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Share-Based Compensation - Benefit recognized (Details) - USD ($)
$ in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Share based compensation (benefit) expense recognized in connection with the STAP        
Total share-based compensation expense before tax $ 65.5 $ 29.1 $ 44.4 $ 69.2
STAP awards        
Share based compensation (benefit) expense recognized in connection with the STAP        
Total share-based compensation expense before tax 52.1 16.4 18.7 42.1
Related income tax benefit (10.5) (2.6) (3.9) (7.5)
Share-based compensation expense, net of taxes 41.6 13.8 14.8 34.6
Cash payments on awards exercised during the period     25.7 42.2
Cost of product sales | STAP awards        
Share based compensation (benefit) expense recognized in connection with the STAP        
Total share-based compensation expense before tax 1.9 0.8 0.7 1.9
Research and development | STAP awards        
Share based compensation (benefit) expense recognized in connection with the STAP        
Total share-based compensation expense before tax 11.5 2.3 5.5 6.6
Selling, general, and administrative | STAP awards        
Share based compensation (benefit) expense recognized in connection with the STAP        
Total share-based compensation expense before tax $ 38.7 $ 13.3 $ 12.5 $ 33.6