-year performance period (2023-2025) tied to research and development achievements. To the extent

earned, these RSUs cliff vest at the end of the three-year period. The number of shares shown is at "maximum". The number of shares that

are ultimately earned may be lower, depending on performance over the relevant three-year period.

(12)The market value of these awards is based on the closing price of our common stock on December 29, 2023 ($219.89), as reported

on Nasdaq.

Executive Compensation

2024 Proxy Statement 67

Option Exercises and Stock Vested in 2023

The following table shows the number of shares of our common stock acquired upon exercise of stock options by each of our NEOs during

the year ended December 31, 2023. We did not have any STAP award exercises or stock awards that vested in 2023. Stock option

exercise activity for our CEO in 2023 was largely related to stock options nearing their expiration dates.

	Option Awards
Name	Number of Shares Acquired on Exercise (#)	Value Realized on Exercise ($)(1)
Martine Rothblatt	664,000	85,384,470
James Edgemond	—	—
Michael Benkowitz	—	—
Paul Mahon	140,500	15,710,975

(1)Represents the difference between the exercise price of the stock options and the fair market value of our common stock on the date of

exercise, multiplied by the number of options exercised.

Pension Benefits in 2023

The table below describes the present value of the accumulated benefit for our NEOs under the SERP. No payments were made under the

SERP to our NEOs during 2023.

Name	Plan Name	Number of Years of Credited Service(1)	Actual Years of Service(2)	Present Value of Accumulated Benefit ($)(3)
Martine Rothblatt	SERP	15.0	27.5	14,175,604
James Edgemond	SERP	11.0	11.0	5,769,435
Michael Benkowitz	SERP	12.8	12.8	7,748,807
Paul Mahon	SERP	15.0	22.6	11,509,531

(1)Reflects the number of years (up to the maximum of 15 years under the terms of the SERP) since each NEO commenced employment with

us, through December 31, 2023.

(2)Reflects the number of years since each NEO commenced employment with us, through December 31, 2023.

(3)The present values of accumulated benefits are based on assumptions used in the financial disclosures for the year ended December 31,

2023 including a discount rate of 4.64% and a lump sum interest rate of 5.50%. The present value represents the lump sum value of the

accrued benefit which is based on service and earnings as of December 31, 2023, and assumes payment at age 60, the normal retirement

date under the SERP. No preretirement death, disability, or termination is assumed. For a discussion of valuation assumptions, see Note 11—

Employee Benefit Plans to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended

December 31, 2023.

Executive Compensation

68 United Therapeutics, a public benefit corporation

Supplemental Executive Retirement Plan

In 2006, our Compensation Committee approved our SERP, which is a non-qualified supplemental defined benefit retirement plan for

select key executives intended to enhance the long-term retention of individuals that have been and will continue to be vital to our success.

Participants in the SERP generally must remain in the employ of United Therapeutics or one of its affiliates until age 60 to receive a benefit

except in the event of death, disability, or a change in control. If a participant terminates employment with us for any reason prior to age 60

(other than due to death, disability, or a change in control), no benefit will be paid. The benefit to be paid under the plan is based on when

an executive commenced participation in the plan. In general, a participant will be eligible for an unreduced benefit under the plan after 15

years of service. Upon a change in control before a participant reaches age 60, they will immediately vest in and receive a prorated benefit

based on years of service to date.

The SERP is administered by our Compensation Committee. Currently, our NEOs and one other member of our senior management

participate in the SERP. Each of our NEOs is eligible, upon retirement after the age of 60, to receive monthly payments equal to the

monthly average of the total gross base salary received by the participant over their last 36 months of active employment (the Final

Average Compensation), reduced by the participant’s estimated social security benefit (determined as provided under the SERP), for the

remainder of the participant’s life (the aggregate amount of such payments, the Normal Retirement Benefit), commencing on the first day

of the sixth month after retirement. For executives who began participating in the plan after July 1, 2006, the retirement benefit is generally

calculated as 100% of the final three year average gross base salary reduced by the estimated social security benefit they would receive in

retirement, multiplied by a fraction (not to exceed one) the numerator of which is their years of service and the denominator of which is 15

(the Normal Retirement Benefit). This means that for participants who have less than 15 years of service with us, the retirement benefit is

prorated by the number of years of actual service divided by 15 years. By age 60, all current participants will have had 15 years of service

if they remain employed by us. In the event of termination of employment due to disability prior to the age of 60 or death prior to retirement,

a participant or the participant’s beneficiary, as applicable, will be entitled to a percentage of the Normal Retirement Benefit, as determined

under the SERP (the aggregate amount of such payments referred to as the Disability Retirement Benefit), commencing on the first day

of the sixth month after termination of employment in the event of a disability and as soon as administratively practicable in the event of

death. All of our NEOs have elected to receive their benefit in the form of a lump sum distribution, although they were also offered a choice

of a single life annuity or an actuarially equivalent joint or survivor annuity.

In the event of a change in control, as defined in the SERP, a participant who is actively employed on the date of the change in control will

be entitled to a lump sum payment equal to the actuarial equivalent present value of a monthly single life annuity equal to (1) the

participant’s Final Average Compensation, reduced by the participant’s estimated future social security benefit (determined as provided

under the SERP), multiplied by (2) a fraction (no greater than one), the numerator of which equals the participant’s years of service and the

denominator of which equals 15, to be paid as soon as administratively practicable following the change in control. In the event that a

participant is entitled to a Normal Retirement Benefit or Disability Retirement Benefit at the time of a change in control, all such payments

(or any remaining payments, with respect to any participant who is receiving payments under the SERP at the time of the change in

control) will be made in a lump sum distribution as soon as administratively practicable following such change in control. Participants in the

SERP will be prohibited from competing with us or soliciting its employees for a period of twelve months following their termination of

employment (or, earlier upon attainment of age 65). Violation of this covenant will result in forfeiture of all benefits under the SERP.

Rabbi Trust

In December 2007, our Compensation Committee adopted the United Therapeutics Corporation Supplemental Executive Retirement Plan

Rabbi Trust Document (Rabbi Trust Document), providing for the establishment of a trust (Rabbi Trust), the assets of which will

be contributed by us and used to pay benefits under the SERP. We entered into the Rabbi Trust Document with Wilmington Trust

Company, which serves as trustee of the Rabbi Trust. The Rabbi Trust is irrevocable, and SERP participants will have no preferred claim

on, nor any beneficial ownership interest in, any assets of the Rabbi Trust.

Currently, the Rabbi Trust does not contain any assets. Generally, we may contribute additional assets to the Rabbi Trust at our sole

discretion. However, pursuant to the terms of the Rabbi Trust Document, within five days following the occurrence of a potential change in

control (as defined in the Rabbi Trust Document), or if earlier, at least five days prior to the occurrence of a change in control (as defined

in the Rabbi Trust Document), we will be obligated to make an irrevocable contribution to the Rabbi Trust in an amount sufficient to pay

each SERP participant or beneficiary the benefits to which they would be entitled pursuant to the terms of the SERP on the date on which

the change in control occurred. The Rabbi Trust will not terminate until the date on which SERP participants or their beneficiaries are no

longer entitled to benefits pursuant to the terms of the SERP.

Executive Compensation

2024 Proxy Statement 69

Potential Payments Upon Termination or Change in Control

Each of our NEOs is eligible to receive certain payments and benefits if their employment is involuntarily terminated without “Cause”,

terminated by the executive for “Good Reason”, terminated by the executive voluntarily with continued status as a “Senior Advisor” to us,

terminated due to disability or death, or terminated in connection with a “Change in Control” of our company in accordance with the

applicable terms of their respective employment agreements, change in control severance agreements, the SERP, our equity

compensation plans (the EIP and 2015 SIP) and related stock option and RSU agreements, as reported in the Potential Payments Upon

Termination or Change in Control table below and described in the narrative table that follows. The summary of these benefits is

qualified in its entirety by the specific language of the various agreements and plans that have been filed with the SEC. The amounts

shown in the Potential Payments Upon Termination or Change in Control table below are estimates of the value of these payments

and benefits, assuming that such termination or triggering event was effective as of December 31, 2023 (except as otherwise noted below

with respect to those NEOs who terminated during the year). The actual compensation to be paid to a NEO can only be determined at the

time such NEO’s employment is terminated and may vary based on factors such as the timing during the year of any such event, our stock

price, the NEO’s age, and any changes to our benefit arrangements and policies. In addition to the benefits described below, our NEOs will

be eligible to receive any benefits accrued under our broad-based benefit plans, such as distributions under life insurance and disability

benefit plans.

Executive Benefits and Payments Upon Separation	Involuntary Termination Without Cause/Resignation for Good Reason/ Resignation While Continuing as Senior Advisor(1)		Disability	Death	Termination upon a Change in Control		Change In Control without Termination of Employment
Martine Rothblatt
Salary and cash incentive		$20,136,456	$1,500,000	$1,500,000		$20,136,456		$—
Equity vesting acceleration(2)		$5,601,164	$5,601,164	$5,601,164		$5,601,164		$5,601,164
Supplemental Executive Retirement Plan(3)		$14,175,604	$14,175,604	$9,833,583		$14,175,604		$14,175,604
Health and other benefits(4)		$148,894	$—	$—		$148,894		$—
Total		$40,062,118	$21,276,768	$16,934,747		$40,062,118		$19,776,768
James Edgemond
Salary and cash incentive		$157,808	$—	$—		$4,086,362		$—
Equity vesting acceleration(2)		$—	$1,567,981	$1,567,981		$1,567,981		$1,567,981
Supplemental Executive Retirement Plan		$—	$5,908,678	$4,053,625		$5,878,653		$5,878,653
Health and other benefits(5)		$—	$—	$—		$71,596		$—
Total		$157,808	$7,476,659	$5,621,606		$11,604,592		$7,446,634
Michael Benkowitz
Salary and cash incentive		$547,973	$—	$—		$5,942,026		$—
Equity vesting acceleration(2)		$—	$2,687,339	$2,687,339		$2,687,339		$2,687,339
Supplemental Executive Retirement Plan		$—	$5,305,985	$3,347,371		$7,217,880		$7,217,880
Health and other benefits(5)		$—	$—	$—		$71,596		$—
Total		$547,973	$7,993,324	$6,034,710		$15,918,841		$9,905,219
Paul Mahon
Salary and cash incentive		$4,580,742	$—	$—		$4,580,742		$—
Equity vesting acceleration(2)		$1,343,670	$1,343,670	$1,343,670		$1,343,670		$1,343,670
Supplemental Executive Retirement Plan(3)		$11,509,531	$11,509,531	$8,071,143		$11,509,531		$11,509,531
Total		$17,433,943	$12,853,201	$9,414,813		$17,433,943		$12,853,201

(1)Benefits upon termination while continuing as a senior advisor are applicable only to employment agreements with Dr. Rothblatt and

Mr. Mahon.

(2)The value shown is based on: (1) the positive difference between the aggregate exercise price of all accelerated stock options and the

aggregate market value of the underlying shares; and (2) the value of the accelerated performance-based RSU awards (PSU) based on the

aggregate market value of the underlying shares. The aggregate market value is calculated based on the closing market price of our common

stock on December 31, 2023, $219.89.

(3)Dr. Rothblatt and Mr. Mahon have attained retirement age and reached the maximum number of years of service under the SERP. As a result,

the value included in this table represents the normal benefits Dr. Rothblatt and Mr. Mahon would receive upon retirement, in accordance with

the terms of the SERP.

Executive Compensation

70 United Therapeutics, a public benefit corporation

(4)Represents the estimated value of continued health care benefits for a three-year period after termination, outplacement services for 12

months, and the fair value of one currently leased vehicle.

(5)Represents the estimated value of continued health care benefits for a two-year period after termination and outplacement services equal

to $4,500.

Severance and Change in Control Payments to Named Executive Officers

Provision	Terms Applicable to Chairperson and CEO	Terms Applicable to Mr. Mahon
Payments Upon Involuntary Termination without Cause, or Resignation for Good Reason, or Resignation while Continuing as Senior Advisor	•Lump sum prorated cash incentive bonus payment* •Lump sum payment equal to 3.0 times base salary + 3.0 times annual cash incentive award* •Continuation of health care benefits for 36 months, outplacement services for 12 months and the transfer of one currently leased vehicle •Immediate vesting of unvested stock options and PSUs**	•Lump sum payment equal to 2.0 times: (1) current base salary; plus (2) annual cash incentive award* •Immediate vesting of unvested stock options and PSUs**
Payments Upon Disability	•Continued payment of current base salary through the end of the calendar year following such disability •Acceleration of SERP benefits •Immediate vesting of unvested stock options and PSUs**	•Immediate vesting of unvested stock options and PSUs** •Acceleration of SERP benefits
Payments Upon Death	•Continued payment of current base salary through the end of the calendar year following such death to Executive’s legal representatives •Acceleration of SERP benefits •Immediate vesting of unvested stock options and PSUs**	•Immediate vesting of unvested stock options and PSUs** •Acceleration of SERP benefits
Payments Upon Termination Following Change in Control	•Same as Payments Upon Involuntary Termination, etc., except that payment of SERP benefits occurs immediately, and is calculated as described above under Supplemental Executive Retirement Plan	•Same as Payments Upon Involuntary Termination, etc. •Acceleration of SERP benefits
Payments Upon Change in Control without Termination	•Acceleration of SERP benefits •Immediate vesting of unvested stock options and PSUs** (if not assumed)	•Immediate vesting of unvested stock options and PSUs** (if not assumed) •Acceleration of SERP benefits

*Payment is equal to greater of payment for the prior year, or the average of such payments for the prior two years

**Unvested performance stock options and PSUs will vest at target

Provision	Terms Applicable to Mr. Edgemond and Mr. Benkowitz
Payments Upon Involuntary Termination without Cause	•Lump sum payment equal to base salary through the remainder of the agreement term
Payments Upon Disability	•Continued payment of current base salary through date of termination •Immediate vesting of unvested stock options and PSUs* •Acceleration of SERP benefits
Payments Upon Death	•Immediate vesting of unvested stock options and PSUs* •Acceleration of SERP benefits

Executive Compensation

2024 Proxy Statement 71

Provision	Terms Applicable to Mr. Edgemond and Mr. Benkowitz
Payments Upon Termination Following Change in Control	•Payment of a lump sum cash amount equal to 2.0 times the sum of (x) base salary plus (y) the highest of (1) the cash incentive paid to the individual for the year immediately preceding the year in which the change in control occurs; (2) the cash incentive award payable to the individual for the year immediately preceding the year in which the termination of employment occurs; or (3) the individual’s annual target cash incentive award •Immediate vesting of unvested stock options and PSUs* •Acceleration of SERP benefits •Continuation of medical benefits for 24 months •Outplacement benefits with a value of $4,500
Payments Upon Change in Control without Termination	•Acceleration of SERP benefits •Immediate vesting of unvested stock options and PSUs* (if not assumed)

*Unvested performance stock options and PSUs will vest at target

As used in the tables above, the following terms are generally defined as follows:

Cause:

•In the case of Dr. Rothblatt, her willful and continued failure to substantially perform her duties, or willfully engaging in gross

misconduct that is materially injurious to us

•In the case of the other NEOs, (1) failure to perform any of the material terms or provisions of his employment agreement;

(2) negligent or unsatisfactory performance of duties, after notice and the opportunity to correct such performance; (3) employment- or

profession-related misconduct; (4) conviction of a crime involving a felony, fraud, or embezzlement; or (5) misappropriation of our

funds or misuse of assets

Good Reason:

•In the case of Dr. Rothblatt, the occurrence of any of the following without her consent: (1) the assignment of any duties that

are inconsistent with her position as Chairperson and Chief Executive Officer; (2) a material adverse change in her reporting

responsibilities, titles, or offices; (3) failure to re-elect her to any position she held with us; (4) a reduction in her base salary or

failure to increase her salary consistent with certain other executive salary increases; (5) relocation of 25 miles or more or additional

substantially more burdensome travel requirements; (6) failure to continue her as a participant in any bonus or other incentive plans in

which she was participating; (7) failure to keep in effect certain benefit plans and arrangements; (8) failure to obtain a successor

entity’s assumption of the employment agreement; (9) failure to abide by certain provisions in the employment agreement; or (10) any

other material breach of the employment agreement

•In the case of Mr. Mahon, the material diminishment of his authority and responsibilities without cause

Change in Control: Transfer of control of our company (generally, as a result of an acquisition, merger, hostile takeover, or any

other reason)

Pay Versus Performance

As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we

are providing the following information about the relationship between executive “compensation actually paid” (sometimes referred to as

CAP) to our principal executive officer (PEO) and other NEOs, and certain financial performance indicators for our company.

Year (a)	Summary Compensation Table Total for PEO (1) (b)	Compensation Actually Paid to PEO (2) (c)	Average Summary Compensation Table Total for Non-PEO NEOs (3) (d)	Average Compensation Actually Paid to Non-PEO NEOs (4) (e)	Value of Initial Fixed $100 Investment Based on:		Net Income ($ in millions) (7) (h)	Revenue ($ in millions) (8) (i)
					Total Share- Holder Return (5) (f)	Peer Group Total Share- Holder Return (6) (g)
2023	$16,958,057	$(10,805,540)	$7,004,879	$(2,186,013)	$249.65	$159.01	$984.8	$2,327.5
2022	$5,322,204	$41,188,180	$2,381,140	$15,387,032	$315.72	$153.08	$727.3	$1,936.3
2021	$3,511,071	$50,428,496	$1,962,289	$18,294,614	$245.32	$137.47	$475.8	$1,685.5
2020	$4,811,672	$49,919,731	$4,145,541	$17,608,882	$172.33	$110.52	$514.8	$1,483.3

(1)The dollar amounts reported in column (b) are the amounts reported for Martine Rothblatt, Chairperson and Chief Executive Officer, for each

of the corresponding years in the “Total” column of the in our Summary Compensation Table. Refer to the Summary Compensation

Table above.

Executive Compensation

72 United Therapeutics, a public benefit corporation

(2)The dollar amounts reported in column (c) represent the amount of “compensation actually paid” to Dr. Rothblatt, as computed in accordance

with Item 402(v) of Regulation S-K and do not reflect the total compensation actually realized or received by Dr. Rothblatt. In accordance with

these rules, these amounts reflect “Total Compensation” as set forth in the Summary Compensation Table for each year, adjusted as shown

below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did

not materially differ from those disclosed at the time of grant.

Compensation Actually Paid to PEO	2023	2022	2021	2020
Summary Compensation Table Total	$16,958,057	$5,322,204	$3,511,071	$4,811,672
Less value of Stock Options and RSUs reported in Summary Compensation Table	$11,302,852	—	—	—
Less Change in Pension Value reported in Summary Compensation Table	—	—	—	$1,575,757
Plus year-end fair value of outstanding and unvested equity awards granted in the year	$24,052,395	—	—	—
Plus fair value as of vesting date of equity awards granted and vested in the year	—	—	—	—
Plus (less) year over year change in fair value of outstanding and unvested equity awards granted in prior years	—	$41,115,001	$42,020,090	$46,738,027
Plus (less) change in fair value from prior fiscal year end to the vesting date of equity awards granted in prior years that vested in the year	$(40,513,140)	$(5,249,025)	$4,897,335	$(54,211)
Less prior year-end fair value for any equity awards forfeited in the year	—	—	—	—
Plus dividends or other earnings paid on awards in the covered fiscal year prior to vesting if not otherwise included in the Summary Compensation Table Total for the covered fiscal year	—	—	—	—
Plus pension service cost for services rendered during the year	—	—	—	—
Compensation Actually Paid to Martine Rothblatt, Chairperson and CEO	$(10,805,540)	$41,188,180	$50,428,496	$49,919,731

(3)The dollar amounts reported in column (d) represent the average of the amounts reported for our NEOs as a group (excluding Dr. Rothblatt) in

the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the NEOs included for these purposes

in each applicable year are as follows: James Edgemond, Chief Financial Officer and Treasurer; Michael Benkowitz, President and Chief

Operating Officer; and Paul Mahon, Executive Vice President and General Counsel.

