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Stockholders' Equity (Details 3) (USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Share-based compensation expense related to outstanding awards      
Share-based compensation expense (benefit) $ 30,115,000 $ (15,715,000) $ 113,942,000
Stock Options
     
Share-based compensation expense related to outstanding awards      
Share-based compensation expense before taxes 3,024,000 511,000 22,352,000
Related income tax benefit (1,115,000) (189,000) (8,226,000)
Share-based compensation expense (benefit), net of taxes 1,909,000 322,000 14,126,000
Share-based compensation capitalized as part of inventory   15,000 290,000
Term of employee stock purchase plan 10 years    
Maximum number of shares authorized to be issued Aggregate number of shares authorized to be issued 29,900,000    
Employee Stock Purchase Plan (ESPP)
     
Share-based compensation expense related to outstanding awards      
Offering period 6 months    
Maximum percentage of compensation employees may contribute for purchase of common stock under the ESPP 15.00%    
Percentage of the lower of the fair market value of common stock on the first or last trading-day of a given offering period 85.00%    
Maximum number of shares of common stock each eligible employees may purchase in any given offering period 4,000    
Term of employee stock purchase plan 20 years    
Maximum number of shares authorized to be issued Aggregate number of shares authorized to be issued 3,000,000    
Share-based compensation expense (benefit) 240,100    
Research and development | Stock Options
     
Share-based compensation expense related to outstanding awards      
Share-based compensation expense before taxes   196,000 3,087,000
Selling, general and administrative | Stock Options
     
Share-based compensation expense related to outstanding awards      
Share-based compensation expense before taxes $ 3,024,000 $ 315,000 $ 19,265,000