Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenues:
Net product sales	$ 1,106,944	$ 906,123	$ 741,094
Other	10,040	9,953	2,089
Total revenues	1,116,984	916,076	743,183
Operating expenses:
Research and development	299,348	173,387	180,015
Selling, general and administrative	394,010	201,746	156,482
Cost of product sales	131,127	119,297	88,904
Total operating expenses	824,485	494,430	425,401
Operating income	292,499	421,646	317,782
Other (expense) income:
Interest income	3,827	3,941	3,450
Interest expense	(18,058)	(16,639)	(21,367)
Other, net	635	31,723	(748)
Total other (expense) income, net	(13,596)	19,025	(18,665)
Income from continuing operations before income taxes	278,903	440,671	299,117
Income tax expense	(104,343)	(136,229)	(81,874)
Income from continuing operations	174,560	304,442	217,243
Discontinued operations
Income from discontinued operations, net of tax			7
Gain on disposal of discontinued operations, net of tax			618
Income from discontinued operations			625
Net income	$ 174,560	$ 304,442	$ 217,868
Basic
Continuing operations (in dollars per share)	$ 3.49	$ 5.84	$ 3.80
Discontinued operations (in dollars per share)	$ 0.00	$ 0.00	$ 0.01
Net income per basic common share (in dollars per share)	$ 3.49	$ 5.84	$ 3.81
Diluted
Continuing operations (in dollars per share)	$ 3.28	$ 5.71	$ 3.66
Discontinued operations (in dollars per share)	$ 0.00	$ 0.00	$ 0.01
Net income per diluted common share (in dollars per share)	$ 3.28	$ 5.71	$ 3.67
Weighted average number of common shares outstanding:
Basic (in shares)	50,076	52,093	57,163
Diluted (in shares)	53,231	53,280	59,395