(4)The dollar amounts reported in column (e) represent the average amount of “compensation actually paid” to the NEOs as a group (excluding

Dr. Rothblatt), as computed in accordance with Item 402(v) of Regulation S-K. In accordance with these rules, these amounts reflect “Total

Compensation” as set forth in the Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in

accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those

disclosed at the time of the grant.

Average Compensation Actually Paid to Non-PEO NEOs	2023	2022	2021	2020
Average Summary Compensation Table Total	$7,004,879	$2,381,140	$1,962,289	$4,145,541
Less average value of Stock Options and RSUs reported in Summary Compensation Table	$3,767,178	—	—	—
Less average Change in Pension Value reported in Summary Compensation Table	$622,514	—	$278,975	$2,461,396
Plus average year-end fair value of outstanding and unvested equity awards granted in the year	$8,017,006	—	—	—
Plus average fair value as of vesting date of equity awards granted and vested in the year	—	—	—	—
Plus (less) average year over year change in fair value of outstanding and unvested equity awards granted in prior years	—	$13,705,000	$14,006,697	$14,907,728
Plus (less) average change in fair value from prior fiscal year end to the vesting date of equity awards granted in prior years that vested in the year	$(13,504,380)	$(1,749,675)	$1,464,630	$69,866
Less prior year-end fair value for any equity awards forfeited in the year	—	—	—	—
Plus dividends or other earnings paid on awards in the covered fiscal year prior to vesting if not otherwise included in the Summary Compensation Table Total for the covered fiscal year	—	—	—	—
Plus average pension service cost for services rendered during the year	$686,174	$1,050,567	$1,139,973	$947,143
Average Compensation Actually Paid to Non-PEO NEOs	$(2,186,013)	$15,387,032	$18,294,614	$17,608,882

(5)Total Shareholder Return (TSR) is calculated by dividing (a) the difference between our share price at the end of each fiscal year shown and

the beginning of the measurement period, and the beginning of the measurement period by (b) our share price at the beginning of the

measurement period. The beginning of the measurement period for each year in the table is December 31, 2019.

(6)The peer group used for this purpose is the following published industry index: Nasdaq U.S. Benchmark Pharmaceuticals TR Index. This is the

peer group that is used in our five-year performance graph that is disclosed in Item 5 of our Annual Report on Form 10-K for the year ended

December 31, 2023.

(7)The dollar amounts reported represent the amount of net income reflected in our audited financial statements for the applicable year.

(8)Revenue was chosen from the five most important performance measures we use to link compensation actually paid to the PEO and other

NEOs in each applicable year to our company’s performance.

Executive Compensation

2024 Proxy Statement 73

Description of Certain Relationships between Information Presented in

the Pay Versus Performance Table

While we use several performance measures to align executive compensation with our performance, all of those measures are not

presented in the Pay Versus Performance table. In accordance with SEC rules, we are providing the following descriptions of the

relationships between information presented in the Pay Versus Performance table.

Compensation Actually Paid, Cumulative TSR, and Peer Group TSR

Compensation Actually Paid and Net Income

Compensation Actually Paid and Company-Selected Measure (Revenue)

Executive Compensation

74 United Therapeutics, a public benefit corporation

Performance Measures

The most important financial and operational performance measures we use to link executive compensation actually paid to our NEOs, for

the most recently completed fiscal year, to our performance are as follows:

•Revenue

•Cash Profit Margin

•Number of Patients

•R&D Performance

•Manufacturing Performance

Pay Ratio

As required by Section 953(b) of the Dodd Frank Wall Street Reform and Consumer Protection Act and Item 402(u) of Regulation S-K, we

are required to disclose the ratio of the 2023 compensation of our principal executive officer to that of our median compensated employee.

During 2023, our principal executive officer was our Chief Executive Officer, Dr. Martine Rothblatt. For purposes of this pay ratio

disclosure, Dr. Rothblatt’s 2023 annual total compensation was $16,976,289, and the 2023 total annual compensation for our median

employee, identified as discussed below, was $210,540, resulting in a pay ratio of approximately 81:1. Dr. Rothblatt’s total compensation

for purposes of this disclosure differs from the total annual compensation reflected in the Summary Compensation Table because we

included the value of employer paid non-discriminatory health and welfare benefits and basic life insurance premiums, which are not

required to be disclosed in the Summary Compensation Table, but which we include here to give a more complete picture of our median

employee’s total rewards compensation.

In accordance with Item 402(u) of Regulation S-K, we identified our employee population as of October 1, 2023 and determined the

median employee by (1) aggregating for each applicable employee (a) annual base salary determined as of October 1, 2023 for salaried

employees (or hourly rate as of the same date, multiplied by estimated hours worked in 2023, for hourly employees); and (b) the target

cash incentive, commissions, and overtime earned in 2023; and (2) ranking this compensation measure for our employees from lowest to

highest. This calculation was performed for all employees except as disclosed in the following paragraph, excluding Dr. Rothblatt, whether

employed on a full time, part time, or seasonal basis.

For purposes of identifying the median employee, all employees located outside of the United States as of October 1, 2023, totaling 17

individuals, were excluded from the determination of the median employee pursuant to the so-called de minimis exemption, which permits

us to exclude foreign employees, up to 5% of our total employee population of 1,071, on a whole country basis. As of October 1, 2023,

these employees were located in the following countries: Canada (12), United Kingdom (4) and Ireland (1). Applying this de minimis

exemption, as of October 1, 2023, we considered a total of 1,054 U.S.-based employees (excluding our CEO) and no employees located

outside of the United States. Irrespective of the de minimis exemption, on this same date we had 1,054 U.S.-based employees (excluding

our CEO) and 17 employees located outside of the United States.

The pay ratio reported above is a reasonable estimate calculated in a manner consistent with SEC rules based on our internal records and

the methodology described above. The SEC rules for identifying the median compensated employee and calculating the pay ratio based

on that employee’s annual total compensation, allows companies to adopt a variety of methodologies, to apply certain exclusions, and to

make reasonable estimates and assumptions that reflect their employee populations and compensation practices. Therefore, the pay ratio

reported by other companies may not be comparable to the pay ratio reported above, as other companies have different employee

populations and compensation practices and may utilize different methodologies, exclusions, estimates, and assumptions in calculating

their own pay ratios. 

Executive Compensation

2024 Proxy Statement 75

3 Approval of The Amendment and Restatement of The United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

We are asking our shareholders to approve an amendment and restatement (the 2024 Restatement) of the United Therapeutics

Corporation Amended and Restated 2015 Stock Incentive Plan (the Plan). On April 29, 2015, our Board of Directors unanimously adopted

and approved the Plan. Our shareholders subsequently approved the Plan at our 2015 Annual Meeting of Shareholders. Our shareholders

subsequently approved an amendment and restatement of the Plan at each of our 2018, 2019, 2020, 2021, 2022, and 2023 Annual

Meetings of Shareholders. We refer to the 2023 amendment and restatement of the Plan as the 2023 Restatement.

Our Board of Directors adopted and approved the Plan to stimulate the efforts of non-employee directors, officers, employees, and other

service providers, in each case who are selected to be participants in the Plan, by heightening the desire of such persons to continue

working toward and contributing to our success and progress. The Plan allows grants of stock options, stock appreciation rights, restricted

stock, restricted stock units, and stock awards, any of which may be performance-based, and for cash incentives.

We believe that a comprehensive equity compensation program serves as a necessary and powerful tool to attract, retain, and incentivize

individuals essential to our financial success and accordingly benefits all of our shareholders by allowing us to retain individuals who are

expected to make significant contributions to the creation of shareholder value.

The 2024 Restatement makes the following key changes to the 2023 Restatement of the Plan, in addition to certain other

administrative changes:

•Increases the maximum number of shares of our common stock that may be issued under the Plan by 1,320,000 shares

•Extends the expiration date of the Plan to April 25, 2034

•Revises the minimum vesting provisions under the Plan to permit certain exceptions in line with best practices

•Revises the limit on non-employee director compensation to address certain special assignments

Approval of the 2024 Restatement requires the affirmative vote of the holders of a majority of the voting power of all shares of

stock entitled to vote thereon, present in person or by proxy, at our Annual Meeting. Abstentions have the same effect as an

“against” vote. Broker non-votes, if any, have no impact on the vote.

Our Board of Directors recommends that you vote FOR the approval of the amendment and restatement of the United

Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan.

Why You Should Vote For the 2024 Restatement of the Plan

Our Board of Directors recommends that our shareholders approve the 2024 Restatement of the Plan.

•Reasonable Share Request. At the current burn rate for our equity awards, we expect that the existing limit of 12,500,000 shares

available for issuance under the 2023 Restatement of the Plan may be insufficient to fund the annual issuance of awards to our

employees and executives in March 2026.

•Market Competitiveness and Broad-Based Usage. We offer equity-based compensation to all of our full-time employees,

executive officers, and non-employee directors. Like other similarly-situated biotech and pharmaceutical companies, many of which

we compete with for talent, equity is an important part of our compensation program. Our ability to continue granting equity-based

awards is crucial to ensure that we can attract, retain, motivate, and reward key talent so that we can continue to deliver

exceptional performance.

If the 2024 Restatement is not approved, we may need to grant cash-based or other awards in order to remain competitive; these awards

may not align the interests of our key employees and non-employee directors as closely with those of our shareholders as equity awards.

In addition, the use of cash resources to deliver competitive pay would divert cash from use in running other aspects of our business and

investing in future product development.

Promotion of Good Corporate Governance Practices

Our company and our Board of Directors have designed the Plan to include a number of provisions that we believe promote best practices

by reinforcing the alignment between equity compensation arrangements for non-employee directors, officers, employees, and other

service providers and shareholders’ interests. These provisions include, but are not limited to:

•the Plan allows for awards to be granted with performance-based vesting conditions;

Executive Compensation

76 United Therapeutics, a public benefit corporation

•stock options and stock appreciation rights may not be granted with exercise prices lower than the fair market value of the underlying

shares on the grant date;

•no award may vest prior to the first anniversary of grant, subject to limited exceptions;

•the share pool under the Plan is not subject to liberal “recycling” provisions (among other things, shares used to pay the exercise

price for stock options do not again become available for grant under the Plan);

•at any time when the exercise price of a stock option or stock appreciation right is above the market value of our common stock, we

cannot, without shareholder approval, directly or indirectly “reprice” those awards;

•stock options granted under the Plan cannot be subject to a “reload” feature;

•we have the authority under the Plan to cancel outstanding awards (vested or unvested) in the event the applicable plan participant

engages in an “act of misconduct” (as such term is defined in the Plan);

•no participant may receive dividends or dividend equivalents in respect of an unvested award; and

•the Plan specifies limits on cash and equity compensation that may be provided annually to our non-employee directors.

Key Data

The following table includes information regarding all of our outstanding equity awards (under all of our equity-based compensation plans

under which shares of common stock may be issued, other than our Employee Stock Purchase Plan) and shares available for future

awards under the Plan as of March 25, 2024:

Total shares underlying all outstanding stock options	6,466,272
Weighted average exercise price of outstanding stock options	$145.13
Weighted average remaining contractual life of outstanding stock options	3.94 years
Total shares of common stock outstanding	44,159,108
Total shares underlying all outstanding and unvested performance shares	349,800
Total shares underlying all outstanding and unvested restricted stock (excluding performance shares)	865,655
Shares available for future awards that could be issued under Prior Plan(1)	0
Shares available for future awards that could be issued under the 2015 Stock Incentive Plan(2)	1,720,819
Shares available for future awards that could be issued under the 2019 Inducement Stock Incentive Plan(3)	1,448

(1)Certain outstanding stock options were issued under our Amended and Restated Equity Incentive Plan (the Prior Plan), which was approved

by security holders in 1997. Information regarding this plan is contained in Note 8—Share Based Compensation to the consolidated financial

statements included in our Annual Report on Form 10-K for the year ended December 31, 2023. No further awards may be granted pursuant

to the Prior Plan following shareholder approval of the Plan in June 2015 (but outstanding awards under the Prior Plan will continue to be

governed by the Prior Plan). Any shares subject to awards that are forfeited under the Prior Plan will not become available for the issuance of

future awards under either the Plan or the Prior Plan.

(2)This is the Plan being amended and restated and does not include the additional shares to be made available for issuance if the 2024

Restatement is approved. The fungible share ratio of 1.35:1 will apply to full-value awards granted under the 2024 Restatement.

(3)The fungible share ratio of 2.14:1 will apply to full value awards granted under the 2019 Inducement Stock Incentive Plan.

The potential dilution from the additional 1,320,000 shares to be made available for issuance under the Plan is approximately 3.0%

(calculated as the additional shares requested divided by shares outstanding as of March 25, 2024). Our Board of Directors has

considered this potential dilution level in the context of competitive data from our peer group and believes that the resulting dilution levels

would be within normal competitive ranges. Actual dilution from the Plan will depend on several factors, including the type of awards made

under the Plan. This is because the Plan uses a fungible share design, under which each share issued pursuant to a stock option or stock

appreciation right will reduce the number of shares available under the Plan by one share, and each share issued pursuant to other awards

will reduce the number of shares available by 1.35 shares. If all of the shares available under the Plan were to be granted in the form of

restricted stock units, the total potential dilution from the Plan would be approximately 2.2% as of March 25, 2024 (calculated as the

additional shares requested divided first by 1.35 and then by the total shares outstanding as of March 25, 2024).

We manage our long-term dilution goal by limiting the number of shares subject to equity awards that we grant annually, commonly

referred to as burn rate. Burn rate shows how rapidly a company is depleting its shares reserved for equity compensation plans and is

defined as the number of shares granted under our equity incentive plans divided by the weighted average number of common shares

outstanding at the end of the year. We have calculated the burn rate under the Plan for the past three years, as set forth in the

following table:

Executive Compensation

2024 Proxy Statement 77

	Options Granted(1)	Full-Value Shares Granted(1)	Total Granted = Options+ Full-Value Shares	Weighted Average Number of Common Shares Outstanding	Burn Rate
Fiscal 2023	455,996	370,068	826,064	46,788,051	1.8%
Fiscal 2022	40,029	683,280	723,309	45,451,063	1.6%
Fiscal 2021	43,653	188,378	232,031	44,860,950	0.5%
Three-Year Average	179,893	413,909	593,801	45,700,021	1.3%

(1)These figures reflect time-based and performance-based full-value awards granted during the applicable fiscal year and both time-based and

performance-based stock option awards granted during the applicable fiscal year.

An additional metric that we use to measure the cumulative impact of our equity program is overhang (the number of shares subject to

equity awards outstanding but not exercised or settled, plus the number of shares available to be granted, divided by the sum of the total

number of shares of our common stock outstanding, plus the number of shares subject to equity awards outstanding but not exercised or

settled, plus the number of shares available to be granted). Of the shares subject to outstanding awards under our equity plans as of

March 25, 2024, there were no outstanding awards subject to stock options with exercise prices greater than $244.26. If the Plan is

approved, our overhang calculated on this basis would increase to approximately 19.5%, and then would be expected to decline as awards

are exercised and/or become vested.

When considering the Plan, our Board of Directors also reviewed, among other things, projected future share usage and projected future

forfeitures. The projected future usage of shares for long-term incentive awards under the Plan was reviewed under scenarios based on a

variety of assumptions. Depending on assumptions, with the 1,320,000 additional shares to be made available under the Plan, the 2024

Restatement of the Plan is expected to satisfy our equity compensation needs for approximately two to three years of similar levels of

awards based on current utilization levels. Our Board of Directors is committed to effectively managing the number of shares reserved for

issuance under the Plan while minimizing shareholder dilution.

Plan Summary

The following summary of the material terms of the Plan is qualified in its entirety by reference to the complete statement of the Plan, which

is set forth in Annex A to this Proxy Statement.

Administration

The Plan will be administered by our Compensation Committee. Subject to the express provisions of the Plan, the administrator is

authorized and empowered to do all things that it determines to be necessary or appropriate in connection with the administration of the

Plan. All decisions, determinations, and interpretations by our Compensation Committee regarding the Plan and awards granted under the

Plan will be final and binding on all participants and other persons holding or claiming rights under the Plan or an award under the Plan.

Our Compensation Committee may authorize one or more of our officers to perform any or all things that the administrator is authorized

and empowered to do or perform under the Plan. Our Compensation Committee may delegate any or all aspects of the day-to-day

administration of the Plan to one or more of our officers or employees, and/or to one or more agents.

Participants

Any person who is a current or prospective officer or employee of United Therapeutics or of any subsidiary may be eligible for selection by

the administrator for the grant of awards under the Plan. In addition, non-employee directors and any service providers who have been

retained to provide consulting, advisory or other services to us may be eligible for the grant of awards under the Plan. Options intended to

qualify as “incentive stock options” (ISOs) within the meaning of Section 422 of the Code may be granted only to our employees.

Approximately 1,187 officers and employees and 11 non-employee directors currently qualify to participate in the Plan. Although the Plan

permits granting equity awards to consultants, there are not currently any outstanding equity awards held by consultants and we do not

expect to grant any such awards in the future.

Stock Options and RSUs Granted under the Plan

No awards made under the Plan prior to the date of the Annual Meeting were granted subject to shareholder approval. The number and

types of awards that will be granted under the Plan in the future are not determinable, as our Compensation Committee will make these

determinations in its discretion. Notwithstanding the foregoing, in accordance with our non-employee director compensation policy, annual

equity awards in the form of stock options and/or RSUs with a grant date fair value equal to $400,000 are generally granted once per year

on the date of the first meeting of our Board following our Annual Meeting of Shareholders and thus we expect each non-employee director

will receive such a grant subject to continued service at such time. The following table sets forth information with respect to the number of

Executive Compensation

78 United Therapeutics, a public benefit corporation

stock options and RSUs that have been granted to our NEOs, directors, and the specified groups set forth below under the Plan as of

March 25, 2024. No other award types have been granted under the Plan. On March 25, 2024, the closing price of the underlying shares of

our common stock traded on the Nasdaq was $244.26 per share.

Name and Principal Position	Stock Options	Restricted Stock Units(1)
Martine Rothblatt	3,015,094(2)	170,790
Chairperson and Chief Executive Officer
James Edgemond	798,797	51,810
Chief Financial Officer and Treasurer
Michael Benkowitz	1,054,551(2)	85,260
President and Chief Operating Officer
Paul Mahon	905,024	41,940
Executive Vice President and General Counsel
All executive officers as a group (4 persons)(3)	5,773,466	349,800
All non-executive directors as a group (11 persons)	477,320	131,800
Each nominee for election as a director	—	—
Each associate of the above-mentioned directors, executive officers, or nominees	—	—
Each other person who received or is to receive 5% of such options, warrants or rights	—	—
All employees (other than current executive officers) as a group (2,764 persons)(4)	1,736,195	1,854,250

(1)Reflects the actual number of shares of common stock subject to restricted stock units, without applying the fungible share ratio of 1.35:1 or

2.14:1, as applicable.

(2)Of these awards, 3,387,835 are held indirectly by trusts.

(3)Excludes former executive officers.

(4)Includes current and former employees and former executive officers.

Registration of Securities. We intend to file a registration statement on Form S-8 to register the additional shares requested in August 2024.

Shares Subject to the Plan and to Awards

Subject to changes in our capitalization, the aggregate number of shares of our common stock issuable pursuant to all awards under the

Plan will not exceed 13,820,000 shares; provided that (1) any shares granted under options or stock appreciation rights will be counted

against this limit on a one-for-one basis; (2) any shares granted prior to March 17, 2020, as awards other than options or stock

appreciation rights will be counted against this limit as 2.14 shares for every one share subject to such award; and (3) any shares granted

on or after March 17, 2020, as awards other than options or stock appreciation rights shall be counted against this limit as 1.35 shares for

every one share subject to such award. The shares issued pursuant to awards granted under the Plan may be shares that are authorized

and unissued or issued shares that were reacquired by us, including shares purchased in the open market.

