Share-Based Compensation - Share-Based Compensation Expense (Benefit) (Details) - USD ($) $ in Millions	12 Months Ended
Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Share-based compensation expense
Share-based compensation expense before taxes	$ 138.5	$ 163.8	$ 45.4
Stock options
Share-based compensation expense
Share-based compensation expense before taxes	25.4	44.0	70.5
Related income tax benefit	(0.8)	(3.1)	(16.0)
Share-based compensation expense (benefit), net of taxes	24.6	40.9	54.5
Unrecognized compensation cost	$ 25.7
Weighted average remaining vesting period (in years)	1 year 2 months 12 days
Cost of product sales \| Stock options
Share-based compensation expense
Share-based compensation expense before taxes	$ 0.1	0.5	0.8
Research and development \| Stock options
Share-based compensation expense
Share-based compensation expense before taxes	0.5	2.0	3.7
Selling, general, and administrative \| Stock options
Share-based compensation expense
Share-based compensation expense before taxes	$ 24.8	$ 41.5	$ 66.0

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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