Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Net product sales	$ 1,460,570	$ 1,279,533	$ 1,106,944
Other	5,191	8,986	10,040
Total revenues	1,465,761	1,288,519	1,116,984
Operating expenses:
Research and development	245,098	242,549	299,348
Selling, general and administrative	452,612	381,287	394,010
Cost of product sales	69,036	125,883	131,127
Total operating expenses	766,746	749,719	824,485
Operating income	699,015	538,800	292,499
Other (expense) income:
Interest expense	(4,735)	(17,592)	(18,058)
Gain on sale of intangible asset	350,000
Other, net	157	3,972	4,462
Total other income (expense), net	345,422	(13,620)	(13,596)
Income before income taxes	1,044,437	525,180	278,903
Income tax expense	(392,798)	(185,106)	(104,343)
Net income	$ 651,639	$ 340,074	$ 174,560
Net income (loss) per common share:
Basic (in dollars per share)	$ 14.17	$ 7.06	$ 3.49
Diluted (in dollars per share)	$ 12.72	$ 6.28	$ 3.28
Weighted average number of common shares outstanding:
Basic (in shares)	46,000	48,176	50,076
Diluted (in shares)	51,221	54,155	53,231