For purposes of determining the share limits described in the paragraph above, the aggregate number of shares issued under the Plan at

any time will equal only the number of shares actually issued upon exercise or settlement of an award. Notwithstanding the foregoing,

shares subject to an award under the Plan may not again be made available for issuance under the Plan if such shares are: (1) shares that

were subject to a stock-settled stock appreciation right and were not issued upon the net settlement or net exercise of such stock

appreciation right; (2) shares used to pay the exercise price of an option; (3) shares delivered to or withheld by us to pay the withholding

taxes related to an award; or (4) shares repurchased on the open market with the proceeds of an option exercise.

Shares subject to awards that have been canceled, expired, forfeited or otherwise not issued under an award and shares subject to awards

settled in cash will not count as shares issued under the Plan. Any shares that were subject to options or stock appreciation rights and that

again become available for awards under the Plan will be added as one share for every one share subject to such options or stock

appreciation rights. Any shares that were subject to awards other than options or stock appreciation rights that again become available for

awards under the Plan shall: (1) prior to March 17, 2020 be added as 2.14 shares for every one share subject to such awards; and (2) from

and after March 17, 2020, be added as 1.35 shares for every one share subject to such awards.

Subject to certain adjustments, the aggregate number of shares subject to awards granted under the Plan during any calendar year to any

one participant will not exceed 1,000,000 and the aggregate number of shares that may be issued pursuant to the exercise of ISOs granted

under the Plan will not exceed 13,820,000. The maximum amount payable pursuant to that portion of a cash incentive award granted in

any calendar year to any participant under the Plan will not exceed $5 million.

In addition, the aggregate dollar value of awards (based on the aggregate accounting value on the date of grant) granted pursuant to the

Plan during any calendar year to any non-employee director may not exceed $400,000 for annual equity grants (plus, for the year an

individual first becomes a non-employee director (x) an initial equity grant valued at $400,000, plus (y) a pro-rata portion of the $400,000

annual equity-based award value based on the number of months remaining in the Board of Directors service year at the date of grant).

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2024 Proxy Statement 79

The annual equity award may be payable in options, restricted stock units, or a combination, as elected by the non-employee director. The

Plan further provides that the cash compensation paid or payable to a non-employee director with respect to any calendar year may not

exceed $60,000 (with additional cash compensation of $35,000 for the lead independent director, $25,000 for each committee chair, and

$15,000 for each other committee membership), plus a pro-rated portion of the aggregate cash compensation for the roles in which the

non-employee director serves for the year an individual first becomes a non-employee director. In addition, a non-employee director may

be compensated for special assignments in an amount not to exceed $50,000 per year.

Option Awards

The administrator will establish the exercise price per share under each option, which, other than in the event of options granted in

connection with a merger or other acquisition, will not be less than the fair market value (or 110 percent of the fair market value in the case

of ISOs granted to individuals who own more than 10 percent of our common stock) of a share on the date the option is granted. The

administrator will establish the term of each option, which in no case may exceed a period of ten years from the date of grant (or five years

in the case of ISOs granted to individuals who own more than 10 percent of our common stock). Options granted under the Plan may either

be ISOs or options which are not intended to qualify as ISOs, or nonqualified stock options (NQSOs). Unless the administrator determines

otherwise: (1) upon termination of employment other than due to death, disability, or termination for cause, participants may continue to

exercise their options for ninety (90) days (or until the expiration date of the option, if earlier) to the extent that they were exercisable upon

the date of termination; (2) upon death or disability, options become fully vested and remain exercisable for one year (or until the expiration

date of the option, if earlier) following such event; and (3) upon termination of employment for cause, all options are forfeited. Stock options

may not include any “reload” feature. In no event shall any stock option vest before the first anniversary of the date of grant; provided that,

if so determined by the administrator, an option may fully vest before such anniversary in the event of the participant’s death or disability or

a change in control; and provided further, that (i) stock options granted to non-employee directors may become fully vested on the earlier to

occur of (x) the first anniversary of the date of grant; or (y) the date of the next Annual Meeting of Shareholders following the date of grant;

provided, however, that such stock options shall not vest earlier than 50 weeks following the date of grant; and (ii) up to 5% of the

aggregate number of shares authorized for issuance under the Plan may be issued pursuant to awards subject to any, or no, vesting

conditions, as the administrator deems appropriate. No participant will have any rights as a shareholder with respect to any shares subject

to options until such shares have been issued, including, for avoidance of doubt, no voting rights and no rights to receive dividends,

distributions, or dividend equivalents in respect of an option or any shares subject to an option until the participant has become the holder

of record of such shares.

Stock Appreciation Rights

A stock appreciation right provides the right to receive the monetary equivalent of the increase in value of a specified number of the shares

over a specified period of time after the right is granted. Stock appreciation rights may be granted to participants either in tandem with or as

a component of other awards granted under the Plan (tandem SARs) or not in conjunction with other awards (freestanding SARs). All

freestanding SARs will be granted subject to the same terms and conditions applicable to options as set forth above and in the Plan, and

all tandem SARs will have the same exercise price, vesting, exercisability, forfeiture, and termination provisions as the award to which they

relate. Participants will have no voting rights and will have no rights to receive dividends, distributions, or dividend equivalents in respect of

stock appreciation rights or any shares subject to stock appreciation rights until the participant has become the holder of record of

such shares.

Restricted Stock and Restricted Stock Units

Restricted stock is an award or issuance of shares the grant, issuance, retention, vesting, and/or transferability of which is subject during

specified periods of time to such conditions (including continued employment or performance conditions) and terms as the administrator

deems appropriate. Restricted stock units are awards denominated in units of shares under which the issuance of shares is subject to such

conditions (including continued employment or performance conditions) and terms as the administrator deems appropriate.

Notwithstanding the satisfaction of any performance goals, the number of shares granted, issued, retainable, and/or vested under a

restricted stock award or restricted stock units because of either financial performance or personal performance evaluations may be

reduced, but not increased, by the administrator based on such further consideration as the administrator may determine.

In no event shall any restricted stock or restricted stock units vest before the first anniversary of the date of grant; provided that, if so

determined by the administrator, restricted stock or restricted stock units may fully vest before such anniversary in the event of the

participant’s death or disability or a change in control; and provided further, that (i) restricted stock or restricted stock units granted to

non-employee directors may become fully vested on the earlier to occur of (x) the first anniversary of the date of grant; or (y) the date of the

next Annual Meeting of Shareholders following the date of grant; provided, however, that such restricted stock or restricted stock units

shall not vest earlier than 50 weeks following the date of grant; and (ii) up to 5% of the aggregate number of shares authorized for issuance

under the Plan may be issued pursuant to awards subject to any, or no, vesting conditions, as the administrator deems appropriate. Unless

the administrator determines otherwise, (1) upon termination of employment for any reason other than death or disability, all restricted

stock and restricted stock units still subject to restrictions as of the date of termination will be forfeited; and (2) upon death or disability, the

restrictions remaining on a participant’s restricted stock and restricted stock units will lapse.

Executive Compensation

80 United Therapeutics, a public benefit corporation

Unless otherwise determined by the administrator, participants holding shares of restricted stock granted under the Plan may exercise full

voting rights with respect to those shares during the period of restriction, and participants will have no voting rights with respect to shares

underlying restricted stock units unless and until such shares are reflected as issued and outstanding shares in our stock ledger.

Participants in whose name restricted stock is granted will be entitled to receive all dividends and other distributions paid with respect to

those shares, unless determined otherwise by the administrator. Participants will be entitled to receive dividends or dividend equivalents

with respect to shares underlying restricted stock units only to the extent provided by the administrator. However, in no event will dividends,

distributions or dividend equivalents be payable with respect to unvested or unearned awards until such awards vest.

Stock Awards

The administrator may grant stock awards under the Plan, which will be subject to the terms and conditions determined by the

administrator. Participants will have all voting, dividend, liquidation, and other rights with respect to shares underlying a stock award,

subject to any restrictions on transfer determined by the administrator, provided that in no event will dividends, distributions, or dividend

equivalents be currently payable with respect to unvested or unearned stock awards until such awards vest. In no event shall any stock

award fully vest before the first anniversary of the date of grant; provided that, if so determined by the administrator, a stock award may

vest before such anniversary in the event of the participant’s death or disability or a change in control; and provided further, that (i) stock

awards granted to non-employee directors may become fully vested on the earlier to occur of (x) the first anniversary of the date of grant;

or (y) the date of the next Annual Meeting of Shareholders following the date of grant; provided, however, that such stock awards shall not

vest earlier than 50 weeks following the date of grant; and (ii) up to 5% of the aggregate number of shares authorized for issuance under

the Plan may be issued pursuant to awards subject to any, or no, vesting conditions, as the administrator deems appropriate.

Incentive Awards

Each incentive award will confer upon the participant the opportunity to earn a future payment tied to the level of achievement with respect

to one or more performance criteria established for a performance period of not less than one year. The administrator will establish the

performance criteria and level of achievement of these criteria that will determine the target and maximum amount payable under an

incentive award, which criteria may be based on financial performance and/ or personal performance evaluations. Notwithstanding the

satisfaction of any performance goals, the amount paid under an incentive award because of either financial performance or personal

performance evaluations may be reduced, but not increased, by the administrator based on such further consideration as the administrator

may determine. Payment of the amount due under an incentive award may be made in cash or in shares, as determined by the

administrator, provided that no participant will have any rights as a shareholder with respect to any shares payable in respect of an

incentive award until said shares have been issued, including, for avoidance of doubt, no voting rights and no rights to receive dividends,

distributions, or dividend equivalents in respect of an incentive award or any shares subject to an incentive award until the participant has

become the holder of record of such shares.

Suspension or Termination of Awards

Unless otherwise determined by the administrator, (1) if our Chief Executive Officer or any other person designated by the administrator

reasonably believes that a participant may have committed an act of misconduct (as defined in the Plan), then the participant’s rights to

exercise any option, vest in any award and/or receive payment for or shares in settlement of an award may be suspended pending a

determination of whether an act of misconduct has been committed; and (2) if the administrator, our Chairperson and Chief Executive

Officer or any other person designated by the administrator determines that a participant has committed an act of misconduct, then the

participant (a) may not exercise any option or stock appreciation right, vest in, have restrictions on an award lapse or otherwise receive

payment of an award; (b) will forfeit all outstanding awards; and (c) may be required, at the discretion of the committee, to return or repay

any then-unvested shares previously issued under the Plan.

Amendment and Termination

Our Board of Directors may amend, alter or discontinue the Plan, and the administrator may amend or alter any agreement or other

document evidencing an award made under the Plan, except that no such amendment may, without the approval of our shareholders:

(1) increase the maximum number of shares for which awards may be granted under the Plan; (2) reduce the minimum price set forth in

the Plan at which options or stock appreciation rights may be granted; (3) reduce the exercise price of outstanding options or stock

appreciation rights; (4) extend the term of the Plan; (5) change the class of persons eligible to be participants; (6) otherwise amend the

Plan in any manner requiring shareholder approval by law or under Nasdaq listing requirements (or the listing requirements of any

successor exchange that is the primary stock exchange for trading of our shares); or (7) increase the individual maximum limits set forth in

the Plan.

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2024 Proxy Statement 81

No amendment or alteration to the Plan or an award or award agreement may be made that would impair the rights of the holder of

an award without such holder’s consent, provided that no such consent will be required if the administrator determines in its sole discretion

and prior to the date of any change in control that such amendment or alteration either is required or advisable in order for us, the Plan, or

the award to satisfy any law or regulation or to meet the requirements of or avoid adverse financial accounting consequences under any

accounting standard. In addition, the Plan may not be amended in any way that causes the Plan to fail to comply with or be exempt from

Section 409A of the Code, unless our Board expressly determines to amend the Plan to be subject to Section 409A of the Code.

Change in Control

The administrator may determine the effect of a change in control (as defined in the Plan) on outstanding awards in a manner that is fair

and equitable to participants (as determined by the administrator in its reasonable discretion). These effects, which need not be the same

for all participants, may include, but are not limited to: (1) substituting for the shares subject to an outstanding award or portion thereof the

stock or securities of the surviving corporation or any successor corporation, in which event the aggregate exercise price of the award will

remain the same; and/or (2) converting any outstanding award or portion thereof into a right to receive cash or other property following the

consummation of the change in control in an amount equal to the value of consideration to be received for one share of our common stock

in connection with such transaction less the purchase or exercise price of the shares subject to the award, multiplied by the number of

shares subject to the award or portion thereof.

Adjustments

The number and kind of shares available for issuance under the Plan, and the number and kind of shares subject to the individual and ISO

limits set forth under the Plan, will be equitably adjusted by the administrator to reflect any reorganization, reclassification, combination of

shares, stock split, reverse stock split, spin-off, dividend, or distribution of securities, property or cash (other than regular, quarterly cash

dividends), or any other event or transaction that affects the number or kind of shares outstanding. The terms of any outstanding award will

also be equitably adjusted by the administrator as to price, number, or kind of shares subject to such award and other terms to reflect the

foregoing events, which adjustments need not be uniform as between different awards or different types of awards.

In the event there is a change in the number or kind of outstanding shares under the Plan as a result of a change of control, other merger,

consolidation, or otherwise, then the administrator will determine the appropriate and equitable adjustment to be effected. In addition, in the

event of such a change, the administrator may accelerate the time or times at which any award may be exercised and may provide for

cancellation of such accelerated awards that are not exercised within a time prescribed by the administrator in its sole discretion.

Transferability

Unless the administrator determines otherwise, awards may not be sold, transferred, pledged, assigned, or otherwise alienated or

hypothecated by a participant other than by will or the laws of descent and distribution, and each option or stock appreciation right may be

exercisable only by the participant during their lifetime. To the extent permitted by the administrator, the person to whom an award is

initially granted may make certain limited transfers to certain family members, family trusts, or family partnerships.

Effective Date and Termination of the Plan

The Plan was initially adopted by our Board on April 29, 2015 and approved by our shareholders at the 2015 Annual Meeting of

shareholders. The 2018 Restatement was adopted by our Board on April 25, 2018 and approved by our shareholders at the 2018 Annual

Meeting of Shareholders. The 2019 Restatement was adopted by our Board on April 25, 2019 and approved by our shareholders at the

2019 Annual Meeting of Shareholders. The 2020 Restatement was adopted by our Board on April 29, 2020 and approved by our

shareholders at the 2020 Annual Meeting of Shareholders. The 2022 Restatement was adopted by our Board on April 26, 2022 and

approved by our shareholders at the 2022 Annual Meeting of Shareholders. The 2023 Restatement was adopted by our Board on April 20,

2023 and approved by our shareholders at the 2023 Annual Meeting of Shareholders. The 2024 Restatement was adopted by our Board

on April 25, 2024 and will become effective upon approval by our shareholders at the 2024 Annual Meeting. The Plan will remain available

for the grant of awards until April 25, 2034.

Federal Income Tax Treatment

The following tax discussion is a general summary as of the date of this Proxy Statement of the U.S. federal income tax consequences

to us and the participants in the Plan. The discussion is intended solely for general information and does not make specific representations

to any participant. The discussion does not address state, local, or foreign income tax rules or other U.S. tax provisions, such as estate or

gift taxes. A recipient’s particular situation may be such that some variation of the basic rules is applicable to him or her. In addition, the

federal income tax laws and regulations frequently have been revised and may be changed again at any time. Therefore, each recipient is

Executive Compensation

82 United Therapeutics, a public benefit corporation

urged to consult a tax advisor before exercising any award or before disposing of any shares acquired under the Plan both with respect to

federal income tax consequences as well as any foreign, state, or local tax consequences.

Stock Options

ISOs and NQSOs are treated differently for federal income tax purposes. ISOs are intended to comply with the requirements of

Section 422 of the Code. NQSOs need not comply with such requirements.

An optionee is not taxed on the grant or exercise of an ISO. The difference between the exercise price and the fair market value of the

shares on the exercise date will, however, be a preference item for purposes of the alternative minimum tax. If an optionee holds the

shares acquired upon exercise of an ISO until the later of two years following the option grant date and one year following exercise,

the optionee’s gain, if any, upon a subsequent disposition of such shares is long term capital gain. The measure of the gain is the

difference between the proceeds received on disposition and the optionee’s basis in the shares (which generally equals the exercise price).

If an optionee disposes of stock acquired pursuant to exercise of an ISO before satisfying these holding periods, the optionee will

recognize ordinary income in the year of disposition an amount equal to the excess of the fair market value of the shares at the time of

exercise (or, if less, the amount realized on the disposition of the shares), over the exercise price paid for the shares, and capital gain or

loss for any other difference between the sale price and the exercise price. Our company is not entitled to an income tax deduction on the

grant or exercise of an ISO or on the optionee’s disposition of the shares after satisfying the holding period requirement described above. If

the holding periods are not satisfied, we will be entitled to a deduction in the year the optionee disposes of the shares in an amount equal

to the ordinary income recognized by the optionee.

In order for an option to qualify for ISO tax treatment, the grant of the option must satisfy various other conditions more fully described in

the Code. We do not guarantee that any option will qualify for ISO tax treatment even if the option is intended to qualify for such treatment.

In the event an option intended to be an ISO fails to so qualify, it will be taxed as an NQSO described below.

An optionee is not taxed on the grant of an NQSO. On exercise, the optionee recognizes ordinary income equal to the difference between

the exercise price and the fair market value of the shares acquired on the date of exercise. Our company is entitled to an income tax

deduction in the year of exercise in the amount recognized by the optionee as ordinary income. The optionee’s gain (or loss) on

subsequent disposition of the shares is long-term capital gain (or loss) if the shares are held for at least one year following exercise, and

otherwise is short-term capital gain (or loss). Our company does not receive a deduction for any such capital gain.

Stock Appreciation Rights

Generally, the recipient of a freestanding SAR will not recognize any taxable income at the time the freestanding SAR is granted. If the

freestanding SAR is settled in cash, the cash will be taxable as ordinary income to the recipient at the time that it is received. If the

freestanding SAR is settled in shares, the recipient will recognize ordinary income equal to the excess of the fair market value of the

shares on the day they are received over any amounts paid by the recipient for the shares.

With respect to tandem SARs, if a holder elects to surrender the underlying option in exchange for cash or stock equal to the appreciation

inherent in the underlying option, the tax consequences to the employee will be the same as discussed above relating to freestanding

SARs. If the employee elects to exercise the underlying option, the holder will be taxed at the time of exercise as if they had exercised an

NQSO (discussed above).

Our company generally is entitled to a deduction with respect to a SAR at the same time the recipient recognizes ordinary income with

respect thereto.

Restricted Stock and Restricted Stock Units

Grantees of restricted stock or restricted stock units do not recognize income at the time of the grant. When the award vests or is paid,

grantees generally recognize ordinary income in an amount equal to the fair market value of the stock or units at such time, and we will

receive a corresponding deduction. Dividends (if any) paid with respect to unvested shares of restricted stock generally will be taxable as

ordinary income to the participant at the time the dividends are received.

Subject to Section 162(m) of the Code, we generally will be entitled to a deduction with respect to restricted stock and restricted stock units

at the same time the recipient recognizes ordinary income with respect thereto.

Stock Awards

Grantees of stock awards generally are required to recognize ordinary income in an amount equal to the excess of the fair market value of

the shares on the date the shares are granted over the purchase price (if any) paid for the shares. Subject to Section 162(m) of the Code,

we generally will be entitled to a deduction with respect to stock awards at the same time the recipient recognizes ordinary income with

respect thereto.

