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Segment Information
6 Months Ended
Jun. 30, 2022
Segment Reporting [Abstract]  
Segment Information Segment InformationWe operate as one operating segment with a focus on the development and commercialization of products to address the unmet needs of patients with chronic and life-threatening conditions. Our Chief Executive Officer, as our chief operating decision maker, manages and allocates resources to the operations of our company on a consolidated basis. This enables our Chief Executive Officer to assess our overall level of available resources and determine how best to deploy these resources across functions, therapeutic areas, and research and development projects in line with our long-term company-wide strategic goals.
Net product sales, cost of product sales, and gross profit for each of our commercial products were as follows (in millions):
Three Months Ended June 30,
2022
Tyvaso(1)
Remodulin(2)
OrenitramUnituxinAdcircaTotal
Net product sales$201.0 $132.0 $79.0 $44.5 $10.4 $466.9 
Cost of product sales6.5 8.6 6.4 3.5 4.7 29.7 
Gross profit$194.5 $123.4 $72.6 $41.0 $5.7 $437.2 
2021
Net product sales$153.8 $139.8 $76.2 $53.1 $23.6 $446.5 
Cost of product sales9.7 8.4 3.8 5.0 10.3 37.2 
Gross profit$144.1 $131.4 $72.4 $48.1 $13.3 $409.3 
Six Months Ended June 30,
2022
Tyvaso(1)
Remodulin(2)
OrenitramUnituxinAdcircaTotal
Net product sales$373.0 $263.7 $161.8 $100.1 $20.2 $918.8 
Cost of product sales12.7 15.8 11.6 6.8 8.7 55.6 
Gross profit$360.3 $247.9 $150.2 $93.3 $11.5 $863.2 
2021
Net product sales$276.8 $270.0 $148.6 $97.0 $33.2 $825.6 
Cost of product sales12.8 16.6 7.9 8.6 14.3 60.2 
Gross profit$264.0 $253.4 $140.7 $88.4 $18.9 $765.4 
(1) Net product sales and cost of product sales include both the drug product and the respective inhalation devices for both Tyvaso and Tyvaso DPI.
(2) Net product sales and cost of product sales include sales of infusion devices, such as the Remunity Pump.
Geographic revenues are determined based on the country in which our customers (distributors) are located. Total revenues from external customers by geographic area are as follows (in millions):
Three Months Ended June 30,Six Months Ended June 30,
 2022202120222021
United States$440.4 $411.7 $850.2 $766.0 
Rest of World(1)
26.5 34.8 78.6 59.6 
Total(1)
$466.9 $446.5 $928.8 $825.6 
(1) Includes other revenue of $10.0 million for the six months ended June 30, 2022, reflecting an up-front payment from an international distributor.
We recorded revenue from three distributors in the United States that exceeded ten percent of total revenues. Revenue from these three distributors as a percentage of total revenues is as follows:
Three Months Ended June 30,Six Months Ended June 30,
 2022202120222021
Distributor 151 %48 %49 %50 %
Distributor 231 %29 %30 %27 %
Distributor 3%11 %10 %11 %