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Assignment and License Agreements (Details) - USD ($)
$ / shares in Units, $ in Millions
1 Months Ended 12 Months Ended
Jul. 31, 2011
Nov. 30, 2008
Dec. 31, 2007
Dec. 31, 1997
Dec. 31, 2015
Dec. 31, 2014
Assignment and License Agreements            
Common stock issued (in shares)         68,987,919 65,988,561
GlaxoSmithKline PLC (Glaxo)            
Assignment and License Agreements            
Minimum term of royalty payment       10 years    
Eli Lilly and Company            
Assignment and License Agreements            
Royalty as a percentage of net sales   5.00%        
Toray            
Assignment and License Agreements            
Common stock issued (in shares)     200,000      
Common stock issued shares split     400,000      
Price per share (in dollars per share)     $ 27.21      
Notice period     30 days      
Non-refundable payments to be made under the license $ 50.0          
Term of installment payments under license 5 years