Executive Compensation

2024 Proxy Statement 83

Cash Incentive Awards

A participant will have taxable income at the time a cash incentive award is paid or, if the participant has timely elected deferral to a later

date, such later date. At that time, the participant will recognize ordinary income equal to the value of the amount then payable and, subject

to Section 162(m) of the Code, we will be entitled to a corresponding deduction.

Company Deduction and Section 162(m)

Our company generally will be entitled to a deduction for federal income tax purposes as described above with respect to each type of

award. However, pursuant to the Tax Cuts and Jobs Act that was signed into law in December 2017, for taxable years beginning on or

after January 1, 2018, the compensation deductible with respect to the Chief Executive Officer, the Chief Financial Officer, and the

individuals serving as our officers at the end of such year who are among the three highest compensated executive officers (other than the

Chief Executive Officer and Chief Financial Officer) for proxy reporting purposes, as well as for individuals who were proxy officers for any

taxable year beginning after December 31, 2016, Section 162(m) limits the amount of compensation otherwise deductible by us and our

subsidiaries for such year to $1,000,000. The “performance-based compensation” exception to this limitation generally is no longer

applicable for awards granted after November 3, 2017 (but may be available for tax deductions for grants made on or prior to that date).

New Plan Benefits

The benefits that will be awarded or paid under the Plan are not currently determinable. Awards granted under the Plan are within the

discretion of our Compensation Committee, and our Compensation Committee has not determined future awards or who might receive

them. Information about awards granted in fiscal year 2023 under our prior plans to our NEOs can be found in the table under the heading

Grants of Plan-Based Awards. As of March 25, 2024, the closing price of a share of our common stock on the Nasdaq was $244.26.

Securities Authorized for Issuance Under Equity

Compensation Plans

The following table presents information as of December 31, 2023, regarding our securities authorized for issuance under equity

compensation plans:

Plan category	Number of securities to be issued upon exercise of outstanding options and RSUs (a)(3)	Weighted average exercise price of outstanding options (b)(4)		Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) (c)(5)
Equity compensation plan approved by security holders(1)	7,153,777		$136.60	5,273,018
Equity compensation plans not approved by security holders(2)	24,835		—	24,586
Total	7,178,612		$136.60	5,297,604

(1)All outstanding stock options were issued under our two equity incentive plans approved by security holders in 1999 (the 1999 Plan) and 2015

(the 2015 Plan). The majority of outstanding restricted stock units (RSUs) were issued under the 2015 Plan. In addition, our employees have

outstanding rights to purchase our common stock at a discount as part of our Employee Stock Purchase Plan (ESPP), which was approved by

security holders in 2011. No further awards will be issued under the 1999 Plan. Information regarding these plans is contained in Note 8—

Share-Based Compensation to our consolidated financial statements included in our Annual Report on Form 10-K for the year ended

December 31, 2023.

(2)We have one equity incentive plan, the United Therapeutics Corporation 2019 Inducement Stock Incentive Plan (the 2019 Inducement Plan),

that has not been approved by our shareholders, as permitted by the Nasdaq Stock Market rules. The 2019 Inducement Plan was approved by

our Board of Directors in February 2019 and provides for the issuance of up to 99,000 shares of our common stock in the aggregate under

awards granted to newly-hired employees. Information regarding this plan is contained in Note 8—Share-Based Compensation to our

consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2023.

(3)Column (a) includes 6,213,853 shares of our common stock issuable upon the exercise of outstanding stock options issued under the

1999 Plan and 2015 Plan; 939,924 shares issuable upon the vesting of outstanding RSUs issued under the 2015 Plan; and 24,835 shares

issuable upon the vesting of outstanding RSUs issued under the 2019 Inducement Plan. The number under column (a) represents the actual

number of shares issuable under our outstanding awards without giving effect to the share counting formula described below in footnote 5.

(4)Column (b) represents the weighted average exercise price of the outstanding stock options only. The outstanding RSUs are not included in

this calculation because they do not have an exercise price.

Executive Compensation

84 United Therapeutics, a public benefit corporation

(5)Column (c) includes 2,506,133, 2,766,885, and 24,586 of shares available for future issuance under the ESPP, the 2015 Plan, and the

2019 Inducement Plan, respectively, including 20,414 shares subject to purchase under the ESPP for the purchase periods in effect as of

December 31, 2023. Under the ESPP, employees may purchase shares based upon a six-month offering period at an amount equal to the

lesser of (1) 85 percent of the closing market price of the Common Stock on the first day of the offering period, or (2) 85 percent of the closing

market price of the Common Stock on the last day of the offering period. Refer to Note 8—Share-Based Compensation—ESPP in our

consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2023 for more information.

The 2015 Plan and 2019 Inducement Plan use a share counting formula for determining the number of shares available for issuance under the

plans. In accordance with this formula, each RSU granted prior to March 17, 2020 under the 2015 Plan and each RSU granted under the 2019

Inducement Plan depletes the number of shares available for future issuance by 2.14 shares, while each RSU granted on or after March 17,

2020 under the 2015 Plan depletes the number of shares available for future issuance by 1.35 shares. Therefore, if any RSU does not vest,

the number of shares available for future issuance will increase by 1.35 and 2.14 under the 2015 Plan and 2019 Plan, respectively, because of

the share counting formula described above. Each stock option granted under the 2015 Plan depletes the number of shares available for

future issuance by one share and does not use the share counting formula described above.

Executive Compensation

2024 Proxy Statement 85

AUDIT MATTERS

4 Ratification of The Appointment of Ernst & Young LLP as United Therapeutics Corporation’s Independent Registered Public Accounting Firm for 2024

The Audit Committee of our Board has appointed Ernst & Young LLP (EY) as our independent registered public accounting firm for the

year 2024. Services provided to us and our subsidiaries by EY in 2023 are described under the section entitled Principal Accountant Fees

and Services below.

We ask that our shareholders vote to ratify the appointment of EY as our independent registered public accounting firm. Although

ratification is not required by our bylaws or otherwise, our Board has chosen to submit the ratification of EY’s appointment to our

shareholders as a matter of good corporate practice. In the event our shareholders do not ratify the appointment of EY, such appointment

will be reconsidered by our Audit Committee and our Board. Following such reconsideration, our Audit Committee may still appoint EY if it

determines doing so to be in the best interests of the company. Even if the appointment of EY is ratified, our Audit Committee, in its

discretion, may select a different independent registered public accounting firm at any time during the year if it determines that such a

change would be in our best interests and those of our shareholders.

Approval of this proposal requires the affirmative vote of the holders of a majority of the voting power of all shares of stock

entitled to vote thereon, present in person or by proxy, at our Annual Meeting. Abstentions have the same effect as an “against” vote.

If you hold your shares through brokerage accounts, it is expected that brokers may have the discretion to vote on this item in the absence

of your instructions.

Representatives of EY are expected to be present at our Annual Meeting to respond to appropriate shareholder questions and to make

such statements as they may desire.

Our Board of Directors recommends that you vote FOR the ratification of the appointment of EY as our independent registered

public accounting firm for 2024.

Report of our Audit Committee

As the members of the Audit Committee, we oversee United Therapeutics’ financial reporting process on behalf of our Board of Directors.

We are all independent directors under the applicable Nasdaq listing standards and the independence standards set forth in Rule

10A-3(b)(1) under the Exchange Act. Our Board has determined that Richard Giltner, our Audit Committee Chair, is an audit committee

financial expert as defined under the rules and regulations of the SEC (based on the relevant experience described in his biography above)

and that each member of our Audit Committee meets the financial sophistication requirement of the Nasdaq listing standards. Our Audit

Committee operates under a written charter, which we review periodically, and which was adopted by our Board. Our charter is consistent

with the provisions of the Sarbanes-Oxley Act of 2002, as well as the corporate governance rules issued by the SEC and Nasdaq, as they

relate to audit committee requirements.

We have met and held discussions with management and our independent auditors regarding financial reporting. Management is

responsible for the financial reporting process and preparation of United Therapeutics’ quarterly and annual consolidated financial

statements, including maintaining a system of internal controls and disclosure controls and procedures. Our Audit Committee is directly

responsible for the appointment, compensation, retention, oversight, and termination of our independent auditors. EY functioned as our

independent auditors for 2023 and has served as our auditor since 2003. EY is responsible for expressing an opinion on (1) the conformity

of our consolidated financial statements with generally accepted accounting principles; and (2) our internal control over financial reporting.

Our Audit Committee does not prepare financial statements or conduct audits.

In conjunction with the December 31, 2023, audited consolidated financial statements, we have:

•Reviewed and discussed United Therapeutics’ 2023 audited consolidated financial statements with our management and EY,

including discussions about critical accounting policies, other financial accounting and reporting principles and practices appropriate

for us, and the reasonableness of significant judgments.

•Reviewed and discussed management’s assessments of the effectiveness of internal controls over financial reporting and EY’s

related assessments and auditing procedures.

86 United Therapeutics, a public benefit corporation

•Discussed with EY the overall scope of and plans for our audits and reviews. Our Audit Committee has met with EY, with and without

management present, to discuss our financial reporting processes and internal accounting controls. We have reviewed all important

audit findings prepared by EY.

•Discussed with EY matters that are required to be discussed by applicable Public Company Accounting Oversight Board (PCAOB)

and SEC requirements. EY also provided to our Audit Committee the written disclosures and the letter required by applicable

requirements of the PCAOB regarding its communications with our Audit Committee concerning independence. We also discussed

with EY their independence, including any relationships that may have an impact on their objectivity and independence, and satisfied

ourselves as to EY’s independence. We also reviewed and pre-approved the scope and fees for all audit and other services

performed by EY for us.

•Met and reviewed with members of senior management and EY the certifications provided by our Chairperson and Chief Executive

Officer and our Chief Financial Officer under the Sarbanes-Oxley Act of 2002 and the rules and regulations of the SEC relating to

these certifications and the overall certification process.

Based on these reviews and discussions, our Audit Committee recommended to our Board of Directors that our audited consolidated

financial statements for 2023 be included in our Annual Report on Form 10-K for the year ended December 31, 2023, as filed with

the SEC.

Submitted by the Audit Committee:

RICHARD GILTNER (Chair)

CHRISTOPHER CAUSEY

JUDY OLIAN

LINDA MAXWELL

TOMMY THOMPSON

Principal Accountant Fees and Services

Fees for professional services provided by EY in each of the last two years in each of the following categories were:

	2023	2022
Audit fees	$2,332,695	$2,089,249
Audit-related fees	—	—
Tax fees:
Fees for tax compliance services	370,275	370,136
Fees for tax consulting services (including tax advice and tax planning)	6,755	26,480
Total tax fees	377,030	396,616
All other fees	7,632	9,082
	$2,717,357	$2,494,947

Audit fees include the aggregate fees billed for the audit of our consolidated annual financial statements, reviews of our interim

consolidated financial statements included in quarterly reports, accounting and financial reporting consultations, and services in connection

with registration statements. Audit-related fees include the aggregate fees billed for assurance and related services that are reasonably

related to the performance of the audit or review of our consolidated financial statements and are not reported as audit fees. Tax fees

include the aggregate fees billed for professional services for tax compliance, tax advice, and tax planning. All other fees included license

fees for an accounting research online software tool.

The Audit Committee of our Board of Directors has considered and determined that the provision of non-audit services by EY is compatible

with maintaining EY’s independence. Since EY’s appointment as our independent registered public accounting firm, our Audit Committee

has pre-approved all of the services performed by EY.

Audit Matters

2024 Proxy Statement 87

Policy on Audit Committee Pre-Approval of Audit Services and

Permissible Non-Audit Services of our Independent Auditors

Our Audit Committee’s policy is to pre-approve all audit and permissible non-audit services performed by our independent auditors. These

services may include audit services, audit-related services, tax services, and other services. For audit services, our independent auditor

provides an engagement letter to our Audit Committee prior to commencing its second quarter review work, which outlines the scope of the

proposed audit and audit-related fees. Our Audit Committee reviews the letter and negotiates with and formally engages the auditor.

For non-audit services, our senior management may from time to time recommend to our Audit Committee that it engage our independent

auditor to provide non-audit services, and request our Audit Committee to approve such engagement. Our senior management and our

independent auditor will each confirm to our Audit Committee that each non-audit service is permissible under all applicable legal

requirements. A budget estimating non-audit service spending for the fiscal year will be provided to our Audit Committee along with the

request. Our Audit Committee must approve the permissible non-audit services and the budget for such services. Our Audit Committee has

delegated authority to our Audit Committee Chair to pre-approve Audit and permissible non-audit services below a certain threshold. Our

Audit Committee will be informed periodically as to the non-audit services actually provided by our independent auditor pursuant to this

pre-approval process.

OTHER MATTERS

Certain Relationships and Related Party Transactions

Review and Approval of Related Party Transactions

We have adopted a written policy for the review of transactions, arrangements, and relationships between our company and our directors,

director nominees, executive officers, greater than 5% shareholders, and their immediate family members where the amount involved

exceeds $100,000. The policy requires our Audit Committee to review certain transactions subject to the policy and determine whether to

approve or ratify those transactions. In doing so, our Audit Committee considers, among other things, whether the transaction is on terms

that are no less favorable to our company than terms generally available to an unaffiliated third party under similar circumstances and the

extent of the related person’s interest in the transaction. The policy also provides the Chairperson of our Audit Committee with the authority

to approve or ratify transactions in which the amount involved is expected to be less than $500,000. Information on transactions approved

or ratified by the Chairperson of our Audit Committee is provided to our Audit Committee at its next regularly scheduled meeting.

Our Audit Committee has considered and adopted standing pre-approvals under the policy for certain limited transactions with related

persons that meet specific criteria. Information on transactions subject to pre-approval is provided to our Audit Committee at its next

regularly scheduled meeting. Pre-approved transactions are limited to:

•executive officers’ compensation that is subject to required Proxy Statement disclosure or Compensation Committee approval;

•non-employee director compensation that is subject to required Proxy Statement disclosure;

•certain transactions with other companies and certain charitable contributions that do not exceed the greater of $200,000 or 5% of

the other company’s or non-profit organization’s total annual revenues or receipts; and

•transactions where all shareholders receive proportional benefits.

Related Party Transactions

From time to time, we may employ family members of certain executive officers. During 2023, Dr. Rothblatt’s daughter, Jenesis Rothblatt,

was employed as Project Leader, Corporate Telepresence & Robotics, and received total compensation valued at approximately $145,000.

Audit Matters

88 United Therapeutics, a public benefit corporation

Beneficial Ownership of Common Stock

The following table sets forth certain information as of April 15, 2024 (unless otherwise noted), with respect to the beneficial ownership of

our common stock by: (1) each person or entity who we know beneficially owns more than 5% of the outstanding shares of our common

stock; (2) each director and director nominee; (3) each of our NEOs (which include our Chairperson and Chief Executive Officer, our Chief

Financial Officer and Treasurer, our President and Chief Operating Officer, and our Executive Vice President and General Counsel); and

(4) all of our directors and executive officers as a group. Unless otherwise noted, the address of each person listed below is our

co-headquarters address at 1000 Spring Street, Silver Spring, Maryland 20910. In accordance with SEC rules, the number of shares of

common stock beneficially owned and the percentage of outstanding shares shown in this table exclude any STAP awards held by our

directors and executive officers because they are cash settled awards that do not involve the issuance of shares of common stock.

Name	Number of Shares of Common Stock Beneficially Owned(1)	Percentage of Outstanding Shares(2)	Vested STAP Awards(3)
Beneficial Owners
BlackRock, Inc.(4) 50 Hudson Yards New York, NY 10001	5,294,844	11.9%	—
The Vanguard Group(5) 100 Vanguard Boulevard Malvern, PA 19355	4,673,678	10.5%	—
Wellington Management Group LLP(6) 280 Congress Street Boston, MA 02210	3,794,010	8.6%	—
Avoro Capital Advisors LLC(7) 110 Greene Street, Suite 800 New York, NY 10012	2,858,888	6.4%	—
FMR LLC(8) 245 Summer Street Boston, MA 02210	2,321,039	5.2%	—
Executive Officers, Directors, and Nominees
Martine Rothblatt(9)	3,525,982	7.5%	—
Michael Benkowitz(10)	820,896	1.8%	32,200
James Edgemond(11)	655,706	1.5%	40,160
Paul Mahon(12)	453,650	1.0%	116,250
Tommy Thompson(13)	74,710	*	—
Katherine Klein(14)	69,600	*	19,584
Christopher Patusky(15)	57,364	*	—
Ray Kurzweil(16)	57,110	*	—
Richard Giltner(17)	30,620	*	—
Linda Maxwell(18)	30,110	*	—
Nilda Mesa(19)	29,123	*	—
Christopher Causey(20)	27,955	*	—
Louis Sullivan(21)	25,880	*	—
Judy Olian(22)	21,925	*	—
Raymond Dwek(23)	16,750	*	3,000
Jan Malcolm	—	*	—
All directors, nominees, and executive officers as a group (16 persons)(24)	5,897,381	11.9%	211,194

*Less than one percent

(1)Beneficial ownership is determined in accordance with the rules of the SEC and generally includes ownership of those shares over which the

person has sole or shared voting or investment power. Beneficial ownership also includes ownership of shares of our common stock subject to

rights and options currently exercisable or convertible, or exercisable or convertible within 60 days after April 15, 2024. Except where indicated

otherwise, and subject to community property laws where applicable, to our knowledge, the persons listed in the table above have sole voting

and investment power with respect to their shares of our common stock.

(2)Ownership percentage is based on 44,330,494 shares of our common stock outstanding on April 15, 2024, plus, as to the holder thereof and

no other person, the number of shares (if any) that the person has the right to acquire as of April 15, 2024, or within 60 days thereafter,

through the exercise of stock options or other similar rights.

Other Matters

2024 Proxy Statement 89

(3)Represents the number of outstanding, vested STAP awards on April 15, 2024. None of the individuals in the table above have STAP awards

scheduled to vest within 60 days after April 15, 2024. Because STAP awards are cash settled and do not involve the issuance of shares of

stock, they are excluded from the other columns of this table.

(4)Beneficial ownership information obtained from a Schedule 13G/A filed by BlackRock, Inc. on January 24, 2024, reporting beneficial ownership

as of December 31, 2023. According to the Schedule 13G/A, BlackRock, Inc. has sole voting power over 5,008,832 shares and sole

dispositive power over 5,294,844 shares.

(5)Beneficial ownership information obtained from a Schedule 13G/A filed by The Vanguard Group on February 13, 2024, reporting beneficial

ownership as of December 29, 2023. According to the Schedule 13G/A, The Vanguard Group has shared voting power over 26,381 shares,

sole dispositive power over 4,609,929 shares, and shared dispositive power over 63,749 shares.

(6)Beneficial ownership information obtained from a Schedule 13G/A filed by Wellington Management Group LLP, Wellington Group

Holdings LLP, Wellington Investment Advisors Holdings LLP, and Wellington Management Company LLP (together, Wellington) on February

8, 2024, reporting beneficial ownership as of December 29, 2023. According to the Schedule 13G, Wellington has shared voting power over

3,304,591 shares, and shared dispositive power over 3,794,010 shares, with the exception of Wellington Management Company LLP, which

has shared voting power over 2,965,754 shares, and shared dispositive power over 3,195,591 shares.

(7)Beneficial ownership information obtained from a Schedule 13G/A filed by Avoro Capital Advisors LLC (Avoro) and Behzad Aghazadeh, who

serves as the portfolio manager and controlling person of Avoro, on February 14, 2024, reporting beneficial ownership as of

December 31, 2023. According to the Schedule 13G/A, Avoro and Behzad Aghazadeh each have sole voting power and sole dispositive

power over 2,858,888 shares.

(8)Beneficial ownership information obtained from a Schedule 13G/A filed by FMR LLC (FMR) and Abigail P. Johnson on February 9. 2024

reporting beneficial ownership as of December 29, 2023. According to the Schedule 13G/A, FMR has sole voting power over 2,288,360 shares

and FMR and Ms. Johnson each have sole dispositive power over 2,321,039 shares.

