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Commitments and Contingencies - Milestone Payments and Royalty Obligations (Details) - USD ($)
$ in Thousands
12 Months Ended 73 Months Ended
Jan. 24, 2019
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Net product sales   $ 1,685,500 $ 1,483,300 $ 1,448,800  
Adcirca          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Net product sales   55,900 67,300 107,200  
Unituxin          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Net product sales   $ 202,300 $ 122,900 $ 113,700  
Lilly | Adcirca | Forecast          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Royalty as a percentage of net sales         10.00%
Royalty expenses         $ 325
Net product sales         $ 1,000
The Scripps Research Institute | Unituxin          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Royalty as a percentage of net sales   1.00%      
MannKind Corporation | Tyvaso DPI          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Maximum potential milestone payment to be made   $ 50,000      
Arena | Marketing approval in the United States          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Milestone payment to be made upon marketing approval $ 250,000        
Arena | Marketing approval in any of Japan, France, Italy, the United Kingdom, Spain or Germany          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Milestone payment to be made upon marketing approval $ 150,000        
Arena | Ralinepag | Marketing approval in the United States          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Milestone payment to be made upon marketing approval   250,000      
Arena | Ralinepag | Marketing approval in any of Japan, France, Italy, the United Kingdom, Spain or Germany          
Collaborative Arrangements and Non-collaborative Arrangement Transactions          
Milestone payment to be made upon marketing approval   $ 150,000