CONDENSED CONSOLIDATED BALANCE SHEETS (USD $) In Thousands, unless otherwise specified	Mar. 31, 2014	Dec. 31, 2013
Current assets:
Cash and cash equivalents	$ 125,275	$ 143,510
Short-term investments	245,648	321,615
Accounts receivable, net of allowances of $209 and $89 at March 31, 2014 and December 31, 2013	3	199
Receivables from collaborative arrangements (including amounts from a related party of $775 and $2,247 at March 31, 2014 and December 31, 2013)	865	3,181
Prepaid expenses and other current assets	6,391	4,287
Inventories	11,014	10,406
Total current assets	389,196	483,198
Marketable securities	59,831	55,374
Restricted cash	833	833
Property and equipment, net	9,734	10,238
Intangible assets, net	137,477	124,257
Other assets	7,963	7,355
Total assets	605,034	681,255
Current liabilities:
Accounts payable	5,546	7,583
Payable to a related party	0	40,000
Accrued personnel-related expenses	13,829	10,881
Accrued clinical and development expenses	9,890	9,714
Accrued interest on convertible subordinated notes	1,273	2,800
Other accrued liabilities	4,792	4,137
Deferred revenue, current	8,814	9,289
Total current liabilities	44,144	84,404
Convertible subordinated notes	287,500	287,500
Deferred rent	4,891	4,774
Deferred revenue	5,247	5,455
Commitments and contingencies (Notes 3, 8 and 10)
Stockholders' equity:
Common stock, $0.01 par value; authorized: 200,000 shares; outstanding: 112,519 and 111,516 at March 31, 2014 and December 31, 2013	1,125	1,115
Additional paid-in capital	1,834,862	1,803,048
Accumulated other comprehensive income	171	162
Accumulated deficit	(1,572,906)	(1,505,203)
Total stockholders' equity	263,252	299,122
Total liabilities and stockholders' equity	$ 605,034	$ 681,255