(9)Includes currently exercisable options to purchase 327,869 shares held directly by Dr. Rothblatt and currently exercisable options to purchase

2,527,340 shares held by a trust (the Options Trust) established by Dr. Rothblatt of which Bessemer Trust Company of Delaware, N.A.

(Bessemer) is the sole trustee but over which Dr. Rothblatt retains sole investment power and sole voting power in her role as Investment

Direction Adviser for the Options Trust. The term of the Options Trust is three years from the date of funding, which was March 31, 2023,

subject to certain exceptions. Bessemer’s address is 20 Montchanin Rd. Suite 1500, Wilmington, Delaware 19807. Also includes 227,083

shares held indirectly by trusts over which Dr. Rothblatt has sole investment power and sole voting power, 21,215 shares held indirectly by

trusts over which Dr. Rothblatt’s spouse has sole investment power and sole voting power, 263,040 shares held indirectly by trusts over which

Dr. Rothblatt and her spouse have shared investment power and shared voting power, 91,210 additional shares held indirectly by trusts over

which Dr. Rothblatt has shared investment power and shared voting power, 45,596 additional shares held indirectly by trusts over which

Dr. Rothblatt’s spouse has shared investment power and shared voting power, 166 shares held directly by Dr. Rothblatt’s spouse, and 22,333

shares held by charitable organizations over which Dr. Rothblatt has shared investment and shared voting power.

(10)Includes currently exercisable options to purchase 818,319 shares held indirectly by a trust over which Mr. Benkowitz has sole investment

power and sole voting power.

(11)Includes currently exercisable options to purchase 654,128 shares.

(12)Includes currently exercisable options to purchase 416,940 shares.

(13)Includes currently exercisable options to purchase 52,230 shares. Also includes 5,800 shares held in a limited liability company owned by Gov.

Thompson's family, over which Gov. Thompson has sole investment power and sole voting power, and 8,200 shares held in a family trust with

Gov. Thompson as trustee, over which Gov. Thompson has sole investment power and sole voting power. Also includes 880 shares of

common stock to be issued on or about July 8, 2026, as the result of the July 7, 2023 vesting of RSUs for which Governor Thompson elected

to defer receipt of shares.

(14)Includes currently exercisable options to purchase 65,960 shares. Also includes 3,640 shares held indirectly by a trust over which Ms. Klein

has sole investment power and sole voting power.

(15)Includes currently exercisable options to purchase 56,260 shares. Also includes 1,100 shares held in a family trust with Mr. Patusky as trustee,

and over which Mr. Patusky has sole investment power and sole voting power.

(16)Includes currently exercisable options to purchase 45,930 shares.

(17)Includes currently exercisable options to purchase 15,000 shares.

(18)Includes currently exercisable options to purchase 30,110 shares.

(19)Includes currently exercisable options to purchase 23,750 shares.

(20)Includes currently exercisable options to purchase 23,770 shares.

(21)Includes currently exercisable options to purchase 25,880 shares.

(22)Includes currently exercisable options to purchase 14,620 shares.

(23)Includes currently exercisable options to purchase 15,000 shares.

(24)Includes currently exercisable options to purchase 5,113,106 shares.

Other Matters

90 United Therapeutics, a public benefit corporation

Delinquent Section 16(a) Reports

Section 16(a) of the Exchange Act requires our directors, officers and greater than 10% shareholders to file reports of ownership and

changes in ownership of our equity securities with the SEC. We routinely assist our officers and directors in preparing and filing these

reports. Based solely on a review of the copies of reports furnished to us and related written representations from reporting persons, we

believe that for the fiscal year ended December 31, 2023, all reporting persons filed the required reports on a timely basis under Section

16(a), except for the exercise of 2,500 STAP awards by Governor Thompson on March 24, 2023. Due to administrative error, this

transaction was not reported on Form 4 until April 3, 2023.

Shareholder Proposals and Director Nominations

Proposals for Inclusion in the Proxy Statement for the 2025

Annual Meeting

Shareholder proposals intended for inclusion in our Proxy Statement and form of proxy for our 2025 Annual Meeting of Shareholders

pursuant to Rule 14a-8 of the Exchange Act must be received by us at the address indicated below no later than 5:00 p.m. Eastern Time

on December 30, 2024, unless the date of the 2025 Annual Meeting is more than 30 days before or after the anniversary of the Annual

Meeting, in which case the deadline is a reasonable time before we begin to print and send our proxy materials. In addition, proposals must

otherwise comply with the rules of the SEC for inclusion in our Proxy Statement and form of proxy relating to that meeting. The submission

of a shareholder proposal does not guarantee that it will be included in our Proxy Statement and form of proxy.

Director Nominees for Inclusion in the Proxy Statement for the 2025

Annual Meeting

In 2015, we amended our bylaws to implement proxy access, which allows a shareholder or a group of up to 20 shareholders owning

shares representing at least 3% of our outstanding voting stock entitled to vote in the election of directors continuously for at least three

years to nominate and include in our Proxy Statement their own director nominees constituting up to 20% of the total number of directors

then serving on our Board (or up to 25% if fewer than 10 directors are then serving on our Board), provided that the shareholder(s) and the

nominee(s) satisfy the requirements in our bylaws. Notice of director nominees submitted under these bylaw provisions must include the

information required under our bylaws. Such notice must be delivered to our Corporate Secretary at the address indicated below no earlier

than the close of business on November 30, 2024 and no later than the close of business on December 30, 2024 unless the date of the

2025 Annual Meeting is more than 30 days before or 45 days after the anniversary of the Annual Meeting, in which case such notice must

be received by our Corporate Secretary no later than the close of business on the later of the 120th day prior to the 2025 Annual Meeting

or the close of business on the tenth day following the day on which public announcement of the date of the 2025 Annual Meeting is

first made.

Other Proposals or Nominees for Presentation at the 2025

Annual Meeting

In order for a shareholder to properly bring other business before the 2025 Annual Meeting of Shareholders, including shareholder

proposals and director nominations that are not submitted for inclusion in our Proxy Statement, our bylaws require that the shareholder

give timely notice of the proposal or nomination, as applicable, to our Corporate Secretary at the address indicated below in advance of the

meeting. Such notice must be given no less than 90 days nor more than 120 days prior to the anniversary of the Annual Meeting unless the

date of the 2025 Annual Meeting is advanced by more than 30 days or delayed (other than as a result of adjournment) by more than 30

days from the anniversary of the Annual Meeting, in which case notice of a proposal or nomination, as applicable, must be delivered no

later than the close of business on the later of the 90th day prior to the 2025 Annual Meeting or the tenth day following the date on which

public announcement of the date of the 2025 Annual Meeting of Shareholders is first made. Accordingly, for the 2025 Annual Meeting,

notice of a proposal or nomination, as applicable, must be received by our Corporate Secretary no later than March 28, 2025 and no earlier

than February 26, 2025. The notice of such proposal or nomination must provide the information (which includes information required

under Rule 14a-19, the SEC’s universal proxy rule) set forth in and meet all other requirements contained in our bylaws. If a shareholder

fails to meet these requirements or fails to satisfy the requirements of Rule 14a-4 under the Exchange Act, we may exercise discretionary

voting authority under proxies that we solicit to vote on any such proposal or nomination in accordance with our best judgment.

All notices of proposals or nominations, as applicable, must be given in writing to our Corporate Secretary by overnight mail, acceptance

signature required, to United Therapeutics Corporation, Attention: Corporate Secretary, 1735 Connecticut Avenue N.W., Washington,

D.C. 20009.

Other Matters

2024 Proxy Statement 91

Other Business

Management knows of no matters to be presented for action at the Annual Meeting other than as described above. However, if any other

matter properly comes before the meeting, it is intended that the persons named in the accompanying form of proxy will vote on such

matters in accordance with their judgment of the best interests of our company.

Shareholders Sharing the Same Address

SEC rules permit the delivery of a single copy of a company’s annual report and Proxy Statement, or Notice of Internet Availability, as

applicable, to any household at which two or more shareholders reside. Each shareholder will continue to receive a separate proxy card.

This procedure, referred to as householding, reduces the volume of duplicate information shareholders receive, reduces mailing and

printing expenses, and benefits the environment.

The bank, broker, trust, or other holder of record for any shareholder who is a beneficial owner, but not the record holder, of United

Therapeutics shares may deliver only one copy of our 2023 Annual Report on Form 10-K and this Proxy Statement, or one copy of the

Notice of Internet Availability, as applicable, to multiple shareholders who share the same address, unless the bank, broker, trust, or other

holder of record has received contrary instructions from one or more of the shareholders. Beneficial owners sharing an address who are

receiving multiple copies of the 2023 Annual Report on Form 10-K and this Proxy Statement, or the Notice of Internet Availability, as

applicable, and who would prefer to receive a single copy in the future should contact their bank, broker, trust, or other holder of record to

request delivery of a single copy in the future.

Our 2023 Annual Report on Form 10-K and this Proxy Statement are available at our website at ir.unither.com/annual-and-proxy. We will

deliver promptly upon written or oral request a separate copy of the 2023 Annual Report on Form 10-K and this Proxy Statement, or the

Notice of Internet Availability, as applicable, to any shareholder of record at a shared address to which a single copy of any of those

documents was delivered. To receive a separate copy of these materials, now or in the future, write to: Investor Relations, 1000 Spring

Street, Silver Spring, Maryland 20910 or call (301) 608-9292 and ask for Investor Relations. Shareholders of record sharing an address

who are receiving multiple copies of proxy materials and annual reports and wish to receive a single copy of such materials in the future

should submit their request by contacting us in the same manner.

Annual Report

A copy of our Annual Report on Form 10-K for the year ended December 31, 2023, has been delivered or made available concurrently with

this Proxy Statement to all shareholders entitled to notice of and to vote at our Annual Meeting. The Annual Report is not incorporated into

this Proxy Statement and is not considered proxy soliciting material. Shareholders may obtain printed copies of our Annual Report on

Form 10-K for the year ended December 31, 2023, as filed with the SEC, without charge by mailing a request to United

Therapeutics Corporation, Attention: Investor Relations, 1000 Spring Street, Silver Spring, Maryland 20910. Our copying costs

will be charged if copies of exhibits to the Annual Report on Form 10-K are requested. An electronic copy is available on our

website: ir.unither.com/annual-and-proxy.

Other Matters

92 United Therapeutics, a public benefit corporation

INFORMATION ABOUT THE MEETING,

VOTING, AND PROXIES

Attending the Annual Meeting

This year’s Annual Meeting will be held solely online as a virtual live audio webcast on Wednesday, June 26, 2024, beginning at 10:30 a.m.

Eastern Time, and will be accessible through the Internet at virtualshareholdermeeting.com/UTHR2024. A virtual format will enable

shareholders to participate from any location and at no cost, while safeguarding the health of our shareholders, management, and Board.

Information regarding how shareholders can attend the meeting, vote their shares, and submit questions is provided below.

Admission. The Annual Meeting is limited to shareholders of United Therapeutics as of April 29, 2024 (the Record Date) or holders of a

valid proxy for the Annual Meeting. In order to be admitted to the Annual Meeting online, you must enter the 16-digit control number

provided in the Notice of Internet Availability, proxy card, or voting instruction form. To avoid any delay due to technical issues, we

encourage shareholders to log in to the website and access the webcast 15 minutes before the virtual Annual Meeting’s start time. To

attend the meeting online, vote your shares electronically, submit questions, go to virtualshareholdermeeting.com/UTHR2024. Our list of

shareholders as of the Record Date will also be available for inspection for the ten days prior to the Annual Meeting. To inspect the list,

please email our Investor Relations department at IR@unither.com.

Questions. The Annual Meeting will include a question and answer session, and you may submit appropriate questions before and

live during the Annual Meeting. Questions may be submitted in advance at investorvote.com/uthr after logging in with your unique control

number provided in your Notice. Questions may also be submitted during the Annual Meeting through virtualshareholdermeeting.com/

UTHR2024. We will address questions during the Q&A session portion of the Annual Meeting. We will try to answer as many

stockholder-submitted questions that comply with the meeting rules of conduct as time permits. However, we reserve the right to edit

profanity or other inappropriate language, or to exclude questions that are not pertinent to meeting matters or that are otherwise

inappropriate. If we receive substantially similar questions, we will summarize such questions and provide a single response to avoid

repetition. We will post questions and answers on our website shortly after the Annual Meeting.

Control Number. If you are a shareholder of record (your shares are held directly in your name on our stock records and you have the

right to vote your shares yourself or by proxy at the Annual Meeting), your valid control number is a 16-digit control number provided in

your Notice of Internet Availability or proxy card. You will need your valid 16-digit control number to login to the virtual annual meeting

website at virtualshareholdermeeting.com/UTHR2024, and attend the virtual meeting as a shareholder, including in order to vote and ask

questions during the Annual Meeting. If your shares are held beneficially in the name of a bank, broker or other holder of record

(sometimes referred to as holding shares “in street name”), and your voting instruction form or Notice of Internet Availability indicates that

you may vote those shares through the www.proxyvote.com website, then you may access, participate in, and vote at the Annual Meeting

with the 16-digit access code indicated on that voting instruction form or Notice of Internet Availability. Otherwise, you should contact your

bank, broker or other nominee (preferably at least five days before the Annual Meeting) and obtain a “legal proxy” in order to be able to

attend, participate in or vote at the Annual Meeting.

Technical Support. For help with technical difficulties on the meeting day, phone numbers to call for assistance will be available on the log

in page (virtualshareholdermeeting.com/UTHR2024) Technical support will be available starting at 9:45 a.m. Eastern Time and until the

meeting has finished.

Future Meetings. Future Annual Meetings may be held virtually or in person in various locations, including without limitation locations

where United Therapeutics has operations.

General

This Proxy Statement and the accompanying proxy card are being furnished to shareholders of United Therapeutics Corporation in

connection with the solicitation by our Board of Directors of proxies to be voted at our 2024 Annual Meeting of Shareholders and any

adjournment or postponement thereof. Proxy materials or a Notice of Internet Availability of Proxy Materials are first being sent to

shareholders on or about April 29, 2024. The mailing address of our principle executive offices is 1000 Spring Street, Silver Spring,

Maryland 20910.

Record Date and Outstanding Shares

On the Record Date, there were approximately 44,366,494 shares of our common stock outstanding and entitled to vote at our Annual

Meeting. Only shareholders of record on the Record Date will be entitled to vote, either online or by proxy, at our Annual Meeting, and each

share will have one vote for each director nominee and one vote for each other matter to be voted on.

2024 Proxy Statement 93

Internet Availability of Proxy Materials

As permitted by the rules of the Securities and Exchange Commission, we are making our proxy materials available to shareholders

primarily via the Internet, rather than mailing printed copies of these materials to shareholders. On or about April 29, 2024, we are sending

to many of our shareholders a Notice containing instructions on how to access and review our proxy materials, including our Proxy

Statement and our 2023 Annual Report on Form 10-K, and vote online.

This process is designed to expedite shareholders’ receipt of proxy materials, lower the cost of the Annual Meeting, and help conserve

natural resources. If you received a Notice by mail, you will not receive a printed copy of the proxy materials unless you request one. If you

would prefer to receive printed proxy materials, please follow the instructions included in the Notice. Shareholders who requested paper

copies of the proxy materials did not receive the Notice and will receive the proxy materials in the format requested.

Solicitation

We will bear the cost of soliciting proxies. Our directors, officers, and employees may solicit proxies in person or by telephone, fax, email,

or regular mail, and they will receive no additional compensation for such work. Copies of solicitation materials may be furnished to

brokers, custodians, nominees, and other fiduciaries for forwarding to beneficial owners of shares of our common stock held in street

name, and normal handling charges may be paid for such forwarding service. We have also retained Georgeson Inc. to assist in soliciting

proxies for a fee of approximately $12,000 plus customary expenses.

Voting Rights and Quorum

Shares can be voted at our Annual Meeting only by shareholders who are present online at our virtual Annual Meeting or represented by

proxy. Whether or not you plan to attend our Annual Meeting online, you are encouraged to vote your shares. The representation online at

the virtual Annual Meeting or by proxy of at least a majority of the outstanding shares entitled to vote is necessary to achieve a quorum for

the transaction of business at the Annual Meeting.

If you are a shareholder of record, you may revoke any proxy given pursuant to this solicitation at any time before it is exercised at

the Annual Meeting by delivering to the Corporate Secretary of United Therapeutics Corporation at 1735 Connecticut Avenue N.W.,

Washington, D.C. 20009, a written notice of revocation or a fully executed proxy bearing a later date, voting online before the meeting at

proxyvote.com at a date after the date of your previous proxy, or by attending the Annual Meeting and voting during the meeting at

virtualshareholdermeeting.com/UTHR2024. See the section entitled Attending the Annual Meeting for information regarding how to

attend the Annual Meeting online.

If you are a shareholder of record, your shares will not be voted if you do not provide a proxy or attend the Annual Meeting. “Broker

non-votes” occur for shares held by brokers, banks, trusts, or other nominees that are represented at the meeting but with respect to which

they have no discretionary power to vote on a particular matter and have received no instructions from the beneficial owners thereof.

Proposal No. 4 (ratification of the appointment of our independent registered public accounting firm) is expected to be the only proposal

with respect to which brokerage firms will be permitted, but not required, to exercise discretion. Brokers are not expected to be able to

exercise discretionary authority regarding Proposals No. 1, 2, and 3. Abstentions and broker non-votes will be counted as present in

determining whether the quorum requirement is satisfied. Even with respect to matters where brokers may otherwise have the ability to

exercise discretionary voting, some brokers are choosing not to exercise discretionary voting authority. As a result, we urge you to direct

your broker, bank, trustee or other nominee how to vote your shares on all proposals to ensure that your vote is counted.

Proxy

If the enclosed proxy card is properly executed and returned prior to the Annual Meeting, the shares represented by the proxy card will be

voted in accordance with the shareholder’s directions. If the proxy card is signed and returned without any direction given, shares of our

common stock represented by the proxy will be voted in accordance with our Board’s recommendations as follows: (1) FOR the election of

each of the director nominees named on the proxy card; (2) FOR the advisory resolution to approve executive compensation; (3) FOR the

amendment and restatement of the United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan; and (4) FOR the

ratification of the appointment of EY as our independent registered public accounting firm for 2024. Each shareholder may appoint only one

proxy holder or representative to attend the Annual Meeting on his or her behalf.

Information About the Meeting, Voting, and Proxies

94 United Therapeutics, a public benefit corporation

ANNEX A - UNITED THERAPEUTICS

CORPORATION AMENDED AND RESTATED

2015 STOCK INCENTIVE PLAN

(effective June 26, 2024)

1. Purpose

The purpose of the United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan (this “Plan”) is to advance the

interests of United Therapeutics Corporation (the “Company”) by stimulating the efforts of employees, officers, non-employee directors and

other service providers, in each case who are selected to be participants, by heightening the desire of such persons to continue working

toward and contributing to the success and progress of the Company. This Plan amends and restates, effective June 26, 2024 (the

“Effective Date”), the Amended and Restated United Therapeutics Corporation 2015 Stock Incentive Plan, which was approved by

stockholders on June 26, 2023. The United Therapeutics Corporation 2015 Stock Incentive Plan was first approved by shareholders on

June 26, 2015 (the “Original Effective Date”), and superseded the Company’s Amended and Restated Equity Incentive Plan (as amended

effective as of September 24, 2004) (the “Prior Plan”). This Plan provides for the grant of Incentive and Nonqualified Stock Options, Stock

Appreciation Rights, Restricted Stock, Restricted Stock Units and Stock Awards, any of which may be performance-based, and for

Incentive Bonuses, which may be paid in cash or stock or a combination thereof, as determined by the Administrator. No new awards were

to be issued under the Prior Plan following the Original Effective Date, but outstanding awards under the Prior Plan as of the Original

Effective Date shall continue to be governed by the Prior Plan. The Plan is hereby amended and restated effective as of the Effective Date

to increase the number of Shares issuable pursuant to Awards.

