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Stock Based Compensation (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2022
Mar. 31, 2022
Jun. 30, 2021
Mar. 31, 2021
Jun. 30, 2022
Jun. 30, 2021
Share-based Compensation [Abstract]            
Vesting period         4 years  
Stock-based compensation expense         $ 1,590 $ 1,853
Payment of withholding taxes on shares issued upon conversion of RSUs         29 196
General and Administrative Expense [Member]            
Share-based Compensation [Abstract]            
Stock-based compensation expense $ 487   $ 463   953 846
Research and Development Expense [Member]            
Share-based Compensation [Abstract]            
Stock-based compensation expense $ 325   $ 511   $ 637 $ 1,007
Stock Options [Member]            
Share-based Compensation [Abstract]            
Term of award 10 years   10 years   10 years 10 years
Options granted (in shares) 801,004   779,500   801,004 779,500
Options granted, weighted average grant date fair value (in dollars per share) $ 1.18   $ 3.45   $ 1.18 $ 3.45
Dividend yield         0.00% 0.00%
Volatility         86.00% 91.00%
Risk-free rate         3.00% 1.00%
Expected option term         6 years 6 years
Unrecognized stock-based compensation expense expected to be recognized related to unvested stock options $ 5,242       $ 5,242  
Weighted average amortization period         3 years 7 days  
Common stock issued upon exercise of options (in shares) 0   0   0 0
Number of stock options returned to plan upon expiration (in shares) 255,000   255,000   390,000 390,000
Restricted Stock Units (RSUs) [Member]            
Share-based Compensation [Abstract]            
RSUs granted (in shares) 258,363 0 236,661 0    
RSUs granted, weighted average fair values (in dollars per share) $ 1.46   $ 4.61      
Payment of withholding taxes on shares issued upon conversion of RSUs $ 29   $ 196      
Unrecognized stock-based compensation expense expected to be recognized related to unvested RSUs $ 1,988       $ 1,988  
Weighted average amortization period         2 years 11 months 4 days  
Common stock issued upon vesting RSUs (in shares) 191,795 0 174,285 0    
2013 Plan [Member]            
Share-based Compensation [Abstract]            
Shares available for grant (in shares) 1,435,929       1,435,929  
2013 Plan [Member] | Stock Options [Member]            
Share-based Compensation [Abstract]            
Vesting period         4 years  
Term of award         10 years  
2013 Plan [Member] | Incentive Stock Options [Member] | Minimum [Member]            
Share-based Compensation [Abstract]            
Exercise price of option granted as percentage of fair market value of shares at date of grant         100.00%  
2013 Plan [Member] | Incentive Stock Options [Member] | Named Executive Officers [Member] | Minimum [Member]            
Share-based Compensation [Abstract]            
Exercise price of option granted as percentage of fair market value of shares at date of grant         100.00%  
2013 Plan [Member] | Incentive Stock Options [Member] | 10% Shareholder [Member] | Minimum [Member]            
Share-based Compensation [Abstract]            
Exercise price of option granted as percentage of fair market value of shares at date of grant         110.00%  
2013 Plan [Member] | Nonqualified Stock Options [Member] | Minimum [Member]            
Share-based Compensation [Abstract]            
Exercise price of option granted as percentage of fair market value of shares at date of grant         85.00%  
2013 Plan [Member] | Nonqualified Stock Options [Member] | Named Executive Officers [Member] | Minimum [Member]            
Share-based Compensation [Abstract]            
Exercise price of option granted as percentage of fair market value of shares at date of grant         100.00%  
2013 Plan [Member] | Restricted Stock Units (RSUs) [Member]            
Share-based Compensation [Abstract]            
Vesting period         4 years