CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Millions, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Revenues:
Total revenues	$ 446.5	$ 362.0	$ 825.6	$ 718.3
Revenue from contract with customer, product and service	Net product sales	Net product sales	Net product sales	Net product sales
Operating expenses:
Cost of product sales	$ 37.2	$ 25.9	$ 60.2	$ 49.3
Cost, product and service	Net product sales	Net product sales	Net product sales	Net product sales
Research and development	$ 74.3	$ 89.7	$ 378.0	$ 162.9
Selling, general, and administrative	112.8	105.9	230.0	198.9
Total operating expenses	224.3	221.5	668.2	411.1
Operating income	222.2	140.5	157.4	307.2
Interest income	4.0	7.2	8.7	17.2
Interest expense	(4.7)	(5.6)	(9.3)	(13.8)
Other (expense) income, net	(2.7)	(8.2)	94.5	0.5
Impairments of investments in privately-held companies	(2.3)	0.0	(2.3)	(5.6)
Total other (expense) income, net	(5.7)	(6.6)	91.6	(1.7)
Income before income taxes	216.5	133.9	249.0	305.5
Income tax expense	(43.9)	(26.8)	(48.1)	(60.7)
Net income	$ 172.6	$ 107.1	$ 200.9	$ 244.8
Net income per common share:
Basic (in dollars per share)	$ 3.85	$ 2.43	$ 4.49	$ 5.56
Diluted (in dollars per share)	$ 3.65	$ 2.41	$ 4.28	$ 5.53
Weighted average number of common shares outstanding:
Basic (in shares)	44.8	44.1	44.7	44.0
Diluted (in shares)	47.3	44.4	46.9	44.3
Net product sales
Revenues:
Total revenues	$ 446.5	$ 362.0	$ 825.6	$ 718.3