2. Definitions

As used in the Plan, the following terms shall have the meanings set forth below:

(a)“Act” means the Securities Exchange Act of 1934, as amended.

(b)“Administrator” means the Administrator of the Plan in accordance with Section 19.

(c)“Affiliate” means, with respect to any entity, any other corporation, organization, association, partnership, sole proprietorship or other

type of entity, whether incorporated or unincorporated, directly or indirectly controlling or controlled by or under direct or indirect

common control with such entity.

(d)“Award” means an Incentive Stock Option, Nonqualified Stock Option, Stock Appreciation Right, Restricted Stock, Restricted Stock

Unit, Stock Award or Incentive Bonus granted to a Participant pursuant to the provisions of the Plan, any of which the Administrator

may structure to qualify in whole or in part as a Performance Award.

(e)“Award Agreement” means a written agreement or other instrument as may be approved from time to time by the Administrator

implementing the grant of each Award. An Agreement may be in the form of an agreement to be executed by both the Participant and

the Company (or an authorized representative of the Company) or certificates, notices or similar instruments as approved by

the Administrator.

(f)“Board” means the board of directors of the Company.

(g)“Cause” has the meaning specified in the Participant’s employment agreement (if any) or otherwise means (1) any act of personal

dishonesty taken by the Participant in connection with their responsibilities as an employee or other service provider and intended to

result in substantial personal enrichment of the Participant; (2) the Participant’s conviction of a felony; (3) an act by the Participant

which constitutes willful or gross misconduct and which is demonstrably and materially injurious to the Company; or (4) continued

substantial willful violations by the Participant of the Participant’s duties after there has been delivered to the Participant a written

demand for performance from the Company which specifically sets forth the factual basis for the Company’s belief that the Participant

has not substantially performed their duties.

(h)“Change in Control” means, and shall be deemed to have occurred:

(1)if any person or group (as used in Section 13(d) of the Act) (other than the Company, any trustee or other fiduciary holding

securities under an employee benefit plan of the Company, or any company owned, directly or indirectly, by the shareholders of

the Company in substantially the same proportions as their ownership of stock of the Company) becomes the “beneficial

owner” (as defined in Rule 13d-3 under the Act) of securities of the Company representing more than 30% of (a) the Shares then

outstanding or (b) the combined voting power (other than in the election of directors) of all voting securities of the Company then

outstanding; or

2024 Proxy Statement A-1

(2)if, during any period of 24 consecutive months, individuals who at the beginning of such period constituted the Board, and any

director whose election or nomination for election by the Company’s shareholders was approved by a vote of at least two-thirds

(2/3) of the directors then still in office who either were directors at the beginning of the period or whose election or nomination for

election was previously so approved (the “Incumbent Board”), cease for any reason (other than death or disability) to constitute at

least a majority thereof; or

(3)upon the consummation of a reorganization, merger, statutory share exchange or consolidation or similar transaction involving

the Company or any of its subsidiaries unless, following such event, (A) all or substantially all of the individuals and entities that

were the beneficial owners of the Company’s common stock or the combined voting power of all voting securities of the Company

immediately prior to such transaction beneficially own, directly or indirectly, more than 50% of the then-outstanding shares of

common stock (or, for a non-corporate entity, equivalent securities) and the combined voting power of the then-outstanding

voting securities entitled to vote generally in the election of directors (or, for a non-corporate entity, equivalent governing body),

as the case may be, of the entity resulting from such transaction (including, without limitation, an entity that, as a result of such

transaction, owns the Company either directly or through one or more subsidiaries) in substantially the same proportions as their

ownership immediately prior to such transaction of the Company’s common stock or voting securities, as the case may be, (B) no

person (excluding any corporation resulting from such transaction or any employee benefit plan (or related trust) of the Company

or such corporation resulting from such transaction) beneficially owns, directly or indirectly, 30% or more of, respectively, the

then-outstanding shares of common stock of the corporation resulting from such transaction or the combined voting power of the

then-outstanding voting securities of such corporation, except to the extent that such ownership existed prior to the transaction,

and (C) at least a majority of the members of the board of directors (or, for a non-corporate entity, equivalent governing body) of

the entity resulting from such transaction were members of the Incumbent Board at the time of the execution of the initial

agreement or of the action of the Board providing for such transaction; or

(4)upon the complete liquidation of the Company or the sale or disposition by the Company of all or substantially all of the

Company’s assets, other than a liquidation of the Company into a wholly-owned subsidiary.

(i)“Code” means the Internal Revenue Code of 1986, as amended from time to time, and the rulings and regulations issued thereunder.

(j)“Company” means United Therapeutics Corporation.

(k)“Disability” means, in the Company’s reasonable judgment, either (a) the Participant has been unable to perform the Participant’s

duties because of a physical or mental impairment for 80% or more of the normal working days during six consecutive calendar

months or 50% or more of the normal working days during twelve consecutive calendar months, or (b) the Participant has become

totally and permanently incapable of performing the usual duties of their employment with the Company on account of a physical or

mental impairment.

(l)“Fair Market Value” means, as of any date, the closing price of a Share on the principal exchange on which Shares are then trading, if

any (or as reported on any composite index which includes such principal exchange). If Shares are not traded as of a particular date,

the Fair Market Value of a Share as of such date shall be the closing price on the preceding trading date. If Shares not publicly traded

on an exchange and not quoted on Nasdaq or a successor quotation system, the Fair Market Value of a Share shall be established by

the Administrator in good faith.

(m)“Incentive Bonus” means a bonus opportunity awarded under Section 10 pursuant to which a Participant may become entitled to

receive an amount based on satisfaction of such performance criteria as are specified in the Award Agreement or otherwise.

(n)“Incentive Stock Option” means a stock option that is intended to qualify as an “incentive stock option” within the meaning of

Section 422 of the Code.

(o)“Nonemployee Director” means each person who is, or is elected to be, a member of the Board and who is not an employee of the

Company or any Subsidiary.

(p)“Nonqualified Stock Option” means a stock option that is not intended to qualify as an “incentive stock option” within the meaning of

Section 422 of the Code.

(q)“Option” means an Incentive Stock Option and/or a Nonqualified Stock Option granted pursuant to Section 6 of the Plan.

(r)“Participant” means any individual described in Section 3 to whom Awards have been granted from time to time by the Administrator

and any authorized transferee of such individual.

(s)“Person” has the same meaning as set forth in Sections 13(d) and 14(d)(2) of the Act.

(t)“Performance Award” means an Award, the grant, issuance, retention, vesting or settlement of which is subject to satisfaction of one

or more Qualifying Performance Criteria established pursuant to Section 14.

(u)“Plan” means the 2015 United Therapeutics Corporation Stock Incentive Plan as set forth herein and as amended from time to time.

(v)“Qualifying Performance Criteria” has the meaning set forth in Section 14(b).

(w)“Restricted Stock” means Shares granted pursuant to Section 8 of the Plan.

(x)“Restricted Stock Unit” means an Award granted to a Participant pursuant to Section 8 pursuant to which Shares or cash in lieu

thereof may be issued in the future.

(y)“Share” means a share of the Company’s par value common stock, subject to adjustment as provided in Section 13.

Annex A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

A-2 United Therapeutics, a public benefit corporation

(z)“Stock Appreciation Right” means a right granted pursuant to Section 7 of the Plan that entitles the Participant to receive, in cash or

Shares or a combination thereof, as determined by the Administrator, value equal to or otherwise based on the excess of (i) the Fair

Market Value of a specified number of Shares at the time of exercise over (ii) the exercise price of the right, as established by the

Administrator on the date of grant.

(aa)“Stock Award” means an award of Shares to a Participant pursuant to Section 9 of the Plan.

(ab)“Subsidiary” means any corporation (other than the Company), limited liability company or other form of entity in an unbroken chain of

entities beginning with the Company where each of the entities in the unbroken chain other than the last entity owns stock possessing

at least 50 percent or more of the total combined voting power of all classes of stock in one of the other entities in the chain, and if

specifically determined by the Administrator in the context other than with respect to Incentive Stock Options, may include an entity in

which the Company has a significant ownership interest or that is directly or indirectly controlled by the Company.

(ac)“Substitute Awards” means Awards granted or Shares issued by the Company in assumption of, or in substitution or exchange for,

awards previously granted, or the right or obligation to make future awards, by a company acquired by the Company or any

Subsidiary or with which the Company or any Subsidiary combines.

(ad)“Termination of Employment” means ceasing to serve as an employee of the Company and its Subsidiaries or, with respect to a

Nonemployee Director or other non-employee service provider, ceasing to serve as such for the Company, except that with respect to

all or any Awards held by a Participant (i) the Administrator may determine that a transition of employment to service with a

partnership, joint venture or corporation not meeting the requirements of a Subsidiary in which the Company or a Subsidiary is a party

is not considered a Termination of Employment, (ii) unless otherwise determined by the Administrator, service as a member of the

Board or other service provider shall not be deemed to constitute continued employment with respect to Awards granted to a

Participant while they served as an employee, (iii) service as an employee of the Company or a Subsidiary shall constitute continued

employment with respect to Awards granted to a Participant while they served as a member of the Board or other service provider,

and (iv) the Administrator may determine that an approved leave of absence or approved employment on a less than full-time basis is

considered a Termination of Employment. The Administrator shall determine whether any corporate transaction, such as a sale or

spin-off of a division or subsidiary that employs a Participant, shall be deemed to result in a Termination of Employment with the

Company and its Subsidiaries for purposes of any affected Participant’s Awards, and the Administrator’s decision shall be final

and binding.

3. Eligibility

Any person who is a current or prospective officer or employee of the Company or of any Subsidiary shall be eligible for selection by the

Administrator for the grant of Awards hereunder. In addition, Nonemployee Directors and any other service providers who have been

retained to provide consulting, advisory or other services to the Company or to any Subsidiary shall be eligible for the grant of Awards

hereunder as determined by the Administrator. Options intended to qualify as Incentive Stock Options may only be granted to employees

of the Company or any Subsidiary, as selected by the Administrator.

4. Effective Date and Termination of Plan

The United Therapeutics Corporation 2015 Stock Incentive Plan was originally adopted by the Board as of April 29, 2015 and approved by

shareholders on the Original Effective Date. This Plan hereby amends and restates the Plan as previously amended and restated effective

as of June 26, 2023 as of the Effective Date. All Awards granted under this Plan in excess of the aggregate limitation approved by

shareholders at the 2023 annual meeting of shareholders are subject to, and may not be exercised before, the approval of this Plan by the

shareholders prior to the first anniversary of the date the Board adopts the Plan, by the affirmative vote of the holders of a majority of the

outstanding Shares of the Company present, or represented by proxy, and entitled to vote, at a meeting of the Company’s shareholders or

by written consent in accordance with the laws of the State of Delaware; provided that if such approval by the shareholders of the

Company is not forthcoming, all Awards previously granted under this Plan in excess of the aggregate limitation approved by shareholders

at the 2023 annual meeting of shareholders shall be void. The Plan shall remain available for the grant of Awards until April 25, 2034.

Notwithstanding the foregoing, the Plan may be terminated at such earlier time as the Board may determine. Termination of the Plan will

not affect the rights and obligations of the Participants and the Company arising under Awards theretofore granted and then in effect.

5. Shares Subject to the Plan and to Awards

(a)Aggregate Limits. The aggregate number of Shares issuable pursuant to all Awards shall not exceed 13,820,000; provided that (i) any

Shares granted under Options or Stock Appreciation Rights shall be counted against this limit on a one-for-one basis; (ii) any Shares

granted prior to March 17, 2020, as Awards other than Options or Stock Appreciation Rights shall be counted against this limit as 2.14

Shares for every one (1) Share subject to such Award; and (iii) any Shares granted on or after March 17, 2020, as Awards other than

Options or Stock Appreciation Rights shall be counted against this limit as 1.35 Shares for every one (1) Share subject to such Award.

The aggregate number of Shares available for grant under this Plan and the number of Shares subject to outstanding Awards shall be

subject to adjustment as provided in Section 13. The Shares issued pursuant to Awards granted under this Plan may be shares that

are authorized and unissued or shares that were reacquired by the Company, including shares purchased in the open market.

Annex  A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

2024 Proxy Statement A-3

(b)Issuance of Shares. For purposes of Section 5(a), the aggregate number of Shares issued under this Plan at any time shall equal only

the number of Shares actually issued upon exercise or settlement of an Award. Notwithstanding the foregoing, Shares subject to an

Award under the Plan may not again be made available for issuance under the Plan if such Shares are: (i) Shares that were subject to

a stock-settled Stock Appreciation Right and were not issued upon the net settlement or net exercise of such Stock Appreciation

Right, (ii) Shares used to pay the exercise price of an Option, (iii) Shares delivered to or withheld by the Company to pay the

withholding taxes related to an Award, or (iv) Shares repurchased on the open market with the proceeds of an Option exercise.

Shares subject to Awards that have been canceled, expired, forfeited or otherwise not issued under an Award and Shares subject to

Awards settled in cash shall not count as Shares issued under this Plan. Any Shares that were subject to Options or Stock

Appreciation Rights and that again become available for Awards under the Plan pursuant to this Section shall be added as one (1)

Share for every one (1) Share subject to such Options or Stock Appreciation Rights. Any Shares that were subject to Awards other

than Options or Stock Appreciation Rights that again become available for Awards under the Plan pursuant to this Section shall (i)

prior to March 17, 2020 be added as 2.14 Shares for every one (1) Share subject to such Awards; and (ii) from and after March 17,

2020, be added as 1.35 Shares for every one (1) Share subject to such Awards.

(c)Individual and Tax Code Limits. The aggregate number of Shares subject to Awards granted under this Plan during any calendar year

to any one Participant shall not exceed 1,000,000, which number shall be calculated and adjusted pursuant to Section 13, but which

number shall not count any tandem SARs (as defined in Section 7). The aggregate number of Shares that may be issued pursuant to

the exercise of Incentive Stock Options granted under this Plan shall not exceed 13,820,000, which number shall be calculated and

adjusted pursuant to Section 13 only to the extent that such calculation or adjustment will not affect the status of any option intended

to qualify as an Incentive Stock Option under Section 422 of the Code. The maximum cash amount payable pursuant to that portion of

an Incentive Bonus granted in any calendar year to any Participant under this Plan shall not exceed $5,000,000.

(d)Director Awards.

(1)The aggregate dollar value of Awards (based on the aggregate accounting value on the date of grant) granted pursuant to this

Plan during any calendar year to any Nonemployee Director shall not exceed $400,000 for annual equity grants (plus, for the

year an individual first becomes a Nonemployee Director (x) an initial equity grant valued at $400,000, plus (y) a pro-rata portion

of the $400,000 annual equity-based award value based on the number of months remaining in the Board service year at the

date of grant), payable in Options, Restricted Stock Units, or a split evenly between Options and Restricted Stock Units, based on

an election by the Nonemployee Director. Such dollar limits shall be converted into a number of Awards as follows, unless the

Administrator determines otherwise:

(A)Options: The number of Options shall be calculated by dividing the equity value (e.g., $400,000) by the fair value of each

Option, calculated in accordance with the Black-Scholes methodology utilized by the Company in calculating share-based

compensation for financial reporting purposes. Black-Scholes inputs shall be the same as those used in the Company’s

most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K, except that the Share price input shall be the

closing price of the Shares on the date of grant, or on the preceding trading day of the award is granted on a date when the

Nasdaq is not open.

(B)Restricted Stock Units: The number of Restricted Stock Units shall be calculated by dividing the equity value (e.g.,

$400,000) by the average closing price of the Shares on the date of grant, or on the preceding trading day if the award is

granted on a date when the Nasdaq is not open.

(C)Rounding: The resulting number of Options and/or Restricted Stock Units, calculated as above, shall be rounded to the

nearest 10 Shares.

(2)In addition, the amount of cash compensation paid or payable by the Company to a Nonemployee Director with respect to any

calendar year shall not exceed $60,000 (with additional cash compensation of $35,000 for the lead independent director, $25,000

for each committee chair, and $15,000 for each other committee membership), plus a pro-rated portion of the aggregate cash

compensation for the roles in which the Nonemployee Director serves for the year an individual first becomes a Nonemployee

Director, to reflect the number of months then remaining in the Board service year as of the date the individual becomes a

Nonemployee Director. Nonemployee Directors may also be compensated for special assignments from the Board, in an amount

not to exceed $50,000 per individual director, per annum. For the avoidance of doubt, cash compensation shall be counted

towards the limit specified in this subclause in the year earned (regardless of whether deferred), and any interest or other

earnings on such compensation shall not count towards the limit.

(e)Substitute Awards. Substitute Awards shall not reduce the Shares authorized for issuance under the Plan or authorized for grant to a

Participant in any calendar year. Additionally, in the event that a company acquired by the Company or any Subsidiary, or with which

the Company or any Subsidiary combines, has shares available under a pre-existing plan approved by shareholders and not adopted

in contemplation of such acquisition or combination, the shares available for grant pursuant to the terms of such pre-existing plan (as

adjusted, to the extent appropriate, using the exchange ratio or other adjustment or valuation ratio or formula used in such acquisition

or combination to determine the consideration payable to the holders of common stock of the entities party to such acquisition or

combination) may be used for Awards under the Plan and shall not reduce the Shares authorized for issuance under the Plan;

provided that Awards using such available shares shall not be made after the date awards or grants could have been made under the

terms of the pre-existing plan, absent the acquisition or combination, and shall only be made to individuals who were employees,

directors or other service providers of such acquired or combined company before such acquisition or combination.

Annex A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

A-4 United Therapeutics, a public benefit corporation

6. Options

(a)Option Awards. Options may be granted at any time and from time to time prior to the termination of the Plan to Participants as

determined by the Administrator. No Participant shall have any rights as a shareholder with respect to any Shares subject to Options

hereunder until said Shares have been issued, including, for avoidance of doubt, no voting rights and no rights to receive dividends,

distributions or dividend equivalents in respect of an Option or any Shares subject to an Option until the Participant has become the

holder of record of such Shares. Each Option shall be evidenced by an Award Agreement. Options granted pursuant to the Plan need

not be identical but each Option must contain and be subject to the terms and conditions set forth below.

(b)Price. The Administrator will establish the exercise price per Share under each Option, which, in no event will be less than the Fair

Market Value of the Shares on the date of grant; provided, however, that the exercise price per Share with respect to an Option that is

granted in connection with a merger or other acquisition as a substitute or replacement award for options held by optionees of the

acquired entity may be less than 100% of the Fair Market Value of the Shares on the date such Option is granted if such exercise

price is based on a formula set forth in the terms of the options held by such optionees or in the terms of the agreement providing for

such merger or other acquisition. The exercise price of any Option may be paid in Shares, cash or a combination thereof, as

determined by the Administrator, including an irrevocable commitment by a broker to pay over such amount from a sale of the Shares

issuable under an Option, the delivery of previously owned Shares and withholding of Shares deliverable upon exercise, or in such

other form as is acceptable to the Administrator.

(c)Provisions Applicable to Options. The date on which Options become exercisable shall be determined at the sole and absolute

discretion of the Administrator and set forth in an Award Agreement. However, in no event shall any Option vest before the first

anniversary of the date of grant; provided that, if so determined by the Administrator, an Option may fully or partially vest before such

anniversary in the event of the Participant’s death or disability or a Change in Control; and provided further, that (i) Options granted to

Nonemployee Directors may become fully vested on the earlier to occur of (x) the first anniversary of the date of grant; or (y) the date

of the next Annual Meeting of Shareholders following the date of grant; provided, however, that such Options shall not vest earlier

than 50 weeks following the date of grant; and (ii) up to 5% of the aggregate number of Shares authorized for issuance under this

Plan may be issued pursuant to Awards subject to any, or no, vesting conditions, as the Administrator deems appropriate. Unless

otherwise determined by the Administrator, an approved leave of absence or employment on a less than full-time basis shall not result

in an adjustment to the vesting period and/or exercisability of an Option to reflect the effects of any period during which the Participant

is on an approved leave of absence or is employed on a less than full-time basis. In no event may any Option include a reload feature.

