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Share Tracking Award Plans (Tables) (Share tracking award plans (STAP))
 12 Months Ended
Dec. 31, 2013
Share tracking award plans (STAP)
  
Awards granted under the STAP  
Schedule of assumptions to estimate the fair value of STAP awards
  As of December 31, 2013  
 
   2013   2012   2011  

Expected volatility

     32.7 %   32.8 %   38.0 %

Risk-free interest rate

     1.1 %   0.5 %   0.5 %

Expected term of awards (in years)

     3.9     3.7     3.9  

Expected forfeiture rate

     10.1 %   8.7 %   7.0 %

Expected dividend yield

     0.0 %   0.0 %   0.0 %
Summary of activity and status of STAP awards

  Number of
Awards		   Weighted-
Average
Exercise
Price		   Weighted
Average
Remaining
Contractual
Term
(Years)		   Aggregate
Intrinsic
Value
(in 000s)		  

Outstanding at January 1, 2013

     7,962,375   $ 49.00              

Granted

     3,372,994     57.55              

Exercised

     (2,049,136 )   43.55              

Forfeited

     (551,332 )   62.16              
                       
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Outstanding at December 31, 2013

     8,734,901   $ 52.75     7.7   $ 526,976  
                   
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
                   

Exercisable at December 31, 2013

     3,277,377   $ 47.50     6.2   $ 214,929  
                   
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
                   

Expected to vest at December 31, 2013

     4,895,737   $ 55.95     8.5   $ 279,704  
                   
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
                   
Schedule of share-based compensation expense (benefit) recognized in connection with the STAP

Share-based compensation expense (benefit) recognized in connection with the STAP is as follows (in thousands):

 
   Year Ended December 31,  
 
   2013   2012   2011  

Research and development

   $ 134,355   $ 11,130   $ (8,190 )

Selling, general and administrative

     143,407     14,490     (8,023 )

Cost of product sales

     6,124     1,230     (174 )
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Share-based compensation expense (benefit) before taxes

     283,886     26,850     (16,387 )

Related income tax (benefit) expense

     (106,693 )   (9,902 )   6,058  
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Share-based compensation expense (benefit), net of taxes

   $ 177,193   $ 16,948   $ (10,329 )
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
               

Share-based compensation capitalized as part of inventory

   $ 1,593   $ 275   $ (203 )
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​