Share Tracking Award Plans (Tables) - Share tracking award plans (STAP)

12 Months Ended

Dec. 31, 2015

Awards granted under the STAP

Schedule of assumptions to estimate the fair value of STAP awards

	As of December 31,
	2015			2014			2013
Expected volatility		35.3	%		34.0	%		32.7	%
Risk-free interest rate		1.4	%		1.3	%		1.1	%
Expected term of awards (in years)		3.4			4.0			3.9
Expected forfeiture rate		8.8	%		9.3	%		10.1	%
Expected dividend yield		0.0	%		0.0	%		0.0	%

Summary of activity and status of STAP awards

	Number of Awards			Weighted- Average Exercise Price		Weighted Average Remaining Contractual Term (Years)		Aggregate Intrinsic Value (in 000s)
Outstanding at January 1, 2015		7,716,424		$	62.59
Granted		1,655,388			159.68
Exercised		(2,281,711	)		56.71
Forfeited		(244,938	)		95.37
Outstanding at December 31, 2015		6,845,163		$	86.86		7.3	$	487,010
Exercisable at December 31, 2015		2,115,571		$	67.79		6.1	$	188,683
Expected to vest at December 31, 2015		4,306,092		$	95.34		7.9	$	271,767

Schedule of share-based compensation expense (benefit) recognized in connection with the STAP

        Share-based compensation expense recognized in connection with the STAP is as follows (in thousands):

	Year Ended December 31,
	2015			2014			2013
Research and development	$	87,372		$	72,269		$	134,355
Selling, general and administrative		178,100			82,937			143,407
Cost of product sales		8,706			4,283			6,124
Share-based compensation expense before taxes		274,178			159,489			283,886
Related income tax benefit		(103,431	)		(56,560	)		(106,693	)
Share-based compensation expense, net of taxes	$	170,747		$	102,929		$	177,193
Share-based compensation capitalized as part of inventory	$	7,063		$	2,027		$	1,593