CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands	6 Months Ended
Jun. 30, 2011	Jun. 30, 2010
Cash flows from operating activities
Net loss	$ (47,712)	$ (43,341)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	3,407	3,137
Stock-based compensation	11,134	9,820
Forgiveness of notes receivable	1	4
Changes in operating assets and liabilities:
Receivables	(53)	(159)
Prepaid expenses and other current assets	1,717	1,364
Accounts payable	813	(283)
Accrued personnel-related expenses, accrued clinical and development expenses, accrued interest on convertible subordinated notes and other current liabilities	(3,488)	(1,571)
Deferred rent	1,932	931
Deferred revenue	(11,401)	(10,400)
Other liabilities, non-current		(389)
Net cash used in operating activities	(43,650)	(40,887)
Cash flows from investing activities
Purchases of property and equipment	(2,763)	(133)
Purchases of marketable securities	(176,322)	(103,861)
Sales of marketable securities	8,750
Maturities of marketable securities	119,476	70,000
Release of restricted cash		417
Additions to notes receivable	(140)
Payments received on notes receivable	530	110
Net cash used in investing activities	(50,469)	(33,467)
Cash flows from financing activities
Payments on note payable and capital lease	(113)	(89)
Proceeds from issuances of common stock, net	21,557	96,620
Net cash provided by financing activities	21,444	96,531
Net increase (decrease) in cash and cash equivalents	(72,675)	22,177
Cash and cash equivalents at beginning of period	163,333	47,544
Cash and cash equivalents at end of period	$ 90,658	$ 69,721

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Includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the Entity may deposit additional funds at any time and also effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Compensating balance arrangements that do not legally restrict the withdrawal or usage of cash amounts may be reported as Cash and Cash Equivalents, while legally restricted deposits held as compensating balances against borrowing arrangements, contracts entered into with others, or company statements of intention with regard to particular deposits are not generally reported as cash and cash equivalents. Includes cash and cash equivalents associated with the entity's continuing operations. Excludes cash and cash equivalents associated with the disposal group (and discontinued operation).