(d)Term of Options and Termination of Employment. The Administrator shall establish the term of each Option, which in no case shall

exceed a period of ten (10) years from the date of grant. Unless an Option earlier expires upon the expiration date established

pursuant to the foregoing sentence, upon the Participant’s Termination of Employment, their rights to exercise an Option then held

shall be only as follows, unless the Administrator specifies otherwise:

(1)General. If a Participant’s Termination of Employment is for any reason other than the Participant’s death, Disability, or

termination for Cause, Options granted to the Participant may continue to be exercised in accordance with their terms for a period

of ninety (90) days after such Termination of Employment, but only to the extent the Participant was entitled to exercise the

Options on the date of such termination.

(2)Death. If a Participant dies either while an employee or officer of the Company or a Subsidiary or member of the Board, or after

the Termination of Employment other than for Cause but during the time when the Participant could have exercised an Option,

the Options issued to such Participant shall become fully vested and exercisable by the personal representative of such

Participant or other successor to the interest of the Participant for one year after the Participant’s death.

(3)Disability. If a Participant’s Termination of Employment is due to Disability, then all of the Participant’s Options shall immediately

fully vest, and the Options held by the Participant at the time of such Termination of Employment shall be exercisable by the

Participant or the personal representative of such Participant for one year following such Termination of Employment.

(4)Termination for Cause. If a Participant is terminated for Cause, the Participant shall have no further right to exercise any Options

previously granted. The Administrator or one or more officers designated by the Administrator shall determine whether a

termination is for Cause.

(e)Incentive Stock Options. Notwithstanding anything to the contrary in this Section 6, in the case of the grant of an Option intending to

qualify as an Incentive Stock Option: (i) if the Participant owns stock possessing more than 10 percent of the combined voting power

of all classes of stock of the Company, the exercise price of such Option must be at least 110 percent of the Fair Market Value of the

Shares on the date of grant and the Option must expire within a period of not more than five (5) years from the date of grant, and

(ii) Termination of Employment will occur when the person to whom an Award was granted ceases to be an employee (as determined

in accordance with Section 3401(c) of the Code and the regulations promulgated thereunder) of the Company and its corporate

Subsidiaries. Notwithstanding anything in this Section 6 to the contrary, options designated as Incentive Stock Options shall not be

eligible for treatment under the Code as Incentive Stock Options (and will be deemed to be Nonqualified Stock Options) to the extent

that either (a) the aggregate Fair Market Value of Shares (determined as of the time of grant) with respect to which such Options are

exercisable for the first time by the Participant during any calendar year (under all plans of the Company and any corporate

Subsidiary) exceeds $100,000, taking Options into account in the order in which they were granted, or (b) such Options otherwise

remain exercisable but are not exercised within three (3) months of Termination of Employment (or such other period of time provided

in Section 422 of the Code).

Annex  A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

2024 Proxy Statement A-5

7. Stock Appreciation Rights

Stock Appreciation Rights may be granted to Participants from time to time either in tandem with or as a component of other Awards

granted under the Plan (“tandem SARs”) or not in conjunction with other Awards (“freestanding SARs”) and may, but need not, relate to a

specific Option granted under Section 6. The provisions of Stock Appreciation Rights need not be the same with respect to each grant or

each recipient. Any Stock Appreciation Right granted in tandem with an Award may be granted at the same time such Award is granted or

at any time thereafter before exercise or expiration of such Award. All freestanding SARs shall be granted subject to the same terms and

conditions applicable to Options as set forth in Section 6 (including, without limitation, the vesting provisions of Section 6(c)) and all tandem

SARs shall have the same exercise price, vesting, exercisability, forfeiture and termination provisions as the Award to which they relate.

Subject to the provisions of Section 6 and the immediately preceding sentence, the Administrator may impose such other conditions or

restrictions on any Stock Appreciation Right as it shall deem appropriate. Participants shall have no voting rights and will have no rights to

receive dividends, distributions or dividend equivalents in respect of Stock Appreciation Rights or any Shares subject to Stock Appreciation

Rights until the Participant has become the holder of record of such Shares. Stock Appreciation Rights may be settled in Shares, cash or a

combination thereof, as determined by the Administrator and set forth in the applicable Award Agreement.

8. Restricted Stock and Restricted Stock Units

(a)Restricted Stock and Restricted Stock Unit Awards. Restricted Stock and Restricted Stock Units may be granted at any time and

from time to time prior to the termination of the Plan to Participants as determined by the Administrator. Restricted Stock is an award

or issuance of Shares the grant, issuance, retention, vesting and/or transferability of which is subject during specified periods of time

to such conditions (including continued employment or performance conditions) and terms as the Administrator deems appropriate.

Restricted Stock Units are Awards denominated in units of Shares under which the issuance of Shares is subject to such conditions

(including continued employment or performance conditions) and terms as the Administrator deems appropriate. Each grant of

Restricted Stock and Restricted Stock Units shall be evidenced by an Award Agreement. Unless determined otherwise by the

Administrator, each Restricted Stock Unit will be equal to one Share and will entitle a Participant to either the issuance of Shares or

payment of an amount of cash determined with reference to the value of Shares. To the extent determined by the Administrator,

Restricted Stock and Restricted Stock Units may be satisfied or settled in Shares, cash or a combination thereof. Restricted Stock and

Restricted Stock Units granted pursuant to the Plan need not be identical but each grant of Restricted Stock and Restricted Stock

Units must contain and be subject to the terms and conditions set forth below.

(b)Contents of Agreement. Each Award Agreement shall contain provisions regarding (i) the number of Shares or Restricted Stock Units

subject to such Award or a formula for determining such number, (ii) the purchase price of the Shares, if any, and the means of

payment, (iii) the performance criteria, if any, and level of achievement versus these criteria that shall determine the number of Shares

or Restricted Stock Units granted, issued, retainable and/or vested, (iv) such terms and conditions on the grant, issuance, vesting and/

or forfeiture of the Shares or Restricted Stock Units as may be determined from time to time by the Administrator, (v) the term of the

performance period, if any, as to which performance will be measured for determining the number of such Shares or Restricted Stock

Units, and (vi) restrictions on the transferability of the Shares or Restricted Stock Units. Shares issued under a Restricted Stock Award

may be issued in the name of the Participant and held by the Participant or held by the Company, in each case as the Administrator

may provide.

(c)Vesting and Performance Criteria. The grant, issuance, retention, vesting and/or settlement of shares of Restricted Stock and

Restricted Stock Units will occur when and in such installments as the Administrator determines or under criteria the Administrator

establishes, which may include Qualifying Performance Criteria. However, in no event shall any shares of Restricted Stock or

Restricted Stock Units vest before the first anniversary of the date of grant; provided that, if so determined by the Administrator,

shares of Restricted Stock and Restricted Stock Units may fully or partially vest before such anniversary in the event of the

Participant’s death or disability or a Change in Control; and provided further, that (i) Restricted Stock Units granted to Nonemployee

Directors may become fully vested on the earlier to occur of (x) the first anniversary of the date of grant; or (y) the date of the next

Annual Meeting of Shareholders following the date of grant; provided, however, that such Restricted Stock Units shall not vest earlier

than 50 weeks following the date of grant; and (ii) up to 5% of the aggregate number of Shares authorized for issuance under this

Plan may be issued pursuant to Awards subject to any, or no, vesting conditions, as the Administrator deems appropriate.

(d)Termination of Employment. Unless the Administrator provides otherwise:

(i)General. In the event of Termination of Employment for any reason other than death or Disability, any Restricted Stock or

Restricted Stock Units still subject in full or in part to restrictions at the date of such Termination of Employment shall

automatically be forfeited and returned to the Company.

(ii)Death or Disability. In the event a Participant’s Termination of Employment is because of death or Disability, the restrictions

remaining on any or all Shares remaining subject to a Restricted Stock or Restricted Stock Unit Award shall lapse.

(e)Voting Rights. Unless otherwise determined by the Administrator, Participants holding shares of Restricted Stock granted hereunder

may exercise full voting rights with respect to those shares during the period of restriction. Participants shall have no voting rights with

respect to Shares underlying Restricted Stock Units unless and until such Shares are reflected as issued and outstanding shares on

the Company’s stock ledger.

(f)Dividends and Distributions. Participants in whose name Restricted Stock is granted shall be entitled to receive all dividends and

other distributions paid with respect to those Shares, unless determined otherwise by the Administrator. The Administrator will

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A-6 United Therapeutics, a public benefit corporation

determine whether any such dividends or distributions will be automatically reinvested in additional shares of Restricted Stock and

subject to the same restrictions on transferability as the Restricted Stock with respect to which they were distributed or whether such

dividends or distributions will be paid in cash. Shares underlying Restricted Stock Units shall be entitled to dividends or dividend

equivalents only to the extent provided by the Administrator. Notwithstanding anything herein to the contrary, in no event shall

dividends, distributions or dividend equivalents be currently payable with respect to unvested or unearned Restricted Stock and

Restricted Stock Unit awards.

(g)Payment of Restricted Stock Units. In all events, unless payment with respect to a Restricted Stock Unit is deferred in a manner

consistent with Section 409A of the Code, the Shares and/or cash underlying such Restricted Stock Unit shall be paid to the

Participant no later than two and one-half months following the end of the year in which the Restricted Stock Unit is no longer subject

to a substantial risk of forfeiture.

(h)Legending of Restricted Stock. The Administrator may also require that certificates representing shares of Restricted Stock be

retained and held in escrow by a designated employee or agent of the Company or any Subsidiary until any restrictions applicable to

shares of Restricted Stock so retained have been satisfied or lapsed. Any certificates evidencing shares of Restricted Stock awarded

pursuant to the Plan shall bear the following legend:

The shares represented by this certificate were issued subject to certain restrictions under the United Therapeutics Corporation

2015 Stock Incentive Plan (the “Plan”). This certificate is held subject to the terms and conditions contained in a restricted stock

agreement that includes a prohibition against the sale or transfer of the stock represented by this certificate except in compliance

with that agreement and that provides for forfeiture upon certain events. Copies of the Plan and the restricted stock agreement

are on file in the office of the Secretary of the Company.

9. Stock Awards

(a)Grant. Stock Awards may be granted at any time and from time to time prior to the termination of the Plan to Participants as

determined by the Administrator. Stock Awards shall be subject to such terms and conditions, consistent with the other provisions of

the Plan, as may be determined by the Administrator. However, in no event shall any Stock Award vest before the first anniversary of

the date of grant; provided that, if so determined by the Administrator, a Stock Award may fully or partially vest before such

anniversary in the event of the Participant’s death or disability or a Change in Control; and provided further, that (i) Stock Awards

granted to Nonemployee Directors may become fully vested on the earlier to occur of (x) the first anniversary of the date of grant; or

(y) the date of the next Annual Meeting of Shareholders following the date of grant; provided, however, that such Stock Awards shall

not vest earlier than 50 weeks following the date of grant; and (ii) up to 5% of the aggregate number of Shares authorized for issuance

under this Plan may be issued pursuant to Awards subject to any, or no, vesting conditions, as the Administrator deems appropriate.

(b)Rights as a Shareholder. A Participant shall have all voting, dividend, liquidation and other rights with respect to Shares issued to the

Participant as a Stock Award under this Section 9 upon the Participant becoming the holder of record of the Shares granted pursuant

to such Stock Award; provided, that the Administrator may impose such restrictions on the assignment or transfer of Shares awarded

pursuant to a Stock Award as it considers appropriate. Notwithstanding anything herein to the contrary, in no event shall dividends,

distributions or dividend equivalents be currently payable with respect to unvested or unearned Stock Awards.

10. Incentive Bonuses

(a)General. Each Incentive Bonus Award will confer upon the Participant the opportunity to earn a future payment tied to the level of

achievement with respect to one or more performance criteria established for a performance period of not less than one year.

(b)Incentive Bonus Document. Unless otherwise determined by the Administrator, the terms of any Incentive Bonus will be set forth in an

Award Agreement. Each Award Agreement evidencing an Incentive Bonus shall contain provisions regarding (i) the target and

maximum amount payable to the Participant as an Incentive Bonus, (ii) the performance criteria and level of achievement versus

these criteria that shall determine the amount of such payment, (iii) the term of the performance period as to which performance shall

be measured for determining the amount of any payment, (iv) the timing of any payment earned by virtue of performance,

(v) restrictions on the alienation or transfer of the Incentive Bonus prior to actual payment, (vi) forfeiture provisions and (vii) such

further terms and conditions, in each case not inconsistent with this Plan as may be determined from time to time by the Administrator.

(c)Performance Criteria. The Administrator shall establish the performance criteria and level of achievement versus these criteria that

shall determine the target and maximum amount payable under an Incentive Bonus, which criteria may be based on financial

performance and/or personal performance evaluations.

(d)Timing and Form of Payment. The Administrator shall determine the timing of payment of any Incentive Bonus. Payment of the

amount due under an Incentive Bonus may be made in cash or in Shares, as determined by the Administrator. No Participant shall

have any rights as a shareholder with respect to any Shares payable in respect of an Incentive Bonus until said Shares have been

issued, including, for avoidance of doubt, no voting rights and no rights to receive dividends, distributions or dividend equivalents in

respect of an Incentive Bonus or any Shares subject to an Incentive Bonus until the Participant has become the holder of record of

such Shares. The Administrator may provide for or, subject to such terms and conditions as the Administrator may specify, may permit

a Participant to elect for the payment of any Incentive Bonus to be deferred to a specified date or event. In all events, unless payment

of an Incentive Bonus is deferred in a manner consistent with Section 409A of the Code, any Incentive Bonus shall be paid to the

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2024 Proxy Statement A-7

Participant no later than two and one-half months following the end of the year in which the Incentive Bonus is no longer subject to a

substantial risk of forfeiture.

(e)Discretionary Adjustments. Notwithstanding satisfaction of any performance goals, the amount paid under an Incentive Bonus on

account of either financial performance or personal performance evaluations may, to the extent specified in the Award Agreement or

other document evidencing the Award, be adjusted by the Administrator on the basis of such further considerations as the

Administrator shall determine.

11. Deferral of Awards

The Administrator may, in an Award Agreement or otherwise, provide for the deferred delivery of Shares upon settlement, vesting or other

events with respect to Restricted Stock or Restricted Stock Units, or in payment or satisfaction of an Incentive Bonus. Notwithstanding

anything herein to the contrary, in no event will any deferral of the delivery of Shares or any other payment with respect to any Award be

allowed if the Administrator determines, in its sole and absolute discretion, that the deferral would result in the imposition of the additional

tax under Section 409A(a)(1)(B) of the Code. No award shall provide for deferral of compensation that does not comply with Section 409A

of the Code, unless the Board, at the time of grant, specifically provides that the Award is not intended to comply with Section 409A of the

Code. The Company shall have no liability to a Participant, or any other party, if an Award that is intended to be exempt from, or compliant

with, Section 409A of the Code is not so exempt or compliant or for any action taken by the Board.

12. Conditions and Restrictions Upon Securities Subject to Awards

The Administrator may provide that the Shares issued upon exercise of an Option or Stock Appreciation Right or otherwise subject to or

issued under an Award shall be subject to such further agreements, restrictions, conditions or limitations as the Administrator in its sole

and absolute discretion may specify prior to the exercise of such Option or Stock Appreciation Right or the grant, vesting or settlement of

such Award, including without limitation, conditions on vesting or transferability, forfeiture or repurchase provisions and method of payment

for the Shares issued upon exercise, vesting or settlement of such Award (including the actual or constructive surrender of Shares already

owned by the Participant) or payment of taxes arising in connection with an Award. Without limiting the foregoing, such restrictions may

address the timing and manner of any resales by the Participant or other subsequent transfers by the Participant of any Shares issued

under an Award, including without limitation (i) restrictions under an insider trading policy or pursuant to applicable law, (ii) restrictions

designed to delay and/ or coordinate the timing and manner of sales by Participant and holders of other Company equity compensation

arrangements, (iii) restrictions as to the use of a specified brokerage firm for such resales or other transfers and (iv) provisions requiring

Shares to be sold on the open market or to the Company in order to satisfy tax withholding or other obligations.

13. Adjustment of and Changes in the Stock

(a)General. The number and kind of Shares available for issuance under this Plan (including under any Awards then outstanding),

and the number and kind of Shares subject to the limits set forth in Section 5 of this Plan, shall be equitably adjusted by the

Administrator to reflect any reorganization, reclassification, combination of shares, stock split, reverse stock split, spin-off, dividend or

distribution of securities, property or cash (other than regular, quarterly cash dividends), or any other event or transaction that affects

the number or kind of Shares outstanding. Such adjustment shall be designed to comply with Sections 409A and 424 of the Code as

applicable, or, except as otherwise expressly provided in Section 5(c) of this Plan, may be designed to treat the Shares available

under the Plan and subject to Awards as if they were all outstanding on the record date for such event or transaction or to increase

the number of such Shares to reflect a deemed reinvestment in Shares of the amount distributed to the Company’s security holders.

The terms of any outstanding Award shall also be equitably adjusted by the Administrator as to price, number or kind of Shares

subject to such Award, vesting, and other terms to reflect the foregoing events, which adjustments need not be uniform as between

different Awards or different types of Awards.

In the event there shall be any other change in the number or kind of outstanding Shares, or any stock or other securities into which

such Shares shall have been changed, or for which it shall have been exchanged, by reason of a change of control, other merger,

consolidation or otherwise, then the Administrator shall determine the appropriate and equitable adjustment to be effected.

No right to purchase fractional shares shall result from any adjustment in Awards pursuant to this Section 13. In case of any such

adjustment, the Shares subject to the Award shall be rounded up to the nearest whole share for Awards other than Options and Stock

Appreciation Rights, and shall be rounded down to the nearest whole Share with respect to Options and Stock Appreciation Rights.

The Company shall notify Participants holding Awards subject to any adjustments pursuant to this Section 13 of such adjustment, but

(whether or not notice is given) such adjustment shall be effective and binding for all purposes of the Plan.

(b)Change in Control. The Administrator may determine the effect of a Change in Control on outstanding Awards in a manner that, in the

Administrator’s discretion, is fair and equitable to Participants. Such effects, which need not be the same for every Participant, may

include, without limitation: (x) the substitution for the Shares subject to any outstanding Award, or portion thereof, of stock or other

securities of the surviving corporation or any successor corporation to the Company, or a parent or subsidiary thereof, in which event

the aggregate purchase or exercise price, if any, of such Award, or portion thereof, shall remain the same, and/or (y) the conversion of

any outstanding Award, or portion thereof, into a right to receive cash or other property upon or following the consummation of the

Change in Control in an amount equal to the value of the consideration to be received by holders of Shares in connection with such

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A-8 United Therapeutics, a public benefit corporation

transaction for one Share, less the per share purchase or exercise price of such Award, if any, multiplied by the number of Shares

subject to such Award, or a portion thereof.

14. Qualifying Performance-Based Compensation

(a)General. The Administrator may establish performance criteria and level of achievement versus such criteria that shall determine the

number of Shares to be granted, retained, vested, issued or issuable under or in settlement of or the amount payable pursuant to an

Award, which criteria may be based on Qualifying Performance Criteria or other standards of financial performance and/or personal

performance evaluations.

