Share Tracking Award Plans (Details 2) (USD $)	3 Months Ended	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2013 Share tracking award plans (STAP)	Dec. 31, 2012 Share tracking award plans (STAP)	Dec. 31, 2011 Share tracking award plans (STAP)	Dec. 31, 2013 Research and development Share tracking award plans (STAP)	Dec. 31, 2012 Research and development Share tracking award plans (STAP)	Dec. 31, 2011 Research and development Share tracking award plans (STAP)	Dec. 31, 2013 Selling, general and administrative Share tracking award plans (STAP)	Dec. 31, 2012 Selling, general and administrative Share tracking award plans (STAP)	Dec. 31, 2011 Selling, general and administrative Share tracking award plans (STAP)	Dec. 31, 2013 Cost of product sales Share tracking award plans (STAP)	Dec. 31, 2012 Cost of product sales Share tracking award plans (STAP)	Dec. 31, 2011 Cost of product sales Share tracking award plans (STAP)
Share-based compensation (benefit) expense recognized in connection with the STAP
Share-based compensation expense (benefit) before taxes		$ 283,886,000	$ 26,850,000	$ (16,387,000)	$ 134,355,000	$ 11,130,000	$ (8,190,000)	$ 143,407,000	$ 14,490,000	$ (8,023,000)	$ 6,124,000	$ 1,230,000	$ (174,000)
Related income tax (benefit) expense		(106,693,000)	(9,902,000)	6,058,000
Share-based compensation expense (benefit), net of taxes	111,200,000	177,193,000	16,948,000	(10,329,000)
Share-based compensation capitalized as part of inventory		1,593,000	275,000	(203,000)
Cash payments on awards exercised during the period		$ 55,900,000	$ 31,800,000	$ 28,700,000