Summary of Significant Accounting Policies (Details 2) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended	12 Months Ended
	Sep. 30, 2015	Sep. 30, 2015	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Goodwill and other intangible assets
Goodwill, Gross			$ 10,264	$ 10,264
Goodwill, Net			10,264	10,264
Other intangible assets, Accumulated			(9,519)	(8,432)
Other intangible assets, Net			2,614
Total intangible assets, Gross			37,897	37,897
Total intangible assets, Net			28,378	29,465
Aggregate amortization expense relating to intangible assets			1,100	1,400	$ 2,600
Amortization relating to other intangible assets
2016			621
2017			456
2018			125
2019			125
2020			125
Thereafter			1,162
Other intangible assets, Net			2,614
Proceeds from sale of Rare Pediatric Priority Review Voucher	$ 350,000	$ 350,000	350,000
Technology, patents and trade names
Goodwill and other intangible assets
Other intangible assets, Gross			6,494	6,494
Other intangible assets, Accumulated			(4,691)	(4,100)
Other intangible assets, Net			1,803	2,394
Amortization relating to other intangible assets
Other intangible assets, Net			1,803	2,394
In-process, research and development
Goodwill and other intangible assets
Other intangible assets, Gross			15,500	15,500
Other intangible assets, Net			15,500	15,500
Amortization relating to other intangible assets
Other intangible assets, Net			15,500	15,500
Customer relationships and non-compete agreements
Goodwill and other intangible assets
Other intangible assets, Gross			4,369	4,369
Other intangible assets, Accumulated			(3,558)	(3,062)
Other intangible assets, Net			811	1,307
Amortization relating to other intangible assets
Other intangible assets, Net			811	1,307
Contract-based
Goodwill and other intangible assets
Other intangible assets, Gross			1,270	1,270
Other intangible assets, Accumulated			$ (1,270)	$ (1,270)