(b)Qualifying Performance Criteria. For purposes of this Plan, the term “Qualifying Performance Criteria” shall mean any one or more of

the following performance criteria, or derivations of such performance criteria, either individually, alternatively or in any combination,

applied to either the Company as a whole or to a business unit or Subsidiary, either individually, alternatively or in any combination,

and measured either annually or cumulatively over a period of years, on an absolute basis or relative to a pre-established target, to

previous years’ results or to a designated comparison group, in each case as specified by the Administrator: (i) net earnings or

earnings per share (including earnings before interest, taxes, depreciation, license fees, share-based compensation, and/or

amortization, or other non-GAAP profitability measures), (ii) income, net income or operating income, (iii) revenues, (iv) net sales,

(v) return on sales, (vi) return on equity, (vii) return on capital (including return on total capital or return on invested capital), (viii) return

on assets or net assets, (ix) economic value added measurements, (x) return on invested capital, (xi) return on operating revenue,

(xii) cash flow (before or after dividends), (xiii) stock price, (xiv) total shareholder return, (xv) market capitalization, (xvi) economic

value added, (xvii) debt leverage (debt to capital), (xviii) operating profit or net operating profit, (xix) operating margin or profit margin,

(xx) cash from operations, (xxi) market share, (xxii) product development or release schedules, (xxiii) new product innovation,

(xxiv) cost reductions, (xxv) customer service, or (xxvi) customer satisfaction. The Administrator (A) shall appropriately adjust any

evaluation of performance under a Qualifying Performance Criterion to eliminate the effects of charges for restructurings, discontinued

operations, extraordinary items and all items of gain, loss or expense determined to be extraordinary or unusual in nature or related to

the disposal of a segment of a business or related to a change in accounting principle all as determined in accordance with applicable

accounting provisions, as well as the cumulative effect of accounting changes, in each case as determined in accordance with

generally accepted accounting principles or identified in the Company’s financial statements or notes to the financial statements, and

(B) may appropriately adjust any evaluation of performance under a Qualifying Performance Criterion to exclude any of the following

events that occurs during a performance period: (i) asset write-downs, (ii) litigation, claims, judgments or settlements, (iii) the effect of

changes in tax law or other such laws or provisions affecting reported results, and (iv) accruals of any amounts for payment under this

Plan or any other compensation arrangement maintained by the Company.

15. Transferability

Unless the Administrator determines otherwise, each Award may not be sold, transferred, pledged, assigned, or otherwise alienated or

hypothecated by a Participant other than by will or the laws of descent and distribution, and each Option or Stock Appreciation Right shall

be exercisable only by the Participant during their lifetime. To the extent permitted by the Administrator, the person to whom an Award is

initially granted (the “Grantee”) may transfer an Award to any “family member” of the Grantee (as such term is defined in Section 1(a)(5) of

the General Instructions to Form S-8 under the Securities Act of 1933, as amended (“Form S-8”)), to trusts solely for the benefit of such

family members and to partnerships in which such family members and/or trusts are the only partners; provided that, (i) as a condition

thereof, the transferor and the transferee must execute a written agreement containing such terms as specified by the Administrator, and

(ii) the transfer is pursuant to a gift or a domestic relations order to the extent permitted under the General Instructions to Form S-8. Except

to the extent specified otherwise in the agreement the Administrator provides for the Grantee and transferee to execute, all vesting,

exercisability and forfeiture provisions that are conditioned on the Grantee’s continued employment or service shall continue to be

determined with reference to the Grantee’s employment or service (and not to the status of the transferee) after any transfer of an Award

pursuant to this Section 15, and the responsibility to pay any taxes in connection with an Award shall remain with the Grantee

notwithstanding any transfer other than by will or intestate succession.

16. Suspension or Termination of Awards

Except as otherwise provided by the Administrator, if at any time (including after a notice of exercise has been delivered or an award has

vested) the Company’s chief executive officer or any other person designated by the Administrator (each such person, an “Authorized

Officer”) reasonably believes that a Participant may have committed an Act of Misconduct as described in this Section 16, the Authorized

Officer, Administrator or the Board may suspend the Participant’s rights to exercise any Option, to vest in an Award, and/or to receive

payment for or receive Shares in settlement of an Award pending a determination of whether an Act of Misconduct has been committed.

If the Administrator or an Authorized Officer determines a Participant has committed an act of embezzlement, fraud, dishonesty,

nonpayment of any obligation owed to the Company or any Subsidiary, breach of fiduciary duty, violation of Company ethics policy or code

of conduct, or deliberate disregard of the Company or Subsidiary rules resulting in loss, damage or injury to the Company or any

Subsidiary, or if a Participant makes an unauthorized disclosure of any Company or Subsidiary trade secret or confidential information,

solicits any employee or service provider to leave the employ or cease providing services to the Company or any Subsidiary, breaches any

intellectual property or assignment of inventions covenant, engages in any conduct constituting unfair competition, breaches any

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2024 Proxy Statement A-9

non-competition agreement, induces any Company or Subsidiary customer to breach a contract with the Company or any Subsidiary or to

cease doing business with the Company or any Subsidiary, or induces any principal for whom the Company or any Subsidiary acts as

agent to terminate such agency relationship (any of the foregoing acts, an “Act of Misconduct”), then except as otherwise provided by the

Administrator, (i) neither the Participant nor their estate nor transferee shall be entitled to exercise any Option or Stock Appreciation Right

whatsoever, vest in or have the restrictions on an Award lapse, or otherwise receive payment of an Award, (ii) the Participant will forfeit all

outstanding Awards and (iii) the Participant may be required, at the Administrator’s sole and absolute discretion, to return and/or repay to

the Company any then unvested Shares previously issued under the Plan. In making such determination, the Administrator or an

Authorized Officer shall give the Participant an opportunity to appear and present evidence on their behalf at a hearing before the

Administrator or its designee or an opportunity to submit written comments, documents, information and arguments to be considered by the

Administrator.

17. Compliance with Laws and Regulations

This Plan, the grant, issuance, vesting, exercise and settlement of Awards thereunder, and the obligation of the Company to sell, issue or

deliver Shares under such Awards, shall be subject to all applicable foreign, federal, state and local laws, rules and regulations, stock

exchange rules and regulations, and to such approvals by any governmental or regulatory agency as may be required. The Company shall

not be required to register in a Participant’s name or deliver any Shares prior to the completion of any registration or qualification of such

shares under any foreign, federal, state or local law or any ruling or regulation of any government body which the Administrator shall

determine to be necessary or advisable. To the extent the Company is unable to or the Administrator deems it infeasible to obtain authority

from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance

and sale of any Shares hereunder, the Company and its Subsidiaries shall be relieved of any liability with respect to the failure to issue or

sell such Shares as to which such requisite authority shall not have been obtained. No Option shall be exercisable and no Shares shall be

issued and/or transferable under any other Award unless a registration statement with respect to the Shares underlying such Option is

effective and current or the Company has determined that such registration is unnecessary.

In the event an Award is granted to or held by a Participant who is employed or providing services outside the United States, the

Administrator may, in its sole and absolute discretion, modify the provisions of the Plan or of such Award as they pertain to such individual

to comply with applicable foreign law or to recognize differences in local law, currency or tax policy. The Administrator may also impose

conditions on the grant, issuance, exercise, vesting, settlement or retention of Awards in order to comply with such foreign law and/or to

minimize the Company’s obligations with respect to tax equalization for Participants employed outside their home country.

18. Withholding

To the extent required by applicable federal, state, local or foreign law, a Participant shall be required to satisfy, in a manner satisfactory to

the Company, any withholding tax obligations that arise by reason of an Option exercise, disposition of Shares issued under an Incentive

Stock Option, the vesting of or settlement of an Award, an election pursuant to Section 83(b) of the Code or otherwise with respect to an

Award. To the extent a Participant makes an election under Section 83(b) of the Code, within ten days of filing such election with the

Internal Revenue Service, the Participant must notify the Company in writing of such election. The Company and its Subsidiaries shall not

be required to issue Shares, make any payment or to recognize the transfer or disposition of Shares until all such obligations are satisfied.

The Administrator may provide for or permit these obligations to be satisfied through the mandatory or elective sale of Shares and/or by

having the Company withhold a portion of the Shares that otherwise would be issued to him or her upon exercise of the Option or the

vesting or settlement of an Award, or by tendering Shares previously acquired.

19. Administration of the Plan

(a)Administrator of the Plan. The Plan shall be administered by the Administrator who shall be the Compensation Committee of the

Board or, in the absence of a Compensation Committee, the Board itself. Any power of the Administrator may also be exercised by

the Board, except to the extent that the grant or exercise of such authority would cause any Award or transaction to become subject to

(or lose an exemption under) the short-swing profit recovery provisions of Section 16 of the Act. To the extent that any permitted

action taken by the Board conflicts with action taken by the Administrator, the Board action shall control. The Compensation

Committee may by resolution authorize one or more officers of the Company to perform any or all things that the Administrator is

authorized and empowered to do or perform under the Plan, and for all purposes under this Plan, such officer or officers shall be

treated as the Administrator; provided, however, that no such officer shall designate himself or herself as a recipient of any Awards

granted under authority delegated to such officer. The Compensation Committee may delegate any or all aspects of the day-to-day

administration of the Plan to one or more officers or employees of the Company or any Subsidiary, and/or to one or more agents.

(b)Powers of Administrator. Subject to the express provisions of this Plan, the Administrator shall be authorized and empowered to do all

things that it determines to be necessary or appropriate in connection with the administration of this Plan, including, without limitation:

(i) to prescribe, amend and rescind rules and regulations relating to this Plan and to define terms not otherwise defined herein; (ii) to

determine which persons are Participants, to which of such Participants, if any, Awards shall be granted hereunder and the timing of

any such Awards; (iii) to grant Awards to Participants and determine the terms and conditions thereof, including the number of Shares

subject to Awards and the exercise or purchase price of such Shares and the circumstances under which Awards become exercisable

or vested or are forfeited or expire, which terms may but need not be conditioned upon the passage of time, continued employment,

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A-10 United Therapeutics, a public benefit corporation

the satisfaction of performance criteria, the occurrence of certain events (including a Change in Control), or other factors; (iv) to

establish and verify the extent of satisfaction of any performance goals or other conditions applicable to the grant, issuance,

exercisability, vesting and/or ability to retain any Award; (v) to prescribe and amend the terms of the agreements or other documents

evidencing Awards made under this Plan (which need not be identical) and the terms of or form of any document or notice required to

be delivered to the Company by Participants under this Plan; (vi) to determine the extent to which adjustments are required pursuant

to Section 13; (vii) to interpret and construe this Plan, any rules and regulations under this Plan and the terms and conditions of any

Award granted hereunder, and to make exceptions to any such provisions in if the Administrator, in good faith, determines that it is

necessary to do so in light of extraordinary circumstances and for the benefit of the Company (provided that nothing in this Section

19(b) permits the Administrator to provide that any Award may vest before the first anniversary of the date of grant other than in

connection with the Participant’s death or disability or a Change in Control or with respect to a stock-based Award granted to

Nonemployee Directors, which may become fully vested on the earlier to occur of (x) the first anniversary of the date of grant; or (y)

the date of the next Annual Meeting of Shareholders following the date of grant; provided, however, that any such stock-based Award

granted to a Nonemployee Director shall not vest earlier than 50 weeks following the date of grant; and, provided further, that up to

5% of the aggregate number of Shares authorized for issuance under this Plan may be issued pursuant to Awards subject to any, or

no, vesting conditions, as the Administrator deems appropriate); (viii) to approve corrections in the documentation or administration of

any Award; and (ix) to make all other determinations deemed necessary or advisable for the administration of this Plan. The

Administrator may, in its sole and absolute discretion, without amendment to the Plan, waive or amend the operation of Plan

provisions respecting exercise after termination of employment or service to the Company or an Affiliate and, except as otherwise

provided herein, adjust any of the terms of any Award (subject to the proviso in item (vii) of the immediately preceding sentence).

Except in connection with a corporate transaction involving the Company (including, without limitation, any stock dividend, distribution

(whether in the form of cash, Shares, other securities or other property), stock split, extraordinary cash dividend, recapitalization,

Change in Control, reorganization, merger, consolidation, split-up, spin-off, combination, repurchase or exchange of Shares or other

securities, or similar transaction(s)), the Company may not, without obtaining shareholder approval: (w) amend the terms of

outstanding Options or Stock Appreciation Rights to reduce the exercise price of such outstanding Options or Stock Appreciation

Rights; (x) cancel outstanding Options or Stock Appreciation Rights in exchange for Options or Stock Appreciation Rights with an

exercise price that is less than the exercise price of the original Options or Stock Appreciation Rights; (y) cancel outstanding Options

or Stock Appreciation Rights with an exercise price above the current stock price in exchange for cash or other securities; or (z)

otherwise amend, exchange or reprice Options or Stock Appreciation Rights.

(c)Determinations by the Administrator. All decisions, determinations and interpretations by the Administrator regarding the Plan, any

rules and regulations under the Plan and the terms and conditions of or operation of any Award granted hereunder, shall be final and

binding on all Participants, beneficiaries, heirs, assigns or other persons holding or claiming rights under the Plan or any Award. The

Administrator shall consider such factors as it deems relevant, in its sole and absolute discretion, to making such decisions,

determinations and interpretations including, without limitation, the recommendations or advice of any officer or other employee of the

Company and such attorneys, consultants and accountants as it may select.

(d)Subsidiary Awards. In the case of a grant of an Award to any Participant employed by a Subsidiary, such grant may, if the

Administrator so directs, be implemented by the Company issuing any subject Shares to the Subsidiary, for such lawful consideration

as the Administrator may determine, upon the condition or understanding that the Subsidiary will transfer the Shares to the Participant

in accordance with the terms of the Award specified by the Administrator pursuant to the provisions of the Plan. Notwithstanding any

other provision hereof, such Award may be issued by and in the name of the Subsidiary and shall be deemed granted on such date as

the Administrator shall determine.

(e)Indemnification of Administrator. Neither any member nor former member of the Administrator nor any individual to whom authority is

or has been delegated shall be personally responsible or liable for any act or omission in connection with the performance of powers

or duties or the exercise of discretion or judgment in the administration and implementation of the Plan. Each person who is or shall

have been a member of the Administrator shall be indemnified and held harmless by the Company from and against any cost, liability

or expense imposed or incurred in connection with such person’s or the Administrator’s taking or failing to take any action under the

Plan. Each such person shall be justified in relying on information furnished in connection with the Plan’s administration by any

employee, officer, agent or expert employed or retained by the Administrator or the Company.

20. Amendment of the Plan or Awards

The Board may amend, alter or discontinue this Plan and the Administrator may amend or alter any agreement or other document

evidencing an Award made under this Plan but, except as provided pursuant to the provisions of Section 13, no such amendment shall,

without the approval of the shareholders of the Company:

(a)increase the maximum number of Shares for which Awards may be granted under this Plan;

(b)reduce the price at which Options or Stock Appreciation Rights may be granted below the price provided for in Section 6(a);

(c)amend the last sentence of Section 19(b) (relating to direct and indirect repricings of outstanding Options and Stock

Appreciation Rights);

(d)amend the proviso in Section 19(b)(vii);

(e)extend the term of this Plan;

Annex  A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

2024 Proxy Statement A-11

(f)change the class of persons eligible to be Participants;

(g)otherwise amend the Plan in any manner requiring shareholder approval by law or under Nasdaq Global Select Market listing

requirements (or the listing requirements of any successor exchange or market that is the primary stock exchange or market for

trading of Shares); or

(h)increase the individual maximum limits in Sections 5(c) and (d).

No amendment or alteration to the Plan or an Award or Award Agreement shall be made which would impair the rights of the holder of

an Award, without such holder’s consent, provided that no such consent shall be required if the Administrator determines in its sole

and absolute discretion and prior to the date of any Change in Control that such amendment or alteration either is required or

advisable in order for the Company, the Plan or the Award to satisfy any law or regulation or to meet the requirements of or avoid

adverse financial accounting consequences under any accounting standard. In addition, the Plan may not be amended in any way

that causes the Plan to fail to comply with or be exempt from Section 409A of the Code, unless the Board expressly determines to

amend the Plan to be subject to Section 409A of the Code.

21. No Liability of Company

The Company and any Subsidiary or Affiliate which is in existence or hereafter comes into existence shall not be liable to a Participant or

any other person as to: (a) the non-issuance or sale of Shares as to which the Company has been unable to obtain from any regulatory

body having jurisdiction the authority deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares

hereunder; and (b) any tax consequence expected, but not realized, by any Participant or other person due to the receipt, exercise or

settlement of any Award granted hereunder.

22. Non-Exclusivity of Plan

Neither the adoption of this Plan by the Board nor the submission of this Plan to the shareholders of the Company for approval shall be

construed as creating any limitations on the power of the Board or the Administrator to adopt such other incentive arrangements as either

may deem desirable, including without limitation, the granting of restricted stock or stock options otherwise than under this Plan, and such

arrangements may be either generally applicable or applicable only in specific cases.

23. Governing Law

This Plan and any agreements or other documents hereunder shall be interpreted and construed in accordance with the laws of the

Delaware and applicable federal law. Any reference in this Plan or in the agreement or other document evidencing any Awards to a

provision of law or to a rule or regulation shall be deemed to include any successor law, rule or regulation of similar effect or applicability.

24. No Right to Employment, Reelection or Continued Service

Nothing in this Plan or an Award Agreement shall interfere with or limit in any way the right of the Company, its Subsidiaries and/ or its

Affiliates to terminate any Participant’s employment, service on the Board or service for the Company at any time or for any reason not

prohibited by law, nor shall this Plan or an Award itself confer upon any Participant any right to continue their employment or service for

any specified period of time. Neither an Award nor any benefits arising under this Plan shall constitute an employment contract with the

Company, any Subsidiary and/or its Affiliates. Subject to Sections 4 and 20, this Plan and the benefits hereunder may be terminated at any

time in the sole and exclusive discretion of the Board without giving rise to any liability on the part of the Company, its Subsidiaries and/or

its Affiliates.

25. Unfunded Plan

The Plan is intended to be an unfunded plan. Participants are and shall at all times be general creditors of the Company with respect to

their Awards. If the Administrator or the Company chooses to set aside funds in a trust or otherwise for the payment of Awards under the

Plan, such funds shall at all times be subject to the claims of the creditors of the Company in the event of its bankruptcy or insolvency.

Annex A - United Therapeutics Corporation Amended and Restated 2015 Stock Incentive Plan

A-12 United Therapeutics, a public benefit corporation

ANNEX B - NON-GAAP FINANCIAL

INFORMATION

This Proxy Statement contains a financial measure, EBITDASO, that does not comply with United States generally accepted accounting

principles (GAAP) (see the 2023 Performance in Review and 2023 Compensation Decisions section above). EBITDASO is defined as

net income, adjusted for: (1) interest expense, net; (2) income tax expense; (3) depreciation and amortization expense; and (4) share-

based compensation expense (including expenses relating to stock options, restricted stock units, share tracking awards, and our

employee stock purchase plan). EBITDASO is divided by total revenues to derive EBITDASO margin. A reconciliation of net income to

EBITDASO is presented below:

(In millions, except percentages)	Year Ended December 31, 2023
Net income, as reported	$984.8
Adjusted for the following:
Interest income, net	(103.4)
Income tax expense	289.5
Depreciation & amortization expense	53.2
Share-based compensation expense	39.1
EBITDASO (Non-GAAP)	$1,263.2
Total revenues	$2,327.5
Net income margin	42.3%
EBITDASO margin	54.3%

Our Compensation Committee evaluates our EBITDASO margin compared to our compensation peer group, for purposes of evaluating the

rigor of our cash profit margin performance target and to determine whether achievement of this goal has led to top quintile profitability. We

believe disclosing EBITDASO margin for our company and our compensation peers helps shareholders understand our Compensation

Committee’s process in setting our cash profit margin performance target. However, there are limitations in the use of this non-GAAP

financial measure in that it excludes certain operating expenses that are recurring in nature. The presentation of this non-GAAP financial

measure should not be considered in isolation or as a substitute for our financial results prepared in accordance with GAAP.

2024 Proxy Statement B-1

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