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Stock-Based Compensation (Details 2) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Stock-based compensation      
Stock-based compensation expense $ 6,873 $ 27,390 $ 25,687
Total unrecognized compensation cost related to unvested stock-based compensation 11,258    
Stock options      
Stock-based compensation      
Stock-based compensation expense 789 4,658 4,132
Total unrecognized compensation cost related to unvested stock-based compensation $ 1,531    
Weighted-average remaining service period of recognition of unrecognized compensation cost 2 years 4 months 24 days    
RSUs      
Stock-based compensation      
Stock-based compensation expense $ 2,492 4,564 10,174
Total unrecognized compensation cost related to unvested stock-based compensation $ 1,446    
Weighted-average remaining service period of recognition of unrecognized compensation cost 1 year 1 month 6 days    
RSUs | Performance-contingent      
Stock-based compensation      
Stock-based compensation expense $ 0 3 61
RSAs      
Stock-based compensation      
Stock-based compensation expense 2,850 7,575 9,723
Total unrecognized compensation cost related to unvested stock-based compensation $ 8,275    
Weighted-average remaining service period of recognition of unrecognized compensation cost 3 years 1 month 6 days    
RSAs | Performance-contingent      
Stock-based compensation      
Stock-based compensation expense $ 613 10,580 1,061
Total unrecognized compensation cost related to unvested stock-based compensation $ 6    
Weighted-average remaining service period of recognition of unrecognized compensation cost 2 years 1 month 6 days    
Employee Stock Purchase Plan      
Stock-based compensation      
Stock-based compensation expense $ 129 10 536
Continuing operations      
Stock-based compensation      
Stock-based compensation expense 6,873 15,761 7,898
Discontinued operation      
Stock-based compensation      
Stock-based compensation expense 0 11,629 17,789
Research and development | Continuing operations      
Stock-based compensation      
Stock-based compensation expense 1,036 2,781 573
General and administrative | Continuing operations      
Stock-based compensation      
Stock-based compensation expense $ 5,837 $ 12,980 $ 7,325